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| 1 | 识别癌痛病人中的神经病理性疼痛:关于癌性神经病理性疼痛的专家共识和诊断标准的建立显示文摘1.前言癌痛病人常常合并神经病理性疼痛(neuropathicpain, NP),当合并NP时,病人往往对常规的镇痛药物治疗效果反应不佳,而需要增加辅助药物协同阿片类药物的镇痛效果。国际疼痛学会(InternationalAssociation for the Study of Pain, IASP)提出NP定义,以及IASP特别兴趣组(IASP NeuPSIG)有关的NP诊断标准有助于NP的诊断,但这一定义在癌痛合并NP的人群中,是否适用尚有待商榷。 | Brunelli C.Pain 闫伟东(译) 宋莉(校) | 2019 | 中国疼痛医学杂志2019，25，2： | 12 |
| 2 | Cardiac toxicity of trastuzumab in elderly patients with breast cancer显示文摘乳癌(BC ) 在 ≥ 被诊断;65 个岁女人在关于盒子的一半。专家们当前建议,那全身的治疗基于他们的全面条件和预期寿命与 BC 被提供给老病人,好处将超过治疗的风险,这能相当被期望。为年轻题目,相似对人的表皮的生长因素 receptor-2 (HER-2 ) 的 monoclonal 抗体, trastuzumab,代表一种有效治疗学的选择什么时候 BC 在表示上这受体。不幸地, trastuzumab 的管理与左室的机能障碍和长期的心失败(CHF ) 的出现被联系,因为有 homeostatic 的干扰,可能在心 HER-2 工作。基于登记的、回顾的分析在在没为 BC 给任何治疗的那些与 10%-15% 相比收到 trastuzumab 的老女人在 25% 附近报导了 CHF 的发生,并且 CHF 的风险被估计了在 > 更高双重;60-65 岁 trastuzumab 用户对非用户。极其先进的年龄和先存在的心脏病被显示了预先安排到 trastuzumab cardiotoxicity。因此,为有 trastuzumab 的治疗的更老的病人的选择应该主要基于他们的一般地位和 comorbidities 的存在;特别与 anthracyclines,以前的化疗应该也被考虑。一旦治疗开始了,努力应该被作保证常规心脏的监视。选择 biomarkers 的角色,例如心脏的 troponin,或新成像技术(三尺寸,织物 Doppler echocardiography,磁性的回声成像) 是有希望的,但是必须进一步在特别被调查老。而且,另外的研究被需要以便更好理解 trastuzumab 由影响旧心的机制。 | Andrea Denegri Tiziano Moccetti Marco Moccetti Paolo Spallarossa Claudio Brunelli Pietro Ameri | 2016 | Journal of Geriatric Cardiology2016，13，4： | 10 |
| 3 | Contrast-enhanced ultrasound evaluation of hepatic microvascular changes in liver diseases显示文摘AIM:To assess if software assisted-contrast-enhanced ultrasonography (CEUS) provides reproducible perfusion parameters of hepatic parenchyma in patients affected by chronic liver disease. METHODS:Forty patients with chronic viral liver disease, with (n = 20) or without (n = 20) cirrhosis, and 10 healthy subjects underwent CEUS and video recordings of each examination were then analysed with Esaote's Qontrast software. CEUS dedicated software Qontrast was used to determine peak (the maximum signal intensity), time to peak (TTP), region of blood value (RBV) proportional to the area under the time-intensity curve, mean transit time (MTT) measured in seconds and region of blood flow (RBF). RESULTS:Qontrast-assisted CEUS parameters displayed high inter-observer reproducibility (k coefficients of 0.87 for MTT and 0.90 TTP). When the region of interest included a main hepatic vein, Qontrast-calculated TTP was significantly shorter in cirrhotic patients (vs non-cirrhotics and healthy subjects) (71.0 ± 11.3 s vs 82.4 ± 15.6 s, 86.3 ± 20.3 s, P < 0.05). MTTs in the patients with liver cirrhosis were significantly shorter than those of controls (111.9 ± 22.0 s vs 139.4 ± 39.8 s, P < 0.05), but there was no significant difference between the cirrhotic and non-cirrhotic groups (111.9 ± 22.0 s vs 110.3 ± 14.6 s). Peak enhancement in the patients with liver cirrhosis was also higher than that observed in controls (23.9 ± 5.9 vs 18.9 ± 7.1, P = 0.05). There were no significant intergroup differences in the RBVs and RBFs. CONCLUSION:Qontrast-assisted CEUS revealed reproducible differences in liver perfusion parameters during the development of hepatic fibrogenesis. | Francesco Ridolfi Teresa Abbattista Paolo Busilacchi Eugenio Brunelli | 2012 | World Journal of Gastroenterology2012，18，37： | 10 |
| 4 | Clinical characteristics and prognostic impact of atrial fibrillation in patients with chronic heart failure显示文摘AIM To assess the prevalence, clinical characteristics and independent prognostic impact of atrial fibrillation(AF) in chronic heart failure(CHF) patients, and the potential protective effect of disease-modifying medications, particularly beta-blockers(BB). METHODS We retrospectively reviewed the charts of patients referred to our center since January 2004, and collected all clinical information available at their first visit. We assessed mortality to the end of June 2015. We compared patients with and without AF, and assessed the association between AF and all-cause mortality by multivariate Cox regression and Kaplan-Meyer analysis, particularly accounting for ongoing treatment with BB.RESULTS A total of 903 patients were evaluated(mean age 68 ± 12 years, 73% male). Prevalence of AF was 19%, ranging from 10% to 28% in patients ≤ 60 and ≥ 77 years, respectively. Besides the older age, patients with AF had more symptoms(New York Heart Association II-III 60% vs 44%), lower prevalence of dyslipidemia(23% vs 37%), coronary artery disease(28% vs 52%) and left bundle branch block(9% vs 16%). On the contrary, they more frequently presented with an idiopathic etiology(50% vs 24%), a history of valve surgery(13% vs 4%) and received overall more devices implantation(31% vs 21%). The use of disease-modifying medications(i.e., BB and ACE inhibitors/angiotensin receptor blockers) was lower in patients with AF(72% vs 80% and 71% vs 79%, respectively), who on the contrary were more frequently treated with symptomatic and antiarrhythmic drugs including diuretics(87% vs 69%) and digoxin(51% vs 11%). At a mean follow-up of about 5 years, all-cause mortality was significantly higher in patients with AF as compared to those in sinus rhythm(SR)(45% vs 34%, P value < 0.05 for all previous comparisons). However, in a multivariate analysis including the main significant predictors of allcause mortality, the univariate relationship between AF and death(HR = 1.49, 95%CI: 1.15-1.92) became not statistically significant(HR = 0.98, 95%CI: 0.73-1.32). Nonetheless, patients with AF not receiving BB treatment were found to have the worst prognosis, followed by patients with SR not receiving BB therapy and patients with AF receiving BB therapy, who both had similarly worse survival when compared to patients with SR receiving BB therapy.CONCLUSION AF was highly prevalent and associated with older age, worse clinical presentation and underutilization of disease-modifying medications such as BB in a population of elderly patients with CHF. AF had no independent impact on mortality, but the underutilization of BB in this group of patients was associated to a worse long-term prognosis. | Lorenzo Gigli Pietro Ameri Gianmarco Secco Gabriele De Blasi Roberta Miceli Alessandra Lorenzoni Francesco Torre Francesco Chiarella Claudio Brunelli Marco Canepa | 2016 | World Journal of Cardiology2016，8，11： | 4 |
| 5 | High body mass index predicts multiple prostate cancer lymph node metastases after radical prostatectomy and extended pelvic lymph node dissection显示文摘Our aim is to evaluate the association between body mass index(BMI)and preoperative total testosterone(TT)levels with the risk of single and multiple metastatic lymph node invasion(LNI)in prostate cancer patients undergoing radical prostatectomy and extended pelvic lymph node dissection.Preoperative BMI,basal levels of TT,and prostate-specific antigen(PSA)were evaluated in 361 consecutive patients undergoing radical prostatectomy with extended pelvic lymph node dissection between 2014 and 2017・Patients were grouped into either nonmetastatic,one,or more than one metastatic lymph node invasion groups.The association among clinical factors and LNI was evaluated.LNI was detected in 52(14.4%)patients:28(7.8%)cases had one metastatic node and 24(6.6%)had more than one metastatic node.In the overall study population,BMI correlated inversely with TT(r=-0.256;P<0.0001).In patients without metastases,BMI inversely correlated with TT(r=-0.282;P<0.0001).In patients with metastasis,this correlation was lost.In the overall study population,BMI(odds ratio[OR]=1.268;P=0.005)was the only in dependent clinical factor associated with the risk of multiple metastatic LNI compared to cases with one metastatic node.In the nonmetastatic group,TT was lower in patients with BMI>28 kg m^2(P<0.0001).In patients with any LNI,this association was lost(P=0.232).The median number of positive nodes was higher in patients with BMI>28 kg m^2(P-0.048).In our study,overweight and obese patients had a higher risk of harboring multiple prostate cancer lymph node metastases and lower TT levels when compared to patients with normal BMI. | Antonio B Porcaro Alessandro Tafuri Marco Sebben Tania Processali Marco Pirozzi Nelia Amigoni Riccardo Rizzetto Aliasger Shakir Maria Angela Cerruto Matteo Brunelli Salvatore Siracusano Walter Artibani | 2020 | Asian Journal of Andrology2020，22，3： | 3 |
| 6 | Left atrial thrombosis in an anticoagulated patient after bioprosthetic valve replacement:Report of a case显示文摘We present the case of a 74 year old woman suffering from severe mitral valve incompetence and rapid atrial fibrillation. After an appropriate vitamin K antagonist(VKA) therapy, the patient underwent mitral valve replacement by bioprosthesis. Then, the patient was rehospitalized for jaundice. Suspecting hepatotoxicity, VKA was discontinued and fondaparinux was started. During this treatment, the patient developed a symptomatic atrial thrombus. After exclusion of a hepatic disease, VKA was re-established with hemodynamic and liver enzymes normalization and atrial thrombus resolution. Caution has to be used when considering fondaparinux as an alternative strategy to VKA in patients with multiple thrombotic risk factors. | Gian Marco Rosa Antonello Parodi Ulrico Dorighi Federico Carbone Franois Mach Alessandra Quercioli Fabrizio Montecucco Nicolas Vuilleumier Manrico Balbi Claudio Brunelli | 2014 | World Journal of Clinical Cases2014，2，1： | 2 |
| 7 | 显示文摘 | Lanzara A Saini N L Brunelli M | 1998 | Phys Rev Lett1998，81，： | 2 |
| 8 | Face recognition: features versus templates 显示文摘 | Brunelli R Poggio T | 1993 | IEEE Transactions on Pattern Analysis and Machine Intelligence1993，15，10： | 1 |
| 9 | The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo显示文摘 | Brunelli D Tavecchio M Falcioni C | 2009 | Biochemical Pharmacology2009，79，8： | 1 |
| 10 | Ultrasound biomicroscopy mechanisms of deep sclerectomy with reticulated hyaluronic acid implant 显示文摘 | Marehini G Marraffa M Brunelli and intraocular-pressure-lowering C | 2001 | J Cataract Refract Surg2001，27，4： | 1 |
| 11 | Feature recognition:features versus template显示文摘 | BRUNELLI R POGGIO T | 1993 | IEEE Transactions on PAMI1993，15，： | 1 |
| 12 | Comparison between numerical rat- ing scale and six-level verbal rating scale in cancer patients with pain : a preliminary report显示文摘 | Ripamonti CI Brunelli C | 2009 | Support Care Cancer2009，17，11： | 1 |
| 13 | Field strains of Stemphylium vesicarium with a resistance to dicarboximide fungicides correlated with changes in a two-component histidine kinase 显示文摘 | Alberoni G Collina M Lanen C Leroux P Brunelli A | 2010 | Eur J Plant Pathol2010，128，： | 1 |
| 14 | Magnetic resonance imaging in the evaluation o{ placental adhesive disorders: correla- tion with color Doppler ultrasound显示文摘 | Masselli G Brunelli R Casciani E | 2008 | Eur Radiol2008，18，6： | 1 |
| 15 | Contrast-enhanced ultrasound to evaluate the severity of chronic hepatitis C显示文摘 | F. Ridolfi T. Abbattista F. Marini A. Vedovelli P. Quagliarini P. Busilacchi E. Brunelli | 2007 | Digestive and Liver Disease2007，，10： | 1 |
| 16 | Problems in never lesions显示文摘 | Brushart TM Monini L Brunelli F | 1985 | Microsurgery1985，6，4： | 1 |
| 17 | Ultrasound biomicroscopic and conventional ultrasono- graphic study of ocular dimensions in primary angle-closure glaucoma显示文摘 | Marchini G Pagliarasco A Toscano A Tosi R Brunelli C Bono- mi L | 1998 | Ophthalmology1998，105，11： | 1 |
| 18 | High prevalence of mild hyperhomoeysteinemia in patients with abdominal aortic aneurysm显示文摘 | Brunelli T Priseo D Fedi S | 2000 | J Vase Surg2000，32，3： | 1 |
| 19 | Corona - charged aerosol detection in supercritical fluid chromatography for pharma- ceutical analysis 显示文摘 | BRUNELLI C GORECK T ZHAO Y | 2007 | Anal Chem2007，79，6： | 1 |
| 20 | Combination of PI3K/mTOR inhibitors: antitumor activity and molecular correlates 显示文摘 | Mazzoletti M Bortolin F Brunelli L | 2011 | Cancer Res2011，71，13： | 1 |
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