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| 1 | Gsα^(R201C)and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells显示文摘The Gsα/cAMP signaling pathway mediates the effect of a variety of hormones and factors that regulate the homeostasis of the post-natal skeleton.Hence,the dysregulated activity of Gsαdue to gain-of-function mutations (R201C/R201H)results in severe architectural and functional derangements of the entire bone/bone marrow organ.While the consequences of gain-of-function mutations of Gsαhave been extensively investigated in osteoblasts and in bone marrow osteoprogenitor cells at various differentiation stages,their effect in adipogenically-committed bone marrow stromal cells has remained unaddressed.We generated a mouse model with expression of Gsα^(R201C) driven by the Adiponectin(Adq)promoter.Adq-Gsα^(R201C) mice developed a complex combination of metaphyseal,diaphyseal and cortical bone changes.In the metaphysis,Gsα^(R201C) caused an early phase of bone resorption followed by bone deposition.Metaphyseal bone formation was sustained by cells that were traced by Adq-Cre and eventually resulted in a high trabecular bone mass phenotype.In the diaphysis,Gsα^(R201C),in combination with estrogen,triggered the osteogenic activity of Adq-Cre-targeted perivascular bone marrow stromal cells leading to intramedullary bone formation.Finally,consistent with the previously unnoticed presence of Adq-Cre-marked pericytes in intraosseous blood vessels,Gsα^(R201C) caused the development of a lytic phenotype that affected both cortical(increased porosity)and trabecular(tunneling resorption)bone.These results provide the first evidence that the Adq-cell network in the skeleton not only regulates bone resorption but also contributes to bone formation,and that the Gsα/cAMP pathway is a major modulator of both functions. | Biagio Palmisano Rossella Labella Samantha Donsante Cristina Remoli Emanuela Spica Ilenia Coletta Giorgia Farinacci Michele Dello Spedale Venti Isabella Saggio Marta Serafini Pamela Gehron Robey Alessandro Corsi Mara Riminucci | 2022 | Bone Research2022，10，4： | 1 |
| 2 | Development of resistance to fluconazole by Candida albicans during treatment of oropharyngeal candidiasis in AIDS: documentation by in vitro susceptibility testing and DNA subtype analyses显示文摘 | Redding S Smith J Farinacci G | 1994 | Clin Infect Dis1994，18，： | 1 |
| 3 | Resistance of Candida albicans to fluconazole during treatment of oropharyngeal candidiasis in a patient with AIDS:documentation by in vitro susceptibility testing and DNA subtype analysis显示文摘 | Redding S Smith J Farinacci G | 1994 | Clin Infect Dis1994，18，： | 1 |
| 4 | Development of resistance to fluconazole by Candida albicans during treatment of oropharyngeal candidiasis in AIDS:documentation by in vitro susceptibility testing and DNA subtype analyses 显示文摘 | Smith J Farinacci G | 1994 | Clin Infect Dis1994，18，2： | 1 |
| 5 | Resistance of Candida albicans to fluconazole during treatment of oropharyngeal candidiasis in a patient with AIDS:documentation by in vitro susceptibility testing and DNA subtype analysis显示文摘 | Redding S Smith J Farinacci G | 1994 | Clin Infect Dis1994，，： | 1 |
| 6 | The PIM Architecture for Wide-Area Multieast Routing显示文摘 | S DEERING D ESTRIN D FARINACCI | | 0，，02： | 1 |
| 7 | Expression and localization studies of hSDA, the human ortholog of the yeast SDA1 gene显示文摘 | Babbio F Farinacci M Saracino F | 2004 | Cell Cycle2004，3，： | 1 |
| 8 | Introduction to Enhanced IGRP(EIGRP)显示文摘 | FARINACCI DINO | 1993 | cisco systems1993，，7： | 1 |
| 9 | The PIM architecture for wide-area multicast routing显示文摘 | Estrin D L Farinacci D | 1996 | IEEE/ACM Transactions on Networking1996，4，2： | 1 |
| 10 | MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil reeruitment显示文摘 | Dorhoi A Iannaccone M Farinacci M | 2013 | J Clin Invest2013，123，11： | 1 |
| 11 | Robotic right colectomy for cancer with intracorporeal anastomosis: short-term outcomes from a single institution显示文摘 | Stefano Trastulli Jacopo Desiderio Federico Farinacci Francesco Ricci Chiara Listorti Roberto Cirocchi Carlo Boselli Giuseppe Noya Amilcare Parisi | 2013 | International Journal of Colorectal Disease2013，，6： | 1 |
| 12 | MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment显示文摘 | Dorhoi Anca Iannaccone Marco Farinacci Maura Fa? Kellen C Schreiber J?rg Moura-Alves Pedro Nouailles Geraldine Mollenkopf Hans-Joachim Oberbeck-M?ller Dagmar J?rg Sabine Heinemann Ellen Hahnke Karin L?we Delia Del Nonno Franca Goletti Delia | 2013 | Journal of Clinical Investigation2013，，11： | 1 |
| 13 | The PIM architecture for wide-area multicast routing显示文摘 | Deering S Estrin D L Farinacci D | 1996 | IEEE/ACM Transactions on Networking1996，4，2： | 1 |
| 14 | Eosinophilic granuloma of the lung显示文摘 | Farinacci CJ Jeffrey HC Lackey RW | 1951 | Armed Forces Med J1951，2，： | 1 |
| 15 | The PIM architecture for wide-area multicast routing显示文摘 | Deering S Estrin D Farinacci D | 1996 | IEEE/ACM Transactions on Networking1996，4，2： | 1 |
| 16 | The PIM architecture for wide-area multicast routing显示文摘 | DEERING S ESTRIN D FARINACCI D | 1996 | IEEE/ACM Transactions on Networking1996，4，2： | 1 |
| 17 | Role of Damage Control Surgery in the Treatment of Hinchey III and IV Sigmoid Diverticulitis: A Tailored Strategy显示文摘 | Roberto Cirocchi Alberto Arezzo Nereo Vettoretto Davide Cavaliere Eriberto Farinella Claudio Renzi Gaspare Cannata Jacopo Desiderio Federico Farinacci Francesco Barberini Stefano Trastulli Amilcare Parisi Abe Fingerhut | 2014 | Medicine2014，，25： | 1 |
| 18 | The PIM architecture for wide-area multicast routing显示文摘 | Deering S Estrin DL Farinacci D | 1996 | IEEE/ACM Transactions on Networking1996，4，2： | 1 |
| 19 | Development of resistance to fluconazole by Candida albicans during treatment of oropharyngeal candidiasis in AIDS:documentation by in vitro susceptibility testing and DNA subtype analyses显示文摘 | Redding S Smith J Farinacci G | 1994 | Clin Infect Dis1994，18，2： | 1 |
| 20 | Generic Routing Encapsulation over IPv4 networks显示文摘 | Hanks S Li T Farinacci D | 1994 | RFC17021994，，： | 1 |
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