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| 1 | Evaluation of the Xpert MTB/RIF assay for diagnosis of tuberculosis and rifampin resistance in county-level laboratories in Hunan province, China显示文摘 | Hu Peilei Bai Liqiong Liu Fengping Ou Xichao Zhang Zhiying Yi Songlin Chen Zhongnan Gong Daofang Liu Binbin Guo Jingwei Tan Yunhong | 2014 | Chinese Medical Journal2014，，21： | 24 |
| 2 | Ultrasensitive terahertz metamaterial sensor based on vertical split ring resonators显示文摘An ultrasensitive metamaterial sensor based on double-slot vertical split ring resonators(DVSRRs) is designed and numerically calculated in the terahertz frequency. This DVSRR design produces a fundament LC resonance with a quality factor of about 20 when the incidence magnetic field component normal to the DVSRR array. The resonant characteristics and sensing performance of the DVSRR array design are systematically analyzed employing a contrast method among three similar vertical split ring resonator(SRRs) structures. The research results show that the elimination of bianisotropy, induced by the structural symmetry of the DVSRR design, helps to achieve LC resonance of a high quality factor. Lifting the SRRs up from the substrate sharply reduces the dielectric loss introduced by the substrate. All these factors jointly result in superior sensitivity of the DVSRR to the attributes of analytes. The maximum refractive index sensitivity is 788 GHz/RIU or 1.04 × 10~5 nm∕RIU.Also, the DVSRR sensor maintains its superior sensing performance for fabrication tolerance ranging from -4% to 4% and wide range incidence angles up to 50° under both TE and TM illuminations. | WEI WANG FENGPING YAN SIYU TAN HONG ZHOU YAFEI HOU | 2017 | Photonics Research2017，5，6： | 9 |
| 3 | Enhancing sensing capacity of terahertz metamaterial absorbers with a surface-relief design显示文摘Metamaterial absorbers(MAs)serve as important electromagnetic wave-absorbing devices that have captured the attention of researchers for a long term.Functioning as sensitive detectors to determine perturbations in an ambient environment is another significant subsidiary function.Here,we theoretically propose an optimized fabrication method to implement terahertz MAs with fewer steps and also evaluate both absorption and sensing performances of such MAs realized by the new method.Simulation findings demonstrate that such MAs can basically maintain the original absorption features perfectly,including near-complete absorption at resonance as well as strong robustness to wide incident angles.Specifically,the full width at half-maximum and quality factor of the absorption resonances attenuate less than 26%and 8%with this new method,remaining in the ranges of^0.03–0.04 THz and^20–27 for two selected example MAs.More significantly,sensing capacities of this type of MA,in terms of maximum detection range(enhancing at least 9%),observable spectral modulation(increasing at least 6.3%),and refractive index sensitivity,are improved to a large extent because of more intense coupling between resonant field and matter in the case of surface-relief MAs.This stronger coupling results from exposing more spots of the resonantly high field to direct contact with an approaching analyte,which is illustrated by field profiles of the MAs at resonance in this work.Additionally,other desirable absorber features are also explored with such MAs,like functioning as building blocks to configure multiband MAs and strong robustness against fabrication errors.Such new-style terahertz MAs shown in the paper,acting as good examples,not only prove that terahertz MAs can be fabricated by the proposed time-and cost-saving route in contrast to the traditional MA fabrication process,but also can serve as novel platforms to explore other intriguing terahertz photonic effects,such as the field enhancement effect. | WEI WANG FENGPING YAN SIYU TAN HAISU LI XUEMEI DU LUNA ZHANG ZHUOYA BAI DAN CHENG HONG ZHOU YAFEI HOU | 2020 | Photonics Research2020，8，4： | 3 |
| 4 | Immune-adjuvant loaded Bi2Se3 nanocage for photothermal-improved PD-L1 checkpoint blockade immune-tumor metastasis therapy显示文摘Checkpoint blockade based immune therapy has shown to be effective but benefit only the minority of patients whose tumors have been pre-infiltrated by T cells. To overcome this obstacles, a PEG-modified Bi2Se3 nanocage (NC) loaded with imiquimod (R848), which could efficiently destroy the tumors thus producing enough tumor-associated antigens (TAA) and with the existence of R848, a toll-like-receptor-7 agonist, could generate strong anti-cancer immune responses is reported in this study. Moreover, immunogenic Bi2Se3 NC-PEG/R848 mediated photothermal therapy (PTT) sensitizes tumors to checkpoint inhibition mediated by a PD-L1 antibody, not only ablating cancer cells upon NIR laser but also causing strong anti-cancer immunity to suppress distant tumor growth post PTT. Both in vitro and in vivo experiments demonstrate that the Bi2Se3 NC-PEG/R848 could effectively activate a PTT-induced immune response as well as silence immune resistance based on PD-L1 checkpoint blockade to ablate the primary tumor and further inhibit the tumor metastasis. Bi2Se3 NC reported here exhibits high photothermal conversion efficiency and stability, as well as competent drug loading capacity with large hollow structures and high surface area. Our study not only provides a facial way to synthesize Bi2Se3 NC, but also offers an alternative strategy for tumor metastasis. | Yilin Song Yidan Wang Siyu Wang Yu Cheng Qianglan Lu Lifang Yang Fengping Tan Nan Li | 2019 | Nano Research2019，12，8： | 2 |
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