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| 1 | G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis显示文摘Estrogens play important roles in the development and progression of multiple tumor types.Accumulating evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly understood.Studies on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative colitis.GPER is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC cells.Thus,multiple lines of evidence suggest that GPER may play an important role in colorectal carcinogenesis.In this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC. | Damian Jacenik Ellen J Beswick Wanda M Krajewska Eric R Prossnitz | 2019 | World Journal of Gastroenterology2019，25，30： | 6 |
| 2 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 3 | Ordered Polyelectrolyte Assembly at the Oil-Water Interface 显示文摘 | Daniel K B Ellen J R and Geraldine L R | 2012 | Proceedings of the National Academy of Sciences of the United States of America2012，109，： | 1 |
| 4 | Overview, history and objec- tives of performance measurement 显示文摘 | Dennis M Lisa R Ellen J H | 2001 | Health Care Finan- cing Review2001，22，3： | 1 |
| 5 | Use of streamflow data to estimate base flow/ground-water recharge for Wisconsin显示文摘 | Warren A G Mandy J R Ellen J C | 2007 | Journal of the American Water Resources Association2007，43，1： | 1 |
| 6 | Architecture and development environment of a knowledge-based monitor that facilitate incremental knowledge-base development显示文摘 | Bass Ellen J Ernst-Fortin Samuel T Small R L | 2004 | IEEE Transactions on Systems Man And Cybernetics-Part A:Systems and Humans2004，34，4： | 1 |
| 7 | Tripelet radical pairs of 3-carboxyproxyl encapsulated in a dendritic box显示文摘 | JANSEN J F G A JANSEN R A J ELLEN M M | | 0，，06： | 1 |
| 8 | Competency-Based Pay:A Concept in Evolution显示文摘 | DARRELL J C ELLEN R B | 1998 | Compensation and Benefits Review1998，30，5： | 1 |
| 9 | A randomized controlled trial of fentanyl for abortion pain显示文摘 | Mollie J Rawling MB Ellen R | 2001 | American Journal of Obstetrics and Gynecology2001，185，： | 1 |
| 10 | Rhizoctonia solani sup- pression and plant growth promotion in cucumber as affected by biochar pyrolysis temperature, feedstock and concentration 显示文摘 | AMIT K J YIGAL E ELLEN R G | 2014 | Soil Biology & Biochemistry2014，69，： | 1 |
| 11 | Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People显示文摘 | Diana G Redwood Elvin D Asay Ian D Blake Pamela E Sacco Claudia M Christensen Frank D Sacco James J Tiesinga Mary E Devens Steven R Alberts Douglas W Mahoney Tracy C Yab Patrick H Foote Thomas C Smyrk Ellen M Provost David A Ahlquist | 2016 | Mayo Clinic Proceedings2016，，： | 1 |
| 12 | Mucosa-Associated lymphoid tissue lymphomas with t (11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways 显示文摘 | Ellen D R Paul J | 2002 | Am J Pathol2002，161，： | 1 |
| 13 | Planned caesarean section versus planned vaginal birth for breech presentation at term: a randomised multicentre trial显示文摘 | Mary E Hannah Walter J Hannah Sheila A Hewson Ellen D Hodnett Saroj Saigal Andrew R Willan | 2000 | The Lancet . 2000 (9239)2000，，9239： | 1 |
| 14 | Tip oriented adherence of Treponema denticala to fibronectin 显示文摘 | DAWSON J R ELLEN R P | 1990 | Infect lmmun1990，58，12： | 1 |
| 15 | Effect of metronidazole on Porphro monas gingivalis biofilms显示文摘 | WRIGHT T L ELLEN R P LACROIX J M | 1997 | J Periodont Res1997，32，5： | 1 |
| 16 | Perceived Need and Unmet Need for Vocational, Mental Health, and Other Support Services AfterSevere Lower-Ex- tremityTrauma 显示文摘 | Archer Kristin R Castillo Renan C MacKenzie Ellen J | 2010 | Arehives of Physical Medicine and Reha- bilitation2010，91，5： | 1 |
| 17 | Effect of metronidazole on porphromonas gingivalis biofilms显示文摘 | Wright T L Ellen R P Lacroix J M | 1997 | J Periodont Res1997，32，5： | 1 |
| 18 | High-level semi-synthetic production of the potent antimalarial artemisinin显示文摘 | Paddon C J Westfall P J Pitera D J Benjamin K Fisher K Mcphee D Leavell M D Tai A Main A Eng D Polichuk D R Teoh H Reed D W Treynor T Lenihan J Fleck M Bajad S Dang G Dengrove D Diola D Dorin G Ellens K W Fickes S Galazzo J Gaucher S P Geistlinger T Henry R Hepp M Horning T Iqbal T Jiang H Kizer L Lieu B Melis D Moss N Regentin R Secrest S Tsuruta H Vazquez R Westblade L F Xu L Yu M Zhang Y Zhao L Lievense J Covello P S Keasling J D Reiling K K Renninger N S Newman J D | 2013 | Nature2013，496，7446： | 1 |
| 19 | Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases显示文摘 | John R Somoza Robert J Skene Bradley A Katz Clifford Mol Joseph D Ho Andy J Jennings Christine Luong Andrew Arvai Joseph J Buggy Ellen Chi Jie Tang Bi-Ching Sang Erik Verner Robert Wynands Ellen M Leahy Douglas R Dougan Gyorgy Snell Marc Navre Mark W Knut | 2004 | Structure2004，，7： | 1 |
| 20 | Oxidative metabolism of clarithromycin in the presence of human liver microsomes显示文摘 | Rodrigues A D Ellen M R Darcy J M | 1997 | Drug Metab And Dispos1997，25，5： | 1 |
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