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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 3 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 4 | Development of a PCR ELISA assay for the identification of Campylobacter jejuni and Campylobacter coli 显示文摘 | SAILS A D FOX A J BOLTON F J | 2001 | Mol Cell Probe2001，15，： | 1 |
| 5 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 6 | Proton exchange membrane(PEM)electrolyzer operation under anode liquid and cathode vapor feed configurations显示文摘 | GREENWAY S D FOX E B EKECHUKWU A A | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 7 | Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events(TRA 2°P)-TIMI 50 trial 显示文摘 | MORROW D A SCIRICA B M FOX K A | 2009 | Am Heart J2009，158，3： | 1 |
| 8 | Social Media Use by Government:from the Routine to the Critical 显示文摘 | Kavanaugh A L Fox E A Sheetz S D | 2012 | Government Information Quarterly2012，29，： | 1 |
| 9 | The role of titanium in the non-metallic inclusions which nucleate acicular ferrite in the submerged arc weld fusion zones of navy HY - 100 steel显示文摘 | Fox A G Brothers D G | 1995 | Scripta Metallurgica Materialia1995，32，7： | 1 |
| 10 | Cutting balloon-as sisted angioplasty of an anastomouc carotid-brachial bypass graft stenosis显示文摘 | PRABHUDESAI V ORME R FOX A D | 2004 | Cardiovasc Intervent Radionl2004，27，4： | 1 |
| 11 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 12 | Incremental clustering for very large document databases: Initial MARIAN experience显示文摘 | CAN F FOX E A SNAVELY C D | 1995 | Information sciences1995，84，12： | 1 |
| 13 | Use of detachable balloons for proximal artery occlusion in the treatment of unclippable cerebral aneurysms显示文摘 | Fox A J Vinuela F Pelz D M | 1987 | J Neurosurg1987，66，1： | 1 |
| 14 | Principal mechanisms of damping in cast iron 显示文摘 | Adams R D Fox M A O | 1973 | Journal of the Iron and Steel Institute1973，，7： | 1 |
| 15 | Evaluation of realtime PCR for diagnosis of Bordetella pertussis infection显示文摘 | KNORR L FOX J D TILLEY P A | 2006 | BMC Infect Dis2006，，6： | 1 |
| 16 | The role of soil surface crusting in desertification and strategies to reduce crusting显示文摘 | Fox D M Bryan R B Price A G | 2004 | Environmental Monitoring and Assessment2004，99，13： | 1 |
| 17 | Doxycycline-mediated inhibition of matrix metalloproteinases improves healing after rotator cuff repair显示文摘 | Bedi A Fox AJ Kovacevic D | | 0，，02： | 1 |
| 18 | A cardiac prevention and rehabilitation programme for all patients at first presentation with coronary artery disease显示文摘 | Fox K F Nuttall M Wood D A | | 0，，05： | 1 |
| 19 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 20 | Trends in Biotechnology,显示文摘 | Fox D B Moody T S | 2001 | 19:292001，19，： | 1 |
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