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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Mapping aboveground biomass and its prediction uncertainty using LiDAR and field data, accounting for tree-level allometric and LiDAR model errors显示文摘Background: The increasing availability of remotely sensed data has recently challenged the traditional way of performing forest inventories, and induced an interest in model-based inference. Like traditional design-based inference, model-based inference allows for regional estimates of totals and means, but in addition for wall-to-wall mapping of forest characteristics. Recently Light Detection and Ranging(LiDAR)-based maps of forest attributes have been developed in many countries and been well received by users due to their accurate spatial representation of forest resources. However, the correspondence between such mapping and model-based inference is seldom appreciated. In this study we applied hierarchical model-based inference to produce aboveground biomass maps as well as maps of the corresponding prediction uncertainties with the same spatial resolution. Further, an estimator of mean biomass at regional level, and its uncertainty, was developed to demonstrate how mapping and regional level assessment can be combined within the framework of model-based inference.Results: Through a new version of hierarchical model-based estimation, allowing models to be nonlinear, we accounted for uncertainties in both the individual tree-level biomass models and the models linking plot level biomass predictions with LiDAR metrics. In a 5005 km2 large study area in south-central Sweden the predicted aboveground biomass at the level of 18 m×18 m map units was found to range between 9 and 447 Mg·ha^-1. The corresponding root mean square errors ranged between 10 and 162 Mg·ha^-1. For the entire study region, the mean aboveground biomass was 55 Mg·ha^-1 and the corresponding relative root mean square error 8%. At this level 75%of the mean square error was due to the uncertainty associated with tree-level models.Conclusions: Through the proposed method it is possible to link mapping and estimation within the framework of model-based inference. Uncertainties in both tree-level biomass models and models linking plot level biomass with LiDAR data are accounted for, both for the uncertainty maps and the overall estimates. The development of hierarchical model-based inference to handle nonlinear models was an important prerequisite for the study. | Svetlana Saarela AndréWästlund Emma Holmström Alex Appiah Mensah Sören Holm Mats Nilsson Jonas Fridman Göran Ståhl | 2020 | Forest Ecosystems2020，7，3： | 3 |
| 3 | Advanced multimodality imaging of inflammatory bowel disease in 2015: An update显示文摘The diagnosis and effective management of inflammatory bowel disease(IBD) requires a combination clinical, endoscopic, histological, biological, and imaging data. While endoscopy and biopsy remains the gold standard for diagnosis of IBD, imaging plays a central role in the assessment of extra mural disease, in disease surveillance and in the assessment of response to medical treatments, which are often expensive. Imaging is also vital in the detection and diagnosis of disease related complications, both acute and chronic. In this review, we will describe, with illustrative images, the imaging features of IBD in adults, with emphasis on upto-date imaging techniques focusing predominantly on cross sectional imaging and new magnetic resonance imaging techniques. | Emma Stanley Heather K Moriarty Carmel G Cronin | 2016 | World Journal of Radiology2016，8，6： | 2 |
| 4 | The Genetic Architecture of Multiple Myeloma显示文摘 | Steven M. Prideaux Emma Conway O’Brien Timothy J. Chevassut G?sta Gahrton | 2014 | Advances in Hematology2014，，： | 2 |
| 5 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 6 | Is the Broido-Shafizadeh Model for Cellulose Pyrolysis True?显示文摘 | VARHEGYI G JAKAB EMMA Michael Jerry Antal | 1994 | Energy&Fuels1994，，8： | 1 |
| 7 | Predictors of adolescents academic motiva-tion : Personality, self - efficacy and adolescents' characteristics 显示文摘 | Sarah P Dave P Emma G | 2014 | Personal Indivi Differe2014，，32： | 1 |
| 8 | Collapsing glomerulopathy associ ated with inherited mitochondriai injury显示文摘 | Barisoni L Diomedi-Camassei F Santorelli F M Caridi G Thomas D B Emma F | 2008 | Kidney Int2008，74，： | 1 |
| 9 | 'Novel' bromi natesd flame retardants in Belgian and UK indoor dust:implica- tions {or human exposure 显示文摘 | NADEEM A STUART H EMMA G | 2011 | Chemosphere2011，83，10： | 1 |
| 10 | Sunitinib 显示文摘 | DEEKS E D EMMA D KEATING G M | 2006 | Drugs2006，66，17： | 1 |
| 11 | Branch History Table Prediction of Moving Target Branches due to Subroutine Returns显示文摘 | D R Kaeli P G Emma | 1991 | ACM SIGARCH Computer Architecture News1991，19，3： | 1 |
| 12 | Systemic and translesional of coagulation,fibrinolytic,and inhibitory,systems in candidates for coronary angioplasty:basal state and effect of successful dilation显示文摘 | Emma G Bui DT | 1999 | Am Heart J1999，137，： | 1 |
| 13 | A case of mesenteric inflammatory veno-occlusive disease mimicking new onset inflammatory bowel disease in a healthy 71-year-old man显示文摘 | Therese B Jesse G Emma F | 2014 | Inflammatory Bowel Diseases2014，20，1： | 1 |
| 14 | Pancreatitis-associated protein suppresses NF-κB activation through a JAK/STAT-mediated mechanism in epithelial cells显示文摘 | Emma FP Susana G Jean C | 2006 | The Journal of Immunology2006，176，： | 1 |
| 15 | Dendritic cell expression of the Notch ligand jagged is not essential for Th2response induction in vivo显示文摘 | Alan G Salome L Emma S | 2008 | Eur J Immunol2008，38，： | 1 |
| 16 | Antenatal risk factors for- postpartum depression:A synthesis of recent literature显示文摘 | Emma R Sherry G Tamara W | 2004 | Gen- eral Hospital Psychiatry2004，26，： | 1 |
| 17 | Antenatal risk factors for postpartum depression: a synthesis of recent literature显示文摘 | Emma R Sherry G Tamara W | 2004 | General Hospital Psychiatry2004，26，： | 1 |
| 18 | Antenatal risk factors for postpartum depression:a synthesis of recent literature显示文摘 | Emma R Sherry G Tamara W | 2004 | Gen Hos Psychiatry2004，26，4： | 1 |
| 19 | Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo 显示文摘 | Alan G Salome L Emma S | 2008 | Eur J Immunol2008，38，： | 1 |
| 20 | Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa显示文摘 | EMMA G DIANA H | 1998 | Biology of Reproduction1998，59，： | 1 |
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