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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Intelligent monitoring method of cow ruminant behavior based on video analysis technology显示文摘To overcome the limitations of traditional dairy cow's rumination detection methods,a video-based analysis on the intelligent monitoring method of cow ruminant behavior was proposed in this study.The Mean Shift algorithm was used to track the jaw motion of dairy cows accurately.The centroid trajectory curve of the cow mouth motion was subsequently extracted from the video.In this way,the monitoring of the ruminant behavior of dairy cows was realized.To verify the accuracy of the method,six videos,a total of 99'00',24000 frames were selected.The test results demonstrated that the success rate of this method was 92.03%,despite the interference of behaviors,such as raising or turning of the cow’s head.The results demonstrate that this method,which monitors the ruminant behavior of dairy cows,is effective and feasible. | Chen Yujuan He Dongjian Fu Yinxi Song Huaibo | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 11 |
| 3 | Effect of cooling rates on the dendritic morphology transition of Mg–6Gd alloy by in situ X-ray radiography显示文摘The effect of cooling rate on the transition of dendrite morphology of a Mg-6 Gd(wt%) alloy was semiquantitatively analyzed under a constant temperature gradient by using synchrotron X-ray radiographic technique. Results show that equiaxed dendrites, including exotic 'butterfly-shaped' dendrite morphology, dominate at high cooling rate(>1 K/s). When the cooling rate decreases in the range of 0.5–1 K/s, the equiaxed-to-columnar transition takes place, and solute segregates at the center of two long dendrite arms(LDA) of the 'butterfly-shaped' dendrite. When the cooling rate is lower than 0.3 K/s, directional solidification occurs and the columnar dendritic growth direction gradually rotates from the crystalline axis to the thermal gradient direction with an increase in cooling rate. Meanwhile, interface moves faster but the dendrite arm spacing decreases. Floating, collision and rotation of dendrites under convection were also studied in this work. | Yongbiao Wang Liming Peng Yanzhou Ji Xiaoxing Cheng Cunlong Wang Yujuan Wu Yanan Fu Long-Qing Chen | 2018 | Journal of Materials Science & Technology2018，34，7： | 8 |
| 4 | Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways显示文摘Objective:Obesity is closely associated with metastasis in breast cancer patients.Secreted frizzled-related protein 5(SFRP5),one of the novel adipokines with anti-inflammatory properties,is associated with obesity.This study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying mechanism.Methods:3T3-L1 pre-adipocytes were differentiated to mature adipocytes and a hypertrophic adipocyte model was induced with palmitic acid(PA).Cell motility was measured in MDA-MB-231 and MCF-7 breast cancer cells co-cultured with adipocytes conditioned medium(CM)with or without SFRP5 protein.Wnt and epithelialmesenchymal transition(EMT)signal pathways were investigated by western blot.Circulating SFRP5 level in 218 breast cancer patients and the association with clinicopathologic characteristics of breast cancer were further determined.Online databases ENCORI and PREDICT Plus were used to exam the link between SFRP5 and prognosis.Results:Reduced SFRP5 level was detected in the hypertrophic adipocyte model.Recombinant SFRP5 protein inhibited MDA-MB-231 and MCF-7 cells invasion and migration induced by PA-treated adipocyte CM,and SFRP5 inhibition by specific antibody reversed the effect of SFRP5.Furthermore,SFRP5 significantly inhibited Wnt and downstream EMT in breast cancer cells.Low circulating SFRP5 level correlated with body mass index(BMI),lymph node(LN)metastasis,TNM stage and high Ki67 expression in breast cancer patients.Increased SFRP5 level was associated with favorable predicted survival.Kaplan-Meier curves showed high SFRP5 level in tumor tissue was associated with better outcome of breast cancer patients.Conclusions:Our findings demonstrated SFRP5 is a vital adipokine that mediates the crosslink between obesity and the metastatic potential of breast cancer.Promotion of SFRP5 expression in the adipose microenvironment may represent a novel approach for preventing breast cancer metastasis. | Wenzhong Zhou Chunmiao Ye Liang Li Liyuan Liu Fei Wang Lixiang Yu Fei Zhou Yujuan Xiang Yongjiu Wang Gengshen Yin Zhongbing Ma Qinye Fu Qiang Zhang Dezong Gao Shuya Huang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 5 |
| 5 | The role of MAPK and FAS death receptor pathways in testicular germ cell apoptosis induced by lead显示文摘现在的学习的目的是调查在阴囊的细菌房间的导致铅的 apoptosis 涉及 MAPK 的信号小径和船边交货的死亡信号受体小径的基因表示。首先,房间生存能力被 MTT 试金决定。第二,使用单个房间胶化电气泳动测试(彗星试金) 和染色技术, apoptotic 率和阴囊的细菌房间的房间 apoptosis 本地化的 TUNEL 在分别地与 0.15% , 0.3% ,和 0.6% 铅一起对待的老鼠被测量。第三, K 地岬, c-fos,船边交货,和活跃 caspase-3 蛋白质的 immunolocalization 被 immunohistochemistry 决定。最后,在 K 地岬, c-fos,船边交货,和活跃 caspase-3 的翻译层次的变化被西方的污点分析进一步检测。我们的结果证明铅能显著地以一种剂量依赖者方式导致阴囊的细菌房间 apoptosis (P < 0.01 ) 。机制是仔细与在 apoptotic 细菌房间的 K 地岬, c-fos,船边交货,和活跃 caspase-3 的增加的表情有关。在结论, K-ras/c-fos 和 Fas/caspase-3 死亡发信号受体小径在老鼠涉及阴囊的细菌房间的导致铅的 apoptosis。 | Shuying Dong Duoping Liang Na An Li Jia Yujuan Shan Chao Chen Kuo Sun Fei Niu Huiyan Li Songbin Fu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 4 |
| 6 | Melt grafting of maleic anhydride onto polypropylene with assistance of a- methylstyrene显示文摘 | Luo Weihua Liu Xingxing Fu Yujuan | 2012 | Polymer Engineering and Science2012，52，4： | 1 |
| 7 | Simultaneous determination of Repaglinide and Irbesartan in biological plasmas using micellar enhanced excitation-emission matrix fluorescence coupled with ATLD method显示文摘A highly sensitive and selective 3D excitation-emission fluorescence method has been proposed to rapidly quantify the combined antidiabetics Repaglinide(Re) and Irbesartan(Ir) in rat and human plasmas with the aid of second-order calibration method based on alternating trilinear decomposition(ATLD) method. Re and Ir with weak fluorescence can be endowed with strong fluorescent property by changing the microenvironment in samples and improving the fluorescence quantum yield by using an appropriate micellar enhanced surfactant. The enhanced excitation-emission matrix fluorescence of Re and Ir can be accurately resolved and can simultaneously attain the optimal concentration even in the presence of a potentially strong intrinsic fluorescence from complex biological matrices, such as rat and human plasmas, by using the ATLD method, which completely exploits the 'second-order advantage'. The average recoveries of Re and Ir obtained from ATLD with the factor number of 3(N=3) were 101.0%±4.3% and 99.1%±4.1% for rat plasma and 100.5%±5.4% and 97.1%±3.6% for human plasma. Several statistical methods, including Student's t-test, figures of merit, and elliptical joint confidence region, have been utilized to evaluate the accuracy of the proposed method. Results show that the developed method can maintain second-order advantage in simultaneous determinations of the weak fluorescent analytes of interest in different biological plasma matrices. | Haiyan Fu Hedong Li Mei Shao Tianming Yang Xu Zhang Rujing Xu Yujuan Wei Shuhua Chen Chuang Ni Hailong Wu | 2016 | Science China Chemistry2016，59，7： | 1 |
| 8 | Effect of ultra-high pressure homogenisation processing on phenolic compounds, antioxidant capacity and anti-glucosidase of mulberry juice显示文摘 | Yuanshan Yu Yujuan Xu Jijun Wu Gengsheng Xiao Mangqin Fu Yousheng Zhang | 2013 | Food Chemistry2013，，： | 1 |
| 9 | Comparing characteristic of banana juices from banana pulp treated by high pressure carbon dioxide and mild heat显示文摘 | Yuanshan Yu Gengsheng Xiao Daobang Tang Jijun Wu Yulong Chen Yujuan Xu Jing Wen Mangqin Fu | 2012 | Innovative Food Science and Emerging Technologies2012，，： | 1 |
| 10 | Association of SOST gene polymorphisms with peak bone mineral density in Chinese nuclear families with male-offspring显示文摘Peak bone mineral density(BMD)achieved during early adulthood is a highly heritable trait and a strong determinant of subsequent osteoporotic fracture risk.Evidence has already suggested that 50–80% of the variance in peak BMD is genetically determined [1].Human SOST gene comprises three exons and two introns,mapping to chromosomal region 17q12–q21.It inhibits osteoblastic bone formation by inhibiting the Wnt signaling pathway,which is critically important for the development and function of osteoblasts [2].Our previous study in large samples of postmenopausal Chinese women showed that the polymorphisms in the SOST gene are associated with BMD of the lumbar spine [3],but little is known in men.Thus,the objective of this study was to investigate whether polymorphisms in the SOST gene are associated with variations of peak BMD in Chinese nuclear families with male-offspring. | Luyue Qi Shoukui Xiang Li Li Jinwei He Wenzhen Fu Yujuan Liu Yunqiu Hu Zhenlin Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 0 |
| 11 | Electron modulation by atomic Ir site decoration in porous Co/N co-doped carbon for electrocatalytic hydrogen evolution显示文摘The rational design of materials at atomic scale as efficient and stable electrocatalysts for hydrogen evolution reaction(HER)is critical for energy conversion.Herein,we report a novel hybrid nanostructure with iridium(Ir)and cobalt(Co)atomic pair configuration anchored in porous nitrogen-doped carbon(pNC)nanosheets(denoted as IrCo-pNC)for electrocatalytic HER.Experimental investigations and theoretical calculations reveal that the interaction between Ir and Co species in pNC promotes electron accumulation and depletion around isolated Ir and Co atoms,respectively,resulting in a local asymmetry electron density distribution.Density functional theory calculations also suggest that the electrons transfer from Co to adjacent Ir atom causing the down shift of the d-band center of Ir 5d in IrCo-pNC catalyst,thus optimizing the adsorption of hydrogen on Ir sites.The as-prepared IrCo-pNC exhibits significant HER performance with an overpotential of 21 mV to achieve a current density of 10 mA·cm^(−2)in 0.5 M H2SO4.This work provides insight into the role of asymmetry electron density distribution in nanomaterials in regulating HER electrocatalysis. | Youkui Zhang Zitong Yan Yeli Gao Yaqin Fu Wenhao Li Yunxiang Lin Chuanqiang Wu Yujuan Pu Tao Duan Li Song | 2023 | Nano Research2023，16，2： | 0 |
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