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| 1 | Sphincter of Oddi dysfunction:Psychosocial distress correlates with manometric dyskinesia but not stenosis显示文摘AIM:To compare postcholecystectomy patients with Sphincter of Oddi(SO)dyskinesia and those with normal SO motility to determine the psychosocial distress,gender and objective clinical correlates of dyskinesia,and contrast these findings with comparisons between SO stenosis and normal SO motility.METHODS:Within a cohort of seventy-two consecutive postcholecystectomy patients with suspected SO dysfunction,manometric assessment identified subgroups with SO dyskinesia(n=33),SO stenosis(n=18)and normal SO motility(n=21).Each patient was categorized in terms of Milwaukee Type,sociodemographic status and the severity of stress-coping experiences.RESULTS:Logistic regression revealed that in combination certain psychological,sociodemographic and clinical variables significantly differentiated SO dyskinesia,but not SO stenosis,from normal SO function.Levels of psychosocial stress and of coping with this stress(i.e.anger suppressed more frequently and the use of significantly more psychological coping strategies)were highest among patients with SO dyskinesia,especially women.Higher levels of neuroticism(the tendency to stressproneness)further increased the likelihood of SO dyskinesia.CONCLUSION:A motility disturbance related to psychosocial distress may help to explain the finding of SO dyskinesia in some postcholecystectomy patients. | Ethelle Bennett Peter Evans John Dowsett John Kellow | 2009 | World Journal of Gastroenterology2009,15,48: | 4 |
| 2 | Functional gastrointestinal disorders in eating disorder patients:Altered distribution and predictors using ROME Ⅲ compared to ROME Ⅱ criteria显示文摘AIM:To compare the prevalence of Functional gastrointestinal disorders(FGIDs)using ROMEⅢand ROMEⅡand to describe predictors of FGIDs among eating disorder(ED)patients.METHODS:Two similar cohorts of female ED inpatients,aged 17-50 years,with no organic gastrointestinal or systemic disorders,completed either the ROMEⅢ(n=100)or the ROMEⅡ(n=160)questionnaire on admission for ED treatment.The two ROME cohorts were compared on continuous demographic variables(e.g.,age,BMI)using Student’s t-tests,and on categorical variables(e.g.,ED diagnosis)usingχ2-tests.The relationship between ED diagnostic subtypes and FGID categories was explored usingχ2-tests.Age,BMI,and psychological and behavioural predictors of the common(prevalence greater than 20%)ROMEⅢFGIDs were tested using logistic regression analyses.RESULTS:The criteria for at least one FGID were fulfilled by 83%of the ROMEⅢcohort,and 94%of the ROMEⅡcohort.There were no significant differences in age,BMI,lowest ever BMI,ED diagnostic subtypes or ED-related quality of life(QOL)scores between ROMEⅡand ROMEⅢcohorts.The most prevalent FGIDs using ROMEⅢwere postprandial distress syndrome(PDS)(45%)and irritable bowel syndrome(IBS)(41%),followed by unspecified functional bowel disorders(U-FBD)(24%),and functional heartburn(FH)(22%).There was a 29%or 46%increase(depending on presence or absence of cyclic vomiting)in functional gastroduodenal disorders because of the introduction of PDS in ROMEⅢcompared to ROMEⅡ.There was a 35%decrease in functional bowel disorders(FBD)in RomeⅢ(excluding U-FBD)compared to ROMEⅡ.The most significant predictor of PDS was starvation(P=0.008).The predictor of FH(P=0.021)and U-FBD(P=0.007)was somatisation,and of IBS laxative use(P=0.025).Age and BMI were not significant predictors.The addition of the 6-mo duration of symptoms requirement for a diagnosis in ROMEⅢadded precision to many FGIDs.CONCLUSION:ROMEⅢconfers higher precision in diagnosing FGIDs but self-induced vomiting should be excluded from the diagnosis of cyclic vomiting.Psychological factors appear to be more influential in ROMEⅡthan ROMEⅢ. | Xiaojie Wang Georgina M Luscombe Catherine Boyd John Kellow Suzanne Abraham | 2014 | World Journal of Gastroenterology2014,20,43: | 4 |
| 3 | Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia显示文摘 | A. M. Scott FRACP Dr. J. E. Kellow MD FRACP B. Shuter MSc H. Cowan RN A.-M. Corbett NMT J. W. Riley MD FRACP M. R. Lunzer FRCP FRACP R. P. Eckstein FRCPA R. H?schl MD S.-K. Lam MD FRCP FRACP M. P. Jones PhD | 1993 | Digestive Diseases and Sciences1993,,12: | 2 |
| 4 | Ineffective oesophageal motility:Manometric subsets exhibit different symptom profiles显示文摘AIM:To compare the demographic and clinical features of different manometric subsets of ineffective oesophageal motility(IOM;defined as ≥ 30% wet swallows with distal contractile amplitude < 30 mmHg) ,and to determine whether the prevalence of gastro-oesophageal reflux differs between IOM subsets. METHODS:Clinical characteristics of manometric subsets were determined in 100 IOM patients(73 female,median age 58 years) and compared to those of 100 age-and gender-matched patient controls with oesophageal symptoms,but normal manometry. Supine oesophageal manometry was performed with an eight-channel DentSleeve water-perfused catheter,and an ambulatory pH study assessed gastro-oesophageal reflux. RESULTS:Patients in the IOM subset featuring a majority of low-amplitude simultaneous contractions(LASC) experienced less heartburn(prevalence 26%) ,but more dysphagia(57%) than those in the IOM subset featuring low-amplitude propagated contractions(LAP;heartburn 70%,dysphagia 24%;both P ≤ 0.01) . LASC patients also experienced less heartburn and more dysphagia than patient controls(heartburn 68%,dysphagia 11%;both P < 0.001) . The prevalence of heartburn and dysphagia in IOM patients featuring a majority of non-transmitted sequences(NT) was 54%(P = 0.04 vs LASC) and 36%(P < 0.01 vs controls) ,respectively. No differences inage and gender distribution,chest pain prevalence,acid exposure time(AET) and symptom/reflux association existed between IOM subsets,or between subsets and controls. CONCLUSION:IOM patients with LASC exhibit a different symptom profile to those with LAP,but do not differ in gastro-oesophageal reflux prevalence. These findings raise the possibility of different pathophysiological mechanisms in IOM subsets,which warrants further investigation. | Horst Gunter Haack Ross David Hansen Allison Malcolm John Edward Kellow | 2008 | World Journal of Gastroenterology2008,14,23: | 2 |
| 5 | Enhanced perception of physiological intestinal motility in the irritable bowel syndrome显示文摘 | Kellow JE | 1991 | Gastroenterlolgy1991,101,: | 1 |
| 6 | Applied principles of neurogastroenterology:physiology/mrtality sensasion显示文摘 | Kellow JE Fernando A Michel D | | 0,,: | 1 |
| 7 | Comparison of the effects of propofol and isoflurance anaesthesia on right ventricular function and shunt fraction during thoracic surgery显示文摘 | Kellow NH Scott AD White SA | 1995 | Br J Anaesth1995,75,4: | 1 |
| 8 | Applied Principles of neurogastroenterology: physiology/motility sensation 显示文摘 | Kellow JE Azpiroz F Delvaux M | 2006 | Gastroenterol2006,130,5: | 1 |
| 9 | Pacemaker failure during transurethral resection of the prostate显示文摘 | Kellow NH | 1993 | Anaesthesia1993,48,2: | 1 |
| 10 | Disorders of gastrointestinal motil- ity : towards a new classification 显示文摘 | Wingate D Hongo M Kellow J | 2002 | J Gastrointestinal Hepatol2002,17,: | 1 |
| 11 | Disorders of gastrointestinal motility: Towards a new classification 显示文摘 | Wingate D Hongo M Kellow J | 2002 | J Gastroenterol Hepetol2002,,: | 1 |
| 12 | Suppression of anger and gastric emptying in patients with functional dyspepsia显示文摘 | Bennett EJ Kellow JE Cowan H | 1992 | Scand J Gastroenterol1992,27,10: | 1 |
| 13 | Manometry based randomised trial of endoecopic sphincterotomy for sphincter of Oddi dysfunction显示文摘 | ToouliJ Roberts-Thomson IC Kellow J | | 0,,: | 1 |
| 14 | Manometry based randomized trial of endoscpic sphincterotomy for sphincter of Oddi dysfunction显示文摘 | Robeas-Thomsom IC Kellow J | 2000 | Gut2000,46,: | 1 |
| 15 | Disorders of gastrointestinal motility:towards a new classification显示文摘 | Wingate D Hongo M | 2002 | J Gastroenterol Hepatol2002,,: | 1 |
| 16 | Applied principles of neumgas- troenterology : physiology/motility sensasion 显示文摘 | Kellow JE Azpiroz F Delvaux M | 2006 | Gastroenterology2006,130,5: | 1 |
| 17 | Manome- try based randomised trial of endoscopic sphincterotomy for sphincter of Oddi dysfunction? 显示文摘 | Toouli J Roberts-Thomson I C Kellow J | 2000 | Gut2000,46,1: | 1 |
| 18 | A numerical procedure for the calculation of the temperature rise and ampaeity of underground cables显示文摘 | KELLOW M A | | 0,,07: | 1 |
| 19 | An Asia - Pacific, double blind, placebo controlled, randomised study to evaluate the efficacy, safety, and tolerability of tegaserod in patients with irritable bowel syndrome 显示文摘 | Kellow J Lee OY Chang FY | 2003 | Gut2003,52,5: | 1 |
| 20 | Dysmotility of the small intestine in irritable bowel syndrome显示文摘 | Kellow JE Phillips SF Mller LJ | 1988 | Gut1988,29,: | 1 |