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| 1 | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs显示文摘African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig industry.An efficacious vaccine is urgently required.Here,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses.The virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV. | Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng Zhang Fang Li Dan Shan Hefeng Chen Jiwen Zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu | 2020 | Science China(Life Sciences)2020，63，5： | 72 |
| 2 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 3 | Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters显示文摘Since metabolic process differs between humans and mice, studies were performed in hamsters, which are generally considered to be a more appropriate animal model for studies of obesityrelated metabolic disorders. The modulation of gut microbiota, bile acids and the farnesoid X receptor(FXR) axis is correlated with obesity-induced insulin resistance and hepatic steatosis in mice. However,the interactions among the gut microbiota, bile acids and FXR in metabolic disorders remained largely unexplored in hamsters. In the current study, hamsters fed a 60% high-fat diet(HFD) were administeredvehicle or an antibiotic cocktail by gavage twice a week for four weeks. Antibiotic treatment alleviated HFD-induced glucose intolerance, hepatic steatosis and inflammation accompanied with decreased hepatic lipogenesis and elevated thermogenesis in subcutaneous white adipose tissue(sWAT). In the livers of antibiotic-treated hamsters, cytochrome P450 family 7 subfamily B member 1(CYP7 B1) in the alternative bile acid synthesis pathway was upregulated, contributing to a more hydrophilic bile acid profile with increased tauro-β-muricholic acid(TβMCA). The intestinal FXR signaling was suppressed but remained unchanged in the liver. This study is of potential translational significance in determining the role of gut microbiota-mediated bile acid metabolism in modulating diet-induced glucose intolerance and hepatic steatosis in the hamster. | Lulu Sun Yuanyuan Pang Xuemei Wang Qing Wu Huiying Liu Bo Liu George Liu Min Ye Wei Kong Changtao Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 29 |
| 4 | Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively delineate the PDAC intra-tumoral heterogeneity and the underlying mechanism for PDAC progression, we employed single-cell RNA-seq (scRNA-seq) to acquire the transcriptomic atlas of 57,530 individual pancreatic cells from primary PDAC tumors and control pancreases, and identified diverse malignant and stromal cell types, including two ductal subtypes with abnormal and malignant gene expression profiles respectively, in PDAC. We found that the heterogenous malignant subtype was composed of several subpopulations with differential proliferative and migratory potentials. Cell trajectory analysis revealed that components of multiple tumor-related pathways and transcription factors (TFs) were differentially expressed along PDAC progression. Furthermore, we found a subset of ductal cells with unique proliferative features were associated with an inactivation state in tumor-infiltrating T cells, providing novel markers for the prediction of antitumor immune response. Together, our findings provide a valuable resource for deciphering the intra-tumoral heterogeneity in PDAC and uncover a connection between tumor intrinsic transcriptional state and T cell activation, suggesting potential biomarkers for anticancer treatment such as targeted therapy and immunotherapy. | Junya Peng Bao-Fa Sun Chuan-Yuan Chen Jia-Yi Zhou Yu-Sheng Chen Hao Chen Lulu Liu Dan Huang Jialin Jiang Guan-Shen Cui Ying Yang Wenze Wang Dan Guo Menghua Dai Junchao Guo Taiping Zhang Quan Liao Yi Liu Yong-Liang Zhao Da-Li Han Yupei Zhao Yun-Gui Yang Wenming Wu | 2019 | Cell Research2019，29，9： | 24 |
| 5 | miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A显示文摘增加的证据建议 hsa-miR-126 (miR-126 ) 在房间衬里的非小的房间肺癌症(NSCLC ) 是下面调整的, miR-126 的恢复由指向特定的分子损害肿瘤房间增长,移植,侵略,和幸存。这里,我们第一次报导 miR-126 涉及调整 NSCLC 房间的反应到癌症化疗。在有 miR-126 的房间模仿的 transfected A549 或禁止者以后,我们发现 miR-126 的提高的水平显著地与减少的一半被联系 adriamycin ( ADM )和长春新碱的最大的禁止的集中, ADM 的增加的累积,脉管的 endothelial 生长因素 A ( VEGFA )和 multidrug 的下面规定联系抵抗的蛋白质 1 ( MRP1 ),并且 Akt 的 inactivation 发信号的小径。而且,提高了 miR-126 的表示压制了 A549 异种皮移植的生长并且禁止了 VEGFA 和 MRP1 的表示。miR-126 能高效地通过和 VEGFA 3-untranslated 区域的相互作用的下面调整 VEGFA 表示,而 VEGFA 的恢复能部分由 miR-126 稀释 MRP1 的抑制。然而, LY294002,表明小径的 PI3K/Akt 的一个禁止者,减少这效果,建议 miR-126 的那提高的表情通过发信号的 VEGF/PI3K/Akt/MRP1 的否定规定增加了 NSCLC 房间的敏感到 anticancer 代理人小径。 | Xiaolan Zhu Hao Li Lulu Long Lulu Hui Haining Chen Xuefeng Wang Huiling Shen Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 23 |
| 6 | Analogic China map constructed by DNA显示文摘In this research,a nanoscale DNA structure of analogic China map is created. The nanostructure of roughly 150 nm in diameter with a spatial resolution of 6 nm is purely constructed by folding DNA. The picture observed by atomic force microscopy (AFM) is almost identical with the de-signed shape. The DNA origami technology invented by Rothemund in 2006 is employed in the construc-tion of this shape,which has proved the capability of constructing almost any complicated shape enabled by DNA origami,and provides new bottom-up method for constructing nanostructures. | QIAN Lulu WANG Ying ZHANG Zhao ZHAO Jian PAN Dun ZHANG Yi LIU Qiang FAN Chunhai HU Jun HE Lin | 2006 | Chinese Science Bulletin2006，51，24： | 20 |
| 7 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 8 | H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis显示文摘 | Xiaozhuan Dai Youhuang Bai Lihua Zhao Xianying DOU Yanhui Liu Lulu Wang Yi Li Weimin Li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin | 2017 | Molecular Plant2017，10，10： | 14 |
| 9 | Experimental research on coal seam similar material proportion and its application显示文摘In this paper, the optimization design of the low strength mechanical test and orthogonal test have been analyzed in order to simulate the mechanical properties of thick and extra-thick coal seam accurately in a similar material simulation test. The results show that the specimen can reach a wider range of strength when cement has been used compared to that of gypsum, suggesting that cement is more suitable for making coal seam in similar material simulation tests. The uniaxial compressive strength is more sensitive to cement than coal or sand. The proportion of coal and sand do not play a decisive role in uniaxial compressive strength. The uniaxial compressive strength and specimen density decrease as the mass percent of coal and aggregate–binder ratio rise. There is a positive correlation between uniaxial compressive strength and density. The No. 5 proportion(cement: sand: water: activated carbon: coal = 6:6:7:1.1:79.9)was chosen to be used in the similar material simulation test of steeply dipping and extra-thick coal seam with a density of 0.913 g/cm^3 and an uniaxial compressive strength of 0.076 MPa which are in accordance with the similarity theory. The phenomenon of overburden stratum movement, fracture development and floor pressure relief were obtained during the similar material simulation test by using the proportion. | Cheng Weimin Sun Lulu Wang Gang Du Wenzhou Qu Hongyuan | 2016 | International Journal of Mining Science and Technology2016，26，5： | 12 |
| 10 | Integrative genome-wide analysis reveals HLP1, a novel RNA-binding protein, regulates plant flowering by targeting alternative polyadenylation显示文摘 | Yong Zhang Lianfeng Gu Yifeng Hou Lulu Wang Xian Deng Runlai Hang Dong Chen Xiansheng Zhang Yi Zhang Chunyan Liu Xiaofeng Cao | 2015 | Cell Research2015，25，7： | 11 |
| 11 | The Belt and Road:Geographical pattern and regional risks显示文摘Building the Belt and Road is initiatives of China to promote win-win international cooperation in the new era,aiming at green,health,intellect and peace and the joint developme nt with people of the coun tries along the route.Systematic an alysis on envir on mental characteristics,evolutionary tendency and future risks are certainly the scie ntific fun dame ntals of sustainable development for the Belt and Road construction.Applied remote sensing monitoring,statistical analysis,this paper investigates the regional characteristics of climate,topography,soil,hydrology,vegetation cover and terrestrial ecosystems production,as well as socio-economic conditions.Based on the regional characteristics,the Belt and Road is divided into 9 sub-regions:Central and Eastern Europe sub-region with cold and humid climate,Mongolia and Russia sub-region with cold and arid climate,Central and West Asia arid sub-region,Southeast Asia sub-region with warm and humid climate,Pakistan arid sub-region,Bangladesh-India-Myanmar sub-region with warm and humid climate,Eastern China monsoon sub-region,Northwest China arid sub-region and Tibetan Plateau sub-region.Combining modeling simulation with seenario projections,natural disaster assessment methodology is used to assess the risk of extreme events including heat waves,droughts and floods in the coming 30 years(2021-2050).Results show that,on the basis of the regional framework,the western Eurasia would be a warming trend;both sides of Qinghai-Tibet Plateau in high temperature and heat waves risk;Central and Eastern Europe sub-region with cold and humid climate in high drought risk;Bangladesh-lndia-Myanmar sub-region with warm and humid climate as well as Eastern China in high risk of flooding. | WU Shaohong LIU Lulu LIU Yanhua GAO Jiangbo DAI Erfu FENG Aiqing WANG Wentao | 2019 | Journal of Geographical Sciences2019，29，4： | 11 |
| 12 | Toxicity evaluation in a paper recycling mill effluent by coupling bioindicator of aging with the toxicity identification evaluation method in nematode Caenorhabditis elegans显示文摘Toxicity identification evaluation (TIE) can be used to determine the specific toxicant(s) in industrial effluents.In the current study,the authors have attempted to combine the advantages of the model organism,Caenorhabditis elegans,with the virtues of the TIE technique,to evaluate and identify the toxicity on aging from a paper recycling mill effluent.The results indicate that only the toxicities from mixed cellulose (MC) filtration and EDTA treatment are similar to the baseline aging toxicity,suggesting that the suspect toxicants inducing aging toxicity may largely be the heavy metal substances in this industrial effluent.Examination of the accumulation of intestinal autofluorescence in adult animals further confirms that the short lifespans are actually due to accelerated aging.In addition,exposure to fractions of EDTA manipulations cannot result in severe defects of reproduction and locomotion behaviors in C.elegans.Moreover,high levels of Ca,Al,and Fe in the effluent may account for the severe toxicity on aging of exposed nematodes,by TIE assay.The study here provides a new method for evaluating environmental risk and identifying toxicant(s) from the industrial effluent using C.elegans. | WANG, Xiaoyi SHEN, Lulu YU, Hongxia WANG, Dayong | 2008 | Journal of Environmental Sciences2008，20，11： | 11 |
| 13 | Integrated removal of NO and mercury from coal combustion flue gas using manganese oxides supported on TiO_2显示文摘A catalyst composed of manganese oxides supported on titania(MnO_x/TiO_2) synthesized by a sol–gel method was selected to remove nitric oxide and mercury jointly at a relatively low temperature in simulated flue gas from coal-fired power plants. The physico-chemical characteristics of catalysts were investigated by X-ray fluorescence(XRF), X-ray diffraction(XRD), and X-ray photoelectron spectroscopy(XPS) analyses, etc. The effects of Mn loading,reaction temperature and individual flue gas components on denitration and Hg^0 removal were examined. The results indicated that the optimal Mn/Ti molar ratio was 0.8 and the best working temperature was 240°C for NO conversion. O_2 and a proper ratio of [NH_3]/[NO]are essential for the denitration reaction. Both NO conversion and Hg^0 removal efficiency could reach more than 80% when NO and Hg^0 were removed simultaneously using Mn0.8 Tiat 240°C.Hg^0 removal efficiency slightly declined as the Mn content increased in the catalysts. The reaction temperature had no significant effect on Hg^0 removal efficiency. O_2 and HCl had a promotional effect on Hg^0 removal. SO2 and NH_3were observed to weaken Hg^0 removal because of competitive adsorption. NO first facilitated Hg^0 removal and then had an inhibiting effect as NO concentration increased without O_2, and it exhibited weak inhibition of Hg^0 removal efficiency in the presence of O_2. The oxidation of Hg^0 on Mn O x/TiO_2 follows the Mars–Maessen and Langmuir–Hinshelwood mechanisms. | Shibo Zhang Yongchun Zhao Zonghua Wang Junying Zhang Lulu Wang Chuguang Zheng | 2017 | Journal of Environmental Sciences2017，29，3： | 11 |
| 14 | Observations of atmospheric pollutants at Lhasa during 2014-2015:Pollution status and the influence of meteorological factors显示文摘Atmospheric pollutants including SO_2, NO_2, CO, O_3 and inhalable particulate matter(PM2.5 and PM10) were monitored continuously from March 2014 to February 2015 to investigate characteristics of air pollution at Lhasa, Tibetan Plateau. Species exhibited similar seasonal variations except O_3, with the peaks in winter but low valleys in summer. The maximum O_3 concentration was observed in spring, followed by summer, autumn, and winter. The positive correlation between O_3 and PM10 in spring indicated similar sources of them, and was assumed to be turbulent transport. Temperature was the dominant meteorological factor for most species in spring. High temperature accelerates O_3 photochemistry, and favors air disturbance which is conductive to dust resuspension in spring. Relative humidity(RH) and atmospheric pressure were the main meteorological factors in summer. RH showed negative correlations with species, while atmospheric pressure posed opposite situation. Wind speed(WS) was the dominant meteorological factor in autumn, the negative correlations between WS and species indicated diffusion by wind. Most species showed non-significant correlations with meteorological factors in winter, indicating the dependence of pollution on source emission rather than restriction by meteorology. Pollution weather character indicated that emissions were from biomass burning and dust suspension, and meteorological factors also played an important role. Air stream injection from the stratosphere was observed during O_3 pollution period. Air parcels from Southwest Asia were observed during air pollution period in winter. An enhancement in air pollutants such as O_3 would be expected in the future, more attention should be given to countermeasures for prevention of air pollution in the future. | Bu Duo Lulu Cui Zhenzhen Wang Rui Li Liwu Zhang Hongbo Fu Jianmin Chen Huifang Zhang A.Qiong | 2018 | Journal of Environmental Sciences2018，30，1： | 9 |
| 15 | Silicon-based four-mode division multiplexing for chip-scale optical data transmission in the 2 μm waveband显示文摘Based on a silicon platform, we design and fabricate a four-mode division(de)multiplexer for chip-scale optical data transmission in the 2 μm waveband for the first time, to the best of our knowledge. The(de)multiplexer is composed of three tapered directional couplers for both mode multiplexing and demultiplexing processes. In the experiment, the average crosstalk for four channels is measured to be less than-18 dB over a wide wavelength range(70 nm) from 1950 to 2020 nm, and the insertion losses are also assessed. Moreover, we further demonstrate stable 5 Gbit/s direct modulation data transmission through the fabricated silicon photonic devices with nonreturn-to-zero on–off keying signals. The experimental results show clear eye diagrams, and the penalties at a bit error rate of 3.8 × 10-3 are all less than 2.5 dB after on-chip data transmission. The obtained results indicate that the presented silicon four-mode division multiplexer in the mid-infrared wavelength band might be a promising candidate facilitating chip-scale high-speed optical interconnects. | SHUANG ZHENG MENG HUANG XIAOPING CAO LULU WANG ZHENGSEN RUAN LI SHEN JIAN WANG | 2019 | Photonics Research2019，7，9： | 7 |
| 16 | Effect of simvastatin on the expression of farnesoid X receptor in diabetic animal models of altered glucose homeostasis显示文摘 | Wang Lulu Huang Xianping Hu Su Ma Xiaoli Wang Shaolian Pang Shuguang | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 17 | Effects of artificially cultivated biological soil crusts on soil nutrients and biological activities in the Loess Plateau显示文摘Biological soil crusts(BSCs) play an important role in the early succession of vegetation restoration in the Loess Plateau, China. To evaluate the effects of artificially cultivated BSCs on the soil surface micro-environment, we obtained natural moss crusts and moss-lichen crusts from the Loess Plateau of Shaanxi province, and subsequently inoculated and cultivated on horizontal and sloping surfaces of loess soil in a greenhouse. The chemical and biological properties of the subsoil under cultivated BSCs were determined after 10 weeks of cultivation. The results indicated that BSCs coverage was more than 65% after 10 weeks of cultivation. Moss crust coverage reached 40% after 5 weeks of cultivation. Compared with the control, soil organic matter and available nitrogen contents in moss crust with the horizontal treatments increased by 100.87% and 48.23%, respectively; increased by 67.56% and 52.17% with the sloping treatments, respectively; they also increased in moss-lichen crust with horizontal and sloping treatments, but there was no significant difference. Available phosphorus in cultivated BSCs was reduced, soil pH was lower and cationic exchange capacity was higher in cultivated BSCs than in the control. Alkaline phosphatase, urease and invertase activities were increased in artificially cultivated BSCs, and alkaline phosphatase activity in all cultivated BSCs was obviously higher than that in the control. Numbers of soil bacteria, fungi and actinomycetes were increased in the formation process of cultivated BSCs. These results indicate that BSCs could be formed rapidly in short-term cultivation and improve the micro-environment of soil surface, which provides a scientific reference for vegetation restoration and ecological reconstruction in the Loess Plateau, China. | YanMin ZHAO QingKe ZHU Ping LI LeiLei ZHAO LuLu WANG XueLiang ZHENG Huan MA | 2014 | Journal of Arid Land2014，6，6： | 7 |
| 18 | PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis显示文摘histone H3 离氨酸 9 的 Dimethylation (H3K9me2 ) 是与抄写压抑联系的一个重要 epigenetic 标记。这里,我们识别了 PHF8, JmjC-domain-containing 蛋白质,为这个镇压标记特定的 histone demethylase。Recombinant 全身的野类型蛋白质能把 methylation 从 H3K9me2 移开,但是到丙氨酸 H247A 的保存 histidine 的变化废除 demethylase 活动。Overexpressed 外长的 PHF8 是 colocalized, B23 染色。内长的 PHF8 也是有 B23 和 fibrillarin 的 colocalized,二生长得很好的核蛋白质,建议那 PHF8 在核是局部性的并且可以调整 rRNA 抄写。确实, PHF8 跳了到 rDNA 基因的倡导者区域。减少的 PHF8 击倒 rRNA 的表示,和基因的 overexpression 导致了 rRNA 的 upregulation 抄本。附随地, H3K9me2 水平在 PHF8 击倒的房间在 rDNA 基因的倡导者区域被提高并且当野类型然而并非催化地不活跃的 H247A 变异的 PHF8 是 overexpressed 时,显著地减少了。因此,我们的学习为调整 rRNA 抄写的 H3K9me2 识别了 histone demethylase。 | Ziqi Zhu Yanru Wang Xia Li Yiqin Wang Longyong Xu Xiang Wang Tianliang Sun Xiaobin Dong Lulu Chen Hailei Mao Yi Yu Jingsong Li Pin Adele Chen Charlie Degui Chen | 2010 | Cell Research2010，20，7： | 7 |
| 19 | Changes in tropospheric ozone levels over the Three Representative Regions of China observed from space by the Tropospheric Emission Spectrometer (TES), 2005-2010显示文摘Tropospheric ozone observations over China from 2005 to 2010 at three pressure levels (484,681 and 825 hPa) from the Tropospheric Emission Spectrometer on board the NASA Aura satellite have been analyzed.Fourier Transform analysis revealed the trends and seasonality of regionally-averaged,monthly-mean ozone concentrations over western,northern and southern China.Significant increases in ozone levels are found over all three regions at 464 hPa and the rate of increase is fastest over northern China,reaching 0.89±0.059 nL/(La).At 681 hPa,ozone shows increases over northern and western China,at a rate of 0.57± 0.065 nL/(La) and 0.41±0.041 nL/(La) respectively,but is constant over southern China.At 825 hPa,ozone increases at a rate of 0.36±0.074 nL/(La) over northern China,while decreasing over southern China at a rate of 0.21±0.061 nL/(La).Over the three regions,ozone levels are generally higher in summer and lower in winter.Over southern China at all three pressure levels and northern China at the 825 hPa level,ozone shows double peaks occurring in spring and autumn as a result of the combined effects of atmospheric chemistry and global transport.This work provides a useful observational dataset and tools for future analysis of changes in tropospheric ozone over China. | SHEN LuLu WANG YuXuan | 2012 | Chinese Science Bulletin2012，57，22： | 7 |
| 20 | Histological, hormonal and transcriptomic reveal the changes upon gibberellin-induced parthenocarpy in pear fruit显示文摘Phytohormones play crucial roles in fruit set regulation and development.Here,gibberellins(GA4+7),but not GA3,induced pear parthenocarpy.To systematically investigate the changes upon GA4+7 induced pear parthenocarpy,dynamic changes in histology,hormone and transcript levels were observed and identified in unpollinated,pollinated and GA4+7-treated ovaries.Mesocarp cells continued developing in both GA4+7-treated and pollinated ovaries.In unpollinated ovaries,mesocarp cells stopped developing 14 days after anthesis.During fruit set process,GA4+7,but not GA1+3,increased after pollination.Abscisic acid(ABA)accumulation was significantly repressed by GA4+7 or pollination,but under unpollinated conditions,ABA was produced in large quantities.Moreover,indole-3-acetic acid biosynthesis was not induced by GA4+7 or pollination treatments.Details of this GA–auxin–ABA cross-linked gene network were determined by a comparative transcriptome analysis.The indole-3-acetic acid transport-related genes,mainly auxin efflux carrier component genes,were induced in both GA4+7-treated and pollinated ovaries.ABA biosynthetic genes of the 9-cis-epoxycarotenoid dioxygenase family were repressed by GA4+7 and pollination.Moreover,directly related genes in the downstream parthenocarpy network involved in cell division and expansion(upregulated),and MADS-box family genes(downregulated),were also identified.Thus,a model of GA-induced hormonal balance and its effects on parthenocarpy were established. | Lulu Liu Zhigang Wang Jianlong Liu Fengxia Liu Rui Zhai Chunqin Zhu Huibin Wang Fengwang Ma Lingfei Xu | 2018 | Horticulture Research2018，5，1： | 7 |
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