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| 1 | Progress in transdermal drug delivery systems for cancer therapy显示文摘Transdermal drug delivery is an appealing option except for oral and hypodermic administration.With the advancement of skin penetration strategies,various anticancer therapeutics ranging from liphilic small-molecule drugs to hydrophilic biomacromolecules,can be administered transdermally,offering an optional regimen to treat skin cancers.In addition,the activation of the skin immune systems can also assist the treatment of distal sites.Current approaches on enhancing the transdermal delivery efficacy of anticancer drugs are summarized in this review.We also survey recent advances in micro-and nanotechnology-based transdermal formulations for cancer treatment,such as chemotherapy,gene therapy,immunotherapy,phototherapy and combination therapy.New penetration enhancers,materials,formulations and their hypothesized mechanisms for transdermal delivery are highlighted.Advantages and limitations regarding the state-of-the-art transdermal delivery technologies,as well as future perspective are also discussed. | Tianyue Jiang Guo Xu Guojun Chen Yu Zheng Bingfang He Zhen Gu | 2020 | Nano Research2020，13，7： | 5 |
| 2 | 基于高分子材料的有机/无机纳米杂合体递药系统的抗肿瘤治疗研究进展显示文摘基于高分子材料的有机/无机纳米杂合体递药系统,是将有机高分子材料与无机纳米粒子制备成用于药物递送的纳米杂合体,具有易修饰、高靶向性、良好的稳定性与生物相容性等优点。有机/无机纳米杂合体以突出的协同治疗效果备受关注,其在诊疗一体化中的应用为抗肿瘤治疗提供了新思路和新方法。对有机/无机纳米杂合体的构建策略及应用进行综述,并讨论其用于抗肿瘤治疗的优势和挑战,为有机/无机纳米杂合体的进一步应用提供参考。 | 梁晓阳 王思宇 周岳 李雯 李楠 | 2022 | 药学进展2022，46，7： | 0 |
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