|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver angiogenesis as a risk factor for hepatocellularcarcinoma development in hepatitis C virus cirrhotic patients显示文摘AIM: To evaluate the predictive value of hepatocyte proliferation and hepatic angiogenesis for the occurrence of Hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) cirrhotic patients. METHODS: One hundred-five patients (69 males, 36 females; age range, 51-90 year; median 66 year) with biopsy proven HCV cirrhosis were prospectively monitored for HCC occurrence for a median time of 64 mo. Angiogenesis was assessed by using microvessel density (MVD), hepatocyte turnover by MIB1 and PCNA indexes at inclusion in liver biopsies. RESULTS: Forty six patients (43.8%) developed HCC after a median time of 55 (6-120) mo while 59 (56.2%) did not. Patients were divided into two groups according to the median value of each index. The difference between patients with low (median MVD = 3; range 0-20) and high (median MVD = 7; range 1-24) MVD was statistically significant (χ2 = 22.06; P < 0.0001) which was not the case for MIB1 or PCNA (MIB-1: χ2 = 1.41; P = 0.2351; PCNA: χ2 = 1.27; P = 0.2589). The median MVD was higher in patients who developed HCC than in those who did not. HCC-free interval was significantly longer in patients with the MVD ≤ 4 (P = 0.0006). No relationship was found between MIB1 or PCNA and MVD (MIB-1 r2 = 0.00007116, P = 0.9281; PCNA: r2 =0.001950; P = 0.6692). MVD only was able to predict the occurrence of HCC in these patients. Among other known risk factors for HCC, only male sex was statistically associated with an increased risk. CONCLUSION: Liver angiogenesis has a role for in HCV- related liver carcinogenesis and for defining patients at higher risk. | Roberto Mazzanti Luca Messerini Camilla E Comin Lorenzo Fedeli Nathalie Gannè-Carrie Michel Beaugrand | 2007 | World Journal of Gastroenterology2007，13，37： | 3 |
| 2 | Lymph Node Recovery from Colorectal Tumor Specimens:Recommendation for a Minimum Number of Lymph Nodes to be Examined显示文摘 | Fabio Cianchi Annarita Palomba Vieri Boddi Luca Messerini Filippo Pucciani Giuliano Perigli Paolo Bechi Camillo Cortesini | 2002 | World Journal of Surgery2002，，3： | 2 |
| 3 | Primary signet-ring cell carcinoma of the colon and rectum显示文摘 | Dr. Luca Messerini M.D. Annarita Palomba M.D. Giancarlo Zampi M.D | 1995 | Diseases of the Colon & Rectum1995，，11： | 1 |
| 4 | Lymph Node Recovery from Colorectal Tumor Specimens:Recommendation for a Minimum Number of Lymph Nodes to be Examined显示文摘 | Fabio Cianchi Annarita Palomba Vieri Boddi Luca Messerini Filippo Pucciani Giuliano Perigli Paolo Bechi Camillo Cortesini | 2002 | World Journal of Surgery2002，，： | 1 |
| 5 | Incidence and prognostic significance of occult tumor cells in lymph nodes from patients with stage IIA colorectal carcinoma显示文摘 | Luca Messerini Fabio Cianchi Camillo Cortesini Camilla E. Comin | 2006 | Human Pathology2006，，10： | 1 |
| 6 | Adequacy of Lymphadenectomy in Laparoscopic Colorectal Cancer Surgery: A Single-centre, Retrospective Study显示文摘 | Fabio Cianchi Camillo Cortesini Giacomo Trallori Luca Messerini Luca Novelli Camilla Eva Comin Etleva Qirici Andrea Bonanomi Giuseppe Macrì Benedetta Badii Aurora Kokomani Giuliano Perigli | 2012 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2012，，1： | 1 |
| 7 | Character of the invasive margin in colorectal cancer显示文摘 | Fabio Cianchi Luca Messerini Annarita Palomba Vieri Boddi Giuliano Perigli Filippo Pucciani Paolo Bechi Camillo Cortesini | 1997 | Diseases of the Colon & Rectum1997，，10： | 1 |
| 8 | Gastric and duodenal polyps in familial adenomatous polyposis patients: Conventional endoscopy vs virtual chromoendoscopy(fujinon intelligent color enhancement) in dysplasia evaluation显示文摘AIM To test the fujinon intelligent color enhancement(FICE) in identifying dysplastic or adenomatous polyps in familial adenomatous polyposis(FAP) patients.METHODS Seventy-six consecutive FAP patients, already treated by colectomy and members of sixty-five families, were enrolled. A FICE system for the upper gastro-intestinal tract with an electronic endoscope system and a standard duodenoscope(for side-viewing examination) were used by two expert examiners. Endoscopic resection was performed with diathermic loop for polyps ≥ 6 mm and with forceps for polyps < 6 mm. Formalin-fixed biopsy specimens were analyzed by two expert gastrointestinal pathologists blinded to size, location and number of FAPassociated fundic gland polyps.RESULTS Sixty-nine(90.8%) patients had gastric polyps(34 only in the corpus-fundus, 7 only in the antrum and 28 in the whole stomach) and 52(68.4%) in duodenum(7 in the bulb, 35 in second/third duodenal portion, 10 both in the bulb and the second portion of duodenum). In the stomach fundus after FICE evaluation, 10 more polyps were removed from 10 patients for suspicious features of dysplasia or adenomas, but they were classified as cystic fundic gland after histology. In the antrum FICE identified more polyps than traditional endoscopy, showing a better tendency to identify adenomas and displastic areas. In the duodenum FICE added a significant advantage in identifying adenomas in the bulb and identified more polyps in the Ⅱ/Ⅲ portion.CONCLUSION FICE significantly increases adenoma detection rate in FAP patients but does not change any Spigelman stage and thus does not modify patient's prognosis and treatment strategies. | Gabriele Lami Andrea Galli Giuseppe Macrì Emanuele Dabizzi Maria Rosa Biagini Mirko Tarocchi Luca Messerini Rosa Valanzano Stefano Milani Simone Polvani | 2017 | World Journal of Clinical Oncology2017，8，2： | 1 |
| 9 | Anatomic plane of separation between external anal sphincter and puborectalis muscle显示文摘 | Dr. Claudio Fucini M.D. Claudio Elbetti M.D. Luca Messerini M.D | 1999 | Diseases of the Colon & Rectum1999，，3： | 1 |
| 10 | Primary signet-ring cell carcinoma of the colon and rectum显示文摘 | Dr. Luca Messerini M.D. Annarita Palomba M.D. Giancarlo Zampi M.D | 1995 | Diseases of the Colon & Rectum1995，，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员