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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Reliability in endoscopic diagnosis of portal hypertensive gastropathy显示文摘AIM: To analyze reliability among endoscopists in diagnosing portal hypertensive gastropathy (PHG) and to determine which criteria from the most utilized classifications are the most suitable. METHODS: From January to July 2009, in an academic quaternary referral center at Santa Casa of S o Paulo Endoscopy Service, Brazil, we performed this singlecenter prospective study. In this period, we included 100 patients, including 50 sequential patients who had portal hypertension of various etiologies; who were previously diagnosed based on clinical, laboratory and imaging exams; and who presented with esophageal varices. In addition, our study included 50 sequentialpatients who had dyspeptic symptoms and were referred for upper digestive endoscopy without portal hypertension. All subjects underwent upper digestive endoscopy, and the images of the exam were digitally recorded. Five endoscopists with more than 15 years of experience answered an electronic questionnaire, which included endoscopic criteria from the 3 most commonly used Portal Hypertensive Gastropathy classifications (McCormack, NIEC and Baveno) and the presence of elevated or flat antral erosive gastritis. All five endosco- pists were blinded to the patients' clinical information, and all images of varices were deliberately excluded for the analysis. RESULTS: The three most common etiologies of portal hypertension were schistosomiasis (36%), alcoholic cirrhosis (20%) and viral cirrhosis (14%). Of the 50 patients with portal hypertension, 84% were Child A, 12% were Child B, 4% were Child C, 64% exhibited previous variceal bleeding and 66% were previously endoscopic treated. The endoscopic parameters, presence or absence of mosaic-like pattern, red point lesions and cherry-red spots were associated with high inter-observer reliability and high specificity for diagnosing Portal Hypertensive Gastropathy. Sensitivity, specificity and reliability for the diagnosis of PHG (%) were as follows: mosaic-like pattern (100; 92.21; High); fine pink speckling (56; 76.62; Unsatisfactory); superficial reddening (69.57; 66.23; Unsatisfactory); red-point lesions (47.83; 90.91; High); cherry-red spots (39.13; 96.10; High); isolated red marks (43.48; 88.31; High); and confluent red marks (21.74; 100; Unsatisfactory). Antral elevated erosive gastritis exhibited high reliability and high specificity with respect to the presence of portal hypertension (92%) and the diagnosis of portal hypertensive gastropathy (88.31%). CONCLUSION: The most suitable endoscopic criteria for the diagnosis of PHG were mosaic-like pattern, redpoint lesions and cherry-red spots with no subdivisions,which were associated with a high rate of inter-observer reliability. | George Fred Soares de Macedo Fabio Gon alves Ferreira Maurício Alves Ribeiro Luiz Arnaldo Szutan Mauricio Saab Assef Lucio Giovanni Battista Rossini | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 9 |
| 3 | Non-invasive tests for the prediction of primary hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies in the world and it is one of the main complications of cirrhosis and portal hypertension.Even in the presence of a well-established follow-up protocol for cirrhotic patients,to date poor data are available on predictive markers for primary HCC occurrence in the setting of compensated advanced chronic liver disease patients(cACLD).The gold standard method to evaluate the prognosis of patients with cACLD,beyond liver fibrosis assessed with histology,is the measurement of the hepatic venous pressure gradient(HVPG).An HVPG≥10 mmHg has been related to an increased risk of HCC in cACLD patients.However,these methods are burdened by additional costs and risks for patients and are mostly available only in referral centers.In the last decade increasing research has focused on the evaluation of several,simple,non-invasive tests(NITs)as predictors of HCC development.We reviewed the currently available literature on biochemical and ultrasound-based scores developed for the noninvasive evaluation of liver fibrosis and portal hypertension in predicting primary HCC.We found that the most reliable methods to assess HCC risk were the liver stiffness measurement,the aspartate aminotransferase to platelet ratio index score and the fibrosis-4 index.Other promising NITs need further investigations and validation for different liver disease aetiologies. | Giovanni Marasco Antonio Colecchia Giovanni Silva Benedetta Rossini Leonardo Henry Eusebi Federico Ravaioli Elton Dajti Luigina Vanessa Alemanni Luigi Colecchia Matteo Renzulli Rita Golfieri Davide Festi | 2020 | World Journal of Gastroenterology2020，26，24： | 8 |
| 4 | Osteoporosis Treatment:When to Discontinue and When to Re-start显示文摘A number of effective therapies for the treatment of osteoporosis have become available in recent years.However,uncertainty exists regarding their long-term use and effectiveness.Bisphosphonate treatment,unlike hormone replacement,denosumab or teriparatide,is associated with benefits extended even after treatment discontinuation.The extended benefits are most apparent for alendronate(ALN)and zoledronate(ZOL).A drug holiday might be considered in patients at low-moderate risk and who have been fully compliant with treatment,and who have had a response to treatment.In patients at low-moderate risk of fractures the decision to consider a drug holiday should be balanced also with the safety profile of each treatment. | Silvano Adami Luca Idolazzi Elena Fracassi Davide Gatti Maurizio Rossini | 2013 | Bone Research2013，1，4： | 6 |
| 5 | Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: Report of 100 consecutive cases显示文摘 | Marco Pennazio Renato Santucci Emanuele Rondonotti Carla Abbiati Gizela Beccari Francesco P. Rossini Roberto De Franchis | 2004 | Gastroenterology2004，，3： | 5 |
| 6 | 双磷酸盐关节腔内注射用于治疗膝关节骨关节炎显示文摘膝关节骨关节炎是造成残疾的主要原因之一,对55岁以上的人群的10%造成影响。既往多中心研究发现,关节腔内注射氯膦酸二钠(双磷酸盐的一种)可显著改善膝关节骨关节炎患者疼痛和功能,其疗效与透明质酸相当。本研究进一步评定了在膝关节骨关节炎的患者中,关节腔内氯膦酸二钠注射的有效性和患者对上述治疗的耐受性。 | Rossini M Adami S Fracassi E 吴毅 | 2015 | 中国康复2015，30，5： | 4 |
| 7 | Arthroscopic vs open ankle arthrodesis:A prospective case series with seven years follow-up显示文摘BACKGROUND The osteoarthritis of the ankle,although less common than other joints,is associated with severe functional limitation.Surgical options are ankle arthroscopic debridement,osteotomies,ankle arthrodesis and ankle arthroplasty.Ankle arthroplasty is increasingly used thanks to the new implants design,but ankle arthrodesis still represents the most used technique and it can be performed arthroscopically or with an open procedure.AIM To compare mid-term results of arthroscopic vs open ankle arthrodesis of patients affected by end-stage ankle arthritis.METHODS This study enrolled 23 patients,which underwent ankle arthrodesis.The patients were divided into 2 groups:group A(open procedure;n=11)and group B(arthroscopic procedure,n=12),the two groups were homogeneous with regard to age and body mass index(P=0.347).The American Orthopaedic Foot and Ankle score(AOFAS),Freiburg Ankle score(FAS)and visual analogue scale for pain intensity were evaluated preoperatively,at six months and at final follow-up of 7.6 years in group A and 7.3 years in group B(P=0.364).RESULTS Patients in the arthroscopic group showed better results at six-month follow-up compared to the open group at the AOFAS(group A,62.2;group B,78.5;P<0.05)and the FAS(group A,61.1;group B,70.3;P=0.015)scores.Pain relief was achieved in both groups at six-month follow-up(group A,1.4;group B,0.9;P=0.162).Both open and arthroscopic groups showed improved clinical outcomes from baseline to final follow-up(P>0.05).Hospital stay was shorter in group B than in group A(P=0.001).More complications were reported in the open group than in the arthroscopic group(P=0.459).CONCLUSION The arthroscopic and the open arthrodesis are valid and safe options for the treatment of ankle arthritis on the basis of clinical outcomes at 7 years follow-up.Moreover,the arthroscopic treatment shows faster improvement at six-month follow-up in comparison with the open group. | Federico Morelli Giorgio Princi Matteo Romano Cantagalli Marco Rossini Ludovico Caperna Daniele Mazza Andrea Ferretti | 2021 | World Journal of Orthopedics2021，12，12： | 3 |
| 8 | Genetics of barley tiller and leaf development显示文摘In cereals, tillering and leaf development are key factors in the concept of crop ideotype, introduced in the 1960 s to enhance crop yield, via manipulation of plant architecture. In the present review, we discuss advances in genetic analysis of barley shoot architecture,focusing on tillering, leaf size and angle. We also discuss novel phenotyping techniques, such as 2 D and 3 D imaging, that have been introduced in the era of phenomics, facilitating reliable trait measurement. We discuss the identification of genes and pathways that are involved in barley tillering and leaf development,highlighting key hormones involved in the control of plant architecture in barley and rice. Knowledge on genetic control of traits related to plant architecture provides useful resources for designing ideotypes for enhanced barley yield and performance. | Salar Shaaf Gianluca Bretani Abhisek Biswas Irene Maria Fontana Laura Rossini | 2019 | Journal of Integrative Plant Biology2019，61，3： | 3 |
| 9 | Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: Report of 100 consecutive cases显示文摘 | Marco Pennazio Renato Santucci Emanuele Rondonotti Carla Abbiati Gizela Beccari Francesco P. Rossini Roberto De Franchis | 2004 | Gastroenterology2004，，3： | 3 |
| 10 | Nicotinic cholinergic receptors in esophagus:Early alteration during carcinogenesis and prognostic value显示文摘AIM: To compare expression of nicotinic cholinergic receptors(CHRNs) in healthy and squamous cell carcinoma-affected esophagus and determine the prognostic value.METHODS: We performed RT-q PCR to measure the expression of CHRNs in 44 esophageal samples from healthy individuals and in matched normal surrounding mucosa, and in tumors from 28 patientsdiagnosed with esophageal squamous cell carcinoma(ESCC). Next, we performed correlation analysis for the detected expression of these receptors with the habits and clinico-pathological characteristics of all study participants. In order to investigate the possible correlations between the expression of the different CHRN subunits in both healthy esophagus and tissues from ESCC patients, correlation matrices were generated. Subsequently, we evaluated whether the detected alterations in expression of the various CHRNs could precede histopathological modifications during the esophageal carcinogenic processes by using receiver operating characteristic curve analysis. Finally, we evaluated the impact of CHRNA5 and CHRNA7 expression on overall survival by using multivariate analysis.RESULTS: CHRNA3, CHRNA5, CHRNA7 and CHRNB4, but not CHRNA1, CHRNA4, CHRNA9 or CHRNA10, were found to be expressed in normal(healthy) esophageal mucosa. In ESCC, CHRNA5 and CHRNA7 were overexpressed as compared with patient-matched surrounding non-tumor mucosa(ESCC-adjacent mucosa; P < 0.0001 and P = 0.0091, respectively). Positive correlations were observed between CHRNA3 and CHRNB4 expression in all samples analyzed. Additionally, CHRNB4 was found to be differentially expressed in the healthy esophagus and the normalappearing ESCC-adjacent mucosa, allowing for distinguishment between these tissues with a sensitivity of 75.86% and a specificity of 78.95%(P = 0.0002). Finally, CHRNA5 expression was identified as an independent prognostic factor in ESCC; patients with high CHRNA5 expression showed an increased overall survival, in comparison with those with low expression. The corresponding age- and tumor stage-adjusted hazard ratio was 0.2684(95%CI: 0.075-0.97, P = 0.0448).CONCLUSION: Expression of CHRNs is homogeneous along healthy esophagus and deregulated in ESCC, suggesting a pathogenic role for these receptors in ESCC development and progression. | Marina Chianello Nicolau Luis Felipe Ribeiro Pinto Pedro Nicolau-Neto Paulo Roberto Alves de Pinho Ana Rossini Tatiana de Almeida Simao Sheila Coelho Soares Lima | 2016 | World Journal of Gastroenterology2016，22，31： | 2 |
| 11 | Selective uptake of major and trace elements in Erica andevalensis,an endemic species to extreme habitats in the Iberian Pyrite Belt显示文摘To assess the ecophysiological traits and the phytoremediation potential of the endemic heather Erica andevalensis,we determined the concentrations of major and trace elements in different plant parts and in rizosphere soils from Riotinto mining district (Huelva,Spain).The results showed that E.andevalensis may grow on substrates with very high As,Cu,Fe and Pb concentrations (up to 4114,1050,71900 and 15614 μg/g dry weight,respectively),very low availability of macro-and micronutrients and with pH values ranging from 3.3 to 4.9.In these harsh edaphic conditions E.andevalensis selectively absorbed and translocated essential nutrients and excludes potentially phytotoxic elements,which were accumulated in the root epidermis.The concentrations of major and trace elements in E.andevalensis aerial parts from the Riotinto mining district were in the normal range for plants;likewise other Erica species it accumulated Mn and only in a very polluted site we measured leaf concentrations of As and Pb within the excessive or toxic limits for plants.Differently from previous studies,which emphasized the soil pH and bioavailability of phytotoxic elements as the main stress factors,this study showed that in the Riotinto region,E.andevalensis can tolerate wide range of pH and toxic element concentrations;the harshest environments colonized by monospecific patches of this species were characterized above all by very low availability of nutrients.The extraordinary capability to adapt to these extreme habitats made E.andevalensis a priority species to promote the phytostabilization and the development of a self-sustaining vegetative cover on Riotinto mine tailings. | Fabrizio Monaci Eduardo O.Leidi Maria Dolores Mingorance Benito Valdés Sabina Rossini Oliva Roberto Bargagli | 2011 | Journal of Environmental Sciences2011，23，3： | 2 |
| 12 | HMGB1 -stimulated human primary cardiac fibroblasts exert a paracrine action on human and murine cardiac stem cells显示文摘 | Rossini A Zacheo A Mocini D | 2008 | J Mol Cell Cardiol2008，44，4： | 1 |
| 13 | 5 - HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients 显示文摘 | Kato M Zanardi R Rossini D | 2009 | Psychiatry Res2009，167，12： | 1 |
| 14 | Induction of immunologic tolerance for transplantation 显示文摘 | ROSSINI A | 1999 | Physiology Reviews1999，79，1： | 1 |
| 15 | Poststroke plastic organization in the aduh显示文摘 | Rossini PM Calautti C Pauri F | 2009 | Lancet Neurology2009，8，6： | 1 |
| 16 | The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal Prognosis in IgANephropathy显示文摘 | Tores DD Rossini M Manno C | 2008 | Kidney Int2008，73，3： | 1 |
| 17 | Galvanic sludge metals recov- ery by pyrometallurgical and hydrometallurgical treatment显示文摘 | ROSSINI G BERNARDES A M | 2006 | Journal of Hazardous Materials2006，131，123： | 1 |
| 18 | Long -term denervation in humans causes degeneration of both contractile and excitation -contraction coupling apparatus, which is reversible by functional electrical stimulation (FES): a role for myofiber regeneration 显示文摘 | Kern H Boncompagni S Rossini K | 2004 | J Neuropathol Exp Neurol2004，63，9： | 1 |
| 19 | Germination responses of Erica andevalensis to different chemical and physical treatments显示文摘 | S. Rossini Oliva E. O. Leidi B. Valdés | 2009 | Ecological Research2009，，3： | 1 |
| 20 | Methods of measuring residual stresses in components显示文摘 | Rossini N S Dassisti M Benyounis K Y | 2012 | Materials and Design2012，，35： | 1 |
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