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| 1 | Immune-mediated bile duct injury:The case of primary biliary cirrhosis显示文摘Autoimmune cholangitis would be the appropriate name to define the immune-mediated bile duct injury following the breakdown of tolerance to mitochondrial proteins and the appearance of serum autoantibodies and autoreactive T cells.Nevertheless,the conditionis universally named primary biliary cirrhosis(PBC).The disease etiology and pathogenesis remain largely unknown despite the proposed lines of evidence.One twin study and numerous epidemiology reportssuggest that both a susceptible genetic background and environmental factors determine disease onsetwhile a recent genome-wide association study proposed highly significant associations with several commongenetic polymorphisms in subgroups of patients.Specific infectious agents and chemicals may contribute to the disease onset and perpetuation in a geneticallysusceptible host,possibly through molecular mimicry.Importantly,several murine models have been proposed and include strains in which PBC is genetically determined or induced by immunization with chemicals and bacteria.From a pathogenetic standpoint,new exciting data have demonstrated the unique apoptotic features of bile duct cells that allow the mitochondrial autoantigens to be taken up in their intact form within apoptotic blebs.We are convinced that the application of the most recent molecular techniques will soon pro-vide developments in PBC etiology and pathogenesis with likely implications in diagnostics and therapeutics. | Carlo Selmi Andrea Affronti Laura Ferrari Pietro Invernizzi | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，4： | 6 |
| 2 | B-Lynch suture, intrauterine balloon, and endouterine hemostatic suture for the management of postpartum hemorrhage due to placenta previa accreta显示文摘 | Maurizio Arduini Giorgio Epicoco Graziano Clerici Elvira Bottaccioli Saverio Arena Giuseppe Affronti | 2009 | International Journal of Gynecology and Obstetrics2009，，3： | 3 |
| 3 | B-Lynch suture, intrauterine balloon, and endouterine hemostatic suture for the management of postpartum hemorrhage due to placenta previa accreta显示文摘 | Maurizio Arduini Giorgio Epicoco Graziano Clerici Elvira Bottaccioli Saverio Arena Giuseppe Affronti | 2009 | International Journal of Gynecology and Obstetrics2009，，3： | 1 |
| 4 | Chronic Pancreatitis and Exocrine Insufficiency显示文摘 | John Affronti | 2011 | Primary Care: Clinics in Office Practice2011，，3： | 1 |
| 5 | Pancreas divisum, an evidence-based review: part I, pathophysiology显示文摘 | Steven D. Klein John P. Affronti | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 6 | HLA Bw15 and tuberculosis in a North American black population 显示文摘 | AL-Arif LL Goldstein RA Affronti LF and Janicki BW | 1979 | Am Rev Respir Dis1979，120，8： | 1 |
| 7 | Placenta Previa Percreta: A Case Report of Successful Management via Conservative Surgery显示文摘 | Silvia Canonico Maurizio Arduini Giorgio Epicoco Giuseppe Luzi Saverio Arena Graziano Clerici Giuseppe Affronti Y. Ezra A. Kofinas M. G. Porpora | 2013 | Case Reports in Obstetrics and Gynecology2013，，： | 1 |
| 8 | HLA-Bwt5 and tuberculosis in a North American black population 显示文摘 | Al-Arif LI Goldstein RA Affronti LF | 1979 | Am Rev Respir Dis1979，120，6： | 1 |
| 9 | Pancreas divisum, an evidence- based review:part I显示文摘 | SKLEIN J AFFRONTI | 2004 | Gastrointestinal Endoscopy2004，60，： | 1 |
| 10 | Low-grade fever: how to distin- guish organic from non-organic forms 显示文摘 | Affronti M Mansueto P Soresi M | 2010 | Int J Clin Pract2010，64，3： | 1 |
| 11 | Palonosetron in the management of chemo- therapy-induced nausea and vomiting in patients receiving multiple- day chemotherapy 显示文摘 | Affronti ML Bubalo J | 2014 | Cancer Manag Res2014，5，6： | 1 |
| 12 | Palonosetron in the managementof chemotherapy-induced nausea and vomiting in patientsreceiving multiple-day chemotherapy 显示文摘 | Affronti ML Bubalo J | 2014 | Cancer ManagRes2014，6，6： | 1 |
| 13 | Low-grade fever:how to distinguish organic from non-organic forms显示文摘 | Affronti M Mansueto P Soresi M | 2010 | Int J Clin Pract2010，64，3： | 1 |
| 14 | HLA-Bw15 and tuberculosis in a North American black population显示文摘 | AL-Arif LL Goldstein RA Affronti LF | 1979 | Am Rev Respir Dis1979，120，8： | 1 |
| 15 | HLA-Bw15 and tuberculosis in a North American black population显示文摘 | A1-Arif LI Goldstein RA Affronti LF | | 0，，06： | 1 |
| 16 | A case of bowel schitosomiasis not adhering to endoscopic findings显示文摘Schistosomiasis is a chronic worm infection caused by a species of trematodes, the Schistosomes. We may distinguish a urinary form from Schistosomes haematobium and an intestinal-hepatosplenic form mainly from Schistosomes mansonicharacterized by nausea, meteorism, abdominal pain, bloody diarrhea,rectal tenesmus, and hepatosplenomegaly. These infections represent a major health issue in Africa,Asia, and South America, but recently S mansoni has increased its prevalence in other countries, such as Europe countries and USA, due to international travelers and immigrants, with several diagnostic and prevention problems. We report a case of a 24-yearold patient without HIV infection, originated from Ghana, admitted for an afebrile dysenteric syndrome.All microbiologic studies were negative and colonoscopy revealed macroscopic lesions suggestive of a bowel inflammatory chronic disease. Since symptoms became worse, a therapy with mesalazine (2 g/d) was started,depending on the results of a bowel biopsy, but without any resolution. The therapy was stopped after 2 wk when the following result was available: a diagnosis of'intestinal schistosomiasis' was done (two Schistosoma eggs were detected in the colonic mucosa) and this was confirmed by the detection of Schistosoma eggs in the feces. Therapy was therefore changed to praziquantel(40 mg/kg, single dose), a specific anti-parasitic agent,with complete recovery. Schistosomiasis shows some peculiar difficulties in terms of differential diagnosis from the bowel inflammatory chronic disease, as the two disorders may show similar colonoscopic patterns.Since this infection has recently increased its prevalence worldwide, it was considered in the differential diagnosis of our patient with gastrointestinal symptoms. | Manfredi Rizzo Pasquale Mansueto Daniela Cabibi Elisetta Barresi Kaspar Berneis Mario Affronti Gabriele Di Lorenzo Sergio Vigneri Giovam Battista Rini | 2005 | World Journal of Gastroenterology2005，11，44： | 0 |
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