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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | The PI3K/AKT Pathway and Renal Cell Carcinoma显示文摘The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. | Huifang Guo Peter German Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding | 2015 | Journal of Genetics and Genomics2015，42，7： | 39 |
| 3 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 4 | Robust Fault-tolerant Iterative Learning Control for Discrete Systems via Linear Repetitive Processes Theory显示文摘This paper addresses the problem of robust iterative learning control design for a class of uncertain multiple-input multipleoutput discrete linear systems with actuator faults. The stability theory for linear repetitive processes is used to develop formulas for gain matrices design, together with convergent conditions in terms of linear matrix inequalities. An extension to deal with model uncertainty of the polytopic or norm bounded form is also developed and an illustrative example is given. | Jian Ding Blazej Cichy Krzysztof Galkowski Eric Rogers Hui-Zhong Yang | 2015 | International Journal of Automation and computing2015，12，3： | 2 |
| 5 | Red meat intake and the risk of endometrial cancer:Metaanalysis of observational studies显示文摘AIM:To evaluate whether red meat intake is related to the risk of endometrial cancer(EC) using meta-analysis.METHODS:We searched Pub Med,EMBASE,and the Cochrane Library up to June 2013,using common keywords related to red meat and EC.Case-control studies and cohort studies comparing the risk of endometrial cancer among categories by the amount of intake were included.Eleven case-control studies and five cohort studies met our criteria.We performed a conventional and a dose-response meta-analysis of case-control studies using the Der Simonian-Laird method for random-effects.For cohort studies we performed a conventional meta-analysis.Publication bias was evaluated using Egger's test.RESULTS:In the meta-analysis of 11 case-control studies including 5419 cases and 12654 controls,higher red meat consumption was associated with an increased risk of EC [summary relative risk(SRR) = 1.43,95%CI:1.15-1.79;I2 = 73.3% comparing extreme intake categories).In a dose-response analysis,for red meat intake of 100 g/d,SRR was 1.84(95%CI:1.64-2.05).In contrast,in the meta-analysis of five prospective studies including a total of 2549 cases among 247746 participants,no significant association between red meat intake and EC risk(SRR = 0.97,95%CI:0.85-1.11;I2 = 4.9% comparing extreme intake categories) was observed.CONCLUSION:Our meta-analysis found a significantlinear association between red meat intake and EC risk based on case-control studies but this was not confirmed in prospective studies. | Woong Ju Na Na Keum Dong Hoon Lee Yun Hwan Kim Seung Cheol Kim Eric L Ding Eunyoung Cho | 2015 | World Journal of Meta-Analysis2015，3，2： | 2 |
| 6 | Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy显示文摘 | Mara H. Sherman Ruth T. Yu Dannielle D. Engle Ning Ding Annette R. Atkins Herve Tiriac Eric A. Collisson Frances Connor Terry Van Dyke Serguei Kozlov Philip Martin Tiffany W. Tseng David W. Dawson Timothy R. Donahue Atsushi Masamune Tooru Shimosegawa Mino | 2014 | Cell2014，，： | 1 |
| 7 | Evapotranspiration components determined by sap flow and microlysimetry techniques of a vineyard in northwest China: Dynamics and influential factors显示文摘 | Yanqun Zhang Shaozhong Kang Eric J. Ward Risheng Ding Xin Zhang Rui Zheng | 2011 | Agricultural Water Management2011，，8： | 1 |
| 8 | Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts显示文摘 | Guo-qiang Cai Anni Zheng Qingjiu Tang Eric S. White Chu-Fang Chou Candece L. Gladson Mitchell A. Olman Qiang Ding | 2010 | Experimental Cell Research2010，，： | 1 |
| 9 | Adiponectin Levels and the Risk of Hypertension: A Systematic Review and Meta-Analysis显示文摘 | Dae Hyun Kim Chul Kim Eric L. Ding Mary K. Townsend Lewis A. Lipsitz | 2013 | Hypertension2013，，： | 1 |
| 10 | Thyrotropin and Thyroid Cancer Diagnosis: A Systematic Review and Dose-Response Meta-Analysis显示文摘 | Donald S. A. McLeod Karen F. Watters Anthony D. Carpenter Paul W. Ladenson David S. Cooper Eric L. Ding | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，8： | 1 |
| 11 | 内源性性激素与2型糖尿病发病风险的性别差异—系统综述与汇总分析显示文摘背景:不同资料提示,2型糖尿病的某些病因有赖于患者性别,而内源性性激素可能在其中发挥着一定作用。举例而言,高水平的雄激素可增加女性发生2型糖尿病的风险,降低男性发生2型糖尿病的风险。
目的:很多研究观测了血浆睾酮、性激素结合球蛋白(sexhormone-binding globulin,SHBG)以及雌二醇水平与2型糖尿病发病风险的关系,对这些相关研究进行系统评估。资料来源:采用关键词diabetes(糖尿病)、testosterone(睾酮)、sexhormone-binding globulin(性激素结合球蛋白)和estradiol(雌二醇)系统检索EMBASE和MEDLINE(1996年至2005年6月)收录的英文文献,检出文章的参考文献,并与作者直接联系。
研究选取:在检出的80篇文献中发现43篇前瞻性、横断面研究,这些研究共纳入6974名女性和6427名男性,均提供了病例和对照的相对危险度(relative risks,RRs)或激素水平。
数据提取:由两名研究者运用标准方案分别提取有关研究设计、参试者特征、激素水平和危险评估的资料。数据综合:采用随机效应和汇总回归分析、汇总研究结果。横断面研究显示,与对照组(平均差异,6.1rig/dL;95%可信区间[confidenceinterval,CI],2.3-10.1)相比,2型糖尿病男性患者睾酮水平显著下降(平均差异,-76.6ng/dL;95%CI,-99.4-53.6),而2型糖尿病女性患者睾酮水平升高,性别间的差异具有显著性(P〈0.001)。前瞻性研究还发现,睾酮水平较高的男性发生2型糖尿病的风险可下降42%(RR,0.58;95%CI,0.39—0.87),睾酮水平升高可增加女性患2型糖尿病的风险(性别差异P=0.06)。前瞻性横断面研究发现,与男性相比,SHBG更能有效保护女性,避免后者发生2型糖尿病(性别差异P≤0.01)。前瞻性研究显示,SHBG水平较高的女性其2型糖尿病的患病风险可下降80%(RR,0.20;95%CI,0.12—0.30),而SHBG水平较高的男性其患病风险可下降52%(RR,0.48;95%CI,0.33—0.69)。与对照组相比,糖尿病男性患者和绝经后女性患者雌二醇水平明显升高(P=0.007)。
结论:该系统综述表明,内源性性激素可能在特异性调节糖代谢状态和2型糖尿病发病风险方面存在性别差异。睾酮水平升高可增加女性患2型糖尿病的风险,可降低男性患2型糖尿病的风险;SHBG水平与2型糖尿病发病风险呈负相关,女性的相关程度比男性密切。 | Eric L. Ding, BA Yiqing Song, MD, ScD Vasanti S. Malik, MSc Simin Liu, MD, ScD 张华(译) 贾伟平(校) | 2007 | 美国医学会杂志(中文版)2007，26，1： | 1 |
| 12 | Evapotranspiration components determined by sap flow and microlysimetry techniques of a vineyard in northwest China: Dynamics and influential factors显示文摘 | Yanqun Zhang Shaozhong Kang Eric J. Ward Risheng Ding Xin Zhang Rui Zheng | 2011 | Agricultural Water Management2011，，8： | 1 |
| 13 | Determination of banned sudan dyes in chili powder by capillary electrophoresis显示文摘 | ERIC M DING Y S MORA M F | 2007 | Food Chemistry2007，102，4： | 1 |
| 14 | Local officials as land developers:Urban spatial expansion in China显示文摘 | Lichtenberg Eric Chengri Ding | | 0，，： | 1 |
| 15 | Concordance of sustained virological response 4, 12, and 24 weeks post‐treatment with sofosbuvir‐containing regimens for hepatitis C virus显示文摘 | Eric M. Yoshida Mark S. Sulkowski Edward J. Gane Robert W. Herring Vlad Ratziu Xiao Ding Jing Wang Shu‐Min Chuang Julie Ma John McNally Luisa M. Stamm Diana M. Brainard William T. Symonds John G. McHutchison Kimberly L. Beavers Ira M. Jacobson K. Rajender | 2015 | Hepatology2015，，1： | 1 |
| 16 | Clinical results of carotid artery stenting compared with carotid endarterectomy显示文摘 | Soma Brahmanandam Eric L. Ding Michael S. Conte Michael Belkin Louis L. Nguyen | 2008 | Journal of Vascular Surgery2008，，2： | 1 |
| 17 | A cubic B-spline-based hybrid registration of lung CT image for a dynamicairway geometric model with large deformation 显示文摘 | YIN Y B ERIC A H DING K | 2011 | Physics in Medicine and Biology2011，56，： | 1 |
| 18 | Dose Response Between Physical Activity and Risk of Coronary Heart Disease: A Meta-Analysis显示文摘 | Jacob Sattelmair Jeremy Pertman Eric L. Ding Harold W. Kohl William Haskell I-Min Lee | 2011 | Circulation2011，，7： | 1 |
| 19 | A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models显示文摘 | Qiurong Ding Youn-Kyoung Lee Esperance A.K. Schaefer Derek T. Peters Adrian Veres Kevin Kim Nicolas Kuperwasser Daniel L. Motola Torsten B. Meissner William T. Hendriks Marta Trevisan Rajat M. Gupta Annie Moisan Eric Banks Max Friesen Robert T. Schinzel F | 2013 | Cell Stem Cell2013，，： | 1 |
| 20 | Advancements in our understanding of circular and long non-coding RNAs in spinal cord injury显示文摘Spinal cord injury(SCI),either from trauma or degenerative changes,can res ult in severe disability and impaired quality of life.Understanding the cellular processes and molecular mechanisms that underlie SCI is imperative to identifying molecular targets for potential therapy.Recent studies have shown that non-coding RNAs,including both long non-coding RNAs(lncRNAs)and circular RNAs(circRNAs),regulate various cellular processes in SCI.In this review,we will describe the changes in lncRNA and circRNA expression that occur after SCI and how these changes may be related to SCI progression.Current evidence for the roles of lncRNAs and circRNAs in neuronal cell death and glial cell activation will also be reviewed.Finally,the possibility that lncRNAs and circRNAs are novel modulato rs of SCI pathogenesis will be discussed. | Yan Zhang Ho Jun Yun Yu Ji Eric Cosky Wen-Xiu Zhang Wei Han Yu-Chuan Ding | 2022 | Neural Regeneration Research2022，17，11： | 1 |
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