|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gestational diabetes: A clinical update显示文摘Gestational diabetes mellitus(GDM)is increasing in prevalence in tandem with the dramatic increase inthe prevalence of overweight and obesity in women of childbearing age.Much controversy surrounds the diagnosis and management of gestational diabetes,emphasizing the importance and relevance of clarity and consensus.If newly proposed criteria are adopted universally a significantly growing number of women will be diagnosed as having GDM,implying new therapeutic challenges to avoid foetal and maternal complications related to the hyperglycemia of gestational diabetes.This review provides an overview of clinical issues related to GDM,including the challenges of screening and diagnosis,the pathophysiology behind GDM,the treatment and prevention of GDM and the long and short term consequences of gestational diabetes for both mother and offspring. | Ulla Kampmann Lene Ring Madsen Gitte Oeskov Skajaa Ditte Smed Iversen Niels Moeller Per Ovesen | 2015 | World Journal of Diabetes2015，6，8： | 17 |
| 2 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 3 | Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DlO-rats显示文摘 | Gitte HANSEN Jacob JELSlNG Niels VRANG | 2012 | Acta Pharmacologica Sinica2012，33，2： | 6 |
| 4 | 2013 ESC guidelines on the management of stable coronary artery disease显示文摘 | Gilles Montalescot Udo Sechtem Stephan Achenbach Felicita Andreotti Chris Arden Andrzej Budaj Raffaele Bugiardini Filippo Crea Thomas Cuisset Carlo Di Mario J. Rafael Ferreira Bernard J. Gersh Anselm K. Gitt Jean-Sebastien Hulot Nikolaus Marx Lionel H. Op | 2013 | European Heart Journal2013，，38： | 4 |
| 5 | Protein tolerance to standard and high protein meals in patients with liver cirrhosis显示文摘AIM To investigate the plasma amino acid response and tolerance to normal or high protein meals in patients with cirrhosis.METHODS The plasma amino acid response to a 20 g mixed protein meal was compared in 8 biopsy-proven compensated cirrhotic patients and 6 healthy subjects.In addition the response to a high protein meal(1 g/kg body weight) was studied in 6 decompensated biopsy-proven cirrhotics in order to evaluate their protein tolerance and the likelihood of developing hepatic encephalopathy(HE) following a porto-caval shunt procedure.To test for covert HE,the 'number connection test'(NCT) was done on all patients,and an electroencephalogram was recorded in patients considered to be at Child-Pugh C stage.RESULTS The changes in plasma amino acids after a 20 g protein meal were similar in healthy subjects and in cirrhotics except for a significantly greater increase(P < 0.05) in isoleucine,leucine and tyrosine concentrations in the cirrhotics.The baseline branched chain amino acids/aromatic amino acids(BCAA/AAA) ratio was higher in the healthy persons and remained stable-but it decreased significantly after the meal in the cirrhotic group.After the high protein meal there was a marked increase in the levels of most amino acids,but only small changes occurred in the levels of taurine,citrulline,cysteine andhistidine.The BCAA/AAA ratio was significantly higher 180 and 240 min after the meal.Slightly elevated basal plasma ammonia levels showed no particular pattern.Overt HE was not observed in any patients.CONCLUSION Patients with stable liver disease tolerate natural mixed meals with a standard protein content.The response to a high protein meal in decompensated cirrhotics suggests accumulation of some amino acids but it did not precipitate HE.These results support current nutritional guidelines that recommend a protein intake of 1.2-1.5 g/kg body weight/day for patients with cirrhosis. | Octavio Campollo Dirk Sprengers Gitte Dam Hendrik Vilstrup Neil McIntyre | 2017 | World Journal of Hepatology2017，9，14： | 3 |
| 6 | Intra-aortic balloon pump in patients with acute myocardial infarction complicated by cardiogenic shock: results of the ALKK-PCI registry显示文摘 | Uwe Zeymer Mathias Hochadel Karl-Eugen Hauptmann Klaus Wiegand Burghard Schuhmacher Johannes Brachmann Anselm Gitt Ralf Zahn | 2013 | Clinical Research in Cardiology2013，，： | 2 |
| 7 | Clinical benefit of enoxaparin in patients with high - risk acute coronary syndromes without ST ele- vations in clinical practice 显示文摘 | Zeymer U Gitt A Jtinger C | 2006 | Am J Cardiol2006，98，1： | 1 |
| 8 | Preva-lence,serotypes and resistance patterns of Salmonella in Danish pig production显示文摘 | Hector Arguello Gitte Soensen Ana Carvajal | | 0，，： | 1 |
| 9 | Exercise anaerobic threshold and ventilatory efficiency identify heart failure pa- tients for high risk of early death 显示文摘 | Gitt AK Wasserman K Kilkowski C | 2002 | Circulation2002，106，： | 1 |
| 10 | Lung function and exercise gas exchange in chronic heart failure显示文摘 | Wasserman K Zhang YY Gitt A | 1997 | Circulation1997，96，7： | 1 |
| 11 | Adenovirus-mediated gene therapy of osteoblasts in vitro and in vivo显示文摘 | Mehrara BJ Saadeh PB Steinbrech DS Dudziak M Spector JA Greenwald JA Gittes GK Longaker MT | | 0，，： | 1 |
| 12 | Comparison of clinical benef its of clopidogrel therapy in patients with a- cute coronary syndromes taking at orvas tatin versus oth- ers tatin therapies显示文摘 | Weinbergen H Gitt AK Schiele R | 2010 | Am J Cardiol2010，92，3： | 1 |
| 13 | Autoregulation of Cerebral Blood Flow in Patients Resuscitated From Cardiac Arrest显示文摘 | Claus Sundgreen Fin Stolze Larsen Tina Maria Herzog Gitte Moos Knudsen Soren Boesgaard Jan Aldershvile | 2001 | Stroke: Journal of the American Heart Association2001，，1： | 1 |
| 14 | Galectins Structure and function of a large family of animal lectins显示文摘 | Barondes SH Cooper DN Gitt MA | 1994 | J Biol Chem1994，269，20： | 1 |
| 15 | Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors显示文摘 | Galante P E Hanahan D | 1996 | Development1996，122，2： | 1 |
| 16 | Galectins:structure and function of a large family of animal lectins显示文摘 | Barodes SH Cooper DN Gitt MA | 1994 | J Biol Chem1994，269，20： | 1 |
| 17 | Impact of prehospital delay on mortality in patients with acute myocardial irLfaretion treated with primary angioplasty and intravenous thrombolysis Impact of prehospital delay on mortality in patients with acute myocardial irLfaretion treated with primary angioplasty and intravenous thrombolysis 显示文摘 | Zahn R Sehiele R Gitt AK | 2001 | Am Heart J2001，142，： | 1 |
| 18 | Effect of climate change on greenhouse gas emissions from arable crop rotations显示文摘 | J?rgen E. Olesen Gitte H. Rub?k Tove Heidmann S?ren Hansen Christen D. B?rgensen | 2004 | Nutrient Cycling in Agroecosystems2004，，2： | 1 |
| 19 | Female prostatitis显示文摘 | Gittes RF | 2002 | Urol Clin North Am2002，29，3： | 1 |
| 20 | Comparison of Treatment and Outcome of Acute Coronary Syndrome in Patients With Versus Patients Without Diabetes Mellitus显示文摘 | Tal Hasin Matthias Hochadel Anselm K. Gitt Shlomo Behar Héctor Bueno Yonathan Hasin | 2009 | The American Journal of Cardiology2009，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员