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| 1 | Conversion of laparoscopic colorectal resection for cancer: What is the impact on short-term outcomes and survival?显示文摘Laparoscopic resection for colon and rectal cancer is associated with quicker return of bowel function, reduced postoperative morbidity rates and shorter length of hospital stay compared to open surgery, with no differences in long-term survival. Conversion to open surgery is reported in up to 30% of patients enrolled in randomized control trials comparing open and laparoscopic colorectal resection for cancer. In this review, reasons for conversion are anatomical-related factors, disease-related-factors and surgeon-related factors. Body mass index, local tumour extension and co-morbidities are independent predictors of conversion. The current evidence has shown that patients with converted resection for colon cancer have similar outcomes compared to patients undergoing a laparoscopic completed or open resection. The few studies that have assessed the outcomes after conversion of laparoscopic rectal resection reported significantly higher rates of complications and longer length of hospital stay in converted patients compared to laparoscopically treated patients. No definitive conclusions can be drawn when converted and open rectal resections are compared. Early and pre-emptive conversion appears to have more favourable outcomes than reactive conversion; however, further large studies are needed to better define the optimal timing of conversion. With regard to long-term oncologic outcome, overall and disease-free survival in the case of conversion in laparoscopic colorectal cancer surgery seems to be worse than those achieved in patients in whom resection was successfully completed by laparoscopy. Although a worse long-term oncologic outcome has been suggested, it remains difficult to draw a proper conclusion due to the heterogeneity of the long-term outcomes as well as the inclusion of both colon and rectal cancer patients in most of the studies. Therefore, we discuss the currently available evidence of the impact of conversion in laparoscopic resection for colon and rectal cancer on both short-term outcomes and long-term survival. | Marco E Allaix Edgar JB Furnée Massimiliano Mistrangelo Alberto Arezzo Mario Morino | 2016 | World Journal of Gastroenterology2016，22，37： | 11 |
| 2 | 左半结肠恶性梗阻行支架植入作为手术过渡对比急诊手术的长期肿瘤学结果:一项多中心随机对照试验(ESCO试验)显示文摘背景与目的:与急诊手术(emergency surgery,ES)相比,结肠恶性梗阻病例使用支架植入作为手术过渡(stenting asbridge-to surgery,SBTS)可能会降低术后并发症发生率和造口率,但其长期生存预后引发了人们的关注。本研究旨在评估SBTS对比ES治疗左半结肠恶性梗阻的3年总生存率(over-all survival, OS)、疾病进展时间(time to progression,TTP)及无疾病生存率(disease free survival,DFS),这些为此前已发表的一项随机对照研究的次要观察指标。方法:纳入5家欧洲医院收治的左半结肠恶性梗阻病例,按1:1比例随机分配到SBTS组和ES组。各中心病例由计算机生成随机序列并根据cT分期分层,且采用基于网络的隐藏方案。研究者与患者知晓治疗内容,本文分析的次要观察指标是OS、TTP和DFS。研究采用意向性分析。本试验注册号为NCT00591695。结果:2008年3月至2015年11月,144名患者被随机分配到SBTS组或ES组;115例患者可被纳入分析(SBTS组56例,ES组59例),余有20例因诊断为良性疾病、1例因内镜医师无法共同参与、8例退出研究而被剔除。中位随访时间为37个月(1~62个月),SBTS组与ES组在OS【HR=0.93,95%CI:0.49~1.76,P=0.822】、TTP【HR=0.81,95%CI:0.42~1.54, P=0.512】,DFS【HR=1.01, 95%CI:0.56~1.81, P=0.972】方面比较差异均无统计学意义。亚组分析显示两组在年龄、性别、美国麻醉学学会评分、体质量指数和p T分期方面比较差异均无统计学意义。SBTS组降结肠梗阻患者的TTP优于ES组【HR=0.44,95%CI:0.20~0.97,P=0.042】,但这些患者的OS【HR=0.73,95%CI:0.33~1.63,P=0.442】与DFS【HR=0.68,95%CI:0.34~1.34,P=0.261】比较差异均无统计学意义。结论:虽然次要观察指标不能提供强有力的支持依据,但这项随机对照试验表明至少在36个月的随访中两组的OS、TTP和DFS没有组间差异。 | 陈致奋 AREZZO A FORCIGNANò E BONINO M A | 2020 | 结直肠肛门外科2020，26，6： | 5 |
| 3 | Laparoscopy for rectal cancer reduces short-term mortality and morbidity: results of a systematic review and meta-analysis显示文摘 | Alberto Arezzo Roberto Passera Gitana Scozzari Mauro Verra Mario Morino | 2013 | Surgical Endoscopy2013，，5： | 4 |
| 4 | Over-the-scope clips in the treatment of gastrointestinal tract iatrogenic perforation: A multicenter retrospective study and a classification of gastrointestinal tract perforations显示文摘AIM: To determine the outcome of the management of iatrogenic gastrointestinal tract perforations treated by over-the-scope clip(OTSC) placement.METHODS: We retrospectively enrolled 20 patients(13 female and 7 male; mean age: 70.6 ± 9.8 years) in eight high-volume tertiary referral centers with upper or lower iatrogenic gastrointestinal tract perforation treated by OTSC placement. Gastrointestinal tract perforation could be with oval-shape or with round-shape. Ovalshape perforations were closed by OTSC only by suction and the round-shape by the 'twin-grasper' plus suction. RESULTS: Main perforation diameter was 10.1 ± 4.3 mm(range 3-18 mm). The technical success rate was 100%(20/20 patients) and the clinical success rate was 90%(18/20 patients). Two patients(10%) who did not have complete sealing of the defect underwent surgery. Based upon our observations we propose two types of perforation: Round-shape 'type-1 perforation' and oval-shape 'type-2 perforation'. Eight(40%) out of the 20 patients had a type-1 perforation and 12 patients a type-2(60%). CONCLUSION: OTSC placement should be attempted after perforation occurring during diagnostic or therapeutic endoscopy. A failed closure attempt does not impair subsequent surgical treatment. | Benedetto Mangiavillano Angelo Caruso Raffaele Manta Roberto Di Mitri Alberto Arezzo Nico Pagano Giuseppe Galloro Filippo Mocciaro Massimiliano Mutignani Carmelo Luigiano Enrico Antonucci Rita Conigliaro Enzo Masci | 2016 | World Journal of Gastrointestinal Surgery2016，8，4： | 3 |
| 5 | Efficacy of the over-the-scope clip (OTSC) for treatment of colorectal postsurgical leaks and fistulas显示文摘 | Alberto Arezzo Mauro Verra Rossella Reddavid Francesca Cravero Marco Augusto Bonino Mario Morino | 2012 | Surgical Endoscopy2012，，11： | 2 |
| 6 | Nerve growth factor prevents toxic neuropathy in mice 显示文摘 | APFEL SC LIPTON RB AREZZO JC | 1991 | Ann Neurol1991，29，1： | 1 |
| 7 | Laparoscopic Peritoneal Lavage: A Definitive Treatment for Diverticular Peritonitis or a “Bridge” to Elective Laparoscopic Sigmoidectomy?: A Systematic Review显示文摘 | Roberto Cirocchi Stefano Trastulli Nereo Vettoretto Diego Milani Davide Cavaliere Claudio Renzi Olga Adamenko Jacopo Desiderio Maria Federica Burattini Amilcare Parisi Alberto Arezzo Abe Fingerhut | 2015 | Medicine2015，，： | 1 |
| 8 | New developments in the diagnosis of diabetic neuropathy显示文摘 | Arezzo JC | 1999 | Am J Med1999，107，2： | 1 |
| 9 | Diabetic neuropathies:a statement by the American Diabetes Association显示文摘 | Boulton AJ Vinik AI Arezzo JC | 2005 | Diabetes Care2005，28，4： | 1 |
| 10 | Diabetic neuropat hies: a statement by the American Diabetes Assciation显示文摘 | Boulton AJ Vinik AI Arezzo JC | 2005 | Diabetes Care2005，28，4： | 1 |
| 11 | Diabetic neuropathies: A statment by the American Diabetes Association显示文摘 | Bouiton AJ Vinik AI Arezzo JC | 2005 | Diabetes Care2005，28，4： | 1 |
| 12 | Diabetic neuropathies:a statement by the American Diabetes Association显示文摘 | Boulton AJ Vinik AI Arezzo JC | | 0，，： | 1 |
| 13 | Efficacy and safety of endoscopic submucosal dissection for colorectal neoplasia: a systematic review显示文摘 | A. Repici C. Hassan D. De Paula Pessoa N. Pagano A. Arezzo A. Zullo R. Lorenzetti R. Marmo | 2012 | Endoscopy2012，，02： | 1 |
| 14 | The neuropathy of erectile dysfunction显示文摘 | Bleustein CB Arezzo JC Eckholdt H | 2002 | Int J Impot Res2002，14，6： | 1 |
| 15 | Epidemic muhidrug-re- sistant Acinetobacter baumannii related to European clonal types Ⅰ and Ⅱ in Rome(Italy) 显示文摘 | D'Arezzo S Capone A Petrosillo N | 2009 | Clin Microbiol Infect2009，15，4： | 1 |
| 16 | Optical properties of plasma sprayed ZnO+Al2O3 coatings显示文摘 | TULUI M AREZZO F PAWLOWSKI L | 2004 | Surface and Coatings Technology2004，179，： | 1 |
| 17 | Does conversion affect short-term and oncologic outcomes after laparoscopy for colorectal cancer?显示文摘 | Marco Ettore Allaix Maurizio Degiuli Alberto Arezzo Simone Arolfo Mario Morino | 2013 | Surgical Endoscopy2013，，12： | 1 |
| 18 | Diabetic neuropathies:a statement by the American Diabetes Association显示文摘 | Boulton AJ Vinik AI Arezzo JC | | 0，，： | 1 |
| 19 | Diabetic somatic neuropathies 显示文摘 | Boulton A J Malic RA Arezzo JC | 2004 | Diabetes Care2004，27，6： | 1 |
| 20 | Enterovcsical fistulas: diagnosis and management显示文摘 | Scozzari G Arezzo A Morino M | 2010 | Tech Coloproctol2010，14，4： | 1 |
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