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| 1 | 基因组和转录组学分析WHOⅡ/Ⅲ级大脑弥漫性胶质瘤的分子分型有助于患者的预后分层显示文摘将大脑胶质瘤在组织学分类和临床病理上分出Ⅱ级和Ⅲ级,这对WHO而言是一个重大的挑战。本文作者设想利用大规模基因组和转录组学分析是否能分出更为明确的不同预后类型。作者基于微阵列的基因组和转录组方法分析了137例原发大脑胶质瘤,病例来自一个前瞻性的德国胶质瘤网( German Glioma Network),其中包括61例WHO II级和76例WHO III级的肿瘤患者。用综合生物信息学分析确定分子亚型,然后将其与组织学、分子生物标记和患者预后相联系,分子生物标志物包括异柠檬酸脱氢酶1或2( IDH1/2),1p/19q联合缺失和端粒酶逆转录酶(TERT)基因启动子突变。通过基因组分析将其分为5个的胶质瘤组,包括3个IDH1/2突变型和2个IDH1/2野生型。通过表达谱分析发现8个不同的转录组(5个IDH1/2突变型,3个IDH1/2野生型),它们与基因组只有部分关联。结合DNA为基础的分子分层和临床预后划分为3个主要预后组,他们有着特异的基因组突变。 IDH1/2突变和1p/19q染色体联合缺失的患者预后最好。 IDH1/2野生型胶质瘤和类似胶质母细胞瘤基因组变异[包括7q染色体获得(+7q),10q染色体缺失(-10q),TERT启动子突变和癌基因扩增]的患者预后最差。IDH1/2突变但1p/19q染色体正常的患者(主要是星形细胞瘤)和IDH1/2野生型,但没有+7q/-10q 基因型及 TERT启动子突变的胶质瘤患者处于中间位的生存期。这种分子分层将患者分为不同的预后组比组织学分类更好。加入基因组分类的基因表达谱分析并不能更进一步促进预后分层。 | Michael W Ruthild G Edith W 陈达阳 王行富 | 2015 | 临床与实验病理学杂志2015，31，7： | 9 |
| 2 | Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community显示文摘 | Ley Sylvia H Harris Stewart B Mamakeesick Mary Noon Tina Fiddler Edith Gittelsohn Joel Wolever Thomas M S Connelly Philip W Hegele Robert A Zinman Bernard Hanley Anthony J G | 2009 | Canadian Medical Association. Journal2009，，6： | 1 |
| 3 | Tooth mobility and periodontal therapy显示文摘 | Thomas J James W Edith C | | 0，，01： | 1 |
| 4 | Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause显示文摘 | Jean W Edith L Suzanne C | 2003 | Menopause2003，10，4： | 1 |
| 5 | Bal- neotherapy in dermatology显示文摘 | Hagit M Edith O Ronni W | 2003 | Dermatologic Therapy2003，16，2： | 1 |
| 6 | HLA ‐typing, clinical, and immunological characterization of youth with type 2 diabetes mellitus phenotype from the German/Austrian DPV database显示文摘 | Wendy L Awa Bernard O Boehm Silke Rosinger Peter Achenbach Anette G Ziegler Stephanie Krause Thomas Meissner Susanne Wiegand Thomas Reinehr Thomas Kapellen Beate Karges Thomas Eiermann Edith Schober Reinhard W Holl | 2013 | Pediatr Diabetes2013，，8： | 1 |
| 7 | The study ofmechanical properties of Sn-Ag-Cu lead-free solders withdifferent Ag contents and Ni doping under different strain ratesand temperatures 显示文摘 | Che F X Zhu W H Edith S W | 2010 | Journal of Alloys and Compounds2010，507，1： | 1 |
| 8 | HLA ‐typing, clinical, and immunological characterization of youth with type 2 diabetes mellitus phenotype from the German/Austrian DPV database显示文摘 | Wendy L Awa Bernard O Boehm Silke Rosinger Peter Achenbach Anette G Ziegler Stephanie Krause Thomas Meissner Susanne Wiegand Thomas Reinehr Thomas Kapellen Beate Karges Thomas Eiermann Edith Schober Reinhard W Holl | 2013 | Pediatr Diabetes2013，，8： | 1 |
| 9 | Changing geographical distributionof diabetes mellitus type 1 incidence in Austrian children1989-2005显示文摘 | Thomas W Birgit R Edith S | 2008 | Eur J Epidemiol2008，23，： | 1 |
| 10 | Circle of Willis variants are not associated with thrombectomy outcomes显示文摘Background The circle of Willis(COW)is part of the brain collateral system.The absence of COW segments may affect functional outcome in patients with ischaemic stroke undergoing endovascular therapy.Methods In 182 patients in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 Study and the CT Perfusion to Predict Response to Recanalisation in Ischaemic Stroke Project,COW anatomy was evaluated on postinterventional magnetic resonance angiography.The absence of the posterior communicating artery or the first segments of posterior or anterior cerebral arteries ipsilateral to the ischaemic infarction was rated as an incomplete COW.Logistic regression was applied to evaluate an association with the patients’modified Rankin scale(mRS)at 90 days after stroke Results An incomplete ipsilateral COW was not predictive of the patients’mRS at 90 days after stroke.Significant associations were shown for the patients’baseline National Institutes of Health Stroke Scale(NIHSS),age and reperfusion status.The effect size suggests that a significant association of an incomplete COW with the mRS at 90 days may be obtained in cohorts of more than 3000 patients.Conclusions Compared with the established predictors NIHSS,age and reperfusion status,an incomplete COW is not associated with functional outcome after endovascular therapy. | Thomas Seifert-Held Katharina Eberhard Soren Christensen Edith Hofer Christian Enzinger Gregory W Albers Maarten Lansberg | 2021 | Stroke & Vascular Neurology2021，6，2： | 1 |
| 11 | Comparison of Pueraria Iobata with hormone replacement therapy in treating the adverse health consequences of menopause 显示文摘 | Jean W Edith L Suzannc C | 2003 | Menopause2003，10，4： | 1 |
| 12 | Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts显示文摘 | Keira L W Edith M S Gregory S | 2005 | Am J Respir Cell Mol Biol Vol2005，32，4： | 1 |
| 13 | Collaboration between the national tuberculosis programme and a non governmental organization in TB/HIV care at a district level:experience from Tanzania 显示文摘 | Eliud W Neema K Edith T | 2004 | African Health Sciences2004，4，2： | 1 |
| 14 | Predicting language at 2 years of age: a prospective community study显示文摘 | Sheena R Melissa W Edith LB | 2007 | Pediatrics2007，120，6： | 1 |
| 15 | Lactate influx into red blood cells from trained and untrained human subjects显示文摘 | Michele S Skelton Duann E Kremer Edith W smith | 1998 | Med Sci in Sports and Exercise1998，30，4： | 1 |
| 16 | Comparison of Pueraria lohata withhormone replacement therapy in treating the adverse health conse- quences of menopause显示文摘 | Jean W Edith L Suzanne C | 2003 | Menopause2003，104，： | 1 |
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