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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Structure- property relationship in nanostructures of young and ma- ture soot in premixed flames显示文摘 | AIf4 M Apicella B Barbella R | 2009 | Proceedings the Combustion Institute2009，32，1： | 1 |
| 3 | Kinetic and catalytic aspects of the formation of poly( ethylene tereph- thalate) (PET) investigated with model molecules 显示文摘 | APICELLA B DI SERIO M FIOCCA L | 1998 | J App Polymer Sci1998，69，12： | 1 |
| 4 | The effect of temperature on soot properties in premixed methane flames显示文摘 | Alf M Apicella B Rouzaud J-N | 2010 | Combustion and Flame2010，157，10： | 1 |
| 5 | Fluorescence Spectroscopy of Aromatic Species Produced in Rich Premixed Ethylene Flames显示文摘 | Ciajolo A Ragucci R Apicella B | | 0，，5： | 1 |
| 6 | The effect of temperature on soot properties in premixed methane flames显示文摘 | All M Apicella B Rouzaud J-N | 2010 | Combustion and Flame2010，157，10： | 1 |
| 7 | Synthesis and pufification of anthraquinone in a multifunctional reactor显示文摘 | Scaglione A Apicella B | 2001 | Catal Today2001，66，： | 1 |
| 8 | Catal Today显示文摘 | Santacesaria E Scaglione A Apicella B | 2001 | 66:1672001，66，： | 1 |
| 9 | Structure-propertyrelationship in nanostructures of young and mature soot in premixedflames显示文摘 | ALFE M APICELLA B BARBELLA R | 2009 | Proceedings of the Combustion Institute2009，32，1： | 1 |
| 10 | The effect of temperature on soot properties in premixed methane fames显示文摘 | Alfe M Apicella B Rouzaud J | 2010 | Combustion and Flame2010，157，10： | 1 |
| 11 | The effect oftemperature on soot properties in premixed methaneflames显示文摘 | Alfe M Apicella B Rouzaud J N | 2010 | Combustion and Flame2010，157，10： | 1 |
| 12 | Fluorescencespectroscopy Of aromatic species produced in rich premixed ethylene flames显示文摘 | Ciajolo A Ragucci R Apicella B | 2001 | Chemosphere2001，42，57： | 1 |
| 13 | Synthesis and purification of anthraquinone in multifunctional reactor显示文摘 | Santacesaria E Scaglione A Apicella B | 2001 | Catal Today2001，66，： | 1 |
| 14 | Monitor- ing of F~el Consumption and Aromatics Formation in a Kerosene Spray Flame as Characterized by Fluorescence Spectroscopy 显示文摘 | Allouis C Apicella B Barbella R | 2003 | Chemosphere2003，51，： | 1 |
| 15 | Similarities and dis- similarities in n-hexane and benzene sooting premixed flames 显示文摘 | Alfe M Apicella B Barbella R | 2007 | Proc Combust Inst2007，31，1： | 1 |
| 16 | Structure- property relationship in nanostructures of young and ma- ture soot in premixed flames显示文摘 | Alfe M Apicella B Barbella R | 2009 | Proceedings of the Combustion Institute2009，32，1： | 1 |
| 17 | Effect of fuel/air ratio and aromaticity on sooting behavior of premixed heptane flames显示文摘 | Anna A D Alfe M Apicella B | 2007 | Energy & Fuels2007，21，5： | 1 |
| 18 | Fluorescence spectroscopy of aromatic species produced in rich premixed ethylene flames 显示文摘 | Ciajolo A Ragucci R Apicella B | 2001 | Chemosphere2001，42，5： | 1 |
| 19 | Fluorescence spec-troscopy of complex aromatic mixtures显示文摘 | Apicella B Ciajolo A Tregrossi A | | 0，，07： | 1 |
| 20 | Poly(ethylene oxide)(PEO) and different molecular weight PEO blends monolithic derives for drug release显示文摘 | Apicella A Cappeilo B DeiNobile M A | 1993 | Biomaterials1993，14，2： | 1 |
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