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| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 3 | Interleuldn-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility : Ameta -analysis显示文摘 | Duan Zhenhua Pan Faming Zeng Zhen | 2012 | Rheumatol Int2012，32，5： | 1 |
| 4 | Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: A meta-analysis 显示文摘 | Duan Zhenhua Pan Faming Zeng Zhen | 2012 | Rheumatol Int2012，32，5： | 1 |
| 5 | Selective removal of phosphate in waters using a novel of cation adsorbent: Zirconium phosphate (ZrP) behavior and mechanism显示文摘 | Qingrui Zhang Qing Du Tifeng Jiao Bingcai Pan Zhaoxiang Zhang Qina Sun Sufeng Wang Ting Wang Faming Gao | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 6 | Fecal microbiota transplantation is an effective rescue therapy for refractory inflammatory bowel disease显示文摘 | Bota Cui Pan Li Lijuan Xu Zhaoyuan Peng Youquan Zhao Huiquan Wang Zhi He Ting Zhang Guozhong Ji Kaichun Wu Daiming Fan Faming Zhang | 2015 | Inflammation and Cell Signaling2015，，： | 1 |
| 7 | Effects of Dietary Betaine on Production Perform-ance,Egg Quality and Serum Biochemical Indexes of Layers under Heat Stress Condition显示文摘[Objective]This experiment was conducted to study the effects of dietary betaine on performance,egg quality and serum biochemical parameters of laying hens under heat stress condition. [Method]A total of 600 22-week-old commercial Roman laying hens were randomly divided into five groups,with eight replicates in each group and 15 hens in each replicate. Group I was taken as the positive control group,and laying hens in group I were fed with basal diets in normal thermal environment. Temperature humidity index of group I was between 64. 9 and 68. 9. Group II was taken as the negative control group,and laying hens in group II were fed with basal diets under heat stress condition. Temperature humidity index of group II was higher than 72. Laying hens in groups III-V were fed with basal diets supplemented with 200,400 and 600 mg/kg betaine under heat stress condition respectively,and temperature humidity indexes in groups III-V were all higher than 72. The experiment lasted for 14 weeks. [Results]Results showed that there were no significant differences in average daily feed intake,feed egg ratio and broken egg rate among different test groups( P > 0. 05). Hen-housed laying rate,hen-housed egg yield,serum total protein( TP) content and serum alkaline phosphatase( AKP) activity in group II were significantly lower than those in group I( P < 0. 05). However,activities of glutamic-oxalacetic transaminase( GOT),creatine kinase( CK) and glutamic-pyruvic transaminase( GPT) in group II were significantly higher than those in group I( P < 0. 05). Hen-housed laying rate,hen-housed egg yield and serum TP content in group IV were significantly higher than those in group II( P < 0. 05). Hen-housed egg yield,serum TP content and serum albumin( ALB) content in group V were significantly higher than those in group II( P < 0. 05). Activities of serum CK and GPT in groups IV and V were significantly lower than those in group II( P < 0. 05),serum triglyceride( TG) content in group V was significantly lower than that in group II( P < 0. 05).[Conclusion]Metabolism and physiological function of laying hens could be affected by heat stress,and which caused a decline in performance. Adding of dietary betaine in diets could improve hen-housed egg production and hen-housed laying rate,which could also improve the health of laying hens under heat stress condition. The appropriate dietary adding content of betaine was 400 mg/kg. | Hao Shengyan Liu Longsheng Wang Guodong Gu Xian Pan Faming | 2017 | Animal Husbandry and Feed Science2017，9，2： | 1 |
| 8 | Cockroach-inspired Traversing Narrow Obstacles for a Sprawled Hexapod Robot显示文摘Inspired by the cockroach’s use of a pitch-roll mode traverses through narrow obstacles,we improve the RHex-style robot by adding two sprawl joints to adjust the body posture,and propose a novel pitch-roll approach that enables an RHex-style robot to traverse through two cylindrical obstacles with a spacing of 90 mm,about 54%body width.First,the robot can pitch up against the obstacle on the one side by the cooperation of its rear and middle legs.Then,the robot rotates one side rear leg to kick the ground fast,meanwhile the sprawl joint on the other side rotates inward to make the robot roll and fall forward.Finally,the robot can rotate the legs on the ground to move the body forward until it crosses the obstacles.In this article,both cylinder and rectangular columns are considered as the narrow obstacles for traversing.The experiments are demonstrated by using the proposed approach,and the results show that the robot can smoothly traverse through different narrow spaces. | Xingguo Song Jiajun Pan Faming Lin Xiaolong Zhang Chunjun Chen Danshan Huang | 2022 | Journal of Bionic Engineering2022，19，5： | 0 |
| 9 | Research by Online Education for a New Era on the Dependence of Vocational Students on Mobile Phones and Their Loneliness显示文摘More and more problems have been arisen from higher social development level and more and more terminal devices,especially addictive devices have been exposed to the education field during the constant development of cutting-edge techniques,thus making students more and more dependent on mobile phones and other terminal devices.In this process,students tend to more depend on mobile phones,which will make students sort out the exchange and communication with other persons by taking mobile phones as the core and be lonely.It is very important for the current vocational education to research the dependence of students on mobile phones and their loneliness,and break the deadlock.Therefore,in this paper,the online education is researched,and the dependence of vocational students on mobile phones as well as their loneliness are solved based on online education. | Weiwei Zhou Renfang Han Faming Pan | 2021 | Journal of Educational Theory and Management2021，5，2： | 0 |
| 10 | Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment显示文摘Odontogenic maxillary sinusitis (OMS) is a subtype of maxillary sinusitis (MS). It is actually inflammation of the maxillary sinus that secondary to adjacent infectious maxillary dental lesion. Due to the lack of unique clinical features, OMS is difficult to distinguish from other types of rhinosinusitis. Besides, the characteristic infectious pathogeny of OMS makes it is resistant to conventional therapies of rhinosinusitis. Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists and dentists is absolutely urgent to settle these questions and to acquire standardized diagnostic and treatment regimen for OMS. However, this disease has actually received little attention and has been underrepresented by relatively low publication volume and quality. Based on systematically reviewed literature and practical experiences of expert members, our consensus focuses on characteristics, symptoms, classification and diagnosis of OMS, and further put forward multidisciplinary treatment decisions for OMS, as well as the common treatment complications and relative managements. This consensus aims to increase attention to OMS, and optimize the clinical diagnosis and decision-making of OMS, which finally provides evidence-based options for OMS clinical management. | Jiang Lin Chengshuo Wang Xiangdong Wang Faming Chen Wei Zhang Hongchen Sun Fuhua Yan Yaping Pan Dongdong Zhu Qintai Yang Shaohua Ge Yao Sun Kuiji Wang Yuan Zhang Mu Xian Ming Zheng Anchun Mo Xin Xu Hanguo Wang Xuedong Zhou Luo Zhang | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 11 | Real-time monitoring flexible hydrogels based on dual physically cross-linked network for promoting wound healing显示文摘To achieve smart and personalized medicine, the development of hydrogel dressings with sensing properties and biotherapeutic properties that can act as a sensor to monitor of human health in real-time while speeding up wound healing face great challenge. In the present study, a biocompatible dual-network composite hydrogel(DNCGel) sensor was obtained via a simple process. The dual network hydrogel is constructed by the interpenetration of a flexible network formed of poly(vinyl alcohol)(PVA) physical cross-linked by repeated freeze-thawing and a rigid network of iron-chelated xanthan gum(XG) impregnated with Fe^(3+) interpenetration. The pure PVA/XG hydrogels were chelated with ferric ions by immersion to improve the gel strength(compressive modulus and tensile modulus can reach up to 0.62 MPa and0.079 MPa, respectively), conductivity(conductivity values ranging from 9 × 10^(-4) S/cm to 1 × 10^(-3)S/cm)and bacterial inhibition properties(up to 98.56%). Subsequently, the effects of the ratio of PVA and XG and the immersion time of Fe^(3+) on the hydrogels were investigated, and DNGel3 was given the most priority on a comprehensive consideration. It was demonstrated that the DNCGel exhibit good biocompatibility in vitro, effectively facilitate wound healing in vivo(up to 97.8% healing rate) under electrical stimulation, and monitors human movement in real time. This work provides a novel avenue to explore multifunctional intelligent hydrogels that hold great promise in biomedical fields such as smart wound dressings and flexible wearable sensors. | Le Hu Yuxin Wang Qing Liu Man Liu Faming Yang Chunxiao Wang Panpan Pan Lin Wang Li Chen Jingdi Chen | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
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