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| 1 | 2013 ESC guidelines on the management of stable coronary artery disease显示文摘 | Gilles Montalescot Udo Sechtem Stephan Achenbach Felicita Andreotti Chris Arden Andrzej Budaj Raffaele Bugiardini Filippo Crea Thomas Cuisset Carlo Di Mario J. Rafael Ferreira Bernard J. Gersh Anselm K. Gitt Jean-Sebastien Hulot Nikolaus Marx Lionel H. Op | 2013 | European Heart Journal2013，，38： | 4 |
| 2 | Mixed antagonist response and sepsis severity-dependent dysbalance of pro- and anti-inflammatory responses at the onset of postoperative sepsis显示文摘 | Alexander R. Novotny Daniel Reim Volker Assfalg Felicitas Altmayr Helmut M. Friess Klaus Emmanuel Bernhard Holzmann | 2011 | Immunobiology2011，，6： | 3 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Mosaic theory revised:inflammation and salt play central roles in arterial hypertension显示文摘The mosaic theory of hypertension was advocated by Irvine Page~80 years ago and suggested that hypertension resulted from the close interactions of different causes.Increasing evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic injury.Inflammation plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial hypertension.Sodium intake is indispensable for normal body function but can be detrimental when it exceeds dietary requirements.Recent data show that sodium levels also modulate the function of monocytes/macrophages,dendritic cells,and different T-cell subsets.Some of these effects are mediated by changes in the microbiome and metabolome due to high-salt intake.The purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt,immunity,and hypertension research.Salt and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces. | Felicitas E.Hengel Jean-Pierre Benitah Ulrich O.Wenzel | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 5 | Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity显示文摘Dear Editor,Next-generation sequencing revealed that the majority of the human genome is transcribed but has no coding function.It is estimated that.30000 long noncoding RNAs(lncRNAs)are expressed in humans,but their functions are largely unknown(Suckau et al.,2009;Rinn and Chang,2012;Poller et al.,2013).Consideration of noncoding genomic elements in pathogenetic studies is warranted and enabled by technological advances allowing comprehensive transcriptome mapping of protein-coding genes as well as small and long ncRNAs. | Martina Gast Blanche Schroen Antje Voigt Jan Haas Uwe Kuehl Dirk Lassner Carsten Skurk Felicitas Escher Xiaomin Wang Adelheid Kratzer Katharina Michalik Anna Papageorgiou Tim Peters Madlen Loebel Sabrina Wilk Nadine Althof Kannanganattu VPrasanth Hugo Katus Benjamin Meder Shinichi Nakagawa Carmen Scheibenbogen Heinz-Peter Schultheiss Ulf Landmesser Stefanie Dimmeler Stephane Heymans Wolfgang Poller | 2016 | Journal of Molecular Cell Biology2016，8，2： | 2 |
| 6 | Quantification of dependencies between electrical and information infrastructures显示文摘 | Marco Beccuti Silvano Chiaradonna Felicita Di Giandomenico Susanna Donatelli Giovanna Dondossola Giuliana Franceschinis | 2012 | International Journal of Critical Infrastructure Protection2012，，1： | 2 |
| 7 | Increased proinflammatorycy tokines in patients with chronic stable angina and their reduction by aspirin显示文摘 | Ignatios I Felicita A Emanouel E | 1999 | Circulation1999，100，： | 1 |
| 8 | Polymor- phism+17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk显示文摘 | PATRICIA GA M FELICITAS LC ANA FS | 2008 | BMC Cancer2008，8，： | 1 |
| 9 | What does export diversification do for growth? An econometric analysis显示文摘 | Dierk Herzer Nowak-Lehnmann D. Felicitas | 2006 | Applied Economics2006，，15： | 1 |
| 10 | Early spontaneous intermittent myocardial reperfusion during acute myocardial infarction is associated with augmented thrombogenic activity and less myocardial damage显示文摘 | Agha W. Haider Felicita Andreotti David R. Hackett Dimitris Tousoulis Cornelis Kluft Attilio Maseri Graham J. Davies | 1995 | Journal of the American College of Cardiology1995，，3： | 1 |
| 11 | Inheritance of winterhardiness in roses显示文摘 | Felicitas Svejda | 1979 | Euphytica1979，，2： | 1 |
| 12 | Threats to sandy beach ecosystems: A review显示文摘 | Omar Defeo Anton McLachlan David S. Schoeman Thomas A. Schlacher Jenifer Dugan Alan Jones Mariano Lastra Felicita Scapini | 2008 | Estuarine Coastal and Shelf Science2008，，1： | 1 |
| 13 | Remote Loading of Doxorubicin into Liposomes Driven by a Transmembrane Phosphate Gradient显示文摘 | Andreas F Felicitas H Andrea K | 2006 | BBA2006，1758，： | 1 |
| 14 | The entrepreneur in the Born Global firm in Australia and Sweden 显示文摘 | SVANTE ANDERSSON FELICITAS EVANGELISTA | 2006 | Journal of Small Business and Enterprise Development2006，13，： | 1 |
| 15 | Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells显示文摘 | Christine V Felicitas G Andre M | 2004 | Cancer Res2004，64，15： | 1 |
| 16 | Remote Loading of Doxorubicin into Liposomes Driven by a Transmembrane Phosphate Gradient显示文摘 | Andreas F Felicitas H Andrea K | 2006 | BBS2006，1758，： | 1 |
| 17 | Wastewater denitriflcation process-the influence of methanol and kinetic analysis显示文摘 | Lucija Foglar Felicita Briski | 2003 | Process Biochemistry2003，39，1： | 1 |
| 18 | Respirometric assays at fixed and process temperatures to monitor composting process 显示文摘 | Raquel B G Felicitas V L Bolasell F G | 2005 | Bioresour Technol2005，96，10： | 1 |
| 19 | Xanthogranulomatous pyelonephritis in children:diagnostic and therapeutic aspects显示文摘 | Felicitas E Thomas R Stefan W | 2009 | J Med Ultrasonics2009，36，： | 1 |
| 20 | Natural radioactivity in cultivated land in the vicinity of a phosphate fertilizer plant in Nigeria 显示文摘 | Mark C O Kenneth K A Felicitas U I | 2012 | Radiation Physics and Chemistry2012，，81： | 1 |
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