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| 1 | Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma显示文摘AIM:To introduce an animal model of hepatocellular carcinoma (HCC) in ACI-rats, and to evaluate the therapeutic effects of Poly-lactide-co-glycolide(PIcg)-microspheres in the transarterial chemoembolization (TACE) in this model, as well the value of this model in the experiments of interventional therapy. | Jochen Truebenbach Florian Graepler Philippe Pereira Peter Huppert Thomas Eul Gundula Wiemann Claus Claussen | 2003 | World Journal of Gastroenterology2003，9，1： | 24 |
| 2 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 3 | ACI大鼠肝细胞癌模型在介入治疗实验中的初步应用显示文摘目的 评价在ACI大鼠肝细胞癌模型进行多种介入治疗方案的疗效及该模型在介入治疗实验中的应用价值。方法 在 5 8只雄性ACI大鼠肝包膜下植入MorrisHepatoma 3 92 4A肝癌瘤块( 1mm3) ,移植术后 13d行MR检查 ,测量肿瘤体积 (V1) ,第 14天时 ,经腹部切开术及胃十二指肠动脉逆行插管而采取以下介入治疗方案 :(A)丝裂霉素 4只 ;(B)降解淀粉 4只 ;(C)碘油 5只 ;(D)肝动脉结扎 4只 ;(E)丝裂霉素 +降解淀粉 4只 ;(F)丝裂霉素 +动脉结扎 5只 ;(G)丝裂霉素 +碘油 5只 ;(H)降解淀粉 +动脉结扎 4只 ;(I)碘油 +动脉结扎 4只 ;(J)丝裂霉素 +聚丙交酯复合乙交酯 (poly lactid co glycolid ,Plcg)微球 4只 ;(K)丝裂霉素 +碘油 +动脉结扎 4只 ;(L)丝裂霉素 +降解淀粉 +动脉结扎4只 ;(M) 0 9%生理盐水 (对照组 ,7只 )。 13d后再次行磁共振检查以确定肿瘤体积 (V2 )变化 ,并对各组间V2 /V1的比值进行比较。结果 肝癌移植率为 10 0 %。介入治疗后肿瘤体积与治疗前肿瘤体积之比 (V2 /V1)分别为A组 4 5 0 ,B组 12 73 ,C组 15 84,D组 10 17,E组 90 2 0 ,F组 7 16,G组 4 0 8,H组 3 45 ,I组 9 99,J组 2 86,K组 3 76,L组 7 71,M组 2 7 12。与对照组相比 ,采取A、G、H、J和K组方法能明显抑制肿瘤生长 ( χ2 值分别为 5 | 钱骏 Truebenbach Jochen Eul Thomas Graepler Florian Pereira Philippe Huppert Peter 冯敢生 Claussen Claus | 2003 | 中华放射学杂志2003，37，1： | 5 |
| 4 | 聚丙交酯复合乙交酯微球经肝动脉化疗栓塞术治疗肝癌的动物实验显示文摘目的 :在肝细胞癌动物模型上观察聚丙交酯复合乙交酯 (PLcG)微球经肝动脉化疗栓塞术 (TACE)治疗肝癌的疗效。方法 :在雄性ACI大鼠 ( 15例 )肝包膜下植入MorrisHepatoma 392 4A肝癌小瘤块 ( 1mm3) ,移植术后 13天时行磁共振检查。再经正中腹切开术和经胃十二指肠动脉逆行插管进行以下介入治疗 :治疗组A( 40mgPLcG + 0 .0 5mg丝裂霉素 ,4例 )、对照组B( 0 .0 5mg丝裂霉素 + 0 .0 4mg碘化油 +肝动脉结扎 ,4例 )和对照组C( 1.5ml生理盐水 ,7例 )。插管术后 13天再次行磁共振术观察肝肿瘤体积变化。结果 :在C组 ,肿瘤体积在实验期间增长 2 7.12倍 ,在B组 ,肿瘤体积增长 3.76倍 ,而在A组 ,肿瘤体积仅增长 2 .87倍。A组与C组肿瘤体积增长率在t检验时均有显著性差异 (P <0 .0 5 )。结论 :在动物实验中将PLcG微球运用于TACE可明显抑制肝肿瘤生长。 | 钱骏 冯敢生 TruebenbachJ Pereira PL Huppert PE Graepler F Eul T Claussen CD | 2001 | 放射学实践2001，16，6： | 4 |
| 5 | Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy显示文摘几研究表明了外科手术前的浆液睾丸激素和百分比肿瘤体积(PTV ) 在激进的前列腺切除术以后预言 extra-prostatic 扩展(EPE ) 和生物化学的复发(BCR ) 。这研究在 laparoscopic 激进分子前列腺切除术(LRP ) 以后在与 EPE 和 BCR 的关系调查了浆液睾丸激素和 PTV 的预示的意义。我们考察了经历了在 2004 和 2012 之间的 LRP 的 520 个病人。PTV 在每节作为所有视觉上估计的肿瘤 foci 的和被决定。BCR 被定义为手术后的前列腺特定的抗原(PSA ) 的二连续增加 > 0.2 ng ml 1 。为浆液总数睾丸激素的阀值是 3.0 ng ml 1 。Multivariate 逻辑回归被用来在 EPE 和 BCR 的风险上定义变量的效果。低浆液睾丸激素(< 3.0 ng ml 1) 与高浆液 PSA,格利森分数,前列腺活体检视的积极核心百分比, PTV,和所有病理学的变量被联系。在 multivariate 分析上,类似于以前的研究,浆液 PSA,活体检视积极核心百分比,格利森分数,和病理学的变量预言了 EPE 和 BCR。另外,低浆液睾丸激素(< 3.0 ng ml 1 ,调整或, 8.52;95% CI, 5.04-14.4, P= 0.001 ) 预言的 EPE 和 PTV (调整或, 1.02;95% CI, 1.01-1.05, P= 0.046 ) 预言的 BCR。除了 EPE 和 BCR 的以前的预言者,低浆液睾丸激素和 PTV 在 LRP 以后是 EPE 和 BCR 的珍贵预言者。 | Eu Chang Hwang Seong Hyeon Yu Yang Hyun Jo Seung I1 Jung Taek Won Kang Dong Deuk Kwon Chan Choi Suk Hee Heo Jun Eul Hwang Sung-Hoon Jung Tae-Young Jung | 2016 | Asian Journal of Andrology2016，18，1： | 3 |
| 6 | Phase II study of docetaxel, cisplatin, and 5-FU induction chemotherapy followed by chemoradiotherapy in locoregionally advanced nasopharyngeal cancer显示文摘 | Woo Kyun Bae Jun Eul Hwang Hyun Jeong Shim Sang Hee Cho Joon Kyoo Lee Sang-Chul Lim Woong-Ki Chung Ik-Joo Chung | 2010 | Cancer Chemotherapy and Pharmacology2010，，3： | 2 |
| 7 | Bilateral partial laminectomy : a treatment for lumbar spinal stenosis and midline disc herniation显示文摘 | Eule JM Breeze R Kindt GW | 1999 | Surg Neural1999，52，4： | 1 |
| 8 | Synthesis of 2-substituted indoles by palladium-catalyzed heteroannulation with Pd-NaY zeolite catalysts 显示文摘 | Ki Bum Hong Chul Wee Leeb Eul Kgun Yuma | 2004 | Tetrahedron Letters2004，45，： | 1 |
| 9 | RNA interference for HIF-1alpha inhibits its downstream signalling and affects cellular proliferation显示文摘 | Hanze J Eul BG Savai R | 2003 | Biochem Biophys Res Commun2003，312，3： | 1 |
| 10 | Examinationof US puberty - timing data from 1940 to 1994 for seculartrends : panel findings 显示文摘 | Euling SY Herman - Giddens ME Lee PA | 2008 | Pediatrics2008，121，3： | 1 |
| 11 | Fhl-1, a New Key Protein in Pulmonary Hypertension显示文摘 | Grazyna Kwapiszewska Malgorzata Wygrecka Leigh M. Marsh Sigrid Schmitt Roger Tr?sser Jochen Wilhelm Katja Helmus Bastian Eul Anna Zakrzewicz Hossein A. Ghofrani Ralph T. Schermuly Rainer M. Bohle Friedrich Grimminger Werner Seeger Oliver Eickelberg Ludger | 2008 | Circulation2008，，11： | 1 |
| 12 | Severe aortic regurgitation and reduced left ventricular ejection fraction: Outcomes after isolated aortic valve replacement and combined surgery显示文摘 | Alessandro Sionis Ana García-Alvarez María ángeles Castel Marco Cordero Miguel Josa Félix Pérez-Villa Eulàlia Roig | 2010 | Journal of Heart and Lung Transplantation2010，，4： | 1 |
| 13 | RIgA interference for HIF - 1 a inhibits its downstream signaling and affects cellular proliferation 显示文摘 | Hanze J Eul BG Savai R et at | 2003 | Biochemical and Biophysical Research Communications2003，312，： | 1 |
| 14 | Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells显示文摘 | Woo K Myung H Eul S | 2005 | J Nutr Biochem2005，16，6： | 1 |
| 15 | Enzymatic production of a soluble-fibre hydrolyzate from carrot pomace and its sugar composition 显示文摘 | KYUNG Young Yoon MYEONGHWA Cha SEUNG Ry- eul Shin | 2005 | Food Chemistry2005，92，1： | 1 |
| 16 | Changes in the cooling rate and medium improve the vascular function in cryopreserved porcine femoral arteries显示文摘 | Montserrat Rigol Magda Heras Anna Martínez María Jesús Zurbano Elba Agustí Eulàlia Roig José Luís Pomar Ginés Sanz | 2000 | Journal of Vascular Surgery2000，，5： | 1 |
| 17 | Fast Digital Image Stabilizer Based on Gray-coded Bit-plane Matching显示文摘 | SUNG J K SEUNG W J EUL S K | 1999 | Consumer Electronics IEEE Transcations on1999，45，3： | 1 |
| 18 | Dental pulp stem cells:characteristics,cryopreservation and therapeutic potentialities显示文摘 | Col art Dutil eul PY Thonat C Jacquemart P | | 0，，03： | 1 |
| 19 | Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model 显示文摘 | Kamlah F Eul BG Li S Lang N Marsh LM Seeger W | 2009 | Cancer Gene Ther2009，16，3： | 1 |
| 20 | Fast Tracking and Noise-Immunised RLS Algorithm Based on Kalaman Filter显示文摘 | KWONG S EOM B EUL J DONG J P | 1996 | Electronics Letters 5th1996，32，25： | 1 |
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