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246篇 您的检索式:作者名="Min BAO"
    题名 作者 年代 出处 被引量
1Effect of hepatitis C virus infection on expression of several cancer-associated gene products in hepatocellular carcinoma显示文摘NTRODUCTIONOurpreviousstudiesbyseroepidemiological,molecularepidemiologicalandimmunopathologicalmethodshaverevealedthathepa...YANG Jian Min, WANG Rong Quan, BU Bao Guo, ZHOU Zi Cheng, FANG Dian Chun and LUO Yuan Hui 1999World Journal of Gastroenterology1999,5,1:42
2Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible.Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO 2005Cell Research2005,15,11:34
3Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma显示文摘AIM: To investigate the expression of programmed death (PD)-1,PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC).METHODS: Liver biopsies and HCC specimens from patients were collected and histologically examined.The expression of PD-1,PD-L1,and PD-L2 in biopsy specimens of chronic hepatitis and HCC specimens was evaluated by immunohistochemical staining.The association between the expression level of PD-1,PD-L1,and PD-L2 and clinical and pathological variables was analyzed statistically.RESULTS: Expression of PD-1 was found in liverinfiltrating lymphocytes.In contrast,PD-L1 and PD-L2 were expressed in non-parenchyma liver cells and tumor cells.The expression of PD-L1 was significantly correlated with hepatitis B virus infection (1.42 ± 1.165 vs 0.50 ± 0.756,P = 0.047) and with the stage of HCC (7.50 ± 2.121 vs 1.75 ± 1.500 vs 3.00 ± 0.001,P = 0.018).PD-1 and PD-Ls were significantly up-regulated in HCC specimens (1.40 ± 1.536 vs 5.71 ± 4.051,P = 0.000;1.05 ± 1.099 vs 4.29 ± 3.885,P = 0.004;1.80 ± 1.473 vs 3.81 ± 3.400,P = 0.020).CONCLUSION: PD-L1 may contribute to negative regulation of the immune response in chronic hepatitis B.PD-1 and PD-Ls may play a role in immune evasion of tumors.Bao-Ju Wang Jun-Jie Bao Jun-ZhongWang Yang Wang Min Jiang Ming-You Xing Wan-Guang Zhang Jun-Ying Qi Michael Roggendorf Meng-Ji Lu Dong-Liang Yang 2011World Journal of Gastroenterology2011,17,28:32
4Hierarchical graphene foam-based phase change materials with enhanced thermal conductivity and shape stability for efficient solar-to-thermal energy conversion and storage显示文摘最近, graphene 泡沫(GF ) 与一三维(3D ) 互连指导模板的化学蒸汽免职(CVD ) 生产的网络被用来与提高的热电导率准备合成阶段变化材料(脉冲编码调制) 。然而, GF 的毛孔尺寸象几百测微计一样大,导致为从在到 GF 神气墙的大毛孔内的 PCM 的热转移的一个显著热电阻。在这研究,新奇 3D 层次 GF (HGF ) 被用空 graphene 网络填满 GF 的毛孔获得。HGF 然后被用来准备基于的石蜡蜡(PW ) 合成脉冲编码调制。PW/HGF 合成脉冲编码调制的热传导性分别地比 PW/GF 合成脉冲编码调制和纯 PW 的高是 87% 和 744% 。PW/HGF 合成脉冲编码调制也与在 100 次骑车比 PW/GF 合成脉冲编码调制,在阶段变化温度的可以忽略的变化,是 95% 纯 PW 的高热的精力存储密度,好热可靠性,和化学稳定性展出更好的形状稳定性。更重要地, PW/HGF 合成脉冲编码调制与高 light-to-thermal 精力变换和存储效率允许光驱动的热精力存储,显示它为在太阳能的利用和存储的应用的大潜力。Guoqiang Qi Jie Yang Ruiying Bao Dongyun Xia Min Cao Wei Yang Mingbo Yang Dacheng Wei 2017Nano Research2017,10,3:18
5Clogging behavior of submerged entry nozzles for Ti-bearing IF steel显示文摘如果钢被 metallographic 分析学习,堵塞 忍受Ti 的行为的嘴,扫描电子 microscopySEM ,精力散 spectroscopyEDS ,和X光检查 diffractionXRD.According 到试验性的结果,嘴堵塞首先出现三 layers.There 是在内部层的很多大尺寸的铁粒子并且主要起炉渣在中间、外部的 layers.The 主管的阶段堵塞内部层的成分是松开的氧化铝簇包括和小粒的塑造的氧化铝包括中间的层的 clog 成分主要是主要阶段在嘴堵塞存在是的树突氧化铝 inclusions.The FeO 牯慭楴湯戬晥牯 ? 敢湩 ? 潳癬摥渠浵牥捩污祬戠 ? 桴 ? 桳潯楴杮洠瑥潨 ? 潂桴愠獳獩楴杮愠摮漠灰獯湩 ? 畢祯湡 ? 汦睯? 敷敲挠湯楳敤敲 ? 瑉椠 ? 潦湵 ? 桴瑡搠慵 ? s 羰 ? 羰 ?Heng Cui Yan-ping Bao Min Wang Wei-shuang Wu 2010International Journal of Minerals,Metallurgy and Materials2010,17,2:17
6Overexpression of heme oxygenasel protects smooth muscle cells against oxidative injury and inhibits cell proliferation显示文摘To investigate whether the expression of exogenous heme oxygenase-1 (HO-l) gene within vascular smooth muscle cells (VSMC) could protect the cells from free radical attack and inhibit cell proliferation,we established an in vitro transfection of human HO-1 gene into rat VSMC mediated by a retroviral vector.The results showed that the profound expression of HO-1 protein as well as HO activity was 1.8- and 2.0-fold increased respectively in the transfected cells compared to the non-transfected ones. The treatment of VSMC with different concentrations of H2O2 led to the remarkable cell damage as indicated by survival rate and LDH leakage. However, the resistance of the HO-1 transfected VSMC against H2O2 was significantly raised. This protective effect was dramatically diminished when the transfected VSMC were pretreated with ZnPP-IX, a specific inhibitor of HO, for 24 h. In addition, we found that the growth potential of the transfected cells was significantly inhibited directly by increased activity of HO-l, and this effect might be related to decreased phosphorylation of MAPK. These results suggest that the overexpression of introduced hHO-1 is potentially able to reduce the risk factors of atherosclerosis, partially due to its cellular protection against oxidative injury and to its inhibitory effect on cellular proliferation.MIN ZHANG, BAO HuI ZHANG, LI CHEN, WEI AN1 Institute of Sports Medicine, The Third Hospital, Peking University, Beijing 100083, China 2Department of Cell Biology, Capital University of Medical Sciences, Beijing 100054, China 2002Cell Research2002,12,2:16
7Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang 2014Cell Research2014,,6:16
8Inner wrinkling control in hydrodynamic deep drawing of an irregular surface part using drawbeads显示文摘Inner wrinkling phenomenon is more likely to develop during hydrodynamic deep drawing(HDD) of complicated component-forms due to the higher demand for controlling deformation sequences. Aiming at the problems in control of inner wrinkling for an irregular surface part featured with both concavity and convex, this research proposes an optimal design method of drawbead parameters to change the material flow. According to theoretical analysis of the mechanism of inner wrinkling, optimizing cavity pressure only is unreasonable to form a wrinkle-free deep-drawn part,so semi-circular drawbeads are employed. The effects of layout and height of drawbeads on forming results are discussed, and a process window is established based on evaluation indicators including the anti-wrinkle coefficient and the minimum wall thickness. Experiments are carried out to validate the process window, and the wall thickness and the wrinkle height are measured and compared with numerical findings. The results show that the anti-wrinkle ability of drawbeads weakens with increasing oblique angle and distance from the die center, while the wall thickness increases with increasing oblique angle and distance, and the inner wrinkling can be completely suppressed by drawbeads arranged in zones I and II with optimum penetration.Meng Bao Wan Min Wu Xiangdong Yuan Sheng Xu Xudong Liu Jie 2014Chinese Journal of Aeronautics2014,27,3:14
9A new triterpene glycoside from sea cucumber Holothuria leucospilota显示文摘A new triterpene glycoside, leucospilotaside A, along with a known saponin, isolated from sea cucumber Holothuria leucospilota, and its structure was elucidated as 3β-O-[4-O-sodiumsulfate-β-D-quinovopyranosyl-(1→2)-β-D-xylopyranosyl]-holosta-22-ketone-9-en-17α,25α-diol (1) by extensive spectroscopic analysis and chemical methods. Leucospilotaside A (1) has a ketone carbonyl group (22) in the aglycon side chain.Hua Han Yang Hua Yi Ling Li Xiao Hua Wang Bao Shu Liu Peng Sun Min Xiang Pan 2007Chinese Chemical Letters2007,18,2:13
10Soil Nematode Response to Biochar Addition in a Chinese Wheat Field显示文摘While studies have focused on the use of biochar as soil amendment, little attention has been paid to its effect on soil fauna. The biochar was produced from slow pyrolysis of wheat straw in the present study. Four treatments, no addition (CK) and three rates of biochar addition at 2 400 (B1), 12 000 (B5) and 48 000 kg ha-1 (B20), were investigated to assess the effect of biochar addition to soil on nematode abundance and diversity in a microcosm trial in China. The B5 and B20 application significantly increased the total organic carbon and the C/N ratio. No significant difference in total nematode abundance was found among the treatments. The biochar addition to the soil significantly increased the abundance of fungivores, and decreased that of plant parasites. The diversity of soil nematodes was significantly increased by B1 compared to CK. Nematode trophic groups were more effectively indicative to biochar addition than total abundance.ZHANG Xiao-Ke LI Qi LIANG Wen-Ju ZHANG Min BAO Xue-Lian XIE Zu-Bin 2013Pedosphere2013,23,1:13
11Control of the precipitation of TiN inclusions in gear steels显示文摘In the 20CrMnTi steel production process, the nitrogen content increased by 19 × 10-6 and 29 × 10-6, respectively, during ladle furnace(LF) refining and during the casting process from ladle to tundish. The protective casting is the key to decrease the N content. The results of thermodynamic calculations and a growth kinetics investigation show that TiN formation occurs only when the solidification fraction is greater than 0.533 under the controlled conditions used in this study for the manufacture of 20CrMnTi steel; the radius of TiN particles decreases as the Ti and N contents decrease and as the cooling rate increases. Furthermore, the theory of austenite grains controlled by second-phase particles was analyzed. The elemental analysis results showed that the Ti content was controlled at 0.04wt%–0.06wt% and the N content decreased to 0.005wt%, which satisfy the requirements for grain refinement but can also effectively prevent the precipitation of TiN inclusions in 20CrMnTi steel.Wen-jun Ma Yan-ping Bao Li-hua Zhao Min Wang 2014International Journal of Minerals,Metallurgy and Materials2014,21,3:12
12Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease,2008-2013显示文摘Objective To investigate the serum total IgE(tlgE) and specific IgE(slgE) to common allergens among allergic patients in Guangzhou,China.Methods 7 085 patients were examined for tlgE and slgE to 15 allergens,based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.Results 3 758(53.04%) patients tested positive for tlgE,and 4 640(65.49%) for slgE.Der pteronyssinus,Der farinae,eggs,and cow's milk were the most common allergens leading to higher positive rates of slgE responses.Several peaks of sensitization were:Der pteronyssinus,Der farinae,and Blomia tropicalis at age 10-12;cow's milk at age below 3;eggs at age 4-6.The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens.Sensitization to Der pteronyssinus(OR,1.6;P<0.05),Der farinae(OR,1.5;P<0.05),Blomia tropicalis(OR,1.4;P<0.05),Blattella germanica(OR,1.5;P<0.05),cow's milk(OR,1.3;P<0.05),and soy beans(OR,2.0;P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.Conclusion The major allergens in Guangzhou include Der pteronyssinus,Der farinae,cow's milk,and eggs.Sensitization to these allergens appears to be predictors of allergy-related disorder.SUN Bao Qing CHEN De Hui ZHENG Pei Yan HUANG Hui Min LUO Wen Ting ZENG Guang Qiao ZHANG Xiao Wen 2014Biomedical and Environmental Sciences2014,27,7:11
13Effect of main inclusions on crack initiation in bearing steel in the very high cycle fatigue regime显示文摘This work aims to investigate the effect of main inclusions on crack initiation in bearing steel in the very high cycle fatigue(VHCF) regime. The size and type of inclusions in the steel were quantitatively analyzed, and VHCF tests were performed. Some fatigue cracks were found to be initiated in the gaps between inclusions(Al2 O3, Mg O-Al2 O3) and the matrix, while other cracks originated from the interior of inclusions(Ti N, Mn S). To explain the related mechanism, the tessellated stresses between inclusions and the matrix were calculated and compared with the yield stress of the matrix. Results revealed that the inclusions could be classified into two types under VHCF; of these two, only one type could be regarded as holes. Findings in this research provide a better understanding of how inclusions affect the high cycle fatigue properties of bearing steel.Chao Gu Yan-ping Bao Peng Gan Min Wang Jin-shan He 2018International Journal of Minerals,Metallurgy and Materials2018,25,6:11
14Micromanufacturing technologies of compact heat exchangers for hypersonic precooled airbreathing propulsion: A review显示文摘The Hypersonic Precooled Combined Cycle Engine(HPCCE), which introduces precooler into traditional hypersonic engine, is regarded as the most promising propulsion system for realizing a single-stage-to-orbit vehicle. The unique demands lead to the application of the compact heat exchangers, which can realize high thrust-to-weight ratio, sufficient specific impulse and high compression ratio. However, it is challenging to accurately manufacture the compact heat exchanger due to its extremely high heat dissipation capacity, remarkable compactness, superior adaptability and harsh operating condition. This review summarizes the precooling schemes of combined cycle propulsions and describes the demands and key issues in the fabrication of a compact heat exchanger for HPCCE. The investigation focuses on the application of various micromanufacturing methods of heat exchangers constructed from tubes of less than 1 mm in diameter and microchannels of less than 200 micrometers. Various micromanufacturing processes, which include microforming, micromachining, stereolithography, chemical etching, 3 D printing, joining and other advanced microfabricating processes, were reviewed. In addition, the technologies are compared in terms of dimensional tolerance, material compatibility, and process applicability. Furthermore, the boundaries of the micromanufacturing constraints are specified as references for the design of compact heat exchangers. Ultimately, the technological difficulties and development trends are discussed for the fabrication of compact heat exchangers for HPCCE.Bao MENG Min WAN Rui ZHAO Zhengping ZOU Huoxing LIU 2021Chinese Journal of Aeronautics2021,34,2:10
15Inclusion variations and calcium treatment optimization in pipeline steel production显示文摘SiCa line and SiCaBaFe alloy were injected into liquid pipeline steel at the end of LF refining as calcium treatment,and samples were taken from the ladles,mould,and slabs.Analysis of Ca content and inclusions shows that Ca content in steel decreases obviously in the following process after calcium treatment;the compositions,morphology,and sizes of inclusions also vary much in the production;primary inclusions in the ladles prior to calcium treatment are mainly Al2O3 inclusions,but they turn to fine irregular CaS-CaO-Al2O3 compound inclusions after the treatment,then become fine globular CaO-Al2O3 inclusions in the mould,and finally change to a few larger irregular CaS-CaO-Al2O3 complex inclusions in the slabs.Thermodynamic study reveals that inclusion variations are related with the preferential reactions among Ca,Al2O3,and S and the precipitation of S in CaO-Al2O3 inclusions with high sulfur capacity.New evaluation standards for calcium treatment in high-grade pipeline steel were put forward according to the inclusion variations and requirements of pipeline steel on inclusion controlling,and the calcium process was studied and optimized.Jian-hua Liu Hua-jie Wu Yan-ping Bao Min Wang 2011International Journal of Minerals,Metallurgy and Materials2011,18,5:10
16Periodontitis may induce gut microbiota dysbiosis via salivary microbiota显示文摘The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary microbes.First,faecal and salivary samples were collected from periodontally healthy participants(PH group,n=16)and patients with severe periodontitis(SP group,n=21)and analysed by 16S ribosomal RNA sequencing.Significant differences were observed in both the faecal and salivary microbiota between the PH and SP groups.Notably,more saliva-sourced microbes were observed in the faecal samples of the SP group.Then,the remaining salivary microbes were transplanted into C57BL6/J mice(the C-PH group and the C-SP group),and it was found that the composition of the gut microbiota of the C-SP group was significantly different from that of the C-PH group,with Porphyromonadaceae and Fusobacterium being significantly enriched in the C-SP group.In the colon,the C-SP group showed significantly reduced crypt depth and zonula occludens-1 expression.The m RNA expression levels of pro-inflammatory cytokines,chemokines and tight junction proteins were significantly higher in the C-SP group.To further investigate whether salivary bacteria could persist in the intestine,the salivary microbiota was stained with carboxyfluorescein diacetate succinimidyl ester and transplanted into mice.We found that salivary microbes from both the PH group and the SP group could persist in the gut for at least 24 h.Thus,our data demonstrate that periodontitis may induce gut microbiota dysbiosis through the influx of salivary microbes.Jun Bao Lili Li Yangheng Zhang Min Wang Faming Chen Shaohua Ge Bin Chen Fuhua Yan 2022International Journal of Oral Science2022,14,3:9
17Strengths, weaknesses, opportunities and threats (SWOT) analysis of reinitiation into methamphetamine abusers: qualitative findings from an exploration of methamphetamine abusers in Shanghai, China显示文摘Background Despite high relapse rate among methamphetamine (MA) abusers, there still have been little empirical data to date detecting the risk factors related to craving and relapse from the perspective of MA abusers. Therefore, the aim of this study was to use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors that could facilitate or impede individuals' abstinence in a real-life context from the perspectives of MA abusers. Aim To use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors relating to individuals' abstinence in a real-life context. Method Semistructured interviews were conducted with 32 MA abusers recruited in Shanghai guided by open-ended questions on narrating the real-life catalysts and inhibitors related to craving, initiation, relapse and abstinence. All data were transcribed verbatim and analysed using a strengths, weaknesses, opportunities and threats (SWOT) analysis. Results The results of the SWOT analysis revealed that contextual factors including peer influence, prevalence and availability of MA, familiar venue of MA use, discrimination, sexual behaviours, alcohol, emotional states and their attitudes towards smoking MA were important factors that contribute to reinitiation and relapse. Surveillance systems, antidrug social workers, vocational skills trainings, moving to another city and family responsibility might serve as counter measures targeti叩 those mentioned weaknesses and threats above. Conclusion This SWOT analysis highlights the complex nature of relapse. Comprehensive interventions strengtheni叩 coping skills such as virtual reality techniques are desperately needed to facilitate individuals1 sustained abstinence.Youwei Zhu Na Zhong Hang Su Xiaolu Ruan Jiayi Bao Lei Zhang Jiang Du Ding Xu Rongjie Ding Ke Xiao Min Zhao 2019General Psychiatry2019,32,3:9
18Two new secolignans from the roots of Urtica mairei Levi.显示文摘Two new secohgnans(1 and 2)were isolated from the roots of Urtica mairei Levi.The structures of these two compounds were determined on the basis of extensive spectroscopic methods including HR-EI-MS,1D and 2D NMR experiments.Wei Wang Xing Guo Yan Li Xin Duan Yuan Zhou Ling Tang Yong Qi Wang Bao Min Feng 2008Chinese Chemical Letters2008,19,10:9
19Treatment of drug-resistant epilepsy with vagus nerve stimulation m review of 45 cases显示文摘背景迷走神经神经刺激( VNS )是为 .The 学习试图探索预后的潜在的因素的药抵抗的癫痫( DRE )的其他的治疗,在有 DRE.Methods 的病人的 VNS 治疗的安全和效果我们回顾地检验了从2004年6月在我们的中心接受了 VNS 治疗到2010年6月并且分析了参数的 DRE 的 45 个盒子(耐心的收到的年龄 VNS ,在 VNS 以及治疗持续时间前后的抓住频率)由学生的 t 测试,菲希尔是准确的并且BAO Min ZHOU Jian LUAN Guo-ming 2011Chinese Medical Journal2011,,24:9
20Progress in ceramic materials and structure design toward advanced thermal barrier coatings显示文摘Thermal barrier coatings(TBCs)can effectively protect the alloy substrate of hot components in aeroengines or land-based gas turbines by the thermal insulation and corrosion/erosion resistance of the ceramic top coat.However,the continuous pursuit of a higher operating temperature leads to degradation,delamination,and premature failure of the top coat.Both new ceramic materials and new coating structures must be developed to meet the demand for future advanced TBC systems.In this paper,the latest progress of some new ceramic materials is first reviewed.Then,a comprehensive spalling mechanism of the ceramic top coat is summarized to understand the dependence of lifetime on various factors such as oxidation scale growth,ceramic sintering,erosion,and calcium–magnesium–aluminium–silicate(CMAS)molten salt corrosion.Finally,new structural design methods for high-performance TBCs are discussed from the perspectives of lamellar,columnar,and nanostructure inclusions.The latest developments of ceramic top coat will be presented in terms of material selection,structural design,and failure mechanism,and the comprehensive guidance will be provided for the development of next-generation advanced TBCs with higher temperature resistance,better thermal insulation,and longer lifetime.Zhi-Yuan WEI Guo-Hui MENG Lin CHEN Guang-Rong LI Mei-Jun LIU Wei-Xu ZHANG Li-Na ZHAO Qiang ZHANG Xiao-Dong ZHANG Chun-Lei WAN Zhi-Xue QU Lin CHEN Jing FENG Ling LIU Hui DONG Ze-Bin BAO Xiao-Feng ZHAO Xiao-Feng ZHANG Lei GUO Liang WANG Bo CHENG Wei-Wei ZHANG Peng-Yun XU Guan-Jun YANG Hong-Neng CAI Hong CUI You WANG Fu-Xing YE Zhuang MA Wei PAN Min LIU Ke-Song ZHOU Chang-Jiu LI 2022Journal of Advanced Ceramics2022,11,7:9
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