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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | New Early Cretaceous Pterosaur-Bird Track Assemblage from Xinjiang, China:Palaeoethology and Palaeoenvironment显示文摘A pterosaur-bird track assemblage from a sandstone-siltstone-mudstone sequence of the Lower Cretaceous Tugulu Group of Xinjiang comprises the first pterosaur track record from this province and the largest specimen thus far known from China.The pterosaur tracks are assigned to the ichnogenus Pteraichnus based on the triangular overall-shape,the four elongate digit traces and the robust manual digit trace III.Supposed trackmakers were dsungaripterid pterodactyloids whose skeletal remains are well known from the Tugulu Group.The bird tracks that occur on the same surface,are those of typical shorebirds,known from different other localities in southeast Asia.The congruence with Koreanaornis dodsoni described from the same stratigraphic level justifies an assignment to this ichnospecies.This is a further evidence of the co-occurrence of pterosaurs and birds in a typical lakeshore environment with possible seasonal alteration of water supply and aerial exposure indicated by wave ripples,mudcracks and repeated cycles of coarse to fine sediment.Pterosaurs and birds frequented the shoreline and may have fed also on the numerous invertebrates such as the Scoyenia tracemaker that left abundant burrows. | HE Qing XING Lida ZHANG Jianping Martin G.LOCKLEY Hendrik KLEIN W.Scott PERSONS IV QI Liqi JIA Chengkai | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 4 |
| 3 | Tracking control and parameter identification with quantized ARMAX systems显示文摘Dear editor,After decades of development,system modeling and control theory have developed thoroughly.Various identification,estimation and control methods have been given(1)However,most of these results are based on accurate measurements of the system inputs and outputs.But now,quantized partial-state feedback stabilization of a class of nonlinear cascaded systems and gave a recursive design method for quantized stabilization.Ref.[3]used quantized data to design feedback stabilization control.Ref.[4]studied the parameter identification of set value systems.Ref.[5]considered the adaptive control of first-order systems.Ref.[6]solved the adaptive tracking control of linear systems with binary-valued observations and periodic target. | Lida JING Jifeng ZHANG | 2019 | Science China(Information Sciences)2019，62，9： | 4 |
| 4 | A new Early Cretaceous dinosaur track assemblage and the first definite non-avian theropod swim trackway from China显示文摘The trackway of a swimming theropod (ichnogenus Characichnos) is reported from the Lower Cretaceous Feitianshan Formation of Sichuan, China. These swim tracks help confirm that non-avian theropods were capable of forging moderately deep bodies of water. The trackway occurs on the same surface as a typical walking trackway of a sauropod (ichnogenus Brontopodus). Both occurrences are the first reported from the Cretaceous of Sichuan, and the swim tracks are the first well-preserved example of a Characichnos trackway from China. Additionally, a theropod walking trackway and several ornithopod walking trackways (similar to the ichnogenus Caririchnium) occur in the same horizon. The ornithopod trackways show a parallel orientation, suggesting gregarious behavior of the trackmakers, which may have been iguanodontiforms and/or hadrosauriforms. The co-occurrence of theropod swim tracks and theropod walking tracks suggests a fluctuation of water depth within a distinct time span. | XING LiDa LOCKLEY Martin G ZHANG JianPing MILNER Andrew R C KLEIN Hendrik LI DaQing PERSONS IV W Scott EBI JieFang | 2013 | Chinese Science Bulletin2013，58，19： | 3 |
| 5 | An emerging technology-wearable wireless sensor networks with applications in human health condition monitoring显示文摘Monitoring health conditions over a human body to detect anomalies is a multidisciplinary task,which involves anatomy,artificial intelligence,and sensing and computing networks.A wearable wireless sensor network(WWSN)turns into an emerging technology,which is capable of acquiring dynamic data related to a human body’s physiological conditions.The collected data can be applied to detect anomalies in a patient,so that he or she can receive an early alert about the adverse trend of the health condition,and doctors can take preventive actions accordingly.In this paper,a new WWSN for anomaly detections of health conditions has been proposed,system architecture and network has been discussed,the detecting model has been established and a set of algorithms have been developed to support the operation of the WWSN.The novelty of the detected model lies in its relevance to chronobiology.Anomalies of health conditions are contextual and assessed not only based on the time and spatial correlation of the collected data,but also based on mutual relations of the data streams from different sources of sensors.A new algorithm is proposed to identify anomalies using the following procedure:(1)collected raw data is preprocessed and transferred into a set of directed graphs to represent the correlations of data streams from different sensors;(2)the directed graphs are further analyzed to identify dissimilarities and frequency patterns;(3)health conditions are quantified by a coefficient number,which depends on the identified dissimilarities and patterns.The effectiveness and reliability of the proposed WWSN has been validated by experiments in detecting health anomalies including tachycardia,arrhythmia and myocardial infarction. | Hairong Yan LiDa Xu Zhuming Bi Zhibo Pang Jie Zhang Yong Chen | 2015 | Journal of Management Analytics2015，2，2： | 2 |
| 6 | Short-DNA Specific Blocker PCR for Efficient and Simple Enrichment of Cell Free Fetal DNAs with Short Lengths显示文摘As an inn ate characteristic,DNA length has attracted more and more atte ntion.The length of some import ant biomarkers such as ctDNA(Circulating tumor DNA)and cffDNA(Cell free fetal DNA)is shorter than that of cell-free DNA.Researchers have utilized the differe nee in length to in crease the abunda nee of ctDNA or cffDNA in total cell-free DNA to overcome the difficulties in detecti on due to their low abundance. | Yangwei Liao Xiaofeng Tang Zhihao Ming Lida Ren Wei Zhang Xianjin Xiao | 2021 | Chinese Journal of Chemistry2021，39，8： | 2 |
| 7 | 3-Oxodapagliflozin as a Potent and Highly Selective SGLT2 Inhibitor for the Treatment of Type 2 Diabetes显示文摘 | ZHANG Shuo WANG Yuli LIU Wei XIE Yafei LIU Yuqiang XU Weiren TANG Lida WANG Jianwua ZHAO Guilong | 2014 | Chemical Research in Chinese Universities2014，30，5： | 2 |
| 8 | Study of moss as air pollution monitor by SRXRF technique显示文摘In order to explore the mechanism of moss as air pollution biomonitor, the moss samples were exposed in a pollution site of Shanghai Institute of Steel Research (SISR) and a control site of Shanghai Institute of Applied Physics (SIAP) simultaneously for one month. The concentrations of trace elements in the micro areas of leaf and stem, as well as in the whole moss tissue, were determined using synchrotron radiation X-ray fluorescence (SRXRF) method. The distributions of some metal elements such as Pb, Cu, Fe, Ni, Mn, Zn, Ca and K in the leaf surface and the stem slice were obtained. The results showed that the metallic ions were not evenly distributed after adsorption. In particular, some elements of K, Ni, Fe, Pb, etc., were concentrated in the leaf apex and the intermediate rib. Under pollution condition, the excessive Pb was adsorbed and deposited in the leaf. It caused serious damage to plant growth and ultrastructure, also suppressed moss’ normal absorption to the nutritive elements of K, Ca, etc. | ZHANG YuanXun CAO Tong ATSUO lida CAO QingChen LOU YuXia ZHANG GuiLin LI Yan | 2009 | Chinese Science Bulletin2009，54，17： | 2 |
| 9 | Braincase Anatomy of the Basal Theropod Sinosaurus from the Early Jurassic of China显示文摘The neuroanatomy of the mid-sized theropod Sinosaurus triassicus from the Lower Jurassic Lufeng Formation, Lufeng Basin in Yunnan Province, China was studied using X-ray computed tomography. The braincase is characterized by a large supraoccipital knob that is capped by a posterior projection of the parietal and two external foramina for the caudal middle cerebral vein, which is completely enclosed by the supraoccipital. The basicranium has well defined, short basipterygoid processes that project ventral to the basal tubera. The basisphenoid is expanded, projects posteroventrally, and is pierced by four pneumatic recesses. The endocranial morphology resembles that observed in other basal theropods—in particular some allosauroids—and has a strongly marked pontine flexure and a large dorsal expansion. The inner ear morphology is also similar to that observed in other basal theropods, with slender semicircular canals. The anterior semicircular canal is 20% larger than the posterior semicircular canal, and the angle formed between them is less than 90° when seen in dorsal view. | XING Lida Ariana PAULINA-CARABAJAL Philip J.CURRIE XU Xing ZHANG Jianping WANG Tao Michael E.BURNS DONG Zhiming | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 2 |
| 10 | Tooth loss and alveolar remodeling in Sinosaurus triassicus (Dinosauria: Theropoda) from the Lower Jurassic strata of the Lufeng Basin, China显示文摘Pathological or traumatic loss of teeth often results in the resorption and remodeling of the affected alveoli in mammals. However, instances of alveolar remodeling in reptiles are rare. A remodeled alveolus in the maxilla of the Chinese theropod Sinosaurus (Lower Jurassic Lower Lufeng Formation) is the first confirmed example of such dental pathology in a dinosaur. Given the known relationship between feeding behavior and tooth damage in theropods (teeth with spalled enamel, tooth crowns embedded in bone) and the absence of dentary, maxillary, and premaxillary osteomyelitis, traumatic loss of a tooth is most likely the cause of alveolar remodeling. Based on the extent of remodeling, the injury and subsequent tooth loss were non-fatal in this individual. | XING LiDa BELL Phil R ROTHSCHILD Bruce M RAN Hao ZHANG JianPing DONG ZhiMing ZHANG Wei CURRIE Philip J | 2013 | Chinese Science Bulletin2013，58，16： | 2 |
| 11 | A real-time PCRmethod for the detection of Salmonella enterica from food usinga target sequence identified by comparative genomic analysis显示文摘 | CHEN Jing ZHANG Lida PAOLI G C | 2010 | International Journal of Food Microbiology2010，137，23： | 1 |
| 12 | A real-time PCR method for the detection of Salmonella enterica from food using a target sequence identified by comparative genomic analysis显示文摘 | Jing Chen Lida Zhang George C. Paoli Chunlei Shi Shu-I Tu Xianming Shi | 2009 | International Journal of Food Microbiology2009，，2： | 1 |
| 13 | A real-time PCR method for the detection of Salmonella enterica from food using a target sequence identified by comparative genomic analysis显示文摘 | CHEN Jing ZHANG Lida PAOLI G C | 2010 | International Journal of Food Microbiology2010，137，9： | 1 |
| 14 | A real-time PCR method for the detection of Salmonella enterica from food u- sing a target sequence identified by comparative genomic a- nalysis 显示文摘 | Chen Jing Zhang Lida Paoli GC | 2010 | International Journal of Food Microbiology2010，137，： | 1 |
| 15 | A real-time PCR method for the detection of Salmonella enterica from food using a target sequence identified by comparative genomic analysis显示文摘 | CHEN Jing ZHANG Lida PAOLI G C | 2010 | Int J Food Microbiol2010，137，23： | 1 |
| 16 | Optimisation of extraction conditions for polysaccharides from the roots of Isatis tinctoria L. by response surface methodology and their in vitro free radicals scavenging activities and effects on IL-4 and IFN-γ mRNA expression in chicken lymphocytes显示文摘 | Jiangwei Han Xingming Jiang Lida Zhang | 2011 | Carbohydrate Polymers2011，，3： | 1 |
| 17 | Enhanced chemoselectivity of a plant cytochrome P450 through protein engineering of surface and catalytic residues显示文摘Cytochrome P450s(P450s)are the most versatile catalysts utilized by plants to produce structurally and functionally diverse metabolites.Given the high degree of gene redundancy and challenge to functionally characterize plant P450s,protein engineering is used as a complementarystrategy to study the mechanisms of P450-mediated reactions,or to alter their functions.We previously proposed an approach of engineering plant P450s based on combining high accuracy homology models generated by Rosetta combined with data-driven design using evoluti onary information of these enzymes.With this strategy,we repurposed a multi-functional P450(CYP87D20)into a monooxygenase after red esigning its active site.Since most plant P450s are membrane-anchored proteins that are adapted to the micro-environments of plant cells,expressing them in heterologous hosts usually results in problems of expression or activity.Here,we applied compu-tational design to tackle these issues by simultaneous optimization of the protein surface and active site.After screening 17 variants,effective su bstitutions of surface residues were observed to improve both expression and activity of CYP87D20.In addition,the identified substitutions were additive and by com-bining them a highly eficient C11 hydroxylase of cucurbitadienol was created to participate in the mogrol biosynthesis.This study shows the importance of considering the interplay between surface and active site residues for P450 engineering.Our integrated strategy also opens an avenue to create more tai loring enzymes with desired functions for the metabolic engineering of high-valued compounds like mogrol,the precursor of natural sweetener mogrosides. | Xiaopeng Zhang Wei Luo Yinying Yao Xuming Luo Chao Han Yang Zhong Bo Zhang Dawei Li Lida Han Sanwen Huang Per Greisen Yi Shang | 2021 | aBIOTECH2021，2，3： | 1 |
| 18 | A rough set approach to knowledge reduction based on inclusion degree and evidence reasoning theory 显示文摘 | ZHANG Mei XU Lida ZHANG Wenxiu | 2003 | Expert Sys- tems2003，20，5： | 1 |
| 19 | Heterosis and polymorphisms of gene expression in an elite rice hybrid as revealed by a microarray analysis of 9198 unique ESTs显示文摘 | Yi Huang Lida Zhang Jianwei Zhang Dejun Yuan Caiguo Xu Xianghua Li Daoxiu Zhou Shiping Wang Qifa Zhang | 2006 | Plant Molecular Biology (-)2006，，4： | 1 |
| 20 | Identification and expression profile of GbAGL2, a C-class gene from G ossypium barbadense显示文摘 | Xiang Liu Kaijing Zuo Fei Zhang Ying Li Jieting Xu Lida Zhang Xiaofen Sun Kexuan Tang | 2009 | Journal of Biosciences2009，，6： | 1 |
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