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| 1 | MicroRNA-21 targets tumor suppressor genes in invasion and metastasis显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 指向编码蛋白质的 mRNAs 的小非编码的 RNA 铺平的自然地发生的一个班。我们的以前的研究建议 mir-21 作为 oncogene 工作并且在 tumorigenesis 有一个角色,部分地通过肿瘤的规定压制或基因对流肌浆球蛋白 1 (TPM1 ) 。给那 TPM1 在房间移植被含有,在我们进一步调查了的这研究在房间侵略和肿瘤转移的 mir-21 的角色。我们发现在变形乳癌 MDA-MB-231 房间的 mir-21 的抑制显著地减少了侵略和肺转移。与这一致, TPM1 的宫外的表示显著地减少了房间侵略。而且,我们识别了二个另外的直接 mir-21 目标,规划房间死亡 4 (PDCD4 ) 并且妈大头针,哪个在侵略和转移被含有。象 TPM1 一样, PDCD4 和妈大头针也减少了 MDA-MB-231 房间的侵略海角。最后, PDCD4 的表示和妈大头针相反地在人的胸肿瘤标本与 mir-21 表示相关,显示由在这些肿瘤的 mir-21 的 PDCD4 和妈大头针的潜在的规定。总起来说,结果建议作为 oncogenic miRNA, mir-21 由指向多重肿瘤 / 转移不仅在肿瘤生长而且在侵略和肿瘤转移有一个角色压制或基因。因此, mir-21 的抑制可以为先进癌症的治疗提供一条新奇途径。 | Shuomin Zhu Hailong Wu Fangting Wu Daotai Nie Shijie Sheng Yin-Yuan Mo | 2008 | Cell Research2008，18，3： | 205 |
| 2 | Suppression of cell growth and invasion by miR-205 in breast cancer显示文摘MicroRNAs (miRNAs ) 内长的、小、非编码的 RNA,它能够在 post-transcriptional 的 silencing 基因表示铺平。在这研究,我们报导 miR-205 是显著地在与匹配的正常的胸织物相比的胸肿瘤的 underexpressed。同样,包括 MCF-7 和 MDA-MB-231,乳癌房间行比非恶意的 MCF-10A 房间表示低级 miR-205。兴趣, miR-205 的宫外的表示显著地禁止房间增长和抛锚独立人士生长,以及房间侵略。而且, miR-205 被显示在一个动物模型压制肺转移。最后,西方的污点与试金表明的酶记者结合了那 ErbB3 和脉管的 endothelial 生长因素 A ( VEGF --一)是为 miR-205 的直接目标,并且这 miR-205-mediated 抑制通过和在 ErbB3 和 VEGF 的 3 鈥? untranslated 区域( 3 鈥? UTR )的通常认为的 miR-205 绑定地点的直接相互作用是可能的--一。一起,这些结果建议 miR-205 是在乳癌的肿瘤 suppressor。 | Hailong Wu Shoumin Zhu Yin-Yuan Mo | 2009 | Cell Research2009，19，4： | 56 |
| 3 | A scientometric review of biochar research in the past 20 years(1998-2018)显示文摘Biochar is the carbon-rich product obtained from the thermochemical conversion of biomass under oxygen-limited conditions.Biochar has attained extensive attention due to its agronomical and environmental benefits in agro-ecosystems.This work adopts the scientometric analysis method to assess the development trends of biochar research based on the literature data retrieved from the Web of Science over the period of 1998-2018.By analysing the basic characteristics of 6934 publications,we found that the number of publications grew rapidly since 2010.Based on a keyword analysis,it is concluded that scholars have had a fundamental recognition of biochar and preliminarily found that biochar application had agronomic and environmental benefits during the period of 1998-2010.The clustering results of keywords in documents published during 2011-2015 showed that the main research hotspots were“biochar production”,“biochar and global climate change”,“soil quality and plant growth”,“organic pollutants removal”,and“heavy metals immobilization”.While in 2016-2018,beside these five main research hotspots,“biochar and composting”topic had also received greater attention,indicating that biochar utilization in organic solid waste composting is the current research hotspot.Moreover,updated reactors(e.g.,microwave reactor,fixed-bed reactor,screw-feeding reactor,bubbling fluidized bed reactor,etc.)or technologies(e.g.,solar pyrolysis,Thermo-Catalytic Reforming process,liquefaction technology,etc.)applied for efficient energy production and modified biochar for environmental remediation have been extensively studied recently.The findings may help the new researchers to seize the research frontier in the biochar field. | Ping Wu Syed Tahir Ata-Ul-Karim Bhupinder Pal Singh Hailong Wang Tongliang Wu Cun Liu Guodong Fang Dongmei Zhou Yujun Wang Wenfu Chen | 2019 | Biochar2019，1，1： | 36 |
| 4 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 5 | Visualizing the emerging trends of biochar research and applications in 2019:a scientometric analysis and review显示文摘Biochar,derived from thermal pyrolysis of biomass,has been regarded as a low-cost,sustainable and beneficial material and widely applied in agriculture,environment and energy during the last two decades.To elucidate the research status timely and future trends in biochar field,CiteSpace is used to systematically analyze the related literature retrieved from the Web of Science core collection in 2019.Based on the keywords clustering analysis,it was found that“biochar production”,“organic pollutants removal”,“heavy metals immobilization”,“bioremediation”were the main hotspots in research covering biochar.“Bioremediation”is an emerging topic and deserves extensive attention due to its highly effective and environmentally friendly treatment of pollutants.Improving the phytoremediation effect,immobilizing functional microorganisms on biochar,and using microorganisms as raw materials to produce biochar were the common methods of biochar-assisted bioremediation.While studies focused on“soil quality and plant growth”and“biochar and global climate change”decreased,investigations concentrated in the toxicity of biochar to soil biota and ruminants are sustainably growing.Research on direct and catalytic thermal pyrolysis of green waste(mainly microalgae)for biofuels(bio-oil,biodiesel,syngas,etc.)and biochar production is increasing.Converting municipal wastes(e.g.,sewage sludge,fallen leaves)into biochar through pyrolysis was a suitable treatment for municipal waste and became a popular topic in recent time.Moreover,the biochar produced from these municipal wastes exhibited excellent performance in the removal of pollutants from wastewater and soil.This review may help to identify future directions in biochar research and applications. | Ping Wu Zeyu Wang Hailong Wang Nanthi S.Bolan Yujun Wang Wenfu Chen | 2020 | Biochar2020，2，2： | 14 |
| 6 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 7 | CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization显示文摘Despite the diverse etiologies of drug-induced liver injury(DILI),innate immunity activation is a common feature involved in DILI progression.However,the involvement of innate immunity regulation in inflammation resolution and liver regeneration in DILI remains obscure.Herein,we identified the chemokine CCL5 as a central mediator of innate immunity regulation in the pathogenesis of DILI.First,we showed that serum and hepatic CCL5 levels are elevated in both DILI patients and an APAP-induced liver injury(AILI)mouse model.Interestingly,both nonparenchymal cells and stressed hepatocytes are cell sources of CCL5 induction in response to liver injury.Functional experiments showed that CCL5 deficiency has no effect on the early phase of AILI but promotes liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration,which are associated with an increased number of hepatic M2 macrophages.Mechanistically,CCL5 can directly activate M1 polarization and impede M2 polarization through the CCR1-and CCR5-mediated activation of the MAPK and NF-κB pathways.We then showed that CCL5 inhibition mediated by either a CCL5-neutralizing antibody or the antagonist Met-CCL5 can greatly alleviate liver injury and improve survival in an AILI mouse model.Our data demonstrate CCL5 induction during DILI,identify CCL5 as a novel innate immunity regulator in macrophage polarization,and suggest that CCL5 blockage is a promising therapeutic strategy for the treatment of DILI. | Meng Li Xuehua Sun Jie Zhao Lei Xia Jichang Li Min Xu Bingrui Wang Han Guo Chang Yu Yueqiu Gao Hailong Wu Xiaoni Kong Qiang Xia | 2020 | Cellular & Molecular Immunology2020，17，7： | 13 |
| 8 | Baicalin extracted from Huangqin(Radix Scutellariae Baicalensis) induces apoptosis in gastric cancer cells by regulating B cell lymphoma(Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9显示文摘OBJECTIVE:To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.METHODS:Cell proliferation and apoptosis assays were performed to investigate the anti-proliferation effects of baicalin in human gastric cancer BGC-823 and MGC-803 cells.Real time-quantitative polymerase chain reaction and Western blotting analysis were performed to elucidate the molecular mechanisms underlying the anti-tumor properties of baicalin.RESULTS:In BGC-823 and MGC-803 gastric cancer cells treated with 80, 120, and 160 μmol/L baicalin for 48 h, a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay showed that baicalin significantly inhibited cell proliferation in a dose-dependent manner, while flow cytometric analysis demonstrated that baicalin could induce apoptosis, also in a dose-dependent manner.Moreover, baicalin up-regulated the expression of caspase-3, caspase-9, and B cell lymphoma(Bcl-2)-associated X protein and down-regulated the expression of Bcl-2 at both the m RNA and protein level.CONCLUSION:Baicalin has potential as a therapeutic agent for gastric cancer by inducing apoptosis in cancer cells. | Wang Hongwei Li Hailong Chen Fengqin Luo Jun Gu Jing Wang Huping Wu Hongyan Xu Yan | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 13 |
| 9 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 10 | In-line imaging measurements of particle size,velocity and concentration in a particulate two-phase flow显示文摘A novel method is developed for in-line measurements of particle size, velocity and concentration in a dilute, particulate two-phase flow based on trajectory image processing. The measurement system consists of a common industrial CCD camera, an inexpensive LED light and a telecentric lens. In this work,the image pre-processing steps include stitching, illumination correction, binarization, denoising, and the elimination of unreal and defocused particles. A top-hat transformation is found to be very effective for the binarization of images with non-uniform background illumination. Particle trajectories measured within a certain exposure time are used to directly obtain particle size and velocity. The particle concentration is calculated by using the statistics of recognized particles within the field of view. We validate our method by analyzing experiments in a gas-droplet cyclone separator. This in-line image processing method can significantly reduce the measurement cost and avoid the data inversion process involved in the light scattering method. | Xiaozhen Chen Wu Zhou Xiaoshu Cai Mingxu Su Hailong Liu | 2014 | Particuology2014，12，2： | 10 |
| 11 | The HY-2 satellite and its preliminary assessment显示文摘The HY-2 satellite was successfully launched on 16 August 2011.It carried four microwave instruments into space for operationally observing dynamic ocean environment parameters on a global scale.The HY-2 satellite altimeter provides sea surface height(SSH),significant wave height(SWH),sea surface wind(SSW)speed,and polar ice sheet elevation,while the HY-2 satellite scatterometer provides SSW fields.At the same time,other oceanic and atmospheric parameters such as sea surface temperature(SST)and wind speed,water vapor and liquid water content can also be obtained by its onboard scanning microwave radiometer.In this paper,we show the data processing methods of the HY-2 satellite’s payloads.The preliminary results show that wind vector,SSH,SWH,and SST conform to the designed technical specifications. | Xingwei Jiang Mingsen Lin Jianqiang Liu Youguang Zhang Xuetong Xie Hailong Peng Wu Zhou | 2012 | International Journal of Digital Earth2012，5，3： | 10 |
| 12 | Short-range ordering and its effects on mechanical properties of high-entropy alloys显示文摘In this letter,we briefly summarize experimental and theoretical findings of fo rmation and characterization of short-range orderings(SROs)as well as their effects on the defo rmation behavior of high-entropy alloys(HEAs).We show that existence of SROs is a common yet key structural feature of HEAs,and tuning the degree of SROs is an effective way for optimizing mechanical properties of HEAs.In additional,the challenges concerning about formation mechanism and characterization of SROs in HEAs are discussed,and future research activities in this regard are also proposed. | Yuan Wu Fei Zhang Xiaoyuan Yuan Hailong Huang Xiaocan Wen Yihan Wang Mengyuan Zhang Honghui Wu Xiongjun Liu Hui Wang Suihe Jiang Zhaoping Lu | 2021 | Journal of Materials Science & Technology2021，，3： | 8 |
| 13 | Stress-strain behavior of multi-phase high performance structural steel显示文摘A series of ferrite/bainite(F/B) multi-phase steels containing different volume fractions of ferrite were obtained.The effect of soft phase(ferrite) content on the work-hardening behavior of the steel was studied by the finite element simulation with V-BCC model and the modified Crussard-Jaoul(C-J) analysis.It is shown that the multi-phase steels have an excellent anti-deformation ability,such as higher stress ratio(R t1.5 /R t0.5),higher uniform elongation and lower yield to tensile strength ratio.For the F/B multi-phase steels,increasing the proportion of ferrite would help to increase the uniform elongation.However,introducing much more fraction of ferrite would not be helpful to improve the stress ratio of multi-phase steel.The ferrite plastic strain constrained by bainite would be beneficial to increasing the work hardening rate.The optimum proportion of ferrite will result both higher stress ratio and uniform elongation in multi-phase steel. | NIE WenJin WANG XueMin WU ShengJie GUAN HaiLong SHANG ChengJia | 2012 | Science China(Technological Sciences)2012，55，7： | 8 |
| 14 | Formulation of a new ocean salinity boundary condition and impact on the simulated climate of an oceanic general circulation model显示文摘The salinity boundary condition at the ocean surface plays an important role in the stability of long-term integrations of an oceanic general circulation model(OGCM) and in determining its equilibrium solutions.This study presents a new formulation of the salt flux calculation at the ocean surface based on physical processes of salt exchange at the air-sea interface.The formulation improves the commonly used virtual salt flux with constant reference salinity by allowing for spatial correlations between surface freshwater flux and sea-surface salinity while preserving the conservation of global salinity.The new boundary condition is implemented in the latest version of the National Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics/Institute of Atmospheric Physics Climate Ocean Model version 2(LICOM2.0).The impact of the new boundary condition on the equilibrium simulations of the model is presented.It is shown that the new formulation leads to a stronger Atlantic meridional overturning circulation(AMOC) that is closer to observational estimates.It also slightly improves poleward heat transport by the oceans in both the Atlantic and the global oceans. | JIN JiangBo ZENG QingCun WU Lin LIU HaiLong ZHANG MingHua | 2017 | Science China Earth Sciences2017，60，3： | 7 |
| 15 | Seismogenic Structure of the April 20, 2013, Lushan Ms7 Earthquake in Sichuan显示文摘At 08:02 on April 20, 2013, a Ms7.0 earthquake occurred in Lushan, Ya'an, in the Longmenshan fault zone, Sichuan. The epicenter was located between Taiping Town and Shuangshi Town, Lushan County and the maximum earthquake intensity at the epicenter reached class IX. Field investigations in the epicenter area found that, although buildings were seriously damaged, no obvious surface rupture structure was produced, only some ground fissures and sand blows and water ejection phenomena being seen. An integrated analysis of high-resolution remote sensing image interpretation, mainshock and aftershock distribution, and focal mechanism solutions indicated that this earthquake was an independent rupturing event in the southwestern segment of the Longmenshan fault zone, belonging to the thrust-type earthquake. Ruptures occurred along the south-central segment of the Shuangshi-Dachuan fault and the principal rupture plane dipped SW at 33-43°. It is inferred that the Lushan earthquake might be related to the ramp activity of the basal detachment zone (13-19 km) of the Longmenshan fault zone. Historically, there occurred at least two Ms6-6.5 earthquakes along the Shuangshi-Dachuan fault zone; thus it is thought that the Lushan earthquake, different from the Wenchuan earthquake, was a characteristic one in the southwestern segment of the Longmenshan fault zone. In-situ stress measurements indicated the Lushan earthquake was the result of stress release of the southwestern segment of the Longmenshan fault zone after the Wenchuan earthquake. This paper analyzes the tectonic setting of the seismogenic structure of this earthquake. | ZHANG Yueqiao DONG Shuwen HOU Chuntang SHI Jusong WU Zhonghai LI Hailong SUN Ping LIU Gang LI Jian | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 7 |
| 16 | Revisiting Late Quaternary Slip-rate along the Maqu Segment of the Eastern Kunlun Fault, Northeast Tibet显示文摘晚第四级沿着东方 Kunlun 差错的 Maqu 片断滑动率用高分辨率的遥感形象解释,地观察和微分全球放系统(GPS ) 的联合被估计偏移量河平台的大小,和 14 从偏移量起床人收集的蜗牛壳标明日期的 C。结果证明沿着片断的离开滑倒率是 3-5 mm/a,并且垂直滑倒率是 0.3-0.5 mm/a。两水平、垂直在在 ∼100 km 的距离上一致的片断遗体上滑倒。当以前建议了,它意味着不滑动坡度沿着 Maqu 片断发生了,并且它可能因此作为一个独立 seismogenic 差错表现。在年轻梯田之中从多重关系判定抵消,我们推断典型地震在 Maqu 差错上与 Ms7.0-7.5 的大小生产的那 co 地震的表面破裂能产生一水平 4.5-5 m 滑倒并且一垂直 0.45-0.5 m 滑倒,与大约 9 的相应比率(Dh/Dv ) 。二个表面破裂事件肯定发生在过去的 3300 年,最近的可能在 1485 cal BP 和 1730 cal BP 之间。 | LI Jian ZHANG Yueqiao LI Hailong XIONG Jinhong LI Jianhua WU Tairan | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 6 |
| 17 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 18 | Biomarker evidence for changes in terrestrial organic matter input into the Yellow Sea mud area during the Holocene显示文摘We present lipid biomarker records of two cores(ZY1 and ZY3) from the central South Yellow Sea mud area to investigate the changes in sources and transport processes of the sedimentary organic matter(OM) throughout the Holocene. Based on the analysis of marine biomarker content(SPB(Phytoplankton Biomarker, total content of brassicasterol, dinosterol and C_(37)-alkenones) and crenarchaeol), and terrestrial biomarkers(Sn-alkanols and br GDGTs) as well as TMBR′ and BIT index values, the marine organic matter(MOM) and terrestrial organic matter(TOM) deposition history was reconstructed. Changes in TOM and MOM were related to variations in land vegetation density and marine productivity, as well as transport processes dominated by the oceanic circulation system. The marine biomarker contents from the South Yellow Sea have generally increased throughout the Holocene, indicating that the increased MOM contents were mainly controlled by the strengthening of the circulation system. The terrestrial biomarkers, on the other hand, were more variable, indicating more complex influence of TOM burial in the Yellow Sea. During the Early Holocene(7200–6000 cal yr BP), the moderate TOM input revealed by the terrestrial proxy records may result from abundant land source supply by strong river transport despite the lack of transport via circulation system. The Mid-Holocene(6000–3000 cal yr BP) was characterized by decreased terrestrial biomarker contents. The balance between the decrease in land source supply and increase of transportation by the current system of the TOM resulted in the lower but stable contents of TOM. During the Late Holocene(3000 cal yr BP to present), the TOM deposition in the South Yellow Sea increased as the current system was further enhanced and thus transported more TOM to the central South Yellow Sea, although the land supply of TOM was further reduced. | WU Peng XIAO XiaoTong TAO ShuQin YANG ZuoSheng ZHANG HaiLong LI Li ZHAO MeiXuna | 2016 | Science China Earth Sciences2016，59，6： | 6 |
| 19 | Removal of PCDD/Fs and PCBs from flue gas using a pilot gas cleaning system显示文摘A 100 Nm3 /hr capacity pilot scale dual bag filter (DBF) system was tested on the flue gas from an actual hazardous waste incinerator (HWI), the removal efficiency of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) was also studied. The first filter collected most of the fly ash and associated chlorinated organic; then activated carbon (AC) was injected and used to collect phase chlorinated organic from the gas. Concentrations of PCDD/Fs and PCBs after the DBF system were 0.07 and 0.01 ng TEQ/Nm3 , respectively, which were both far below the national emission standard. Comparing with the original single bag filter system, the PCDD/Fs concentration dropped a lot from 0.36 to 0.07 ng TEQ/Nm3 . Increasing AC feeding rate enhanced their collection efficiency, yet reduced the AC utilization efficiency, and it still needs further study to select an appropriate feeding rate in the system. These results will be useful for industrial application and assist in controlling emissions of PCDD/Fs and other persistent organic pollutions from stationary sources in China. | Xiaoqing Lin Yuqi Jin Hailong Wu Tong Chen Xiaodong Li Shengyong Lu Xuguang Jiang Jianhua Yan | 2013 | Journal of Environmental Sciences2013，25，9： | 5 |
| 20 | Park7 interacts with p47phox to direct NADPH oxidase- dependent ROS production and protect against sepsis显示文摘 | Wenjun Liu Hailong Wu Lili Chen Yankai Wen Xiaoni Kong Wei-Qiang Gao | 2015 | Cell Research2015，25，6： | 5 |
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