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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Integration of multi-time-scale models in time series forecasting显示文摘 | Fiona T Muray John V Ringwood Paul C Austin | 2000 | International Journal of Systems Science2000，31，10： | 1 |
| 3 | Corporate reputation in the People's Republic of China:A B2B Perspective显示文摘 | MICHAEL T E LYDIA W FIONA J N | 2010 | Industrial Marketing Management2010，，39： | 1 |
| 4 | The Contribution of Manufacturing and Services to Employment Creation and Growth in South Africa显示文摘 | Fiona T | 2008 | South African Journal of Economices2008，76，2： | 1 |
| 5 | Morphological influence of magnesium and organic additives on the precipitation of calcite显示文摘 | Fiona C Meldrum Stephen T Hyde | 2001 | Journal of Crystal Growth2001，231，： | 1 |
| 6 | Conjugated linoleic acid supplementation,insulin sensitivity,and lipoprotein metabolism in patients with type 2 diabetes mellitus显示文摘 | FIONA M YEOW T P ANNE M | 2004 | Am J Clin Nutr2004，80，： | 1 |
| 7 | International Clinical Recommendations on Scar Management显示文摘 | Thomas A. Mustoe Rodney D. Cooter Michael H. Gold F. D. Richard Hobbs Albert-Adrien Ramelet Peter G. Shakespeare Maurizio Stella Luc Téot Fiona M. Wood Ulrich E. Ziegler | 2002 | Plastic and Reconstructive Surgery2002，，2： | 1 |
| 8 | LEAFY,TERMINAL FLOWER1 and AGAMOUS are functionally conserved but do not regulate terminal flowering and floral determinacy in Impatiens balsamina显示文摘 | MATTHEW O TINASHE C FIONA T etal | 2005 | The Plant Journal2005，44，： | 1 |
| 9 | First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial显示文摘 | Gareth J Morgan Faith E Davies Walter M Gregory Kim Cocks Sue E Bell Alex J Szubert Nuria Navarro-Coy Mark T Drayson Roger G Owen Sylvia Feyler A John Ashcroft Fiona Ross Jennifer Byrne Huw Roddie Claudius Rudin Gordon Cook Graham H Jackson J Anthony Chil | 2010 | The Lancet . 2010 (9757)2010，，： | 1 |
| 10 | Thermal ablation therapeutics based on CNx multi-walled nanotubes显示文摘 | Suzy V T Fiona B Orla W | | 0，，04： | 1 |
| 11 | Global map of growth-regulated gene expression in burkholderia pseudomallei,the causative agent of melioidosis显示文摘 | Fiona R Mitali S T Sarah V H | 2006 | J Bacteriol2006，188，23： | 1 |
| 12 | The use of the chelating resin Dowex M-4195 in the adsorption of selected heavy metal ions from manganese solutions 显示文摘 | Claudia V D Virginia S T C Fiona M D | 2005 | Hydrometallurgy2005，78，： | 1 |
| 13 | Integration of Multi-time-scale Models in Time Series Forecasting 显示文摘 | Fiona T Muray John V Rimgwood Paul C Austin | 1999 | Intternational Journal of Systems Science1999，29，4： | 1 |
| 14 | Effect of pH on the adsorption of selected heavy metal ions from concentrated chloride solutions by the chelating resin Dowex M4195显示文摘 | Diniz Claudia V Doyle Fiona M Ciminelli Virginia S T | 2002 | Separation Science and Technology2002，37，14： | 1 |
| 15 | The use of the chelating resin Dowex M4195 in the adsorption of selected heavy metal ions from manganese solutions显示文摘 | Diniz Claudia V Ciminelli Virginia S T Doyle Fiona M | 2005 | Hydrometallurgy2005，78，34： | 1 |
| 16 | Microsatellite evolution in congeneric mammals: domestic and bighorn sheep 显示文摘 | Stephen H Forbes John T Hogg Fiona C Buchanan | 1995 | Mol Biol Evol1995，12，6： | 1 |
| 17 | The current and future roles of eommunity pharmaeists: Views and experiences of pa- tients with type 2 diabetes显示文摘 | MICHAEL J T FIONA P DEBI B | 2013 | Res Soc Admin Pharm2013，9，6： | 1 |
| 18 | Microsatellite evolution in congeneric mammals:domestic and bighorn sheep显示文摘 | Stephen H F John T H Fiona C B | 1995 | Mol Biol Evol1995，12，6： | 1 |
| 19 | Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial显示文摘 | Gareth J Morgan J Anthony Child Walter M Gregory Alex J Szubert Kim Cocks Sue E Bell Nuria Navarro-Coy Mark T Drayson Roger G Owen Sylvia Feyler A John Ashcroft Fiona M Ross Jennifer Byrne Huw Roddie Claudius Rudin Gordon Cook Graham H Jackson Ping Wu Fai | 2011 | Lancet Oncology2011，，8： | 1 |
| 20 | Intrabreed polymorphic information content of microsatellites in cattle and sheep显示文摘 | Tracey D T | 1998 | Canadian Journal of Animal Science1998，78，： | 1 |
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