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| 1 | Therapeutic effect of autologous dendritic cell vaccine on patients with chronic hepatitis B: A clinical study显示文摘AIM: To investigate the therapeutic effect of autologous HBsAg-loaded dendritic cells (DCs) on patients with chronic hepatitis B.METHODS: Monocytes were isolated from fresh peripheral blood of 19 chronic HBV-infected patients by Ficoll-Hypaque density gradient centrifugation and cultured by plastic-adherence methods. DCs were induced and proliferated in the culture medium with recombinant human granulocyte-macrophage-colony- stimulating factor (rhGM-CSF) and human interleukin-4 (rhIL-4). DCs pulsed with HBsAg for twelve hours were injected into patients subcutaneously twice at intervals of two weeks. Two patients received 100 mg oral lamivudine daily for 12 mo at the same time. HBV-DNA and viral markers in sera of patients were tested every two months.RESULTS: By the end of 2003, 11 of 19 (57.9%) patients had a clinical response to DC-treatment. HBeAg of 10(52.6%) patients became negative, and the copies of HBVDNA decreased 101.77±2.39 averagely (t = 3.13, P<0.01).Two cases co-treated with DCs and lamivudine had a complete clinical response. There were no significant differences in the efficient rate between the cases with ALT level lower than 2xULN and those with ALT level higher than 2xULN before treatment (χ2 = 0.0026).CONCLUSION: Autologous DC-vaccine induced in vitro can effectively suppress HBV replication, reduce the virus load in sera, eliminate HBeAg and promote HBeAg/antiHBe transformation. Not only the patients with high serum ALT levels but also those with normal ALT levels can respond to DC vaccine treatment, and the treatment combining DCs with lamivudine can eliminate viruses more effectively. | MinChen Yong-GuoLi Da-ZhiZhang Zhi-YiWang Wei-QunZeng Xiao-FengShi YuanGuo Shu-HuaGuo HongRen | 2005 | World Journal of Gastroenterology2005，11，12： | 40 |
| 2 | Characteristics of authigenic pyrites in shallow core sediments in the Shenhu area of the northern South China Sea: Implications for a possible mud volcano environment显示文摘Distinct pyrites have been recovered from a shallow sediment core from Site 4B in the Shenhu area of the northern South China Sea. Based on the lithology, texture and structure of sediments, the stable sulfur isotope of pyrite and the total organic carbon (TOC) concentration of the sediments, a distinctive sediment interface is identified at a depth of about 1 m below the seafloor in the core sediments. The pyrites only accumulate in the lower part of the core as rods and foraminifera-infillings, and mainly within three intervals marked by high pyrite concentrations. The amount of pyrite in the sediments shows no remarkable correlation with TOC in the Site 4B core sediments. The stable sulfur isotopes of the pyrite have extremely negative values ranging from 41.69‰ to 49.16‰. They are considered to be the mutual product of sulfate bacterial reduction and sulfur bacterial disproportionation. Our research proposes that Site 4B might be located in or near a possible mud volcano sedimentary environment; a large amount of methane could migrate from deep to shallow sediments in an active mud volcano and thereby play a key role in the intensity of sulfate bacterial reduction and the amount of pyrite formed at Site 4B. Further, the variation in flux of deep methane fluid by intermittent mud volcanic eruptions might result in the deposition of authigenic pyrite intervals. | XIE Lei WANG JiaSheng WU NengYou WU DaiDai WANG Zhou ZHU XiaoWei HU Jun CHEN HongRen LIN Qi | 2013 | Science China Earth Sciences2013，56，4： | 14 |
| 3 | Adaptive inverse control of random vibration based on the filtered-X LMS algorithm显示文摘随机的颤动控制针对复制力量光谱在指定控制的密度(PSD ) 指。古典频率光谱均等算法需要计算多重频率反应函数(FRF ) 的一般水准,它变长在均等进程的控制循环时间。同样,反馈控制算法让很慢的集中由于反馈获得参数的小价值评价保证系统的稳定性。克服这些限制,随机的颤动的适应反的控制基于 filtered-X 最不吝啬平方(LMS ) 算法被建议。根据描述和频率领域的随机的颤动测试的重复特征,而且,频率领域 LMS 算法被采用精制 FRF 的反的特征而不是传统的时间领域 LMS 算法。这个反的特征,在控制下面被称为系统的阻抗函数,被用来直接更新驱动器 PSD。测试结果显示除了成功地避免发生在重复过程期间的不稳定性问题,适应控制策略最小化需要获得一个短控制环并且完成均等的时间的数量。关键词随机的颤动 - 力量光谱密度 - 频率反应功能 - 适应反的控制 - filtered-X LMS 算法旁边支持了:不在资助下面在大学里为新世纪优秀才能编程序。 | Yang Zhidong,Huang Qitao~(++),Han Junwei~§and Li Hongren~§National Key Laboratory of Robots Technique and System,Harbin Institute of Technology,Harbin 150080,China PhD Candidate ~++ PhD ~§Professor | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 10 |
| 4 | Multiple cycles of glacier advance and retreat during the Nantuo (Marinoan) glacial termination in the Three Gorges area显示文摘雪球地球假设建议海水完全被使冻结成冰在 Neoproterozoic 冻结百万年,由源于大气的 CO2 的提高的集中的快速、灾难的冰川的消失列在后面。然而,沉积记录不与雪球地球假设一致。在三个峡区域的 Nantuo 形成由 diamictites,沙岩和 siltstones 组成。有内在的 Liantuo 形成的地球年代学和不顺从显示在三个峡区域的 Nantuo 形成可以是部分记录(即,最后的阶段) Nantuo 冻结成冰。我们 Nantuo 形成的沉积继任上的研究相信到 Ediacaran 温室,多重冰河 advanceretreat 在骑车而非灾难的结束的从 Cryogenia 冰库的逐步的转变能被识别[出版摘要] | Jun HU Jiasheng WANG Hongren CHEN Zhou WANG Lei XIE Qi LIN | 2012 | Frontiers of Earth Science2012，6，1： | 4 |
| 5 | Distribution and anti-HBV effects of antisense oligodeoxynu-cleotides conjugated to galactosylated poly-L-lysine显示文摘AIM: To describe distribution of the phosphorothioated antisense oligodeoxynucleotides (PS-asODNs) conjugated to galactosylated poly-L-lysine (Gal-PLL) in mice, and to observe their effects on expression of HBV gene in the 2.2.15 cells and transgenic mice.METHODS: According to the result of direct sequencing of PCR amplified products, a 16 mer phosphorothioate analogue of the antisense oligodeoxynucleotides (PS-asODNs) directed against the HBV U5-like region was conjugated to the hepatotropic Gal-PLL molecules. Its distribution was demonstrated using asODNs labeled with ^32p at the 5' terminus with a T4-polynucleotide Kinase. Its inhibition effect on HBV expression was observed in the transfected 2.2.15 cells and transgenic mice.RESULTS: The Gal-PLL and asODNs could form stable complex at a molar ratio of 2:1. As shown in the HBV-transfected 2.2.15 cells, the inhibition effects of asODNs alone and asODNs conjugated to Gal-PLL, at 10μmol/L for both, on HBsAg and HBeAg production were different,the former being 70 % and 58 %, respectively, and the latter being 96 % and 82 %, respectively. A more pronounced reduction was also observed in viral DNA load in the culture supernatant for the test with Gal-PLL-asODNs. Among many mouse organs, livers retained more asODNs molecules after administration. The preferential concentration in liver was found to be 52.14 % for Gal-PLL-asODNs, as high as 2.38-fold of that for asODNs (21.9 %). Both elements decreased gradually in liver, with 2.9 % of the former, 5.99 % of the latter retained 24 hours after the administration. The injection interval, therefore, was recommended to be 24 hours. In the transgenic mice, serum HBsAg decreased significantly (P<0.01) at the 12th day after administrating Gal-PLL- asODNs, the serum HBV DNA turned negative in 4 of the 6 mice.CONCLUSION: Antisense oligodeoxynucleotides conjugated to Gal-PLL can be concentrated in liver and intaked by hepatocytic cells. This may result in specific inhibition of expression and replication of HBV in vitro and in vivo. | Su-JunZheng SenZhong Jian-JunZhang FengCheng HongRen Cun-LiangDeng | 2003 | World Journal of Gastroenterology2003，9，6： | 2 |
| 6 | The Superior Colliculus:Cell Types,Connectivity,and Behavior显示文摘The superior colliculus(SC),one of the most well-characterized midbrain sensorimotor structures where visual,auditory,and somatosensory information are integrated to initiate motor commands,is highly conserved across vertebrate evolution.Moreover,cell-type-specific SC neurons integrate afferent signals within local networks to generate defined output related to innate and cognitive behaviors.This review focuses on the recent progress in understanding of phenotypic diversity amongst SC neurons and their intrinsic circuits and long-projection targets.We further describe relevant neural circuits and specific cell types in relation to behavioral outputs and cognitive functions.The systematic delineation of SC organization,cell types,and neural connections is further put into context across species as these depend upon laminar architecture.Moreover,we focus on SC neural circuitry involving saccadic eye movement,and cognitive and innate behaviors.Overall,the review provides insight into SC functioning and represents a basis for further understanding of the pathology associated with SC dysfunction. | Xue Liu Hongren Huang Terrance PSnutch Peng Cao Liping Wang Feng Wang | 2022 | Neuroscience Bulletin2022，38，12： | 2 |
| 7 | A current statistical model and adaptive algorithm for estimating maneuvering targets 显示文摘 | Zhou Hongren K S P Kumar | 1984 | AIAA Journal Guidance Control and Dynamics1984，7，5： | 1 |
| 8 | Fluorocarbon and hydrocarbon N-Hetero- cyclic ( C5 - C7) imidazole-based liquid crystals 显示文摘 | Hongren C | 2014 | Chem Asian J2014，9，12： | 1 |
| 9 | A 'current' statistical model and adaptive algorithm for estimating maneuvering targets显示文摘 | Zhou Hongren Kumar K S P | 1984 | A IAA Journal Guidance Control and Dynamics1984，7，5： | 1 |
| 10 | A current statistical model and adaptive algorithm for estimating maneuvering targets 显示文摘 | Zhou Hongren Kumar K S P | 1984 | AIAA Journal of Guidance Control and Dynamics1984，7，5： | 1 |
| 11 | A Current Statistical Model and Adaptive Algorithm for Estimating Maneuvering Targets 显示文摘 | Zhou Hongren Kumar KSP | 1984 | AIAA Journal of Guidance Control and Dynamics1984，7，5： | 1 |
| 12 | Adaptive impulse detection using center-weighted median filters 显示文摘 | CHEN Tao WU Hongren | 2001 | IEEE Signal Processing Letters2001，8，1： | 1 |
| 13 | A Generalized Block-edge Impairment Metric for Video Coding显示文摘 | WU Hongren Yuen Micheal | 1997 | IEEE Signal Processing Letters(S1070-9908)1997，4，11： | 1 |
| 14 | Adaptive impulse detection using center-weighted median filters显示文摘 | Chen Tao Wu Hongren | 2001 | IEEE Signal Processing Letters2001，8，1： | 1 |
| 15 | An Adaptive Scheduler for Distributed Real-time Databases Systems显示文摘 | Chen Hongren Chin Y H | 2003 | Information Sciences2003，153，7： | 1 |
| 16 | A ccurent statistical model and adaptive algorithm for estimating maneuvering targets显示文摘 | Zhou Hongren Kumar K S P | 1984 | AIAA Journal Guidance Control and Dynamics1984，7，： | 1 |
| 17 | Study on power decoupling control of three phase voltage source PWM rectifiers显示文摘 | Wang Jiuhe Yin Hongren Zhang Jinlong | 2006 | Power Electronics and Motion Control Conference2006，，： | 1 |
| 18 | A robust structure-adaptive hybrid vector filter for color image restoration显示文摘 | Ma Zhonghua Wu Hongren Qiu Bin | 2005 | IEEE Transactions on Image Processing2005，14，12： | 1 |
| 19 | Adaptive impulse detection using center-weighted median filters显示文摘 | CHEN Tao WU Hongren | 2001 | IEEE Signal Processing Letters2001，8，1： | 1 |
| 20 | Exploring a particle-size-reduction strategy of YAG:Ce phosphor via a chemical breakdown method显示文摘Particle size reduction of Y_(3)Al_(5)O_(12):Ce(YAG:Ce) phosphor is highly needed for micro-LED display applications.In this work,size control of YAG:Ce phosphor particles is achieved via carbon coating and further heat treatment.A thin layer of carbon is deposited on the surface of YAG:Ce by chemical vapor deposition.During the heat treatment,carbon reacts with oxygen element in the phosphor and escapes from phosphor particles.The reaction results in the phosphor breaking into smaller particles.The phosphors were characterized by laser light scattering for particle size distribution,scanning electron microscopy(SEM),transmission electron microscopy for morphologies,X-ray diffraction refinements for crystal structure and electron energy-loss spectroscopy for elemental analysis.It is demonstrated that the median diameter(D_(50)) of the phosphor particle size is significantly reduced from 19.1 to 0.96 μm yet the photoluminescent properties have little changes.The carbon coating and further heat treatment method show potential application in size control of phosphors. | Hongren Chen Licheng Ju Li Zhang Xin Wang Linbo Zhang Xin Xu Lin Gao Kehui Qiu Liangjun Yin | 2021 | Journal of Rare Earths2021，39，8： | 1 |
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