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| 1 | Robot-assisted laparoscopic vs open gastrectomy for gastric cancer:Systematic review and meta-analysis显示文摘AIM To evaluate the potential effectiveness of robot-assisted gastrectomy(RAG) in comparison to open gastrectomy(OG) for gastric cancer patients.METHODS A comprehensive systematic literature search using PubM ed,EMBASE,and the Cochrane Library was carried out to identify studies comparing RAG and OG in gastric cancer.Participants of any age and sex were considered for inclusion in comparative studies of the two techniques independently from type of gastrectomy.A meta-analysis of short-term perioperative outcomes was performed to evaluate whether RAG is equivalent to OG.The primary outcome measures were set for estimated blood loss,operative time,conversion rate,morbidity,and hospital stay.Secondary among postoperative complications,wound infection,bleeding and anastomotic leakage were also analysed.RESULTS A total of 6 articles,5 retrospective and 1 randomized controlled study,involving 6123 patients overall,with 689(11.3%) cases submitted to RAG and 5434(88.7%) to OG,satisfied the eligibility criteria and were included in the meta-analysis.RAG was associated with longer operation time than OG(weighted mean difference 72.20 min;P < 0.001),but with reduction in blood loss and shorter hospital stay(weighted mean difference-166.83 mL and-1.97 d respectively;P < 0.001).No differences were found with respect to overall postoperative complications(P = 0.65),wound infection(P = 0.35),bleeding(P = 0.65),and anastomotic leakage(P = 0.06).The postoperative mortality rates were similar between the two groups.With respect to oncological outcomes,no statistical differences among the number of harvested lymph nodes were found(weighted mean difference-1.12;P = 0.10).CONCLUSION RAG seems to be a technically valid alternative to OG for performing radical gastrectomy in gastric cancer resulting in safe complications. | Stefano Caruso Alberto Patriti Franco Roviello Lorenzo De Franco Franco Franceschini Graziano Ceccarelli Andrea Coratti | 2017 | World Journal of Clinical Oncology2017，8，3： | 23 |
| 2 | Laparoscopic and robot-assisted gastrectomy for gastric cancer: Current considerations显示文摘Radical gastrectomy with an adequate lymph-adenectomy is the main procedure which makes it possible to cure patients with resectable gastric cancer(GC). A number of randomized controlled trials and meta-analysis provide phase Ⅲ evidence that laparoscopic gastrectomy is technically safe and that it yields better short-term outcomes than conventional open gastrectomy for early-stage GC. While laparoscopic gastrectomy has become standard therapy for early-stage GC, especially in Asian countries such as Japan and South Korea, the use of minimally invasive techniques is still controversial for the treatment of more advanced tumours, principally due to existing concerns about its oncological adequacy and capacity to carry out an adequately extended lymphadenectomy. Some intrinsic drawbacks of the conventional laparoscopic technique have prevented the worldwide spread of laparoscopic gastrectomyfor cancer and, despite technological advances in recent year, it remains a technically challenging procedure. The introduction of robotic surgery over the last ten years has implied a notable mutation of certain minimally invasive procedures, making it possible to overcome some limitations of the traditional laparoscopic technique. Robot-assisted gastric resection with D2 lymph node dissection has been shown to be safe and feasible in prospective and retrospective studies. However, to date there are no high quality comparative studies investigating the advantages of a robotic approach to GC over traditional laparoscopic and open gastrectomy. On the basis of the literature review here presented, robot-assisted surgery seems to fulfill oncologic criteria for D2 dissection and has a comparable oncologic outcome to traditional laparoscopic and open procedure. Robot-assisted gastrectomy was associated with the trend toward a shorter hospital stay with a comparable morbidity of conventional laparoscopic and open gastrectomy, but randomized clinical trials and longer follow-ups are needed to evaluate the possible influence of robot gastrectomy on GC patient survival. | Stefano Caruso Alberto Patriti Franco Roviello Lorenzo De Franco Franco Franceschini Andrea Coratti Graziano Ceccarelli | 2016 | World Journal of Gastroenterology2016，22，25： | 23 |
| 3 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 4 | 氯菊酯和溴氰菊酯对大鼠血清及脑甲状腺激素水平的影响显示文摘目的探讨拟除虫菊酯对大鼠甲状腺激素(TH)水平的影响。方法经口连续15d给予大鼠氯菊酯(PM)100、200、400mg·kg-1·d-1和溴氰菊酯(DM)6.25、12.50、25.00mg·kg-1·d-1。用放射免疫分析法检测大鼠血清、脑组织及其亚细胞结构中的TH水平。结果(1)PM:200、400mg·kg-1·d-1组大鼠血清三碘甲腺原氨酸(T3)、四碘甲腺原氨酸(T4)、游离T3(fT3)、游离T4(fT4)均下降,而促甲状腺激素(TSH)上升,且现PM呈现剂量依赖关系(T4:r=0.679,fT4:r=0.511,TSH:r=0.738,均P<0.01);100mg·kg-1·d-1组大鼠T4和fT4下降,T3、fT3、TSH无明显变化。3个处理组大鼠大脑皮层T4分别为(39.9±5.0)、(33.4±9.2)、(32.3±8.2)pg/mgpro,明显低于对照[(44.2±7.1)g/mgpro],且有剂量依赖性(r=0.529,P<0.01);而PM染毒400mg·kg-1·d-1组的T3[(21.2±5.2)pg/mgpro比对照[(30.9±10.0)pg/mgpro]明显降低。200、400mg·kg-1·d-1组大鼠海马T4为(19.1±5.5)、(19.2±6.5)pg/mgpro。 | 王素青 石年 纪之莹 Graziano Pinna | 2002 | 中华劳动卫生职业病杂志2002，20，3： | 9 |
| 5 | Management of adults with coarctation of aorta显示文摘Coarctation of the aorta(CoA)is a relatively common congenital cardiac defect often causing few symptoms and therefore can be challenging to diagnose.The hallmark finding on physical examination is upper extremity hypertension,and for this reason,CoA should be considered in any young hypertensive patient,justifying measurement of lower extremity blood pressure at least once in these individuals.The presence of a significant pressure gradient between the arms and legs is highly suggestive of the diagnosis.Early diagnosis and treatment are important as long-term data consistently demonstrate that patients with CoA have a reduced life expectancy and increased risk of cardiovascular complications.Surgical repair has traditionally been the mainstay of therapy for correction,although advances in endovascular technology with covered stents or stent grafts permit nonsurgical approaches for the management of older children and adults with native CoA and complications.Persistent hypertension and vascular dysfunction can lead to an increased risk of coronary disease,which,remains the greatest cause of long-term mortality.Thus,blood pressure control and periodic reassessment with transthoracic echocardiography and threedimensional imaging(computed tomography or cardiac magnetic resonance)for should be performed regularly as cardiovascular complications may occur decades after the intervention. | Pradyumna Agasthi Sai Harika Pujari Andrew Tseng Joseph N Graziano Francois Marcotte David Majdalany Farouk Mookadam Donald J Hagler Reza Arsanjani | 2020 | World Journal of Cardiology2020，12，5： | 8 |
| 6 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 7 | Structural health monitoring of asphalt pavements using smart sensor networks: A comprehensive review显示文摘Early, effective and continuous monitoring allows to reduce costs and to extend life of road infrastructure. For this reason, over the years, more and more efforts have been made to implement more advanced and effective monitoring systems at ever more contained costs,going from impractical manual and destructive methods through automated in vehicle equipment to the most recent wireless sensor network(WSN) embedded into the pavement. The purpose of this paper is to provide a comprehensive, up-to-date critical literature review of wireless sensor networks for pavement health monitoring, considering, also,the experience gained for wired sensor as fundamental point of reference. This work presents both the methodology used to collect and analyse the current bibliography and provides a description and comments fundamental characteristics of wireless sensor networks for pavement monitoring for damage detection purposes, among which energy supply, the detection method, the hardware and network architecture and the performance validation procedures. A brief analysis of other possible complementary applications of smart sensor networks, such as traffic and surface condition monitoring, is provided. Finally, a comment is provided on the gaps and possible directions that future research could follow to allow the extensive use of wireless sensor networks for pavement health condition monitoring. | Alessandro Di Graziano Vincenzo Marchetta Salvatore Cafiso | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，5： | 6 |
| 8 | In-vehicle stereo vision system for identification of traffic conflicts between bus and pedestrian显示文摘The traffic conflict technique(TCT) was developed as 'surrogate measure of road safety' to identify near-crash events by using measures of the spatial and temporal proximity of road users.Traditionally applications of TCT focus on a specific site by the way of manually or automated supervision.Nowadays the development of in-vehicle(IV) technologies provides new opportunities for monitoring driver behavior and interaction with other road users directly into the traffic stream.In the paper a stereo vision and GPS system for traffic conflict investigation is presented for detecting conflicts between vehicle and pedestrian.The system is able to acquire geo-referenced sequences of stereo frames that are used to provide real time information related to conflict occurrence and severity.As case study,an urban bus was equipped with a prototype of the system and a trial in the city of Catania(Italy) was carried out analyzing conflicts with pedestrian crossing in front of the bus.Experimental results pointed out the potentialities of the system for collection of data that can be used to get suitable traffic conflict measures.Specifically,a risk index of the conflict between pedestrians and vehicles is proposed to classify collision probability and severity using data collected by the system.This information may be used to develop in-vehicle warning systems and urban network risk assessment. | Salvatore Caofiso Alessandro Di Graziano Giuseppina Pappalarelo | 2017 | Journal of Traffic and Transportation Engineering(English Edition)2017，4，1： | 5 |
| 9 | Atherosclerosis: from biology to pharmacological treatment显示文摘在心血管的风险的数量的最近的爆炸横扫地球。主要预防是比较喜欢的方法降低心血管的风险。降低肥胖的流行是最迫切的事,并且自从它影响血压,类脂化合物侧面,葡萄糖新陈代谢,发炎,和 atherothrombotic 疾病前进,是多种的。给当前的障碍,主要预防的成功仍然保持不明确。同时,延期和迟钝的后果将不可避免地是灾难性的,并且紧急的感觉增长。病理学、流行病学的数据证实那动脉粥样硬化在早童年开始,并且在整个生活无缝地并且无情地进展。在童年的风险因素类似于在在生活的阶段之间的成年人,和轨道的那些。当显示,好攻击的处理应该在最早的指示开始,并且被继续许多年时。为在中间的风险的那些病人,根据全球风险分数, C 反应的蛋白质,冠的动脉钙,和颈动脉, intima 媒介厚度为进一步的层化是可得到的。为主要预防使用 statins 被指南推荐,是流行的,但是留下在下面规定。Statin 药是无与伦比的,降低心血管的风险的基于证据的、主要武器。甚至当低密度脂蛋白胆固醇目标被达到时,继续在病人的一半上有疾病前进和临床的事件。尽管临床的证据高是,改变或涨血不完全的,密度脂蛋白胆固醇水平继续追求。这评论的目的是关于他们的致病和治疗指出脆弱的匾的关键方面的注意。 | Graziano Riccioni Valeriana Sblendorio | 2012 | Journal of Geriatric Cardiology2012，9，3： | 5 |
| 10 | Robot-assisted laparoscopic gastrectomy for gastric cancer显示文摘Phase Ⅲ evidence in the shape of a series of randomized controlled trials and meta-analyses has shown that laparoscopic gastrectomy is safe and gives better short-term results with respect to the traditional open technique for early-stage gastric cancer. In fact, in the East laparoscopic gastrectomy has become routine for early-stage gastric cancer. In contrast, the treatment of advanced gastric cancer through a minimally invasive way is still a debated issue, mostly due to worries about its oncological efficacy and the difficulty of carrying out an extended lymphadenectomy and intestinal reconstruction after total gastrectomy laparoscopically. Over the last ten years the introduction of robotic surgery has implied overcoming some intrinsic drawbacks found to be present in the conventional laparoscopic procedure. Robotassisted gastrectomy with D2 lymphadenectomy has been shown to be safe and feasible for the treatment of gastric cancer patients. But unfortunately, most available studies investigating the robotic gastrectomy for gastric cancer compared to laparoscopic and open technique are so far retrospective and there have not been phase Ⅲ trials. In the present review we looked at scientific evidence available today regarding the new high-tech surgical robotic approach, and we attempted to bring to light the real advantages of robot-assisted gastrectomy compared to the traditional laparoscopic and open technique for the treatment of gastric cancer. | Stefano Caruso Franco Franceschini Alberto Patriti Franco Roviello Mario Annecchiarico Graziano Ceccarelli Andrea Coratti | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，1： | 4 |
| 11 | B-Lynch suture, intrauterine balloon, and endouterine hemostatic suture for the management of postpartum hemorrhage due to placenta previa accreta显示文摘 | Maurizio Arduini Giorgio Epicoco Graziano Clerici Elvira Bottaccioli Saverio Arena Giuseppe Affronti | 2009 | International Journal of Gynecology and Obstetrics2009，，3： | 3 |
| 12 | An integrated approach to investigate climate-driven rockfall occurrence in high alpine slopes: the Bessanese glacial basin, Western Italian Alps显示文摘Rockfalls are one of the most common instability processes in high mountains.They represent a relevant issue,both for the risks they represent for(infra)structures and frequentation,and for their potential role as terrestrial indicators of climate change.This study aims to contribute to the growing topic of the relationship between climate change and slope instability at the basin scale.The selected study area is the Bessanese glacial basin(Western Italian Alps)which,since 2016,has been specifically equipped,monitored and investigated for this purpose.In order to provide a broader context for the interpretation of the recent rockfall events and associated climate conditions,a cross-temporal and integrated approach has been adopted.For this purpose,geomorphological investigations(last 100 years),local climate(last 30 years)and near-surface rock/air temperatures analyses,have been carried out.First research outcomes show that rockfalls occurred in two different geomorphological positions:on rock slopes in permafrost condition,facing from NW to NE and/or along the glacier margins,on rock slopes uncovered by the ice in the last decades.Seasonal thaw of the active layer and/or glacier debutressing can be deemed responsible for slope failure preparation.With regard to timing,almost all dated rock falls occurred in summer.For the July events,initiation may have been caused by a combination of rapid snow melt and enhanced seasonal thaw of the active layer due to anomalous high temperatures,and rainfall.August events are,instead,associated with a significant positive temperature anomaly on the quarterly scale,and they can be ascribed to the rapid and/or in depth thaw of the permafrost active layer.According to our findings,we can expect that in the Bessanese glacierized basin,as in similar high mountain areas,climate change will cause an increase of slope instability in the future.To fasten knowledge deepening,we highlight the need for a growth of a network of high elevation experimental sites at the basin scale,and the definition of shared methodological and measurement standards,that would allow a more rapid and effective comparison of data. | VIANI Cristina CHIARLE Marta PARANUNZIO Roberta MERLONE Andrea MUSACCHIO Chiara COPPA Graziano NIGRELLI Guido | 2020 | Journal of Mountain Science2020，17，11： | 3 |
| 13 | Full Robotic Gastrectomy with Extended (D2) Lymphadenectomy for Gastric Cancer: Surgical Technique and Preliminary Results显示文摘 | Annibale D’Annibale Vito Pende Graziano Pernazza Igor Monsellato Paolo Mazzocchi Giorgio Lucandri Emilio Morpurgo Tania Contardo Gianna Sovernigo | 2011 | Journal of Surgical Research2011，，2： | 2 |
| 14 | Statin Treatment Is Associated with Reduction in Serum Levels of Receptor Activator of NF- κ B Ligand and Neutrophil Activation in Patients with Severe Carotid Stenosis显示文摘 | Sébastien Lenglet Alessandra Quercioli Mathias Fabre Katia Galan Graziano Pelli Alessio Nencioni Inga Bauer Aldo Pende Magaly Python Maria Bertolotto Giovanni Spinella Bianca Pane Domenico Palombo Franco Dallegri Fran?ois Mach Nicolas Vuilleumier Fabrizio | 2014 | Mediators of Inflammation2014，，： | 2 |
| 15 | Cellular actions of nociceptin: transduction mechanisms显示文摘 | Hawes BE Graziano MP Lambert DG | 2000 | Piptides2000，21，7： | 2 |
| 16 | Neurogenesis in the neocortex of adult primates显示文摘 | Gould E Reeves AJ Graziano MS | 1999 | Science1999，286，： | 2 |
| 17 | A role for proteins S3 and S14 in the 30S ribosomal subunit 显示文摘 | RAMAKRISHNAN V GRAZIANO V CAPEL M S | 1986 | J Biol Chem1986，261，15： | 1 |
| 18 | Pharma- cogenetic profiling' in patients with advanced color- ectal cancer treated with first-line FOLFOX-4 chem- otherapy显示文摘 | Ruzzo A Graziano F Loupakis F | 2007 | J ClinOncol2007，25，10： | 1 |
| 19 | A comparative study of fixation techniches for type Ⅱ fractures of the odontoid process 显示文摘 | GRAZIANO G JAGGERS C LEE M | 1993 | Spine1993，18，： | 1 |
| 20 | Functional hemispherectomy in children with epilepsy and CSWS due to unilateral early brain injury including thalamus: Sudden recovery of CSWS显示文摘 | D. Battaglia P. Veggiotti D. Lettori G. Tamburrini T. Tartaglione A. Graziano C. Veredice A. Sacco D. Chieffo A. Pecoraro C. Colosimo C. Di Rocco Ch. Dravet F. Guzzetta | 2009 | Epilepsy Research2009，，2： | 1 |
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