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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | Wheat straw burning and its associated impacts on Beijing air quality显示文摘Based on MODIS images, large-scale flow field charts and environmental monitoring data, we thor- oughly analyzed the spatial distribution of wheat straw burning in North China, with focus on its envi- ronmental impacts on the air quality of Beijing and pollution transport paths. And we anatomized changes of air quality in Beijing under the impacts of pollution generated by wheat straw burning around. The results indicate that: (1) The North China Plain, a winter-wheat growing area, is the main source of pollutants induced by wheat straw burning in Beijing. The direction of south-west is the dominant heavy pollution transport path. (2) Impacts of wheat straw burning on air quality are mainly manifested by significantly increasing CO concentration. (3) Precursors of O3 generated by wheat straw burning, combining with favorable meteorological conditions, can induce increasing O3 concentration greatly. NO concentration will be greatly increased due to decreasing O3 concentration at night. (4) Atmospheric particles, especially the fine ones, from wheat straw burning exert considerable influ- ence on Beijing air quality. (5) Different contributions of wheat straw burning to pollutants are identified. Ratios of PM10/SO2, CO/SO2, etc., can be applied to indicate pollution extent of wheat straw burning. High ratios of PM10/SO2 and CO/SO2 show that the air quality was heavily impacted by wheat straw burning and these ratios can be employed as indicators of contribution of wheat straw burning to the degradation of Beijing air quality. (6) Randomness of wheat straw burning activities renders random outbreak of air pollution of this type. Regional and extensive wheat straw burning activities can cause serious air pollution event. | LI LingJun WANG Ying ZHANG Qiang LI JinXiang YANG XiaoGuang JIN Jun | 2008 | Science China Earth Sciences2008，51，3： | 37 |
| 3 | A highly active oxygen evolution electrocatalyst: Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly显示文摘成本效率、稳定的氧进化 electrocatalyst 为改进精力存储和变换效率是必要的。此处, 2D nanosheets 与随机 cross-linked CoNi 分层的双氢氧化物(LDH ) 并且小咕咕叫 nanocrystals 被设计并且综合经由在在空中的 situ 减小和 interfacedirected 汇编。CoNi LDH/CoO nanosheets 的形成被归因于界面的紧张驾驶的含水的 metaloxide 簇的强壮的挤出。获得了松开、多孔的 nanosheets 由于众多的缺点的存在展出了低 crystallinity。由于在金属 3d 和 O 2p 之间的轨道的杂交, orbitals,和电子在在场的 CoNi LDH 通过 NiOCo,很多个公司和 Ni 原子在金属原子之间转一个高 +3 原子价。在氧进化反应(OER ) 的高密度的这些唯一的特征结果活跃地点,改进与的亲密关系哦 和催化剂,并且为离子吸附和运输导致一个大可存取的表面区域和可渗透的隧道。因此,产生 nanosheets 向 OER 展出了高催化的活动。CoNi LDH/CoO 在碱的媒介展示了 1.48 V 的一个低发作潜力,并且在 10 妈据獥漠 ? 楬桧 ?L 潳灲楴湯漠 ? 桴 ? 的当前的密度要求了仅仅 300 mV 的过电位 ?? 潢瑴浯摥琠慲獮業瑴湡散吗?? | Jun Wu Zhiyu Ren Shichao Du Lingjun Kong Bowen Liu Wang Xi Jiaqing Zhu Honggang Fu | 2016 | Nano Research2016，9，3： | 25 |
| 4 | Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3inflammasome activation in LPS-induced vascular injury显示文摘The loss of endothelial connective integrity and endothelial barrier dysfunction can lead to increased vascular injury, which is related to the activation of endothelial inflammasomes. There are evidences that low concentrations of aspirin can effectively prevent cardiovascular diseases. We hypothesized that low-dose aspirin could ameliorate endothelial injury by inhibiting the activation of NLRP3 inflammasomes and ultimately prevent cardiovascular diseases. Microvascular endothelial cells were stimulated by lipopolysaccharide(2 μg/mL) and administrated by 0.1–2 mmol/L aspirin. The wild type mice were stimulated with LPS(100 μg/kg/day), and 1 h later treated with aspirin(12.5, 62.5, or125 mg/kg/day) and dexamethasone(0.0182 mg/kg/day) for 7 days. Plasma and heart were harvested for measurement of ELISA and immunofluorescence analyses. We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway. We also found that low-concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome and restore the expression of theendothelial tight junction protein zonula occludens-1/2(ZO1/2). We assume that aspirin can ameliorate the endothelial layer dysfunction by suppressing the activation of NLRP3 inflammasome. | Xing Zhou Yanjiao Wu Lifeng Ye Yunting Wang Kaimin Zhang Lingjun Wang Yi Huang Lei Wang Shaoxiang Xian Yang Zhang Yang Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 13 |
| 5 | Generation of hircine-induced pluripotent stem cells by somatic cell reprogramming显示文摘 | Jiangtao Ren Yongjun Pak Lixiazi He Lei Qian Yijun Gu Hui Li Lingjun Rao Jing Liao Chun Cui Xun Xu Jinqiu Zhou Hakchol Ri Lei Xiao | 2011 | Cell Research2011，21，5： | 10 |
| 6 | B-doped and La_(4)NiLiO_(8)-coated Ni-rich cathode with enhanced structural and interfacial stability for lithium-ion batteries显示文摘Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni-rich cathodes still pose substantial obstacles in the practical application of advanced LIBs.Here,we employ a one-step method to synthesize a B-doped and La_(4)NiLiO_(8)-coated LiNi_(0.82)5Co_(0.115)Mn_(0.06)O_(2)(BL-1)cathode with reliable structure and interface,for the first time.The La_(4)NiLiO_(8)coating layer can prevent cathodes from electrolyte assault and facilitate Li+diffusion kinetics.Moreover,B-doping can effectively restrain the pernicious H_(2)-H_(3) phase transition and adjust the orientation of primary particles to a radial alignment,which is obstructive to the arise of microcracks induced by the change of anisotropic volume.Specifically,when tested in pouch cells,the BL-1 cathode exhibits outstanding capacity retention of 93.49%after 500 cycles at 1 C.This dual-modification strategy dramatically enhances the stability of the structure and interface for Ni-rich cathode materials,consequently accelerating the commercialization process of high-energy–density LIBs. | Lingjun Li Lizhi Fu Miao Li Chu Wang Zixiang Zhao Shangchen Xie Haichen Lin Xianwen Wu Haodong Liu Li Zhang Qiaobao Zhang Lei Tan | 2022 | Journal of Energy Chemistry2022，31，8： | 10 |
| 7 | Regression model to estimate flood impact on corn yield using MODIS NDVI and USDA cropland data layer显示文摘Flood events and their impact on crops are extremely significant scientific research issues; however,flood monitoring is an exceedingly complicated process. Flood damages on crops are directly related to yield change,which requires accurate assessment to quantify the damages. Various remote sensing products and indices have been used in the past for this purpose. This paper utilizes the moderate resolution imaging spectroradiometer(MODIS) weekly normalized difference vegetation index(NDVI) product to detect and further quantify flood damages on corn within the major corn producing states in the Midwest region of the US. County-level analyses were performed by taking weighted average of all pure corn pixels(>90%) masked by the United States Department of Agriculture(USDA) Cropland Data Layer(CDL). The NDVI-based time-series difference between flood years and normal year(median of years 2000–2014) was used to detect flood occurrences. To further measure the impact of the flood on corn yield,regression analysis between change in NDVI and change in corn yield as independent and dependent variables respectively was performed for 30 different flooding events within growing seasons of the corn. With the R2 value of 0.85,the model indicates statistically significant linear relation between the NDVI and corn yield. Testing the predictability of the model with 10 new cases,the average relative error of the model was only 4.47%. Furthermore,small error(4.8%) of leave-one-out cross validation(LOOCV) along with smaller statistical error indicators(root mean square error(RMSE),mean absolute error(MAE),and mean bias error(MBE)),further validated the accuracy of the model. Utilizing the linear regression approach,change in NDVI during the growing season of corn appeared to be a good indicator to quantify the yield loss due to flood. Additionally,with the 250 m MODIS-based NDVI,these yield losses can be estimated up to field level. | Ran jay Shrestha Liping Di Eugene G. Yu Lingjun Kang SHAO Yuan-zhen BAI Yu-qi | 2017 | Journal of Integrative Agriculture2017，16，2： | 8 |
| 8 | Interconnected 1D Co3O4 nanowires on reduced graphene oxide for enzymeless H2O2 detection显示文摘无酶的氢过氧化物(H < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 有高敏感和优秀选择的 2 ) 察觉为临床的诊断是合乎需要的。此处,一个维的公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires 成功地经由一个简单热水的过程和随后的热处理在减少的 graphene 氧化物(rGO ) 上被构造了。这些公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires,由小 nanoparticles 集合了,与对方一起被交叉并且在 rGO 上使一只蜘蛛成为像网的结构。公司的形成 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 个 -rGO 混血儿被归因于 DDA 的指导结构、抛锚的角色并且分别地去。产生结构为事散开拥有丰富的活跃地点,电子的面向的传播,和未受阻碍的小径,它资助公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 有优秀 electrocatalytic 性能的 4 个 -rGO 混血儿。作为结果,获得的公司<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 个 -rGO 混血儿能为 H 用作有效电气化学的催化剂<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 氧化和高度敏感察觉。在生理的条件下面, H 的氧化电流<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 与 1.14 妈的敏感从 0.015~0.675 公里关于它的集中线性地变化?????????????? | Lingjun Kong Zhiyu Ren Nannan Zheng Shichao Du Jun Wu Jingling Tang Honggang Fu | 2015 | Nano Research2015，8，2： | 7 |
| 9 | Characterization and performance of Cu/ZnO/Al_2O_3 catalysts prepared via decomposition of M(Cu,Zn)-ammonia complexes under sub-atmospheric pressure for methanol synthesis from H_2 and CO_2显示文摘Methanol synthesis from hydrogenation of CO2 is investigated over Cu/ZnO/Al2O3 catalysts prepared by decomposition of M(Cu,Zn)-ammonia complexes (DMAC) at various temperatures.The catalysts were characterized in detail,including X-ray diffraction,N2 adsorption-desorption,N2O chemisorption,temperature-programmed reduction and evolved gas analyses.The influences of DMAC temperature,reaction temperature and specific Cu surface area on catalytic performance are investigated.It is considered that the aurichalcite phase in the precursor plays a key role in improving the physiochemical properties and activities of the final catalysts.The catalyst from rich-aurichalcite precursor exhibits large specific Cu surface area and high space time yield of methanol (212 g/(Lcat·h);T=513 K,p=3MPa,SV=12000 h-1). | Danjun Wang Jun Zhao Huanling Song Lingjun Chou | 2011 | Journal of Natural Gas Chemistry2011，20，6： | 6 |
| 10 | An Intra-Oceanic Subduction System Influenced by Ridge Subduction in the Diyanmiao Subduction Accretionary Complex of the Xar Moron Area,Eastern Margin of the Central Asian Orogenic Belt显示文摘This study focuses on the geology,geochemistry,Sr-Nd isotopes and their tectonic settings of three types of basalts in Diyanmiao ophiolite in the Xar Moron area located on the eastern margin of the Central Asian Orogenic Belt.Type I basalts are oceanic tholeiites with a depleted light rare earth element(LREE)pattern,which are similar to the typical N-mid-oceanic ridge basalt(MORB)and suggests that they were formed at a mid-oceanic ridge.The initial 87Sr/86Sr ratios of Type I basalts range from 0.703966 to 0.705276 and theεNd(t)values are from 16.49 to 17.15,indicating that they were derived from a depleted mantle source.Type II basalts belong to the medium-potassium calc-akaline series and have the geochem-ical characteristics of Nb-enriched basalt(NEB)with high Nb content(14.5 ppm)and strong enrichment in LREEs,implying that they were created by the partial melting of mantle wedge peridotite that previously metasomatized by slab melts.Type III basalts are high-Al basalt(HAB)with high-Al contents(Al_(2)0_(3)=16.75 wt.%-18.00 wt.%),distinct Nb depletion and high Th/Yb ratios.Thus they were likely gen-erated in a normal island-arc setting.Therefore,the association of MORB,NEB,and HAB in the study area may be due to the subduction of a mid-oceanic ridge,and the Diyanmiao ophiolite is proposed to be formed in the forearc setting of a mid-oceanic ridge subduction system. | Yang Cheng Qinghui Xiao Tingdong Li Liquan Xu Yuxu Fan Yan Li Lingjun Guo Jinli Pang Weiming Yuan | 2021 | Journal of Earth Science2021，32，1： | 6 |
| 11 | Microstructure and flexural properties of carbon/carbon composite with in-situ grown carbon nanotube as secondary reinforcement显示文摘Carbon nanotubes (CNTs) were in-situ grown in carbon felts using ferric chloride as catalyst and natural gas as carbon precursor via thermal gradient chemical vapor infiltration (TGCVI). Subsequently, the carbon felts were densified to obtain CNT reinforced carbon/carbon (C/C) composites in the same furnace. Effects of CNTs on the microstructure and flexural property of C/C composites were investigated by polarized light microscopy, Raman spectroscopy, scanning electron microscopy and universal mechanical testing machine. The results of PLM observation and Raman analysis showed that CNTs have two-sided effects on the microstructure of pyrocarbon: the pyrocarbons in the region without CNTs show medium texture; while, in the region full of CNTs, the microstructure was low-textured or even isotropic though the TGCVD conditions would lead to the deposition of pure low texture pyrocarbons. Analysis based on stress-strain curves demonstrated that the flexural strength increased first and then decreased with the CNT content increasing. When the CNT content was 5.23 wt%, the flexural strength was maximum and had a nearly 35% improvement compared with pure C/C composite. Besides, after adding CNTs, the flexural modulus of the composites decreased and the ductility increased obviously, indicating CNTs can toughen C/C composites. | Hai Zhang Lingjun Guo Qiang Song Qiangang Fu Hejun Li Kezhi Li | 2013 | Progress in Natural Science:Materials International2013，23，2： | 6 |
| 12 | Natural gas leakage of Mizhi gas reservoir in Ordos Basin, recorded by natural gas fluid inclusion显示文摘Abundant natural gas inclusions were found in calcite veins filled in fractures of Central Fault Belt across the centre of Ordos Basin. Time of the calcite veins and characteristics of natural gas fluid inclusion were investigated by means of dating of thermolum luminescence (TL) and analyzing stable isotope of fluid inclusion. Results show that natural gas inclusion formed at 130―140℃ with salinity of 5.5 wt%―6.0 wt% NaCl. It indicates that natural gas inclusion is a kind of thermal hydrocarbon fluid formed within the basin. Method of opening inclusion by heating was used to analyze composition of fluid inclusion online, of which the maximal hydrocarbon gas content of fluid inclusion contained in veins is 2.4219 m3/t rock and the maximal C1/Σci ratio is 91%. Laser Raman spectroscopy (LRS) was used to analyze chemistry of individual fluid inclusion in which the maximal hydrocarbon gas content is 91.6% compared with little inorganic composition. Isotope analysis results of calcite veins show that they were deposited in fresh water, in which the δ13CPDB of calcite veins is from -5.75‰ to 15.23‰ andδ18OSMOW of calcite veins is from 21.33‰ to 21.67‰. Isotope results show thatδ13C1 PDB of natural gas fluid inclusion is from -21.36‰ to -29.06‰ and δDSMOW of that is from -70.89‰ to -111.03‰. It indicates that the gas of fluid inclusion formed from coal source rocks and it is the same as that of natural gas of Mizhi gas reservoir. Results of TL dating show that time of calcite vein is (32.4±3.42)×104 a, which is thought to be formation time of gas inclusion. It indicated that natural gas inclusion contained in calcite veins recorded natural gas leakage from Mizhi gas reservoir through the Central Fault Belt due to Himalayan tectonic movement. | LI RongXi DI LingJun XI ShengLi | 2007 | Science China Earth Sciences2007，50，z2： | 5 |
| 13 | Levels of Metabolic Enzymes and Nitrogenous Compounds in the Swimming Crab Portunus trituberculatus Exposed to Elevated Ambient Ammonia-N显示文摘This study investigated the effects of ammonia-N(control and 1 and 5 mg L^(-1)) on the changes of metabolic enzymes activities and nitrogenous compounds levels in the gills, hepatopancreas, muscles, and hemolymph of the swimming crab Portunus trituberculatus. Results showed that the levels of hemolymph ammonia increased significantly at 6 h and then decreased to control level at 12 h. The activities of key enzymes involved in biosynthesis pathways of glutamine(Gln) and urea, such as glutamate dehydrogenase(GDH), glutamine synthetase(GS), and arginase(ARG), increased remarkably in different tissues of P. trituberculatus. Gln level was the highest in muscles, while urea content was the largest in hepatopancreas. The m RNA expression level of xanthine dehydrogenase(XDH) was downregulated sharply in gills but upregulated in the hepatopancreas and muscles. A small amount of uric acid was detected in the hemolymph. This result suggests that Gln in muscles may be used as an intermediary nitrogen repository, while urea may be primarily synthesized in the hepatopancreas and then transferred to other tissues via the hemolymph. Uric acid could be synthesized by the anabolism of purine nucleotides, in additon to the inhibitory activities of gills. In addition, the levels of Gln, urea and uric acid exhibited dose-and time-dependent effects with ammonia content. Therefore, P. trituberculatus could possibly convert ammonia into Gln, urea, or uric acid to detoxify ammonia during high ambient ammonia-N stress. | PAN Luqing SI Lingjun LIU Shengnan LIU Maoqi WANG Guohui | 2018 | Journal of Ocean University of China2018，17，4： | 5 |
| 14 | Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis显示文摘Efforts to control inflammation and achieve better tissue repair in the treatment of periodontitis have been ongoing for years.Humanβ-defensin 3,a broad-spectrum antimicrobial peptide has been proven to have a variety of biological functions in periodontitis;however,relatively few reports have addressed the effects of human periodontal ligament cells(h PDLCs)on osteogenic differentiation.In this study,we evaluated the osteogenic effects of h PDLCs with an adenoviral vector encoding humanβ-defensin 3 in an inflammatory microenvironment.Then humanβ-defensin 3 gene-modified rat periodontal ligament cells were transplanted into rats with experimental periodontitis to observe their effects on periodontal bone repair.We found that the humanβ-defensin 3 gene-modified h PDLCs presented with high levels of osteogenesis-related gene expression and calcium deposition.Furthermore,the p38 MAPK pathway was activated in this process.In vivo,humanβ-defensin 3 gene-transfected rat PDLCs promoted bone repair in SD rats with periodontitis,and the p38 mitogen-activated protein kinase(MAPK)pathway might also have been involved.These findings demonstrate that humanβ-defensin 3 accelerates osteogenesis and that humanβ-defensin 3 gene modification may offer a potential approach to promote bone repair in patients with periodontitis. | Lingjun Li Han Jiang Rixin Chen Jing Zhou Yin Xiao Yangheng Zhang Fuhua Yan | 2020 | International Journal of Oral Science2020，12，2： | 5 |
| 15 | Characteristics and runoff volume of the Yangtze River paleo-valley at Nanjing reach in the Last Glacial Maximum显示文摘在 No.1, No.3 和 No.4 南京长江桥附近切入山谷的长江的地层学的剖面图与各自的讨厌的人日期和文件一起被建立。由四把钻的样品的 14C 年龄分析,核心接近 No.4 桥(被造) ,我们能发现 paleo 山谷的时间范围在在深度的 LGM 是过时的 ? 60 m 到 ? 南京附近的 90 m。深切入山谷的隧道是狭窄的,河迅速流动了,这也被显示。部分并且深深地介绍的古老的长江深隧道在 No.1 桥附近切入特征。根据以前的出版物,许多研究在长江的主要 paleo 隧道上被做了,但是很少结果在分泌物评价上被完成了。在这篇论文,早期的速度和 LGM 的平均速度被计算与,等等以河形状,沉积谷物尺寸和序列接近 No.3 和 No.1 桥。而且,在长江的南京活动范围的分泌物在 LGM 期间被估计了根据分泌物的关系在 12,00016,000 m3/s 附近,流动和剖面图的速度。 | CAO Guangjie WANG Jian WANG Lingjun LI Yanyan | 2010 | Journal of Geographical Sciences2010，20，3： | 4 |
| 16 | Effect of impregnation strategy on catalytic hydrogenation behavior of PtCo catalysts supported on La2O2CO3 nanorods显示文摘Small Pt and Pt-Co nanoparticles(NPs) stabilized on La_2 O_2 CO_3 nanorods(LOC) were prepared by wet impregnation method,and probed in liquid-phase chemoselective hydrogenation of crotonaldehyde(CRAL) to crotyl alcohol(CROL).It is found that incorporation of Co atoms into Pt catalyst significantly improves the hydrogenation activity and desired selectivity to CROL as it destroys the Pt-lanthanum interfaces and results into the formation of Pt-Co particles.In addition,a close examination of catalyst surface and reactive performance suggests that the impregnation sequence of Pt and Co exerts great influence on the physicochemical property and the catalytic hydrogenation behavior of PtCo/LOC catalysts.As a result of the interaction between Pt and Co species,high alloying degree of Pt-Co NPs is obtained in the co-impregnated catalyst(Pt-Co/LOC),thus achieving the highest hydrogenation activity.The selective deposit of Co atoms onto the low-coordinated Pt sites leads to the smallest metal particle size and high dispersion of Pt-Co NPs over the Pt/Co/LOC,giving rise to the highest selectivity and yield to CROL. | Fengjun Hou Huahua Zhao Huanling Song Lingjun Chou Jun Zhao Jian Yang Liang Yan | 2018 | Journal of Rare Earths2018，36，9： | 4 |
| 17 | Single-dose and multiple-dose pharmacokinetics of zaltoprofen after oral administration in healthy Chinese volunteers显示文摘Zaltoprofen, a propionic acid derivative of non-steroidal anti-inflammatory drugs, has strong inhibitory effects on actue and chronic inflammation. A randomized, dose-escalating study was conducted to evaluate the pharma-cokinetics of single and multiple oral doses of zaltoprofen in 12 healthy Chinese volunteers. Pharmacokinetics was determined from serial blood samples obtained up to 24 h after administration of a single dose of zaltoprofen at 80, 160 or 240 mg and after multiple doses of zaltqorofen at 80 mg 3 times daily. The C max and AUC 0-24 of zaltoprofen were found to be proportional to drug dose. Zaltoprofen was rapidly absorbed (t max =1.46±0.83 h) and cleared (t 1/2 =4.96±2.97 h). Pharmacokinetic parameters after multiple doses were similar to those after single doses. Zaltoprofen was well tolerated. These results support a tid regimen of zaltoprofen for the management of acute and chronic inflammation. | Lingjun Li Pengcheng Ma Yuping Cao Lei Tao Yue Tao | 2011 | The Journal of Biomedical Research2011，25，1： | 4 |
| 18 | Glucocorticoid receptor modulates myeloid-derived suppressor cell function via mitochondrial metabolism in immune thrombocytopenia显示文摘Myeloid-derived suppressor cells(MDSCs)are a heterogeneous population of immature cells and natural inhibitors of adaptive immunity.Intracellular metabolic changes in MDSCs exert a direct immunological influence on their suppressive activity.Our previous study demonstrated that high-dose dexamethasone(HD-DXM)corrected the functional impairment of MDSCs in immune thrombocytopenia(ITP);however,the MDSC population was not restored in nonresponders,and the mechanism remained unclear.In this study,altered mitochondrial physiology and reduced mitochondrial gene transcription were detected in MDSCs from HD-DXM nonresponders,accompanied by decreased levels of carnitine palmitoyltransferase-1(CPT-1),a rate-limiting enzyme in fatty acid oxidation(FAO).Blockade of FAO with a CPT-1 inhibitor abolished the immunosuppressive function of MDSCs in HD-DXM responders.We also report that MDSCs from ITP patients had lower expression of the glucocorticoid receptor(GR),which can translocate into mitochondria to regulate the transcription of mitochondrial DNA(mtDNA)as well as the level of oxidative phosphorylation.It was confirmed that the expression of CPT-1 and mtDNA-encoded genes was downregulated in GR-siRNA-treated murine MDSCs.Finally,by establishing murine models of active and passive ITP via adoptive transfer of DXM-modulated MDSCs,we confirmed that GR-silenced MDSCs failed to alleviate thrombocytopenia in mice with ITP.In conclusion,our study indicated that impaired aerobic metabolism in MDSCs participates in the pathogenesis of glucocorticoid resistance in ITP and that intact control of MDSC metabolism by GR contributes to the homeostatic regulation of immunosuppressive cell function. | Yu Hou Jie Xie Shuwen Wang Daqi Li Lingjun Wang Haoyi Wang Xiaofei Ni Shaoqiu Leng Guosheng Li Ming Hou Jun Peng | 2022 | Cellular & Molecular Immunology2022，19，7： | 4 |
| 19 | Design of good QC-LDPC codes without small girth in the p-plane显示文摘A construction method based on the p-plane to design high-girth quasi-cyclic low-density parity-check (QC-LDPC) codes is proposed. Firstly the good points in every line of the p-plane can be ascertained through filtering the bad points, because the designed parity-check matrixes using these points have the short cycles in Tanner graph of codes. Then one of the best points from the residual good points of every line in the p-plane will be found, respectively. The optimal point is also singled out according to the bit error rate (BER) performance of the QC-LDPC codes at last. Explicit necessary and sufficient conditions for the QC-LDPC codes to have no short cycles are presented which are in favor of removing the bad points in the p-plane. Since preventing the short cycles also prevents the small stopping sets, the proposed construction method also leads to QC-LDPC codes with a higher stopping distance. | Lingjun Kong Yang Xiao | 2011 | Journal of Systems Engineering and Electronics2011，22，2： | 4 |
| 20 | Synthesis,characterization,and photocatalytic activity of porous La–N–co-doped TiO_2 nanotubes for gaseous chlorobenzene oxidation显示文摘The photocatalytic oxidation of gaseous chlorobenzene(CB) by the 365 nm-induced photocatalyst La/N–Ti O2, synthesized via a sol–gel and hydrothermal method, was evaluated. Response surface methodology(RSM) was used to model and optimize the conditions for synthesis of the photocatalyst. The optimal photocatalyst was 1.2La/0.5N–Ti O2(0.5) and the effects of La/N on crystalline structure, particle morphology, surface element content, and other structural characteristics were investigated by XRD(X-ray diffraction), TEM(Transmission Electron Microscopy), FTIR(Fourier transform infrared spectroscopy), UV–vis(Ultraviolet–visible spectroscopy), and BET(Brunauer Emmett Teller). Greater surface area and smaller particle size were produced with the co-doped Ti O2 nanotubes than with reference Ti O2. The removal of CB was effective when performed using the synthesized photocatalyst,though it was less efficient at higher initial CB concentrations. Various modified Langmuir-Hinshelwood kinetic models involving the adsorption of chlorobenzene and water on different active sites were evaluated. Fitting results suggested that competitive adsorption caused by water molecules could not be neglected, especially for environments with high relative humidity. The reaction intermediates found after GC–MS(Gas chromatography–mass spectrometry) analysis indicated that most were soluble, low-toxicity, or both. The results demonstrated that the prepared photocatalyst had high activity for VOC(volatile organic compounds) conversion and may be used as a pretreatment prior to biopurification. | Zhuowei Cheng Zhiqi Gu Jianmeng Chen Jianming Yu Lingjun Zhou | 2016 | Journal of Environmental Sciences2016，28，8： | 4 |
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