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| 1 | Matrix metalloproteinase-9:A deleterious link between hepatic ischemia-reperfusion and colorectal cancer显示文摘Despite the advent of improved surgical techniques and the development of cytotoxic chemotherapeutic agents useful for the treatment of colorectal cancer,the primary clinical challenge remains that of preventing and combating metastatic spread.Surgical resection is the best treatment for colorectal metastases isolated to the liver.However,in rodent models,the hepatic ischemia-reperfusion(I/R) applied during the surgery accelerates the outgrowth of implanted tumors.Among the adverse effects of I/R on cellular function,several studies have demonstrated an over expression of the matrix metalloproteinase-9(MMP-9) in the ischemic liver.Since several studies showed high local levels of expression and activity of this proteolytic enzyme in the primary colorectal adenocarcinoma,the role of MMP-9 might be considered as a potential common mediator,favoring both growth of local tumor and the dissemination of colorectal carcinoma metastases. | Sébastien Lenglet Franois Mach Fabrizio Montecucco | 2012 | World Journal of Gastroenterology2012，18，48： | 6 |
| 2 | Platinum distribution inintraperitoneal tumors afterintraperitoneal cisplatin treatment显示文摘 | Gerrit Los Peter H. A. Mutsaers Willem J. M. Lenglet Glenn S. Baldew J. Gordon McVie | 1990 | Cancer Chemotherapy and Pharmacology1990，，6： | 2 |
| 3 | Statin Treatment Is Associated with Reduction in Serum Levels of Receptor Activator of NF- κ B Ligand and Neutrophil Activation in Patients with Severe Carotid Stenosis显示文摘 | Sébastien Lenglet Alessandra Quercioli Mathias Fabre Katia Galan Graziano Pelli Alessio Nencioni Inga Bauer Aldo Pende Magaly Python Maria Bertolotto Giovanni Spinella Bianca Pane Domenico Palombo Franco Dallegri Fran?ois Mach Nicolas Vuilleumier Fabrizio | 2014 | Mediators of Inflammation2014，，： | 2 |
| 4 | CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion显示文摘 | Montecucco F Lenglet S Braunersreuther V | 2009 | J Mol Cell Cardiol2009，46，5： | 1 |
| 5 | Statistics on the manifold of multivariate normal distributions:Theory and application to diffusion tensor MRI processing显示文摘 | LENGLET M and ROUSSON R | 2006 | Journal of Mathematical Imaging and Vision2006，25，3： | 1 |
| 6 | Role of CCL- 2, CCR -2 and CCR -4 in cer- ulein- induced acute pancreatitis and pancreatitis -asst:i- ated lung injm7 显示文摘 | Jean Louis Frossard Se'bastien Lenglet Fabrizio Montecuc- co | 2011 | Clin Pathol2011，64，： | 1 |
| 7 | DTI segmentation by statistical surface evolution 显示文摘 | Lenglet C Rousson M Deriche R | 2006 | IEEE Transactions on Medical Ima- ging2006，25，6： | 1 |
| 8 | Pulmonary epithelioidhaemangioendothelioma : reports of three cases and a review ofthe literature 显示文摘 | Leleu O Lenglet F Clarot C | 2010 | Rev Mai Respir2010，27，77： | 1 |
| 9 | Single administration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reperfusion injury in mice显示文摘 | Montecucco F Lenglet S Braunersreuther V | 2010 | Arterioscler Thromb Vasc Biol2010，30，7： | 1 |
| 10 | CC che- mokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in miee显示文摘 | Montecucco F Braunersreuther V Lenglet S | 2012 | Ear Heart J2012，33，15： | 1 |
| 11 | Pulnonary epithelioid haemangioendothelioma:reports of three cases and a review of the literature显示文摘 | Leleu O Lenglet F Clarot C | | 0，，： | 1 |
| 12 | Role of Matrix Metalloproteinase-8 in Atherosclerosis显示文摘 | Sébastien Lenglet Fran?ois Mach Fabrizio Montecucco Jane Stubbe | 2013 | Mediators of Inflammation2013，，： | 1 |
| 13 | Recombinant tissue plasminogen activator enhances microglial cell recruitment after stroke in mice显示文摘 | Lenglet S Monteeucco F Denes A | 2014 | J Cereb Blood Flow Metab2014，34，5： | 1 |
| 14 | CB2 cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion显示文摘 | MONTECUCCO F LENGLET S BRAUNERSREUTHER V | 2009 | J Mol Cell Cardiol2009，46，5： | 1 |
| 15 | Nifedipine trials: effectiveness and safety aspects 显示文摘 | Van Geijn HP Lenglet JE Bohe AC | 2005 | Br J Obstet Gynecol2005，112，1： | 1 |
| 16 | Use of nicotinamide to treat hyperphosphatemia in dialysis patients显示文摘 | Lenglet A Liabeuf S Guffroy P | 2013 | Drugs R D2013，13，3： | 1 |
| 17 | Single ad- ministration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reper-fusion injury in mice显示文摘 | Montecucco F Lenglet S Braunersreuther V | 2010 | Arterioscler Thromb Vasc Biol2010，30，： | 1 |
| 18 | Numerical homogenization techniques applied to piezoelectric composites显示文摘 | Eve Lenglet | 2003 | Journal of the Acoustical Society of America2003，113，2： | 1 |
| 19 | Alpha-fetoprotein:A controversial prognostic biomarker for small hepatocellular carcinoma显示文摘The assessment of the prognosis in patients with early hepatocellular carcinoma represents a hot-topic issue that requires further improvements and clarifications. The life expectancy of the patients has been shown to depend on several clinical and histological parameters (such as patient's general conditions,macroscopic tumor morphology and histopathology).Recently,the prognostic role of some biomarkers[i.e.,alpha-fetoprotein(AFP)] has been also investigated with controversial findings mainly on the assessment of patient survival.The study by Giannini et al failed to show a prognostic value of AFP on survival of patients with well-compensated cirrhosis and small hepatocellular carcinoma.Since the study presents some limitations,a larger clinical trial is needed to clarify the potential prognostic role of serum AFP levels in these patients. | Mohamed Asrih Sébastien Lenglet Franois Mach Fabrizio Montecucco | 2013 | World Journal of Gastroenterology2013，19，3： | 1 |
| 20 | Prenatal ultrasound and MRI predict placental localization in a combined intrauterine and extrauterine twin pregnancy显示文摘 | Lenglet JE Bekker MN Akkerman C | | 0，，： | 1 |
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