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| 1 | Relationship between Lightning Activity and Tropospheric Nitrogen Dioxide and the Estimation of Lightning-produced Nitrogen Oxides over China显示文摘To better understand the relationship between lightning activity and nitrogen oxides(NOX) in the troposphere and to estimate lightning-produced NOX(LNOX) production in China more precisely, spatial and temporal distributions of vertical column densities of tropospheric nitrogen dioxide(NO_2VCDs) and lightning activity were analyzed using satellite measurements. The results showed that the spatial distribution of lightning activity is greater in the east than in the west of China, as with NO_2 VCDs. However, the seasonal and annual variation between lightning and NO_2 density show different trends in the east and west. The central Tibetan Plateau is sparsely populated without modern industry, and NO_2 VCDs across the plateau are barely affected by anthropogenic sources. The plateau is an ideal area to study LNOX. By analyzing 15 years of satellite data from that region, it was found that lightning density is in strong agreement with annual, spatial and seasonal variations of NO_2 VCDs, with a correlation coefficient of 0.79 from the linear fit. Combining Beirle's method and the linear fit equation,LNOXproduction in the Chinese interior was determined to be 0.07(0.02–0.27) Tg N yr^(-1) for 1997–2012, within the range of 0.016–0.384 Tg N yr^(-1) from previous estimates. | Fengxia GUO Xiaoyu JU Min BAO Ganyi LU Zupei LIU Yawen LI Yijun MU | 2017 | Advances in Atmospheric Sciences2017，34，2： | 4 |
| 2 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 3 | Hexagonal boron nitride:A metal-free catalyst for deep oxidative desulfurization of fuel oils显示文摘Oxidative desulfurization(ODS)has been proved to be an efficient strategy for the production of clean fuel oil.Numerous metal-based materials have been employed as excellent ODS catalysts,but being hindered by their high-cost and potential secondary pollution.In this work,we employed graphene analogous hexagonal boron nitride(h-BN)as a metal-free catalyst for ODS with hydrogen peroxide(H2O2)as the oxidant.The h-BN catalyst was characterized and proved to be a few-layered structure with relatively high specific surface areas.The h-BN catalyst showed a 99.4%of sulfur removal in fuel oil under the optimized reaction conditions.Besides,the h-BN can be recycled for 8 times without significant decrease in the catalytic performance.Detailed mechanism analysis found that it is the boron radicals in h-BN activated H2O2 to generate·OH species,which can readily oxidize sulfides to corresponding sulfones for separation.This work would provide another choice in choosing metal-free catalysts for ODS. | Peiwen Wu Linjie Lu Jing He Linlin Chen Yanhong Chao Minqiang He Fengxia Zhu Xiaozhong Chu Huaming Li Wenshuai Zhu | 2020 | Green Energy & Environment2020，5，2： | 3 |
| 4 | Synthesis of Amphiphilic Starch Derivatives Using One-pot Synthesis Procedure显示文摘Amphiphilic starch derivatives with high content of functional groups were prepared from potato starch using a one-pot synthesis method with a single reaction medium for the entire procedure. Potato starch was benzylated, followed by the introduction of hydroxypropyltrimethylammonium(HPMA) moieties without the purification of intermediates. The synthesis was performed under heterogeneous conditions, leading to the formation of benzyl 2-hydroxypropyltri methylammonium starch chloride(BnHPMAS) with a total degree of substitution(DS) of up to 1.4. This process improved the efficiency of the preparation of amphiphilic starch derivatives and reduced the time and resources consumed by avoiding a separation process and purification of the intermediate compounds.The DS of BnHPMAS was in the range of 0.36 to 1.4, which could be tuned by varying the molar ratio of the reagents to repeating unit or by changing the reaction temperature, time, and medium. The structure of the amphiphilic starches was characterized using elemental analysis, size exclusion chromatography,fourier transform infrared spectroscopy(FT-IR), and nuclear magnetic resonance(NMR) spectroscopy. Moreover, the surface tension and turbidity of the solutions of the products were measured for their potential application in the removal of dissolved and colloidal substances in paper cycling water. | Tao Song FengXia Yue XueZhu Xu ChunLin Xu Yi-Chen Li FaChuang Lu HaiSong Qi | 2018 | Paper And Biomaterials2018，3，1： | 3 |
| 5 | Finite-time non-fragile filtering for nonlinear networked control systems via a mixed time/event-triggered transmission mechanism显示文摘This paper is aimed at investigating the problem of mixed time/event-triggered finite-time non-fragile filtering for nonlinear networked control systems with delay.First,a fuzzy nonlinear networked control system model is established by interval type-2(IT2)Takagi-Sugeno(T-S)fuzzy model,the designed non-fragile filter resolves the filter parameter uncertainties and uses different membership functions from the IT2 T-S fuzzy model.Second,a novel mixed time/event-triggered transmission mechanism is proposed,which decreases the waste of network resources.Next,Bernoulli random variables are used to describe the cases of random switching mixed time/event-triggered transmission mechanism.Then,the error filtering system is designed by considering a Lyapunov function and a sufficient condition of finite-time boundedness.In addition,the existence conditions for the finite-time non-fragile filter are given by the linear matrix inequalities(LMIs).Finally,two simulation results are presented to prove the effectiveness of the obtained method. | Zhongda LU Junxiao LU Jiaqi ZHANG Fengxia XU | 2020 | Control Theory and Technology2020，18，2： | 2 |
| 6 | Isolation and characterization of a co-producer of fengycins and surfactins, endophytic Bacillus amyloliquefaciens ES-2, from Scutellaria baicalensis Georgi显示文摘 | Lijun Sun Zhaoxin Lu Xiaomei Bie Fengxia Lu Shengyuan Yang | 2006 | World Journal of Microbiology and Biotechnology2006，，12： | 2 |
| 7 | A novel recombinant DNA vaccine encodingMycobacterium tuberculosis ESAT-6 and FL protects againstMycobacterium tuberculosis challenge in mice显示文摘Mycobacterium tuberculosis 6-kDa early secretory antigenic target(ESAT-6)is a dominant target antigen for cell-mediated immunity in the early phase of tuberculosis.The fms-like tyrosine kinase 3 ligand(FL)that induces potent immune response has been used as an adjuvant in vaccine development.In this study,a new recombinant plasmid(pIRES-epitope-peptides-FL)encoding three T cell epitopes of ESAT-6 and FL was constructed,and the immunogenicity of the DNA vaccine was assessed in C57BL/6 mice immunized with the plasmid DNA vaccine.Additionally,a strategy of intramuscular injection with the DNA vaccine(prime)and intranasal administration of the epitope peptides(boost)was employed to induce higher immune reaction of the mice.The results showed that mice vaccinated with the recombinant plasmid DNA vaccine and boosted with the peptides not only increased the levels of Th1 cytokines(IFN-γand IL-12),the number of IFN-γ+T cells and activities of cytotoxic T lymphocytes as well as IgG,but also enhanced protection against Mycobacterium tuberculosis challenge.In conclusion,these data indicate that the novel recombinant pIRES-epitope-peptides-FL plasmid is a useful DNA vaccine for preventing Mycobacterium tuberculosis infection. | Qingtao Jiang Jing Zhang Xia Chen Mei Xia Yanlai Lu Wen Qiu Ganzhu Feng Dan Zhao Yan Li Fengxia He Guangyong Peng Yingwei Wang | 2013 | The Journal of Biomedical Research2013，27，5： | 2 |
| 8 | Cloning and expression of glutamate decarboxylase gene from Streptococcus thermophilus Y2显示文摘 | LIN Qian YANG Shengyuan LU Fengxia | 2009 | J Gen Appl Microbiol2009，55，4： | 1 |
| 9 | Detection of Salmonella enterica serovar Dublin by polymerase chain reaction in multiplex format显示文摘 | Ligong Zhai Xiaohan Kong Zhaoxin Lu Fengxia Lv Chong Zhang Xiaomei Bie | 2014 | Journal of Microbiological Methods2014，，： | 1 |
| 10 | The antibacterialproperties and strain identification of Lactobacillus acidophilus NX2-6screened from Chigee显示文摘 | WUYUNDALAI LU Fengxia SUN Huigang | 2010 | Milchwissenschaft2010，65，2： | 1 |
| 11 | Isolation and Identification of an Endophytic Strain EJS-3 Producing显示文摘 | Fengxia Lu Lijun Sun Zhaoxin Lu | | 0，，： | 1 |
| 12 | Lipase-catalysed acidolysis of lard with caprylic acid to produce structured lipid显示文摘 | ZHAO Haizhen LU Zhaoxin LU Fengxia | 2006 | Inter- national Journal of Food Science and Technology2006，41，9： | 1 |
| 13 | Synthesis and characterisation of galactosyl glycerol by β-galactosidase catalysed reverse hydrolysis of galactose and glycerol显示文摘 | Wei Wei Danping Qi Hai-zhen Zhao Zhao-xin Lu Fengxia Lv Xiaomei Bie | 2013 | Food Chemistry2013，，3： | 1 |
| 14 | Opti- mized enzymatic synthesis of ascorbyl esters from lard using Novozym 435 inco - solventmixtures 显示文摘 | ZHAO Haizhen ZHANG Yu LU Fengxia | 2011 | J MolCatal B Enzym2011，69，3： | 1 |
| 15 | Separation and extraction of antimicrobial lipopeptides produced by Bacillus amyloliquefaciens ES-2 with macroporous resin显示文摘 | Yu Wang Zhaoxin Lu Xiaomei Bie Fengxia Lv | 2010 | European Food Research and Technology2010，，2： | 1 |
| 16 | Study on microencapsulation of curcumin pigments by spray drying显示文摘 | WANG Yu LU Zhaoxin LU Fengxia | 2009 | European Food Research and Technology2009，229，3： | 1 |
| 17 | Lipase-catalysed acidolysis of lard with caprylic acid to produce structured lipid显示文摘 | ZHAO Haizhen LU Zhaoxin LU Fengxia | | 0，，： | 1 |
| 18 | Evaluation of abundant hydrocarbon-generation depressions in the deepwater area of Qiongdongnan Basin,South China Sea显示文摘It has been confirmed that the key source rocks of Qiongdongnan Basin are associated with the Yacheng Formation, which was deposited in a transitional marine-continental environment. Because the distribution and evolution patterns of the source rocks in the major depressions are different, it is important to determine the most abundant hydrocarbon-generation depressions in terms of exploration effectiveness. Based on an analysis of organic matter characteristics of the source rocks, in combination with drilling data and seismic data, this paper establishes a model to evaluate the hydrocarbon-generation depressions in the deepwater area of Qiongdongnan Basin. First of all, by using the method of seismic-facies model analysis, the distribution of sedimentary facies was determined. Then, the sedimentary facies were correlated with the organic facies, and the distribution of organic facies was predicted. Meanwhile, the thickness of source rocks for all the depressions was calculated on the basis of a quantitative analysis of seismic velocity and lithology. The relationship between mudstone porosity and vitrinite reflectance(Ro) was used to predict the maturity of source rocks. Second, using the parameters such as thickness and maturity of source rocks, the quantity and intensity of gas generation for Yacheng and Lingshui Formations were calculated. Finally, in combination with the identified hydrocarbon resources, the quantity and intensity of gas generation were used as a guide to establish an evaluation standard for hydrocarbon-generation depressions, which was optimized for the main depressions in the Central Depression Belt. It is proposed that Lingshui, Ledong, Baodao and Changchang Depressions are the most abundant hydrocarbon depressions, whilst Songnan and Beijiao Depressions are rich hydrocarbon depressions. Such an evaluation procedure is beneficial to the next stage of exploration in the deep-water area of Qiongdongnan Basin. | LIU Zhen SUN Zhipeng WANG Zisong ZHANG Wei LI Tingan HE Weijun LI Fengxia CAO Shang LIU Jingjing LIN Lu | 2016 | Acta Oceanologica Sinica2016，35，2： | 1 |
| 19 | Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations显示文摘 | Jing Chen Wenzhao Wang Shen Lv Peiyuan Yin Xinjie Zhao Xin Lu Fengxia Zhang Guowang Xu | 2009 | Analytica Chimica Acta2009，，1： | 1 |
| 20 | Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation显示文摘The apoptosis of glomerular mesangial cells(GMCs)is considered to be an important contributor to the initiation and development of rat Thy-1 nephritis(Thy-1N)and is accompanied by sublytic C5b-9 deposition.However,the mechanism by which sublytic C5b-9 triggers GMC apoptosis has not been elucidated.In this study,functional and histological examinations were performed on GMCs treated with sublytic C5b-9(in vitro)and renal tissues of Thy-1N rats(in vivo).The in vitro studies found that sublytic C5b-9 could trigger GMC apoptosis through upregulating Egr-1,ATF3,and Gadd45 expression.Egr-1-mediated post-transcriptional modulation of ATF3,Egr-1/ATF3-enhanced Gadd45 promoter activity,and p300-mediated ATF3 acetylation were all involved in GMC apoptosis.More importantly,the effective binding elements for Egr-1 and ATF3 to Gadd45β/γpromoters and the ATF3 acetylation site were identified.In vivo,silencing renal p300,Egr-1,ATF3,and Gadd45β/γsignificantly decreased GMC apoptosis,secondary GMC proliferation,and urinary protein secretion in Thy-1N rats.Together,these findings implicate that sublytic C5b-9-induced activation of Egr-1/p300–ATF3/Gadd45 axis plays a critical role in GMC apoptosis in Thy-1N rats. | Fengxia He Mengya Zhou Tianyi Yu Dan Zhao Jing Zhang Wen Qiu Yanlai Lu Yu Liu Lulu Wang Yingwei Wang | 2016 | Journal of Molecular Cell Biology2016，8，6： | 1 |
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