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1Neurodegeneration:An early event of diabetic retinopathy显示文摘Diabetic retinopathy(DR) has been classically considered to be a microcirculatory disease of the retina caused by the deleterious metabolic effects of hyperglycemia per se and the metabolic pathways triggered by hyperglycemia.However,retinal neurodegeneration is already present before any microcirculatory abnormalities can be detected in ophthalmoscopic examination.In other words,retinal neurodegeneration is an early event in the pathogenesis of DR which predates and participates in the microcirculatory abnormalities that occur in DR.Therefore,the study of the mechanisms that lead to neurodegeneration will be essential to identify new therapeutic targets in the early stages of DR.Elevated levels of glutamate and the overexpression of the renin-angiotensin-system play an essential role in the neurodegenerative process that occurs in diabetic retina.Among neuroprotective factors,pigment epithelial derived factor,somatostatin and erythropoietin seem to be the most relevant and these will be considered in this review.Nevertheless,it should be noted that the balance between neurotoxic and neuroprotective factors rather than levels of neurotoxic factors alone will determine the presence or absence of retinal neurodegeneration in the diabetic eye.New strategies,based on either the delivery of neuroprotective agents or the blockade of neurotoxic factors,are currently being tested in experimental models and in clinical pilot studies.Whether these novel therapies will eventually supplement or prevent the need for laser photocoagulation or vitrectomy awaits the results of additional clinical research.Marta Villarroel Andreea Ciudin Cristina Hernández Rafael Simó 2010World Journal of Diabetes2010,1,2:41
2Right trisegmentectomy with thoracoabdominal approach after transarterial embolization for giant hepatic hemangioma显示文摘Hepatic hemangiomas need to be treated surgically in cases where they are accompanied with symptoms, have a risk of rupture, or are hardly distinguishable from malignancy. The present authors conducted embolization of the right hepatic artery one day before an operation for a huge hemangioma accompanied with symptoms and confirmed a decrease in its size. The authors performed a right trisegmentectomy through a J-shape incision, using a thoracoabdominal approach, and safely removed a giant hemangioma of 32.0 cm × 26.5 cm × 8.0 cm in size and 2300 g in weight. Even for inexperienced surgeons, a J-shape incision with a thoracoabdominal approach is considered a safe and useful method when right-side hepatectomy is required for a large mass in the right liver.Hyung-Il Seo Hong Jae Jo Mun Sup Sim Suk Kim 2009World Journal of Gastroenterology2009,15,27:22
3促进2型糖尿病患者行为的可持续性改变:澳大利亚美好生活俱乐部的自我健康管理计划的评价显示文摘本文分析了澳大利亚美好生活俱乐部18个月的监测数据。美好生活俱乐部是澳大利亚联邦政府资助的'分担卫生服务项目'的一个研究项目,旨在促进50岁及以上糖尿病患者的慢性病自我管理。该项目的干预措施是跨理论行为改变模型和通过电话的动机谈话技术。在患者参加项目的基线、第6个月、第18个月收集数据。数据包括人口学信息、慢性病种类、健康行为、对健康的认识、锻炼程度、功能状态、自我效能、情绪状态、服务利用,以及9个目标行为的改变阶段。本文报告了150名接受18个月监测的患者数据。结果表明,在8个自我评价的症状中,有6个症状明显改善,差异有统计学意义。接受干预的患者对自我健康管理的信心在短期内明显增强。患者的卫生服务利用呈现减少趋势,但无统计学差异。卫生服务利用没有减少的原因,归因于参加者之间卫生服务利用方式的差异较大。参加项目第6个月时,患者行走的活动量增加,但第18个月时回到基线水平。这些发现表明,动机谈话技术能够在行为改变的最初阶段发挥作用,不过如果要长期地维持行为改变,则需要确定个体化和结构性的策略。Colette Browning Shane Thomas Jane Sims Lindner Helen Kelly J 2009中国全科医学2009,12,23:18
4THE NORMALITY OF CAYLEY GRAPHS OF FINITE ABELIAN GROUPS WITH VALENCY 5显示文摘We call a Cayley digraph X = Cay(G, S) normal for G if the right regular representation of G is normal in the full automorphism group Ant(X) of X. In this paper, we give a classification of all nonnormal Cayley graphs of finite abelian groups with valency 5.Young-Gheel Baik (Department of Applied Mathematics Pukyong National University Pusan 608-737, Korea) FENG Yanquan (Department of Mathematics, Northern Jiaotong University, Beijing 100044, China) Hyo-Seob Sim (Department of Applied Mathematics, Pukyong National University, Pusan 608-737, Korea) 2000Systems Science and Mathematical Sciences2000,13,4:17
5Self-expandable metallic stents for palliation of patients with malignant gastric outlet obstruction caused by stomach cancer显示文摘AIM: To ascertain clinical outcome and complications of self-expandable metal stents for endoscopic palliation of patients with malignant obstruction of the gastrointestinal (GI) tract. METHODS: A retrospective review was performed throughout August 2000 to June 2005 of 53 patients with gastric outlet obstruction caused by stomach cancer. All patients had symptomatic obstruction including nausea, vomiting, and decreased oral intake. All received self-expandable metallic stents. RESULTS: Stent implantation was successful in all 53 (100%) patients. Relief of obstructive symptoms was achieved in 43 (81.1%) patients. No immediate stent-related complications were noted. Seventeen patients had recurrent obstruction (tumor ingrowth in 14 patients, tumor overgrowth in 1 patient, and partial distal stent migration in 2 patients). The mean survival was 145 d. Median stent patency time was 187 d. CONCLUSION: Endoscopic placement of self-expandable metallic stents is a safe and effective treatment for the palliation of patients with inoperable malignant gastric outlet obstruction caused by stomach cancer.Tae Oh Kim Dae Hwan Kang Gwang Ha Kim Jeong Heo Geun Am Song Mong Cho Dong Heon Kim Mun Sup Sim 2007World Journal of Gastroenterology2007,13,6:11
6非洲裔美国人体力活动与高血压发生的相关性显示文摘非洲裔美国人在美国各种族(民族)中高血压患病率(男性为40.8%,女性为41.5%)最高。有证据表明,与美国其他种族(民族)相比,非洲裔美国人高血压与因心肌梗死、脑卒中和终末期肾脏疾病引起的过早功能丧失和死亡呈不成比例地升高相关。需要确定控制非洲裔美国人危险因素的措施,以减轻其发生高血压的风险。在许多其他人群中已证实,体力活动对预防高血压有保护作用。因此,高血压指南推荐采用体力活动作为预防性生活行为方式。Diaz KM Booth JN 3rd Seals SR Abdalla M Dubbert PM Sims M Ladapo JA Redmond N Muntner P Shimbo D 2017中华高血压杂志2017,25,2:10
7双氢青蒿素哌喹复方治疗无并发症恶性疟的临床观察显示文摘宋建平 Duong Socheat Suou Seila Thou Tharith SesS arim Sim Yutheasa 谈博 李国桥 2003中华医学杂志2003,83,12:9
8从其他慢性疾病的研究证据看社区干预能否降低老年痴呆病的危险显示文摘目的用科学的证据支持老年痴呆病社区教育战略的开发。方法通过对国家健康优先领域的证据分析,提出慢性疾病社区干预的共性特点,并特别提出针对少数和弱势人群的干预策略。结果需要采取全方位干预策略,并通过周密的计划和评价来保证目标人群能获得足够的健康教育信息。结论应该进一步对降低老年痴呆病危险的干预策略进行深入研究。国际上各种证据一致表明,社区健康教育是现在采取的主要策略。Jocelyn Angus Jane Sims Susan Feldman Harriet Radermacher 2008中国全科医学2008,11,19:9
9A New Tuning Method for Two-Degree-of-Freedom Internal Model Control under Parametric Uncertainty显示文摘内部模型控制(IMC ) 为集合点追踪产出很好的性能,但是为骚乱拒绝问题给懒惰反应。two-degree-of-freedom IMC (2DOF-IMC ) 被开发了克服软弱。然而,如果有一个无常模型,参数的背景成为一件复杂的事。现在的学习为控制器建议一个新调节方法。建议调节方法由三步组成。第一,模型无常的最糟的盒子是坚定的。第二,集合点控制器使用的参数最大的山峰(Mp ) 标准被指定,并且最后,骚乱拒绝的参数控制器使用获得边缘(美国通用汽车公司) 标准被获得。建议方法作为调节方法的 Mp 美国通用汽车公司被表示。调节方法评估了的 Mp 美国通用汽车公司并且与作为凳子标记调节节目(IMCTUNE ) 的 IMC 控制器相比的有效性。评估和比较加死了的时间(FOPDT ) 和更高的顺序过程在很多第一份订单上通过模拟被做了。测试的 FOPDT 过程在范围与可控制性比率包括过程 0.7 ~ 2.5。更高的过程包括第二份订单与欠阻尼并且有 nonminimum 阶段过程的第三份订单。尽管二更高的顺序进程被认为进程同样困难,调节方法的建议 Mp 美国通用汽车公司能甚至在进程无常下面获得好控制器参数。Juwari Purwo sutikno Badhrulhisham Abdul aziz Chin Sim yee Rosbi Mamat 2013Chinese Journal of Chemical Engineering2013,21,9:9
10Mobility of Arsenic and Heavy Metals in a Sandy-Loam Textured and Carbonated Soil显示文摘The continued effect of the pyrite-tailing oxidation on the mobility of arsenic, lead, zinc, cadmium, and copper was studied in a carbonated soil under natural conditions, with the experimental plot preserved with a layer of tailing covering the soil during three years. The experimental area is located in Southern Spain and was affected by a pyrite-mine spill. The climate in the area is typically Mediterranean, which determines the rate of soil alteration and element mobility. The intense alteration processes that occurred in the soil during three years caused important changes in its morphology and a strong degradation of the main soil properties. In this period, lead concentrated in the first 5 mm of the soil, with concentrations higher than 1500 mg kg?1, mainly associated to the neoformation of plumbojarosite. Arsenic was partially leached from the first 5 mm and mainly concentrated between 5–10 mm in the soil, with maximum values of 1239 mg kg-1; the retention of arsenates was related to the neoformation of iron hydroxysulfates (jarosite, schwertmannite) and oxyhydroxides (goethite, ferrihydrite), both with a variable degree of crystallinity. The mobility of Zn, Cd, and Cu was highly affected by pH, producing a stronger leaching in depth; their retention was related to the forms of precipitated aluminium and, in the case of Cu, also to the neoformation of hydroxysulfate.I. GARC íA M. DIEZ F. MART íN M. SIMóN C. DORRONSORO 2009Pedosphere2009,19,2:8
11老年痴呆的负担以及通过社区干预降低老年痴呆的危险显示文摘本文讨论老年痴呆的病因学以及与其他疾病的关系,并讨论采用社区干预方法降低人群的老年痴呆危险。认为针对可治疗的并发症采取积极的诊断和社区教育策略,可以降低或延迟老年痴呆的发病,从而提高病人的生活质量和改善卫生资源的有效利用。Jane Sims Jocelyn Angus Susan Feldman Harriet Radermacher 2008中国全科医学2008,11,17:8
12One fifth of hospitalizations for peptic ulcer-related bleeding are potentially preventable显示文摘AIM:To calculate the proportion of potentially preventable hospitalizations due to peptic ulcer disease(PUD),erosive gastritis(EG)or duodenitis(ED).METHODS:Retrospective cohort study using ICD-10codes to identify all patients with upper gastrointestinal hemorrhage secondary to endoscopically proven PUD,EG or ED during the period from March 2007 to October 2010 in three major metropolitan hospitals in Melbourne,Australia.Patients were divided into'high risk'(those who would benefit from gastroprotection)and'not high risk'groups as defined by established guidelines.Mean Rockall score,transfusion requirement,length of stay,rebleeding rates,need for surgery and in-hospital mortality was compared between'high risk'and'not high risk'groups.Within the'high risk'group,those on gastroprotection and those with no gastroprotection were also compared.RESULTS:Five hundred and seven patients were included for analysis of which 174 were classified as high risk.Median values of complete Rockall Score(5vs 4,P=0.002)and length of stay(5 d vs 4 d,P=0.04)were higher in the high risk group but in-hospital mortality was lower(0.6%vs 3.9%,P=0.03).130out of the 174 patients in the high risk group were not taking recommended gastroprotective therapy prior to hospitalization.Past history of PUD(OR=3.7,P=0.006)and clopidogrel use(OR=3.2,P=0.007)significantly predicted prescription of gastroprotective therapy.Using proton pump inhibitor protection rates of 50%-85%from published studies,an estimation of13%to 22%of the total number of the hospitalizations due to PUD or EG/ED related bleeding may have been preventable.CONCLUSION:Up to one fifth of all hospitalizations for bleeding secondary to PUD or EG/ED are potentially preventable.Ray Boyapati Sim Ye Ong Bei Ye Anuk Kruavit Nora Lee Rhys Vaughan Sanjay Nurkar Peter Gibson Mayur Garg 2014World Journal of Gastroenterology2014,20,30:8
13基于随机减量法的分布式结构模态参数识别显示文摘分区进行平行分析处理的技术已成为大型结构密集布置无线智能传感器网络检测结构系统的重要任务。提出基于随机减量法的分布式数据采集和模态识别方法。以两边简支板模型试验为例,采用ISM400无线智能传感器,通过自然激励法获得测试结构的响应信号,计算随机减量函数,然后运用特征系统实现算法提取系统的状态空间参数,并结合稳定图的方法剔除虚假模态,识别出结构的模态性能参数。以模态置信度为判据对比分析分布式算法与集中式算法的识别效果,结果表明两种算法吻合良好。逯静洲 Sung Han Sim Billie F.Spencer Jr. 2017振动与冲击2017,36,17:7
14What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?显示文摘The kallikrein-kinin system(KKS) is an intricate endogenous pathway involved in several physiological and pathological cascades in the brain. Due to the pathological effects of kinins in blood vessels and tissues, their formation and degradation are tightly controlled. Their components have been related to several central nervous system diseases such as stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy and others. Bradykinin and its receptors(B1R and B2R) may have a role in the pathophysiology of certain central nervous system diseases. It has been suggested that kinin B1R is up-regulated in pathological conditions and has a neurodegenerative pattern, while kinin B2R is constitutive and can act as a neuroprotective factor in many neurological conditions. The renin angiotensin system(RAS) is an important blood pressure regulator and controls both sodium and water intake. AngⅡ is a potent vasoconstrictor molecule and angiotensin converting enzyme is the major enzyme responsible for its release. AngⅡ acts mainly on the AT1 receptor, with involvement in several systemic and neurological disorders. Brain RAS has been associated with physiological pathways, but is also associated with brain disorders. This review describes topics relating to the involvement of both systems in several forms of brain dysfunction and indicates components of the KKS and RAS that have been used as targets in several pharmacological approaches.Maria da Graa Naffah-Mazzacoratti Telma Luciana Furtado Gouveia Priscila Santos Rodrigues Simōes Sandra Regina Perosa 2014World Journal of Biological Chemistry2014,5,2:7
15用于轻金属切削的新工具涂层显示文摘新的碳基涂层已被发展用于切削轻金属 (如铝 )。这类涂层能直接用于工具上或者作为另一种硬质涂层的顶层。切削试验显示 :这类涂层对于容易粘附在工具上的材料 (如铝合金 )具有良好的切削性能 ,因为显著地减少了所谓的切屑瘤 (BUE)的出现。结果延长了工具的寿命并使工件材料在切削后表面光滑。特别是在干切削和深孔加工方面 ,涂层性能非常好。关于涂层性能的观察及原始切削结果将逐一介绍。本文也将介绍由一家主导欧洲的航空航天工业的制造商最近完成的工业领域的试验结果。切削力、切屑瘤的形成和表面粗糙度等数据将用来解释整个干切削过程。Dave Doerwald Thomas Krug Roel Tietema Wei-Ming Sim Quanshun Luo Papken Hovsepian 林松盛 代明江 2004国外金属热处理2004,25,5:7
16参与式渭南地震情景构建:中国地震风险对策的行动研究示范显示文摘中国政府层面自上而下的防震减灾管理卓有成效;但是,对于提升全社会的整体防震减灾能力而言,尚需推动基于此而又有民众与基层自下而上广泛参与的全社会治理模式。为发展这种模式积累经验,渭南市地震情景构建示范项目借助参与式行动研究范式,特别关注了中国防震减灾工作当前存在的以下2点广泛不足:一是社会民众与基层的自下而上办法薄弱,且与政府层面自上而下对策之间的相互衔接与促进不足;二是科学研究向实际减灾对策的转化不足,特别是针对自下而上办法的科学研究与应用转化不足。取得的主要进展有:1)基于广泛参与理念,通过'研究者'和'减灾实践者'、'相关者'、'当事人'2方面人员间的密切合作,共同诊断评估了渭南面临的主要地震灾害风险及隐患、共同提炼了针对性的减灾对策改进建议等,从而使情景构建所得的结果或认识更加可靠、所提对策建议更加符合当地实际需要;借助行动研究过程平台,尝试了风险评估、风险沟通和风险对策改进3大环节的无缝衔接与同步互动,促进了科学研究与实际应用的直接对接与就地转化。2)基于多尺度、多层面视角和同时为'政府'或'部门'与'基层'或'民众'两大类用户服务。在关注改进自上而下对策的同时,针对薄弱的自下而上办法,特别是就这两大对策途径间最广泛与最可持续的接口——宣传教育和家庭、学校、社区减灾,开展了大规模的专项调查分析,梳理了系列化的现今本底与改进方向。3)聚焦改善减灾宣教和促进风险沟通,编创了由'故事'引导的2版内容与形式均有显著差别的地震情景叙事读本:政府版和公众版,以期借助'故事'和艺术呈现'故事'带动人们更好地理解与应用情景构建结果和认识,借助'故事'演绎社会性灾害脆弱成分——'留守儿童家庭与贫困'之于灾害的强化与叠加效应,促进人们对地震灾害风险更加全面与深入的认识;在理性刻板科学中融入感性与人文艺术情怀,以引导共识与共鸣、改善减灾态度、培养减灾价值观,进而激发减灾行动和减灾参与意愿,特别是激励人们就相关问题进行长期思考和持续行动改善。以上3方面进展,从总体上实现了对中国防震减灾工作存在的前述2点广泛不足的有益研讨与部分弥补推动尝试。参与式渭南地震情景构建行动研究示范,对国内相关工作具有抛砖引玉的作用,也为国际同类工作积累了中国经验。苏桂武 Janise Rodgers 田青 齐文华 Philip England Timothy Sim John Young 王东明 李志强 冯希杰 孙磊 陈鲲 Emily So Barry Parsons 赵金礼 石建梁 袁志祥 Yue Cao 周旗 魏本勇 David Milledge Alexander Densmore 2020地震地质2020,42,6:6
17Direct vapor phase growth process and robust photoluminescence properties of large area MoS2 layers显示文摘在那里在收获设备的光电子和精力的领域里在铝二硫化物的使用一直在种研究兴趣,由它的 indirect-to-direct 乐队差距 tunability 的优点。然而,获得大区域瞬间的薄电影 < 潜水艇 class= “ a-plus-plus ” > 为未来设备应用的 2 仍然是挑战。在现在的学习,先锋的数量(S 和哞 < 潜水艇 class= “ a-plus-plus ” > 3 ) 系统地被改变以便优化高度水晶、大的区域瞬间的生长 < 潜水艇 class= “ a-plus-plus ” > 由化学蒸汽免职方法的 2 层。先锋的数量的小心的控制在大区域的合成被发现到关键因素高度水晶的薄片。层的厚度被拉曼光谱学和原子力量显微镜学证实。光性质和化学作文被光致发光(PL ) 和 X 光检查光电子光谱学学习。在 1.82 eV 的强壮的直接激子的排出物的出现(A 激子,与 55 个 thout 事件的规范的 PL 紧张[1.84 ??? 隰酐鱠? 鎄颩 ???? 頿?? 鲰??V. Senthilkumar Le C. Tam Yong Soo Kim Yumin Sim Maeng-Je Seong Joon. I. Jang 2014Nano Research2014,7,12:6
18姚树坤治疗消化道息肉经验介绍显示文摘消化道息肉主要包括胃结肠息肉,随着生活方式的改变,其患病率及复发率都大幅度升高。姚教授认为消化道息肉的发生发展与进食肥甘厚腻密切相关,临证多属湿热夹瘀,治疗方面强调饮食宣教和中药干预,方剂组方精妙、气血津液同调,用药至简、随症加减,预防息肉复发疗效显著,体现了中医药防治消化道息肉及肿瘤的独特优势,值得学习和借鉴。龙思丹 姚树坤 杨振寰 王慧静 牛冰玉 朱晓燃 2020陕西中医2020,41,9:6
19Pretreated Oenan the Javanica extract increases anti-inflammatory cytokines, attenuates gliosis, and protects hippocampal neurons following transient global cerebral ischemia in gerbils显示文摘Recently,we have reported that Oenanthe javanica extract(OJE)displays strong neuroprotective effect against ischemic damage after transient global cerebral ischemia.However,neuroprotective mechanisms of OJE have not been fully identified.Thus,this study investigated the neuroprotection of OJE in the hippocampal CA1 area and its anti-inflammatory activity in gerbils subjected to 5 minutes of transient global cerebral ischemia.We treated the animals by intragastrical injection of OJE(100 and 200 mg/kg)once daily for 1 week prior to transient global cerebral ischemia.Neuroprotection of OJE was observed by immunohistochemistry for neuronal nuclear antigen and histofluorescence staining for Fluoro-Jade B.Immunohistochemistry of glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 was done for astrocytosis and microgliosis,respectively.To investigate the neuroprotective mechanisms of OJE,we performed immunohistochemistry of tumor necrosis factor-alpha and interleukin-2 for pro-inflammatory function and interleukin-4 and interleukin-13 for anti-inflammatory function.When we treated the animals by intragastrical administration of 200 mg/kg of OJE,hippocampal CA1 pyramidal neurons were protected from transient global cerebral ischemia and cerebral ischemia-induced gliosis was inhibited in the ischemic hippocampal CA1 area.We also found that interleukin-4 and-13 immunoreactivities were significantly increased in pyramidal neurons of the ischemic CA1 area after OJE pretreatment,and the increased immunoreactivities were sustained in the CA1 pyramidal neurons after transient global cerebral ischemia.However,OJE pretreatment did not increase interleukin-2 and tumor necrosis factor-alpha immunoreactivities in the CA1 pyramidal neurons.Our findings suggest that pretreatment with OJE can protect neurons and attenuate gliosis from transient global cerebral ischemia via increasing expressions of interleukin-4 and-13.The experimental plan of this study was reviewed and approved by the Institutional Animal Care and Use Committee(IACUC)in Kangwon National University(approval No.KW-160802-1)on August 10,2016.Joon Ha Park In Hye Kim Ji Hyeon Ahn YooHun Noh Sung-Su Kim Tae-Kyeong Lee Jae-Chul Lee Bich-Na Shin Tae Heung Sim Hyun Sam Lee Jeong Hwi Cho In Koo Hwang Il Jun Kang Jong Dai Kim Moo-Ho Won 2019Neural Regeneration Research2019,14,9:6
20人体医疗类干预临床试验研究方案信息与结果的国际注册原则——渥太华声明(第Ⅰ部分)显示文摘临床试验的注册在国际临床医学界已经呼吁了多年,其用意在于避免发表偏倚(一种阳性结果临床试验容易获得发表,而阴性的研究结果不容易获得发表的倾向)和选择性报告偏倚。2004年一个由80多名国际临床医学专家、杂志编辑和研究人员共同签署的声明,由6名具有国际知名度的临床试验专家起草、修订和发表了注册临床试验的宣言,即著名的《渥太华声明》。要求任何临床试验的研究方案及随后的试验结果都应当进行注册,并使公众能够获取。该声明已经翻译成英、法、日文;现由国内学者翻译的该声明在本刊发表具有重要意义,将进一步促进临床试验的规范化和质量的提高,并最终接受公众的评价。刘建平 张晶 陈均超 Karmela Krle■a-Jeri An-Wen Chan Kay Dickersin Ida Sim Jeremy Grimshaw Christian Gluud 2006循证医学2006,6,2:5
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