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| 1 | Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations显示文摘Constipation and fecal impaction are frequent and distressing complaints in pediatric gastroenterology. Especially in neurologically handicapped children, treatment of severe forms of slow-transit constipation (STC) can be difficult. In the majority of cases, STC is of unknown etiology. However, in recent years, there is growing evidence that interstitial cells of Cajal (ICCs), which serve as electrical pacemakers and generate spontaneous electrical slow waves in the gastrointestinal tract, might play an important role in the pathophysiology of STC. It remains unclear whether morphological ICC alterations seen in affected patients are based on congenital developmental anomalies, or whether they are a consequence of long-term constipation with secondary damage of the gastrointestinal nervous system. To the best of our knowledge, we present the first case of a patient with histological alterations in ICC morphology who displayed multiple alterations of c-kit at the level of mRNA. The protein encoded by c-kit is the receptor tyrosine kinase Kit (CD117), which is crucial for development and function of ICCs. Therefore, these findings provide a new explanation for congenital alterations of ICC development that result in gastrointestinal motility disorders. | Christian Breuer Jun Oh Gerhard J Molderings Michael Schemann Birgit Kuch Ertan Mayatepek Rüdiger Adam | 2010 | World Journal of Gastroenterology2010，16，34： | 7 |
| 2 | Immune Activation in Patients With Irritable Bowel Syndrome显示文摘 | Tobias Liebregts Birgit Adam Christoph Bredack Alexander R?th Susanne Heinzel Sue Lester Sarah Downie–Doyle Eric Smith Paul Drew Nicholas J. Talley Gerald Holtmann | 2007 | Gastroenterology2007，，3： | 1 |
| 3 | Regulatory effects of biome-chanical strain on the insulin-like growth factor sys- tem in human periodontal ceUs显示文摘 | Birgit R James D Susanne R | 2009 | J Biomechanics2009，42，15： | 1 |
| 4 | Endophytic bacterial communities of field-grown potato plants and their plant-growth-promoting and antagonistic abilities显示文摘 | ANGELA S BIRGIT R GABRIELE B | 2004 | Microbiol2004，50，： | 1 |
| 5 | Efficient production of raspberry ketone via greenbiocatalytic oxidation 显示文摘 | Kosjek Birgit Stampfer Wolfgang Van Deursen R | 2003 | Tetrahedron2003，59，： | 1 |
| 6 | Response of endophytic bacterial communities in potato plant to infection with Erwinia carotovora subsp, atroseptica显示文摘 | BIRGIT R ULRIKE P HELMUT S | 2002 | Applied and Environment Microbiology2002，，： | 1 |
| 7 | Cultivation -independent population analysis of bacterial endophytes in three potato varieties based on eubacterial and actinomycetes - specific pcr of 16s rRNA genes 显示文摘 | Angela S Birgit R Ulrike P | 2002 | FEMS Microbiology Ecology2002，39，1： | 1 |
| 8 | Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer显示文摘 | Annette Eyking Birgit Ey Michael Rünzi Andres I. Roig Henning Reis Kurt W. Schmid Guido Gerken Daniel K. Podolsky Elke Cario | 2011 | Gastroenterology2011，，6： | 1 |
| 9 | Consumer perceptions of organic foods in Bangkok,Thailand显示文摘 | BIRGIT R S IKA D SUTHICHAI S | 2008 | Food Policy2008，33，： | 1 |
| 10 | Sensor augmented pump therapy from onset of type 1 diabetes: late follow‐up results of the Pediatric Onset Study显示文摘 | Olga Kordonouri Reinhard Hartmann Ewa Pankowska Birgit Rami Thomas Kapellen Régis Coutant Karin Lange Thomas Danne | 2012 | Diabetes2012，，7： | 1 |
| 11 | MS- assign, automated assignment and nomenclature of tandem mass spectra of chemically crosslinked peptides 显示文摘 | BIRGIT S RICHARD H R BRADFORD W G | 2003 | Journal of the American Society for Mass Spectrom- etry2003，14，： | 1 |
| 12 | Omega-3 fatty axids improve liver and pancreas function in postoperative cancer patients 显示文摘 | Axel RH Thomas R Birgit G | 2004 | Int J Canc- er2004，11，4： | 1 |
| 13 | Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study显示文摘 | Heiko Pohl Thomas R?sch Barbara T. Tanczos Birgit Rudolph Karsten Schlüns Daniel C. Baumgart | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 14 | New anti-angiogenic strategies in pediatric solid malignancies: agents and biomarkers of a near future显示文摘 | Melissa Taylor Jochen R?ssler Birgit Geoerger Gilles Vassal Fran?oise Farace | 2010 | Expert Opinion on Investigational Drugs2010，，7： | 1 |
| 15 | Atypical delayed intracranial haematoma following stereotactic biopsy of a right parietal anaplastic oligodendroglioma显示文摘 | Roland K Christian G Birgit R | 2003 | Clini Neurol Neurosurg2003，105，： | 1 |
| 16 | Growth rate and impurity distribution in multicrystalline silicon for solar cells显示文摘 | RANNVEIG K φYVIND M BIRGIT R | | 0，，： | 1 |
| 17 | Reactively Compatibilized Cellulosic Polylactide Microcomposites显示文摘 | Birgit Braun John R Dorgan Daniel M Knauss | 2006 | Journal of Polymers and the Environment2006，14，1： | 1 |
| 18 | The first syntheses of 6,7-dihydroxylated calystegines and homocalystegines显示文摘 | Groetzl Birgit Handa Sandeep Malpass John R | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 19 | Regulatory effects of biome- chanical strain on the insulin-like growth factor system in human periodontal cells显示文摘 | Birgit R James D Susanne R | 2009 | J Biomechanics2009，42，15： | 1 |
| 20 | Measurement of soil microbial biomass by fumigation-extraction-an automated procedure显示文摘 | Wu J Joergensen R G Birgit Pommerening | 1990 | Soil Biol Biochem1990，22，8： | 1 |
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