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| 1 | Diabetes mellitus and electrolyte disorders显示文摘Diabetic patients frequently develop a constellation of electrolyte disorders. These disturbances are particularly common in decompensated diabetics, especially in the context of diabetic ketoacidosis or nonketotic hyperglycemic hyperosmolar syndrome. These patients are markedly potassium-, magnesium- and phosphatedepleted. Diabetes mellitus(DM) is linked to both hypo- and hyper-natremia reflecting the coexistence of hyperglycemia-related mechanisms, which tend to change serum sodium to opposite directions. The most important causal factor of chronic hyperkalemia in diabetic individuals is the syndrome of hyporeninemic hypoaldosteronism. Impaired renal function, potassiumsparing drugs, hypertonicity and insulin deficiency are also involved in the development of hyperkalemia. This article provides an overview of the electrolyte disturbances occurring in DM and describes the underlying mechanisms. This insight should pave the way for pathophysiology-directed therapy, thus contributing to the avoidance of the several deleterious effects associated with electrolyte disorders and their treatment. | George Liamis Evangelos Liberopoulos Fotios Barkas Moses Elisaf | 2014 | World Journal of Clinical Cases2014，2，10： | 13 |
| 2 | Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives显示文摘Gastric cancer(GC)represents a leading cause of cancer related morbidity and mortality worldwide accounting for more than 1 million of newly diagnosed cases and thousands of deaths every year.In the last decade,the development of targeted therapies and the optimization of already available chemotherapeutic drugs has expanded the available treatment options for advanced GC and granted better survival expectations to the patients.At the same time,global efforts have been undertaken to investigate in detail the genomic and epigenomic heterogeneity of this disease,resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression profiling.Nonetheless,several randomized studies aimed at exploring new innovative agents,such as immune checkpoint inhibitors,failed to demonstrate clinically meaningful survival advantages.Therefore,it is essential to further improve the molecular characterization of GC subgroups in order to provide researchers and medical oncologists with new tools for patients’selection and stratification in future clinical development programs and subsequent trials.The aim of the present manuscript is to provide a global overview of the recent molecular classifications from The Cancer Genome Atlas and the Asian Cancer Research Group and to present key promising developments in the field of immunotherapy and targeted therapies in metastatic GC. | Antonio Pellino Erika Riello Floriana Nappo Stefano Brignola Sabina Murgioni Selma Ahcene Djaballah Sara Lonardi Vittorina Zagonel Massimo Rugge Fotios Loupakis Matteo Fassan | 2019 | World Journal of Gastroenterology2019，25，38： | 9 |
| 3 | 白光照明是最佳的照明吗?显示文摘 | Steve Fotios 王其 | 2006 | 中国照明电器2006，，1： | 7 |
| 4 | A case of primary isolated non-Hodgkin’s lymphoma of the esophagus in an immunocompetent patient显示文摘Primary non-Hodgkin’s lymphoma of the esophagus is a rare disease.A case of primary isolated nonHodgkin’s lymphoma of the esophagus in a 77-yearold man without acquired immunodeficiency syndrome is presented.We describe the clinical features and the imaging findings(barium swallow,endoscopic ultrasonography and CT)of a biopsy proven B-cell lymphoma with diffuse transmural involvement of the esophagus wall,which was discovered incidentally.We also briefly review the literature. | Ioannis V Kalogeropoulos Athanasios N Chalazonitis Sofia Tsolaki Fotios Laspas Nikolaos Ptohis Ioannis Neofytou Dimitra Rontogianni | 2009 | World Journal of Gastroenterology2009，15，15： | 5 |
| 5 | Attainment of multifactorial treatment targets among the elderly in a lipid clinic显示文摘ObjectiveTo 检验目标成就类脂化合物阴沉, antihypertensive 和 antidiabetic 治疗在在在 Greece.MethodsThis 的一所大学医院的一个专家背景老是包括连续题目 ≥ 的回顾的研究;65 岁(n = 465 ) 与后续 ≥3 年。低密度的脂蛋白胆固醇( LDL-C ),血压( BP )和 glycated 血红素( HbA1c )目标成就根据心病学/欧洲人动脉粥样硬化社会( ESC/EAS )的欧洲社会被记录,为糖尿病( EASD ) guidelines.ResultsThe LDL-C 目标的学习的高血压( ESH ) /ESC 和欧洲协会的欧洲社会被27%很高、高、中等的风险病人,48%和62%分别地达到。更高完成的那些收到的 statin + ezetimibe 与那些收到的 statin monotherapy 相比 LDL-C 目标成就评价(48% 对 33% , P <0.05 ) 。糖尿病的题目, 71% 有 BP <140/85 mmHg,当没有糖尿病, 78% 那些有 BP < 时;140/90 mmHg。非糖尿病的个人(86%) 的一个更高的比例有 BP <150/90 mmHg。另外,有糖尿病的那些的一个更高的比例有 HbA1c <8% 而非 <7%(88% 和 47% ,分别地) 。笔记,从三个非糖尿病的个人的几乎一个和从十个糖尿病的个人的一个在一所大学医院,在非最优的 LDL-C 的老遗体的一个高比例, BP 和 HbA1c 层次的一个专家背景完成了所有三治疗 targets.ConclusionsEven。药联合的使用能改进 multifactorial 治疗目标成就,当不太严格的目标能更容易在这张人口被完成时。 | Fotios Barkas Evangelos Liberopoulos Eleftherios Klouras Angelos Liontos Moses Elisaf | 2015 | Journal of Geriatric Cardiology2015，12，3： | 5 |
| 6 | The impact of non-traditional activities on the estimation of bank efficiency: International evidence显示文摘 | Ana Lozano-Vivas Fotios Pasiouras | 2010 | Journal of Banking and Finance2010，，7： | 2 |
| 7 | Urethral complications after tension-free vaginal tape procedures:A surgical management case series显示文摘AIM:To analyze the clinical features,diagnostic modalities,and the surgical management of urethral complications after tension-free vaginal tape procedures.METHODS:This study encompasses a retrospective review of nine patients presented with urethral complications after midurethral sling procedures.The patients underwent the procedures during a period from 1999 to 2012 in three different regional hospitals in the southwest part of Sweden.The time from sling placement to diagnosis,the risk factors,clinical features,diagnosis,surgical management,and functional outcome are presented.The presenting symptoms were described as either early onset(< 12 mo) or late onset(> 12 mo) according to when they were first reported.RESul TS:Eight cases of urethral erosion and one case of bladder-neck erosion were detected.The mean interval for diagnoses of the erosions ranged from 3 mo to 11 years.The most common presenting symptoms included de novo urgency with or without incontinence(7/9 patients),urinary retention/voiding dysfunction(4/9 patients),urethritis(4/9 patients),relapse of stress-incontinence(3/9 patients),recurrent urinary tract infections(5/9 patients),and hematuria(1/9 patient).In most cases,voiding dysfunction and urethritis occurred early after the operation.The surgical management applied in most cases was transurethral resection of the intraurethral part of the mesh.The removal of the intraurethral mesh resulted in improvement or complete cure of urgency symptomsin 5/7 patients with urgency.Four patients were reoperated with a new stress-incontinence surgery,one with laparoscopic Burch,and three with retropubic tension-free vaginal tape procedures.COn Clu SIOn:Urethral complications should be suspected in the case of de novo urgency and relapse of stressincontinence.Transurethral excision of the intraurethral mesh is the recommended treatment. | Fotios Sergouniotis Bj?rn Jarlshammar Per-G?ran Larsson | 2015 | World Journal of Nephrology2015，4，3： | 2 |
| 8 | Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors:A meta-analysis of cardiovascular outcome trials显示文摘BACKGROUND Dipeptidyl peptidase-4(DPP-4)inhibitors are a generally safe and well tolerated antidiabetic drug class with proven efficacy in type 2 diabetes mellitus(T2DM).Recently,a series of large,randomized controlled trials(RCTs)addressing cardiovascular outcomes with DPP-4 inhibitors have been published.AIM To pool data from the aforementioned trials concerning the impact of DPP-4 inhibitors on surrogate cardiovascular efficacy outcomes and on major cardiac arrhythmias.METHODS We searched PubMed and grey literature sources for all published RCTs assessing cardiovascular outcomes with DPP-4 inhibitors compared to placebo until October 2020.We extracted data concerning the following“hard”efficacy outcomes:fatal and non-fatal myocardial infarction,fatal and non-fatal stroke,hospitalization for heart failure,hospitalization for unstable angina,hospitalization for coronary revascularization and cardiovascular death.We also extracted data regarding the risk for major cardiac arrhythmias,such as atrial fibrillation,atrial flutter,ventricular fibrillation and ventricular tachycardia.RESULTS We pooled data from 6 trials in a total of 52520 patients with T2DM assigned either to DPP-4 inhibitor or placebo.DPP-4 inhibitors compared to placebo led to a non-significant increase in the risk for fatal and non-fatal myocardial infarction[risk ratio(RR)=1.02,95%CI:0.94-1.11,I2=0%],hospitalization for heart failure(RR=1.09,95%CI:0.92-1.29,I2=65%)and cardiovascular death(RR=1.02,95%CI:0.93-1.11,I2=0%).DPP-4 inhibitors resulted in a non-significant decrease in the risk for fatal and non-fatal stroke(RR=0.96,95%CI:0.85-1.08,I2=0%)and coronary revascularization(RR=0.99,95%CI:0.90-1.09,I2=0%),Finally,DPP-4 inhibitors demonstrated a neutral effect on the risk for hospitalization due to unstable angina(RR=1.00,95%CI:0.85-1.18,I2=0%).As far as cardiac arrhythmias are concerned,DPP-4 inhibitors did not significantly affect the risk for atrial fibrillation(RR=0.95,95%CI:0.78-1.17,I2=0%),while they were associated with a significant increase in the risk for atrial flutter,equal to 52%(RR=1.52,95%CI:1.03-2.24,I2=0%).DPP-4 inhibitors did not have a significant impact on the risk for any of the rest assessed cardiac arrhythmias.CONCLUSION DPP-4 inhibitors do not seem to confer any significant cardiovascular benefit for patients with T2DM,while they do not seem to be associated with a significant risk for any major cardiac arrhythmias,except for atrial flutter.Therefore,this drug class should not be the treatment of choice for patients with established cardiovascular disease or multiple risk factors,except for those cases when newer antidiabetics(glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors)are not tolerated,contraindicated or not affordable for the patient. | Dimitrios Ioannis Patoulias Aristi Boulmpou Eleftherios Teperikidis Alexandra Katsimardou Fotios Siskos Michael Doumas Christodoulos E Papadopoulos Vassilios Vassilikos | 2021 | World Journal of Cardiology2021，13，10： | 2 |
| 9 | Caveolin‐1 is a novel regulator of K‐RAS ‐dependent migration in colon carcinogenesis显示文摘 | Upal K. Basu Roy Rebecca S. Henkhaus Fotios Loupakis Chiara Cremolini Eugene W. Gerner Natalia A. Ignatenko | 2013 | Int J Cancer2013，，1： | 2 |
| 10 | Statin escape phenomenon: Fact or fiction?显示文摘AIM To evaluate the presence of the so called 'statin escape' phenomenon among hyperlipidemic subjects attending a lipid clinic. METHODS This was a retrospective analysis of 1240 hyperlipidemic individuals followed-up for ≥ 3 years. We excluded those individuals meeting one of the following criteria: Use of statin therapy at baseline visit, discontinuation of statin treatment at most recent visit, change in statin treatment during follow-up and poor compliance to treatment. Statin escape phenomenon was defined as an increase in lowdensity lipoprotein cholesterol(LDL-C) levels at the most recent visit by > 10% compared with the value at 6 mo following initiation of statin treatment. RESULTS Of 181 eligible subjects, 31% exhibited the statin escape phenomenon. No major differences regarding baseline characteristics were found between statin escapers and non-statin escapers. Both escapes and non-escapes had similar baseline LDL-C levels [174(152-189) and 177(152-205) mg/d L, respectively]. In comparison with nonescapers, statin escapers demonstrated lower LDL-C levels at 6 mo after treatment initiation [88(78-97) mg/d L vs 109(91-129) mg/d L, P < 0.05], but higher levels at the most recent visit [103(96-118) mg/d L vs 94(79-114) mg/d L, P < 0.05]. CONCLUSION These data confirm the existence of an escape phenomenon among statin-treated individuals. The clinical significance of this phenomenon remains uncertain. | Fotios Barkas Moses Elisaf Eleftherios Klouras Theodora Dimitriou Nikolaos Tentolouris Evangelos Liberopoulos | 2017 | World Journal of Experimental Medicine2017，7，1： | 2 |
| 11 | Modeling of Gold Circular Sub-Wavelength Apertures on a Fiber Endface for Refractive Index Sensing显示文摘一条有限差别的时间域途径被用来在光纤维 endface 上调查圆形的亚波长孔的表面电浆子的刺激。这现象提供了敏感液体的基础折射索引传感器。建议传感器是紧缩的并且有潜力在生物医学的应用被过去常。 | Huy NGUYEN Gregory W. BAXTER Stephen F. COLLINS Fotios SIDIROGLOU Ann ROBERTS Timothy J. DAVIS | 2012 | Photonic Sensors2012，2，3： | 2 |
| 12 | Endoscopic ultrasound fine needle aspiration:Technique and applications in clinical practice显示文摘Since its initial report in 1992,endoscopic ultrasoundguided fine needle aspiration(EUS-FNA) has now been incorporated into the diagnostic and staging algorithm for the evaluation of benign and malignant diseases of the gastrointestinal tract and of adjacent organs.Its introduction constitutes a major breakthrough in the endoscopic field and has gradually transformed EUS from a pure imaging modality into a more interventional procedure.In addition,the possibility of collecting samples,providing a definitive cytological and/or histological evidence of the presence of malignancy,has strongly contributed to changing EUS from a subjective,highly operator dependant procedure into a more objective one.This article will review the instrumentation,technique and the most important clinical applications of EUS-FNA. | Benjamin Tharian Fotios Tsiopoulos Nayana George Salvatore Di Pietro Fabia Attili Alberto Larghi | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，12： | 2 |
| 13 | Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as first-line treatment for metastatic colorectal cancer: a phase 2 trial显示文摘 | Gianluca Masi Fotios Loupakis Lisa Salvatore Lorenzo Fornaro Chiara Cremolini Samanta Cupini Andrea Ciarlo Francesca Del Monte Enrico Cortesi Domenico Amoroso Cristina Granetto Gabriella Fontanini Elisa Sensi Cristiana Lupi Michele Andreuccetti Alfredo Fa | 2010 | Lancet Oncology2010，，9： | 2 |
| 14 | The Golden Mile,Kalgoorlie: agiant gold deposit localized in ductile shear zonesby structurally inducedinfiltration of an auriferous metamorphicfluid显示文摘 | Boulter CA Fotios MG Phillips GN | 1987 | Econ Geol1987，82，： | 1 |
| 15 | Investigation of the chromatographic be- haviour of some selenium species-Comparison with their octa- nol-water partitioning显示文摘 | Fotios Tsopelas Anna Tsantili-Kakoulidou Maria Ochsen-kuhn-Petropoulou | 2007 | Talanta2007，73，： | 1 |
| 16 | 用于公共照明的气体放电灯的电力消耗显示文摘 | Steve Fotios 王其(译) | 2006 | 中国照明电器2006，，12： | 1 |
| 17 | A route for bulk separation of semiconducting from metallic single-wall carbon nanotubes显示文摘 | Debjit Chattopadhyay Izabela Galeska Fotios Papadimitrakopoulos | 2003 | J AM Chem Soc2003，125，： | 1 |
| 18 | Regulations,competition and bank risk-taking in transition countries显示文摘 | Maria-Eleni K.Agorakia Manthos D.Delisb Fotios Pasiourasc | | 0，，07： | 1 |
| 19 | Using obstacle detection to identify appropriate illuminances for lighting in residential roads显示文摘 | Fotios S Cheal C | 2013 | Lighting Research and Technology2013，，3： | 1 |
| 20 | Investigating methods for measuring face recognition under lamps of different spectral power distribution显示文摘 | Lin Y Fotios S | 2015 | Lighting Research and Technology2015，，2： | 1 |
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