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| 1 | Endoscopic ablation of Barrett's esophagus using high power setting argon plasma coagulation: A prospective study显示文摘AIM: This prospective study evaluated the effectiveness of 90 W argon plasma coagulation (APC) for the ablation of Barrett's esophagus (BE) that is considered to be the main risk factor for the development of esophageal adenocarcinoma.METHODS: The results from 25 patients, observed at the First Department of General Surgery, University of Verona, Italy, from October 2000 to October 2003, who underwent APC for histologically proven BE were prospectively analyzed.RESULTS: The ablation treatment was completed in all the patients but one (96%). The mean number of APC sessions needed to complete ablation was 1.6 (total number: 40). The eradication was obtained in the majority of cases by one session only (60%), two sessions were required in 24% of the cases and three or more in 16%.About 43% of the sessions were complicated. Retrosternal pain (22.5%) and fever (17.5%) were the most frequent symptoms. Only one major complication occurred, it was an hemorrhage due to ulcer formation on the treated esophagus that required urgent endoscopic sclerosis and admission. The follow-up was accomplished in all the patients with a mean period of 26.3 mo and 20 patients (84%) with a follow-up period longer than 24 mo. Only one patient showed a relapse of metaplastic mucosa 12 mo after the completion of ablation. The patient was hence re-treated and now is free from recurrence 33 mo later.CONCLUSION: High power setting (90 W) APC showed to be safe and effective. The effects persist at a mean follow-up period of two years with a comparable cost in term of complications with respect to standard power settings. Further studies with greater number of patients are required to confirm these results and to assess if ablation reduces the incidence of malignant progression. | Corrado Pedrazzani Filippo Catalano Mara Festini Germana Zerman Anna Tomezzoli Andrea Ruzzenente Alfredo Guglielmi Giovanni de Manzoni | 2005 | World Journal of Gastroenterology2005，11，12： | 14 |
| 2 | Management of mucinous cystic neoplasms of the pancreas显示文摘The purpose of this study was to investigate the actual management of mucinous cystic neoplasm (MCN) of the pancreas. A systematic review was performed in December 2009 by consulting PubMed MEDLINE for publications and matching the 'pancreatic mucinous cystic neoplasm', 'pancreatic mucinous cystic tumour', 'pancreatic mucinous cystic mass', 'pancreatic cyst', and 'pancreatic cystic neoplasm' to identify English language articles describing the diagnosis and treatment of the mucinous cystic neoplasm of the pancreas. In total, 16 322 references ranging from January 1969 to December 2009 were analysed and 77 articles were identified. No articles published before 1996 were selected because MCNs were not previously considered to be a completely autonomous disease. Definition, epidemiology, anatomopathological findings, clinical presentation, preoperative evaluation, treatment and prognosis were reviewed. MCNs are pancreatic mucinproducing cysts with a distinctive ovarian-type stroma localized in the body-tail of the gland and occurring in middle-aged females. The majority of MCNs are slow growing and asymptomatic. The prevalence of invasive carcinoma varies between 6% and 55%. Preoperative diagnosis depends on a combination of clinical features, tumor markers, computed tomography (CT), magnetic resonance imaging, endoscopic ultrasound with cyst fluid analysis, and positron emission tomography-CT. Surgery is indicated for all MCNs. | Mario Testini Angela Gurrado Germana Lissidini Pietro Venezia Luigi Greco Giuseppe Piccinni | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 3 | Significant factors associated with fatal outcome in emergency open surgery for perforated peptic ulcer显示文摘AIM: To evaluate the main factors associated with mortality in patients undergoing surgery for perforated peptic ulcer referred to an academic department of general surgery in a large southern Italian city.METHODS: One hundred and forty-nine consecutive patients (M:F ratio=110:39, mean age 52 yrs, range 16-95) with peptic ulcer disease were investigated for clinical history (including age, sex, previous history of peptic ulcer, associated diseases, delayed abdominal surgery, ulcer site, operation type, shock on admission, postoperative general complications,and intra-abdominal and/or wound infections), serum analyses and radiological findings.RESULTS: The overall mortality rate was 4.0%. Among all factors, an age above 65 years, one or more associated diseases, delayed abdominal surgery, shock on admission,postoperative abdominal complications and/or wound infections, were significantly associated (χ2) with increased mortality in patients undergoing surgery (0.0001 | Mario Testini Piero Portincasa Giuseppe Piccinni Germana Lissidini Fabio Pellegrini Luigi Greco | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 4 | Helicobacter pylori infection in bleeding peptic ulcer patients after non-steroidal antiinflammatory drug consumption显示文摘AIM:To establish the prevalence of Helicobacter pylori (H. pylori ) infection in patients with a bleeding peptic ulcer after consumption of non-steroidal antiinflamma- tory drugs (NSAIDs). METHODS:A very early upper endoscopy was performed to find the source of upper gastrointestinal bleeding and to take biopsy specimens for analysis of H. pylori infection by the rapid urease (CLO) test, histological examination, and bacterial culture. IgG anti-CagA were also sought. The gold standard for identifying H. pylori infection was positive culture of biopsy specimens or contemporary positivity of the CLO test and the presence of H. pylori on tissue sections. RESULTS:Eighty patients, 61 males (76.3%), mean age 61.2 ± 15.9 years, were consecutively enrolled. Forty-seven (58.8%) patients occasionally consumed NSAIDs, while 33 (41.3%) were on chronic treatment with low-dose aspirin (LD ASA). Forty-four (55.0%) patients were considered infected by H. pylori . The infection rate was not different between patients who occasionally or chronically consumed NSAIDs. The culture of biopsy specimens had a sensitivity of 86.4% and a specificity of 100%; corresponding figures for histological analysis were 65.9% and 77.8%, for the CLO test were 68.2% and 75%, for the combined use of histology and the CLO test were 56.8% and 100%, and for IgG anti-CagA were 90% and 98%. The highest accuracy (92.5%) was obtained with the culture of biopsy specimens.CONCLUSION:Patients with a bleeding peptic ulcer after NSAID/LD ASA consumption frequently have H. pylori infection. Biopsy specimen culture after an early upper gastrointestinal tract endoscopy seems the most efficient test to detect this infection. | Francesco Manguso Elisabetta Riccio Germana de Nucci Maria Luisa Aiezza Gerardino Amato Linda Degl'Innocenti Maria Maddalena Piccirillo Gianfranco De Dominicis Tara Santoro Elena Trimarco Antonio Balzano | 2011 | World Journal of Gastroenterology2011，17，40： | 4 |
| 5 | Hepatitis C virus relies on lipoproteins for its life cycle显示文摘Hepatitis C virus(HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production. | Germana Grassi Giorgia Di Caprio Gian Maria Fimia Giuseppe Ippolito Marco Tripodi Tonino Alonzi | 2016 | World Journal of Gastroenterology2016，22，6： | 3 |
| 6 | Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome显示文摘 | Laura Zanotti Eliana Bignotti Stefano Calza Elisabetta Bandiera Giuseppina Ruggeri Claudio Galli Germana Tognon Monica Ragnoli Chiara Romani Renata A. Tassi Luigi Caimi Franco E. Odicino Enrico Sartori Sergio Pecorelli Antonella Ravaggi | 2012 | Clinical Chemistry and Laboratory Medicine2012，，12： | 2 |
| 7 | Expression and spectroscopic characterization of the hydrogenosomal ferredoxin from the protozoan Trichomonas vaginalis显示文摘 | Vidakovic MS Fraczkiewicz G Germanas JP | 1996 | J Biol Chem1996，271，14： | 2 |
| 8 | Locomotor primitives in newborn babies and their development显示文摘 | DOMINICIN YURI P I GERMANA C | 2011 | Science2011，334，18： | 1 |
| 9 | Age-related changes in the medullary reticular epithelial cells of the pigeon bursa of Fabricius显示文摘 | SANCHEZ-REFUSTA E CIRIACO E GERMANA G | 1996 | Anatomical Record1996，246，： | 1 |
| 10 | Characterization of a polymorphism of CD4 in miniature swine 显示文摘 | Sundt T M LeGuem C Germana S | 1992 | Journal of Immunology1992，148，10： | 1 |
| 11 | The role of in-migrants in the increasing rural HIV - 1 epidemic: results from a village population survey in the Kilimanjaro region of Tanzania显示文摘 | Ella JM Germana HL Akhtar H | 2008 | Int J Infect Dis2008，12，5： | 1 |
| 12 | Discovery of small - molecule inhibitors of tyrosinase 显示文摘 | JURIS P GERMANAS WANG SHUGUANG | 2007 | Bioorganic & Medicinal Chemis- try Letters2007，17，24： | 1 |
| 13 | Effects of increased nerve growth factor plasma levels on the expression of trkA and p75 in rat testi cles显示文摘 | LEVANTI M B GERMANA A DE CARLOS F | 2006 | J Anat2006，208，3： | 1 |
| 14 | Structure of miniature swine class Ⅱ DRB genes:conservation of hypervariable amino acid residues between distantly related mammalian species显示文摘 | Germana S Hirsch F Pratt K LeGuern C Sachs D H | 1990 | Proceedings of the National Academy of Sciences USA1990，87，： | 1 |
| 15 | The crystal structure of Trichomonas vaginalis ferredoxin provides insight into metronidazole activation显示文摘 | Crossnoe CR Germanas JP LeMagueres P | 2002 | J Mol Biol2002，318，： | 1 |
| 16 | RTN4 and FBXL17 genes are associated with coronary heart disease in genome-wide as- sociation analysis of lithuanian families 显示文摘 | Domarkiene I Pranculis A Germanas S | 2013 | Balkan J Med Genet2013，16，2： | 1 |
| 17 | Expression and spectroscopic characterization of the hydrogenosomal ferredoxin from the protozoan Trichomonas vaginalis显示文摘 | Vidakovic MS Fraczkiewicz G Germanas JP | 1996 | J Biol Chem1996，271，14： | 1 |
| 18 | Doubled haploid production in fruit crops 显示文摘 | GERMANA M A | 2006 | Plant Cell Tissue and Organ Culture2006，86，2： | 1 |
| 19 | Class II genes of miniature swine显示文摘 | SACHS D H GERMANA S EL-GAMIL M | 1988 | Immunogentics1988，28，1： | 1 |
| 20 | Flavor compounds of dry cured ham显示文摘 | Germana B Luciana B Giovanni P | 1992 | Agricultural Food Chemistry1992，40，： | 1 |
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