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| 1 | Magnetic resonance imaging:A new tool for diagnosis of acute ischemic colitis?显示文摘AIM:To define the evolution of ischemic lesions with 7T magnetic resonance imaging(7T-MRI)in an animal model of acute colonic ischemia.METHODS:Adult Sprague-Dawley rats were divided into two groups.GroupⅠ underwent inferior mesenteric artery(IMA)ligation followed by macroscopic observations and histological analysis.In groupⅡ,7T-MRI was performed before and after IMA ligation and followed by histological analysis.RESULTS:Morphological alterations started to develop 1 h after IMA ligation,when pale areas became evident in the splenic flexure mesentery and progressively worsened up to 8 h thereafter,when the mesentery was less pale,and the splenic flexure loop appeared very dark.The 7T-MRI results reflected these alterations,showing a hyperintense signal in both the intraperitoneal space and the colonic loop wall 1 h after IMA ligation;the latter progressively increased to demonstrate a reduction in the colonic loop lumen at 6 h.Eight hours after IMA ligation,MRI showed a persistent colonic mural hyperintensity associated with a reduction in peritoneal free fluid.The 7T-MRI findings were correlated with histological alterations,varying from an attenuated epithelium with glandular apex lesions at 1 h to coagulative necrosis and loss of the surface epithelium detected 8 h after IMA ligation.CONCLUSION:MRI may be used as a substitute for invasive procedures in diagnosing and grading acute ischemic colitis,allowing for the early identification of pathological findings. | Francesca Iacobellis Daniela Berritto Francesco Somma Carlo Cavaliere Marco Corona Santolo Cozzolino Franco Fulciniti Salvatore Cappabianca Antonio Rotondo Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，13： | 7 |
| 2 | Impact of radiogenomics in esophageal cancer on clinical outcomes: A pilot study显示文摘BACKGROUND Esophageal cancer(ESCA)is the sixth most common malignancy in the world,and its incidence is rapidly increasing.Recently,several microRNAs(miRNAs)and messenger RNA(mRNA)targets were evaluated as potential biomarkers and regulators of epigenetic mechanisms involved in early diagnosis.In addition,computed tomography(CT)radiomic studies on ESCA improved the early stage identification and the prediction of response to treatment.Radiogenomics provides clinically useful prognostic predictions by linking molecular characteristics such as gene mutations and gene expression patterns of malignant tumors with medical images and could provide more opportunities in the management of patients with ESCA.AIM To explore the combination of CT radiomic features and molecular targets associated with clinical outcomes for characterization of ESCA patients.METHODS Of 15 patients with diagnosed ESCA were included in this study and their CT imaging and transcriptomic data were extracted from The Cancer Imaging Archive and gene expression data from The Cancer Genome Atlas,respectively.Cancer stage,history of significant alcohol consumption and body mass index(BMI)were considered as clinical outcomes.Radiomic analysis was performed on CT images acquired after injection of contrast medium.In total,1302 radiomics features were extracted from three-dimensional regions of interest by using PyRadiomics.Feature selection was performed using a correlation filter based on Spearman’s correlation(ρ)and Wilcoxon-rank sum test respect to clinical outcomes.Radiogenomic analysis involvedρanalysis between radiomic features associated with clinical outcomes and transcriptomic signatures consisting of eight N6-methyladenosine RNA methylation regulators and five up-regulated miRNA.The significance level was set at P<0.05.RESULTS Of 25,five and 29 radiomic features survived after feature selection,considering stage,alcohol history and BMI as clinical outcomes,respectively.Radiogenomic analysis with stage as clinical outcome revealed that six of the eight mRNA regulators and two of the five up-regulated miRNA were significantly correlated with ten and three of the 25 selected radiomic features,respectively(-0.61<ρ<-0.60 and 0.53<ρ<0.69,P<0.05).Assuming alcohol history as clinical outcome,no correlation was found between the five selected radiomic features and mRNA regulators,while a significant correlation was found between one radiomic feature and three up-regulated miRNAs(ρ=-0.56,ρ=-0.64 andρ=0.61,P<0.05).Radiogenomic analysis with BMI as clinical outcome revealed that four mRNA regulators and one up-regulated miRNA were significantly correlated with 10 and two radiomic features,respectively(-0.67<ρ<-0.54 and 0.53<ρ<0.71,P<0.05).CONCLUSION Our study revealed interesting relationships between the expression of eight N6-methyladenosine RNA regulators,as well as five up-regulated miRNAs,and CT radiomic features associated with clinical outcomes of ESCA patients. | Valentina Brancato Nunzia Garbino Lorenzo Mannelli Marco Aiello Marco Salvatore Monica Franzese Carlo Cavaliere | 2021 | World Journal of Gastroenterology2021，27，36： | 3 |
| 3 | Influence of shoulder geometry on microstructure and mechanical properties of friction stir welded 6082 aluminium alloy显示文摘 | A. Scialpi L.A.C. De Filippis P. Cavaliere | 2006 | Materials and Design2006，，4： | 2 |
| 4 | Novel Therapies for Malignant Gliomas显示文摘 | Robert Cavaliere Patrick Y. Wen David Schiff | 2007 | Neurologic Clinics2007，，4： | 2 |
| 5 | 3,5-diiodo- l -thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet显示文摘 | Maria Pina Mollica Lillà Lionetti Maria Moreno Assunta Lombardi Pieter De Lange Alessandro Antonelli Antonia Lanni Gina Cavaliere Antonio Barletta Fernando Goglia | 2009 | Journal of Hepatology2009，，2： | 2 |
| 6 | Effect of welding parameters on mechanical and microstructural properties of AA6082 joints produced by friction stir welding显示文摘 | P. Cavaliere A. Squillace F. Panella | 2007 | Journal of Materials Processing Tech2007，，1： | 2 |
| 7 | Prevalence of incidental thyroid disease in a relatively low iodine intake area 显示文摘 | Tomimori E Pedrinola F Cavaliere H | 1995 | Thyroid1995，5，4： | 1 |
| 8 | Herbal supplement sales experience slight increase in 2008 显示文摘 | Cavaliere C Rea P Lynch ME | 2009 | Herbal Gram2009，82，： | 1 |
| 9 | Glucose deprivation and chemical hypoxia: neuroprotection by P2 receptor antagonists 显示文摘 | Cavaliere F D' Ambrosi N Ciotti MT | 2008 | Neurochem lnt2008，38，： | 1 |
| 10 | Compressive plastic deformation of an AS21X magnesium alloy produced by high pressure die casting at elevated temperatures显示文摘 | Barbagallo S Cavaliere P Cerri E | 2004 | Materials Science and Engineering2004，367，： | 1 |
| 11 | Cutaneous vasculitis:diagnosis and management显示文摘 | Carlson JA Cavaliere LF Grant-Kels JM | | 0，，05： | 1 |
| 12 | Expressional and functional analysis of the male-specific cluster mst36F during Drosophila spermatogenesis显示文摘 | Di Cara F Cavaliere D Galliero V | | 0，，06： | 1 |
| 13 | Mechanical and microstructural behaviour of 2024-7075 aluminium alloy sheets joined by friction stir welding 显示文摘 | P Cavaliere R Nobile F W Panella | 2006 | International Journal of Machine Tools & Manufacture2006，46，： | 1 |
| 14 | Postoperative delirium 显示文摘 | Cavaliere F D'Ambrosio F Volpe C | 2005 | Curr Drug Targets2005，6，7： | 1 |
| 15 | Laparoscopic Peritoneal Lavage: A Definitive Treatment for Diverticular Peritonitis or a “Bridge” to Elective Laparoscopic Sigmoidectomy?: A Systematic Review显示文摘 | Roberto Cirocchi Stefano Trastulli Nereo Vettoretto Diego Milani Davide Cavaliere Claudio Renzi Olga Adamenko Jacopo Desiderio Maria Federica Burattini Amilcare Parisi Alberto Arezzo Abe Fingerhut | 2015 | Medicine2015，，： | 1 |
| 16 | Herbal supplement sales rise in all channels in 2009 显示文摘 | Cavaliere C Rea P Lynch M E | 2010 | HerbalGram2010，86，2： | 1 |
| 17 | Breast cancer in youngwomen:clinicopathological features and biological specificity显示文摘 | Sidoni A Cavaliere A Bellezza G | 2003 | Breast2003，12，4： | 1 |
| 18 | Tandem mass spectrometry in food safety assessment:the determination of phthalates in olive oil显示文摘 | CAVALIERE B MACCHIONE B SINDONA G | 2008 | J Chromatogr A2008，1205，12： | 1 |
| 19 | Compressive plastic deformation of an AS21X magnesium alloy produced by high pressure die casting at elevated temperatures 显示文摘 | BARBAGALLO S CAVALIERE P CERRI E | 2004 | Materials Science and Engineering A2004，367，： | 1 |
| 20 | Effect of welding parameters on mechanical and microstructural proper- ties of AA6056 joints produced by friction stir welding显示文摘 | CAVALIERE P CAMPANILE G PANELLA F | 2006 | Jour- nal of Materials Processing Technology2006，180，： | 1 |
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