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| 1 | The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?显示文摘当跟随主要人的 cytomegalovirus (HCMV ) 感染的主人免疫者反应在停止病毒复制和传播通常是有效的时,病毒从来没被主人并且象所有 herpesviruses 一样清除,永久坚持。至少部分地,这坚持被知道被 HCMV 的能力便于在感染是实质上沉默的与的 myeloid 在房间建立潜伏,重要地新病毒生产的全部的缺乏。然而,尽管病毒的抄写计划很在潜伏期间被压制,很多病毒的基因在蛋白质水平在潜伏的感染期间被表示,这些中的许多被显示了在潜伏的房间和它的环境上有深刻效果。有趣地,许多也在 lysin 的感染期间这些联系潜伏的基因被表示。因此,一样的有势力主人免疫者回答为什么在 lysin 的感染期间产生了到这些病毒的基因产品,没在潜伏期间被认出,从而允许隐而不见地的感染的房间的清理,是远非清楚的。从潜伏的复活也是调停 HCMV 的疾病的一个主要原因,特别地在损害的免疫者和免疫者天真,并且也是可能的是在被建议了与象动脉粥样硬化和一些瘤形成那样的长期的疾病被联系的长期的无临床症状的 HCMV 感染的病毒的主要来源。因而,理解潜伏并且隐而不见地的感染的房间为什么看起来是 immunoprivileged,为 HCMV 的致病的理解是关键的并且可以帮助设计策略消除潜伏的病毒水库,至少在某些临床的背景。 | Mark R Wills Emma Poole Betty Lau Ben Krishna John H Sinclair | 2015 | Cellular & Molecular Immunology2015，12，2： | 6 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 4 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 5 | 急性上消化道出血显示文摘每年,每10万人中就有约100例发生上消化道(食道、胃和十二指肠)出血“。这是一个具有较高病死率的内科急症。2007年英国的一项调査发现,上消化道出血的总病死率为10%。消化性溃疡是上消化道出血最常见的原因(框图1),这一实践指南为上消化道出血的初期处理以及消化性溃疡出血的后续管理提供了指导。 | Emma Sverden Sheraz R Markar Lars Agreus Jesper Lagergren 龚亮(译) 吴东(校) 无 | 2019 | 英国医学杂志中文版2019，22，7： | 1 |
| 6 | Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT 'Pie' 显示文摘 | Zoe R Emma LS Jackie CB | 2009 | 1)MD2009，37，11： | 1 |
| 7 | Branch History Table Prediction of Moving Target Branches due to Subroutine Returns显示文摘 | D R Kaeli P G Emma | 1991 | ACM SIGARCH Computer Architecture News1991，19，3： | 1 |
| 8 | Esomeprazole for Prevention and Resolution of Upper Gastrointestinal Symptoms in Patients Treated With Low-dose Acetylsalicylic Acid for Cardiovascular Protection: The OBERON Trial显示文摘 | James M. Scheiman Johan Herlitz Sander J. Veldhuyzen van Zanten Angel Lanas Stefan Agewall Emma C. Nauclér Lars-Erik Svedberg Péter Nagy | 2013 | Journal of Cardiovascular Pharmacology2013，，： | 1 |
| 9 | Clinicians' Attitudes to Clinical Practice Guidelines: a systematic review显示文摘 | Emma W K Jean R S | 2002 | MJA2002，177，9： | 1 |
| 10 | Molecular pathways and therapeutic targets in lung cancer 显示文摘 | Emma S Thomas H George R | 2014 | Oncotarget2014，5，6： | 1 |
| 11 | Beyond the 'climate versus grazing' impasse: using remote sensing to investigate the effects of grazing system choice on vegetation cover in the eastern Karoo显示文摘 | Emma R M Archer | 2004 | Journal of Arid Environments2004，57，3： | 1 |
| 12 | An SCN9A channelopathy causes congenital inability to experience pain显示文摘 | Cox JJ Frank R Emma R | 2006 | Nature2006，444，7121： | 1 |
| 13 | Association of human cy- clinE with a periodic G1 -S phase protein kinase 显示文摘 | Vjekoslav D Emma L Steven I R | 1992 | Sci- ence1992，257，25： | 1 |
| 14 | Antenatal risk factors for- postpartum depression:A synthesis of recent literature显示文摘 | Emma R Sherry G Tamara W | 2004 | Gen- eral Hospital Psychiatry2004，26，： | 1 |
| 15 | Antenatal risk factors for postpartum depression: a synthesis of recent literature显示文摘 | Emma R Sherry G Tamara W | 2004 | General Hospital Psychiatry2004，26，： | 1 |
| 16 | Antenatal risk factors for postpartum depression:a synthesis of recent literature显示文摘 | Emma R Sherry G Tamara W | 2004 | Gen Hos Psychiatry2004，26，4： | 1 |
| 17 | Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa显示文摘 | EMMA G DIANA H | 1998 | Biology of Reproduction1998，59，： | 1 |
| 18 | Antenatal risk factors for postpartum depression: A synthesis of recent literature显示文摘 | Emma R Sherry G Tamara W | 2004 | General Hospital Psychiatry2004，26，6： | 1 |
| 19 | Antenatal risk factors for postpartum depression: a synthesis of recent literature 显示文摘 | Emma R Sherry G Tamara W | 2004 | General Hospital Psychiatry2004，26，2： | 1 |
| 20 | Characteristilcs of rural dust events shown to impact on asthma severity in Brisbane,Australia显示文摘 | EMMA C GRANT M T | 1999 | Int J Biometeorol1999，42，4： | 1 |
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