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| 1 | A Novel Rice bHLH Transcription Factor, DTD, Acts Coordinately with TDR in Controlling Tapetum Function and Pollen Development显示文摘Dear Editor, Male reproductive development is an essential biological process for flowering plants and crucial for crop seed production.Formation of the male reproductive organ,the anther,involves a number of developmental events,including stamen meristem specification,generation of sporogenous cells and their differentiation into microspore mother cells (MMCs),meiosis,microspore (pollen) maturation,and pollination (Ma,2005).The formation of microspores and their development into mature pollen grains require cooperative interactions between gametophytic (microspores) and sporophytic (anther wall) cells,with the innermost cell layer,the tapetum,playing the most crucial role (Ma,2005).Tapetal cells undergo degeneration by programmed cell death (PCD). | Chonghui Ji Heying Li Libin Chen Min Xie Fengping Wang Yuanling Chen Yao-Guang Liu | 2013 | Molecular Plant2013，6，5： | 14 |
| 2 | Noise-like pulse generation from a thulium-doped fiber laser using nonlinear polarization rotation with different net anomalous dispersion显示文摘A mode-locked thulium-doped fiber laser(TDFL) based on nonlinear polarization rotation(NPR) with different net anomalous dispersion is demonstrated. When the cavity dispersion is-1.425 ps^2, the noise-like(NL) pulse with coherence spike width of 406 fs and pulse energy of 12.342 nJ is generated at a center wavelength of 2003.2 nm with 3 dB spectral bandwidth of 23.20 nm. In the experimental period of 400 min, the 3 dB spectral bandwidth variation, the output power fluctuation, and the central wavelength shift are less than 0.06 nm, 0.04 d B, and0.4 nm, respectively, indicating that the NPR-based TDFL operating in the NL regime holds good long-term stability. | Shuo Liu Fengping Yan Yang Li Luna Zhang Zhuoya Bai Hong Zhou Yafei Hou | 2016 | Photonics Research2016，4，6： | 5 |
| 3 | The POM-DOM piezophilic microorganism continuum(PDPMC)—The role of piezophilic microorganisms in the global ocean carbon cycle显示文摘The deep ocean piezosphere accounts for a significant part of the global ocean,hosts active and diverse microbial communities which probably play a more important role than hitherto recognized in the global ocean carbon cycle.The conventional biological pump concept and the recently proposed microbial carbon pump mechanism provide a foundation for our understanding of the role of microorganisms in cycling of carbon in the ocean.However,there are significant gaps in our knowledge and a lack of mechanistic understanding of the processes of microbially-mediated production,transformation,degradation,and export of marine dissolved and particulate organic matter(DOM and POM)in the deep ocean and the ecological consequence.Here we propose the POM-DOM piezophilic microorganism continuum(PDPMC)conceptual model,to address these important biogeochemical processes in the deep ocean.We propose that piezophilic microorganisms(bacteria and archaea)play a pivotal role in deep ocean carbon cycle where microbial production of exoenzymes,enzymatic breakdown of DOM and transformation of POM fuels the rapid cycling of marine organic matter,and serve as the primary driver for carbon cycle in the deep ocean. | FANG JiaSong ZHANG Li LI Jiang Tao Chiaki KATO Christian TAMBURINI ZHANG YuZhong DANG HongYue WANG GuangYi WANG FengPing | 2015 | Science China Earth Sciences2015，58，1： | 4 |
| 4 | Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma显示文摘Objective:Myeloma bone disease(MBD)is the most common complication of multiple myeloma(MM).Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone disease.However,the mechanism of C3 a/C4 a in osteoclasts MM patients remains unclear.Methods:The formation and function of osteoclasts were analyzed after adding C3 a/C4 a in vitro.RNA-seq analysis was used to screen the potential pathways affecting osteoclasts,and the results were verified by Western blot,q RT-PCR,and pathway inhibitors.Results:The osteoclast area per view induced by 1μg/m L(mean±SD:50.828±12.984%)and 10μg/m L(53.663±12.685%)of C3 a was significantly increased compared to the control group(0μg/m L)(34.635±8.916%)(P<0.001 and P<0.001,respectively).The relative m RNA expressions of genes,OSCAR/TRAP/RANKL/cathepsin K,induced by 1μg/m L(median:5.041,3.726,1.638,and 4.752,respectively)and 10μg/m L(median:5.140,3.702,2.250,and 5.172,respectively)of C3 a was significantly increased compared to the control group(median:3.137,2.004,0.573,and 2.257,respectively)(1μg/m L P=0.001,P=0.003,P<0.001,and P=0.008,respectively;10μg/m L:P<0.001,P=0.019,P<0.001,and P=0.002,respectively).The absorption areas of the osteoclast resorption pits per view induced by 1μg/m L(mean±SD:51.464±11.983%)and 10μg/m L(50.219±12.067%)of C3 a was also significantly increased(33.845±8.331%)(P<0.001 and P<0.001,respectively)compared to the control.There was no difference between the C4 a and control groups.RNA-seq analysis showed that C3 a promoted the proliferation of osteoclasts using the phosphoinositide 3-kinase(PI3 K)signaling pathway.The relative expressions of PIK3 CA/phosphoinositide dependent kinase-1(PDK1)/serum and glucocorticoid inducible protein kinases(SGK3)genes and PI3 K/PDK1/p-SGK3 protein in the C3 a group were significantly higher than in the control group.The activation role of C3 a in osteoclasts of MM patients was reduced by the SGK inhibitor(EMD638683).Conclusions:C3 a activated osteoclasts by regulating the PI3 K/PDK1/SGK3 pathways in MM patients,which was reduced using a SGK inhibitor.Overall,our results identified potential therapeutic targets and strategies for MBD patients。 | Fengjuan Jiang Hui Liu Fengping Peng Zhaoyun Liu Kai Ding Jia Song Lijuan Li Jin Chen Qing Shao Siyang Yan Kim De Veirman Karin Vanderkerken Rong Fu | 2021 | Cancer Biology & Medicine2021，18，3： | 3 |
| 5 | Ultra-stable super-resolution fluorescence cryo-microscopy for correlative light and electron cryo-microscopy显示文摘Remarkable progress in correlative light and electron cryo-microscopy(cryo-CLEM) has been made in the past decade. A crucial component for cryo-CLEM is a dedicated cryo-fluorescence microscope(cryo-FM). Here, we describe an ultra-stable superresolution cryo-FM that exhibits excellent thermal and mechanical stability. The temperature fluctuations in 10 h are less than0.06 K, and the mechanical drift over 5 h is less than 200 nm in three dimensions. We have demonstrated the super-resolution imaging capability of this system(average single molecule localization accuracy of ~13.0 nm). The results suggest that our system is particularly suitable for long-term observations, such as single molecule localization microscopy(SMLM) and cryogenic super-resolution correlative light and electron microscopy(csCLEM). | Xiaojun Xu Yanhong Xue Buyun Tian Fengping Feng Lusheng Gu Weixing Li Wei Ji Tao Xu | 2018 | Science China(Life Sciences)2018，61，11： | 3 |
| 6 | The design and construction of a pulsed beam generation system based on high intensity cyclotron显示文摘In order to perform the studies on a pulsed beam generation system based on a high intensity cyclotron, a test beam line with a pulsed beam generation for a 10 MeV compact cyclotron (CYCIAE-10) has been designed and constructed at China Institute of Atomic Energy (CIAE). A 70 MHz continuous H- beam can be pulsed to the pulse length of less than 10 ns with a repetition rate of 4.4 MHz. The sine waveform with a frequency of 2.2 MHz is adopted for the chopper and a mesh structure with single drift and dual gaps is used for the 70 MHz buncher. A helical resonator is designed and constructed based on simulations and experiments on the RF matching for the chopper. A helical inductance loop that is exceptionally large of its kind and equipped with water cooling for the resonator has been successfully wound and a 500 W solid RF amplifier has been manufactured. A special measuring device has been designed, which can be used to measure both the DC beam and the pulsed beam. The required pulsed beam was obtained after pulsed beam tuning. | AN ShiZhong YIN ZhiGuo LI PengZhan SONG GuoFang WU LongCheng GUAN FengPing XIE HuaiDong JIA XianLu LU YinLong ZHANG TianJue | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 3 |
| 7 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 8 | Enhancing sensing capacity of terahertz metamaterial absorbers with a surface-relief design显示文摘Metamaterial absorbers(MAs)serve as important electromagnetic wave-absorbing devices that have captured the attention of researchers for a long term.Functioning as sensitive detectors to determine perturbations in an ambient environment is another significant subsidiary function.Here,we theoretically propose an optimized fabrication method to implement terahertz MAs with fewer steps and also evaluate both absorption and sensing performances of such MAs realized by the new method.Simulation findings demonstrate that such MAs can basically maintain the original absorption features perfectly,including near-complete absorption at resonance as well as strong robustness to wide incident angles.Specifically,the full width at half-maximum and quality factor of the absorption resonances attenuate less than 26%and 8%with this new method,remaining in the ranges of^0.03–0.04 THz and^20–27 for two selected example MAs.More significantly,sensing capacities of this type of MA,in terms of maximum detection range(enhancing at least 9%),observable spectral modulation(increasing at least 6.3%),and refractive index sensitivity,are improved to a large extent because of more intense coupling between resonant field and matter in the case of surface-relief MAs.This stronger coupling results from exposing more spots of the resonantly high field to direct contact with an approaching analyte,which is illustrated by field profiles of the MAs at resonance in this work.Additionally,other desirable absorber features are also explored with such MAs,like functioning as building blocks to configure multiband MAs and strong robustness against fabrication errors.Such new-style terahertz MAs shown in the paper,acting as good examples,not only prove that terahertz MAs can be fabricated by the proposed time-and cost-saving route in contrast to the traditional MA fabrication process,but also can serve as novel platforms to explore other intriguing terahertz photonic effects,such as the field enhancement effect. | WEI WANG FENGPING YAN SIYU TAN HAISU LI XUEMEI DU LUNA ZHANG ZHUOYA BAI DAN CHENG HONG ZHOU YAFEI HOU | 2020 | Photonics Research2020，8，4： | 3 |
| 9 | SNP-based linkage mapping for validation of adult plant stripe rust resistance QTL in common wheat cultivar Chakwal 86显示文摘Wheat crops in China are constantly challenged by stripe rust. Deployment of cultivars with diverse resistances is the best strategy to control the disease. A recombinant inbred line(RIL) population derived from a cross between the resistant cultivar Chakwal 86 and susceptible landrace Mingxian 169 was studied in multiple environments to examine the underlying genetics and to identify quantitative trait loci(QTL) for stripe rust resistance.One hundred and twenty-eight RILs were genotyped with wheat 35 K SNP array and a genome-wide linkage map with 1480 polymorphic SNP markers, or bins, was constructed.Two major QTL on chromosomes 1BL and 3BS, and one minor QTL on 6BS had significant effects in reducing stripe rust severity. The QTL were validated using composite interval mapping(CIM) and inclusive composite interval mapping(ICIM). These methods explained59.0%–74.1% of the phenotype variation in disease response. The QTL on chromosome 1 BL was confirmed to be Yr29/Lr46 and the one on 3BS was the resistance allele identified in CIMMYT germplasm but was not Yr30/Sr2. The QTL on 6BS probably corresponded to previously known QTL. RILs with combined QTL were more resistant than those with single or no QTL. Kompetitive allele-specific PCR(KASP) assays for the QTL with largest effect QTL on chromosome 3BS were performed on a subset of RILs and 150 unrelated wheat lines. The QTL on 3BS with its linked KASP markers can be used in marker-assisted selection to improve stripe rust resistance in breeding programs. | Qingdong Zeng Jianhui Wu Shuo Huang Fengping Yuan Shengjie Liu Qilin Wang Jingmei Mu Shizhou Yu Li Chen Dejun Han Zhensheng Kang | 2019 | The Crop Journal2019，7，2： | 2 |
| 10 | Scalable synthesis of Na_(3)V_(2)(PO_(4))_(3)/C with high safety and ultrahigh-rate performance for sodium-ion batteries显示文摘NASICON-type Na_(3)V_(2)(PO_(4))_(3) is a promising electrode material for developing advanced sodium-ion batteries.Preparing Na_(3)V_(2)(PO_(4))_(3) with good performance by a cost-effective and large-scale method is significant for industrial applications.In this work,a porous Na_(3)V_(2)(PO_(4))_(3)/C cathode material with excellent electrochemical performance is successfully prepared by an agar-gel combined with freeze-drying method.The Na_(3)V_(2)(PO_(4))_(3)/C cathode displayed specific capacities of 113.4 mAh·g^(-1),107.0 mAh·g^(-1) and 87.1 mAh·g^(-1) at 0.1 C,1 C and 10 C,respectively.For the first time,the 500-mAh soft-packed symmetrical sodium-ion batteries based on Na_(3)V_(2)(PO_(4))_(3)/C electrodes are successfully fabricated.The 500-mAh symmetrical batteries exhibit outstanding low temperature performance with a capacity retention of 83%at 0℃ owing to the rapid sodium ion migration ability and structural stability of Na_(3)V_(2)(PO_(4))_(3)/C.Moreover,the thermal runaway features are revealed by accelerating rate calorimetry(ARC)test for the first time.Thermal stability and safety of the symmetrical batteries are demonstrated to be better than lithium-ion batteries and some reported sodium-ion batteries.Our work makes it clear that the soft-packed symmetrical sodium ion batteries based on Na_(3)V_(2)(PO_(4))_(3)/C have a prospect of practical application in high safety requirement fields. | Guijia Cui Hong Wang Fengping Yu Haiying Che Xiaozhen Liao Linsen Li Weimin Yang Zifeng Ma | 2022 | Chinese Journal of Chemical Engineering2022，35，6： | 2 |
| 11 | Functional micro‐concrete 3D hybrid structures f abricated by two‐photon polymerization显示文摘Arbitrary micro-scale three-dimensional(3D)structures fabrication is a dream to achieve many exciting goals that have been pursued for a long time.Among all these applications,the direct 3D printing to fabricate human organs and integrated photonic circuits are extraordinary attractive as they can promote the current technology to a new level.Among all the 3D printing methods available,two-photon polymerization(2PP)is very competitive as it is the unique method to achieve sub-micron resolution to make any desired tiny structures.For the conventional 2PP,the building block is the photoresist.However,the requirement for the building block is different for different purposes.It is very necessary to investigate and improve the photoresist properties according to different requirements.In this paper,we presented one hybrid method to modify the mechanical strength and light trapping efficiency of the photoresist,which transfers the photoresist into the micro-concretes.The micro-concrete structure can achieve±22%strength modification via a silica nano-particles doping.The structures doped with gold nano-particles show tunable plasmonic absorption.Dye doped hybrid structure shows great potential to fabricate 3D micro-chip laser. | Yang Li Lianwei Chen Fang Kong Zuyong Wang Ming Dao Chwee Teck Lim Fengping Li Minghui Hong | 2017 | 光电工程2017，44，4： | 2 |
| 12 | Immune-adjuvant loaded Bi2Se3 nanocage for photothermal-improved PD-L1 checkpoint blockade immune-tumor metastasis therapy显示文摘Checkpoint blockade based immune therapy has shown to be effective but benefit only the minority of patients whose tumors have been pre-infiltrated by T cells. To overcome this obstacles, a PEG-modified Bi2Se3 nanocage (NC) loaded with imiquimod (R848), which could efficiently destroy the tumors thus producing enough tumor-associated antigens (TAA) and with the existence of R848, a toll-like-receptor-7 agonist, could generate strong anti-cancer immune responses is reported in this study. Moreover, immunogenic Bi2Se3 NC-PEG/R848 mediated photothermal therapy (PTT) sensitizes tumors to checkpoint inhibition mediated by a PD-L1 antibody, not only ablating cancer cells upon NIR laser but also causing strong anti-cancer immunity to suppress distant tumor growth post PTT. Both in vitro and in vivo experiments demonstrate that the Bi2Se3 NC-PEG/R848 could effectively activate a PTT-induced immune response as well as silence immune resistance based on PD-L1 checkpoint blockade to ablate the primary tumor and further inhibit the tumor metastasis. Bi2Se3 NC reported here exhibits high photothermal conversion efficiency and stability, as well as competent drug loading capacity with large hollow structures and high surface area. Our study not only provides a facial way to synthesize Bi2Se3 NC, but also offers an alternative strategy for tumor metastasis. | Yilin Song Yidan Wang Siyu Wang Yu Cheng Qianglan Lu Lifang Yang Fengping Tan Nan Li | 2019 | Nano Research2019，12，8： | 2 |
| 13 | Realization of laser textured brass surface via temperature tuning for surface wettability transition显示文摘Superhydrophobic surfaces have attracted extensive interests and researches into their fundamentals and potential applications.Laser texturing provides the convenience to fabricate the hierarchical micro/nanostructures for superhydrophobicity.However,after laser texturing,long wettability transition time from superhydrophilicity to superhydrophobicity is a barrier to mass production and practical industrial applications.External stimuli have been applied to change the surface composition and/or the surface morphology to reduce wettability transition time.Herein,by temperature tuning,wettability transition of laser textured brass surfaces is investigated.Scanning electron microscopy and surface contact angle measurement are employed to characterize the surface morphology and wettability behavior of the textured brass surfaces.By low-temperature heating(100℃~150℃),partial deoxidation of the top Cu O layer occurs to form hydrophobic Cu_2O.Therefore,superhydrophobicity without any chemical coating and surface modification could be achieved in a short time.Furthermore,after low-temperature heating,the low adhesive force between the water droplet and the sample surface is demonstrated for the laser textured brass surface.This study provides a simple method to fabricate the micro/nanostructure surfaces with controllable wettability for the potential applications. | Huangping Yan Mohamed Raiz B Abdul Rashid Si Ying Khew Fengping Li Minghui Hong | 2017 | 光电工程2017，44，6： | 2 |
| 14 | Comparison of Lipid Levels, Hyperlipidemia Prevalence and Its Risk Factors between Guangxi Hei Yi Zhuang and Han Populations显示文摘 | Yin Ruixing Chen Yuming Pan Shangling He Fengping Liu Tangwei Yang Dezhai Wu Jinzhen Yao Limei Lin Weixiong Li Rongshan Huang Jiandong | 2006 | Archives of Medical Research2006，，6： | 1 |
| 15 | TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat显示文摘Grain development is a crucial determinant of yield and quality in bread wheat(Triticum aestivum L.).However,the regulatory mechanisms underlying wheat grain development remain elusive.Here we report how Ta MADS29 interacts with Ta NF-YB1 to synergistically regulate early grain development in bread wheat.The tamads29 mutants generated by CRISPR/Cas9 exhibited severe grain filling deficiency,coupled with excessive accumulation of reactive oxygen species(ROS)and abnormal programmed cell death that occurred in early developing grains,while overexpression of Ta MADS29 increased grain width and1,000-kernel weight.Further analysis revealed that Ta MADS29 interacted directly with Ta NF-YB1;null mutation in Ta NF-YB1caused grain developmental deficiency similar to tamads29 mutants.The regulatory complex composed of Ta MADS29 and Ta NF-YB1 exercises its possible function that inhibits the excessive accumulation of ROS by regulating the genes involved in chloroplast development and photosynthesis in early developing wheat grains and prevents nucellar projection degradation and endosperm cell death,facilitating transportation of nutrients into the endosperm and wholly filling of developing grains.Collectively,our work not only discloses the molecular mechanism of MADS-box and NF-Y TFs in facilitating bread wheat grain development,but also indicates that caryopsis chloroplast might be a central regulator of grain development rather than merely a photosynthesis organelle.More importantly,our work offers an innovative way to breed high-yield wheat cultivars by controlling the ROS level in developing grains. | Guoyu Liu Runqi Zhang Sen Li Rehmat Ullah Fengping Yang Zihao Wang Weilong Guo Mingshan You Baoyun Li Chaojie Xie Liangsheng Wang Jie Liu Zhongfu Ni Qixin Sun Rongqi Liang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 16 | Characterization of astaxanthin esters in Haematococcus pluvialis by liquid chromatograpHy-atmospHeric pressure chemical ionization mass spectrometry显示文摘 | MIAO Fengping LU Dayan LI Yeguang | 2006 | Analytical Biochemistry2006，352，： | 1 |
| 17 | Long-haul WDM system through conventional single mode optical fiber with dispersion compension bvy chirp fiber Bragg grating显示文摘 | Pei Li Jian Shuisheng Yan Fengping | 2003 | Opitcal communications2003，222，： | 1 |
| 18 | A novel and sensitive formaldehyde gas sensor utilizing thermal desorption coupled with cataluminescence显示文摘 | Shaofang Li Fengping Li Zhiming Rao | | 0，，： | 1 |
| 19 | Burn patients’ experience of pain management: A qualitative study显示文摘 | Li Yuxiang Zhou Lingjun Tang Lu Liu Mengjie Ming Xing Shen Fengping Cui Jing Meng Xianli Zhao Jijun | 2011 | Burns2011，，2： | 1 |
| 20 | Spatial dis- tribution and contamination assessment of heavy metals in ur- ban road dusts from Urumqi, NW China显示文摘 | WEI Binggan J]ANG Fengping LI Xuemei | 2009 | Microchemical Journal2009，93，2： | 1 |
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