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| 1 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 2 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 3 | Pancreatic fistula after a pancreaticoduodenectomy for ductal adenocarcinoma and its association with morbidity: a multicentre study of the F rench S urgical A ssociation显示文摘 | Pietro Addeo Jean Robert Delpero Francois Paye Elie Oussoultzoglou Pascal R Fuchshuber Alain Sauvanet Antonio Sa Cunha Yves Patrice Le Treut Mustapha Adham Jean‐Yves Mabrut Laurence Chiche Philippe Bachellier | 2014 | HPB2014，，1： | 2 |
| 4 | Sarcoplasmic reticulum Ca2+ATPase as a therapeutictarget for heart failure显示文摘 | Larissa Lipskaia Elie R Chemaly Lahouaria Hadri etal | 2010 | Expert Opin Biol Ther2010，10，1： | 1 |
| 5 | Natriuretic Peptide显示文摘 | Elis R Levin David G | 1998 | N Engl J Med1998，339，： | 1 |
| 6 | A double-blind comparison of nefazodone, imipramine, and placebo in major depression显示文摘 | Fontaine R Ontiveros A Elie R | 1994 | Clin Psychiatry1994，55，6： | 1 |
| 7 | Comparison of a new colorimetric assay with the NCCLS broth microdilution method(M27-A) for antifungal drug MIC determination显示文摘 | LI R K ELIE C M CLAYTON G E | 2000 | J Clin Microbiol2000，38，6： | 1 |
| 8 | Nutrient Enrichment in Tropical Wetlands:Shifts from Autotrophic to Heterotrophic Nitrogen Fixation显示文摘 | HanaˇS Eliˇska R Barbora P | 2010 | Biogeochemistry2010，，101： | 1 |
| 9 | Half-integral spiral phase plates for optical wavelengths 显示文摘 | Oemrawsinghl S S R Elie E R Woerdman J P | 2004 | J Opt A: Pure Appl Opt2004，6，： | 1 |
| 10 | Are time and temperature the only constraints to the simulation of organic matter maturation显示文摘 | Landais P Michels R Elie M | 1994 | OrgGeochem1994，22，： | 1 |
| 11 | Preparation and characteristics of polymer-based large adsorbent particles 显示文摘 | ELI R YUE S | 1993 | Journal of Applied Polymer Science1993，61，11： | 1 |
| 12 | Are time and temperature the only constraints to the simulation of organic matter maturation? 显示文摘 | Landais P Michels R Elie M | 1994 | Org Geochem1994，22，： | 1 |
| 13 | Neural network models of rainfallrunoff process显示文摘 | Smith J Eli R | 1996 | Water Res Plan & Manag1996，121，6： | 1 |
| 14 | Antecedents of dental anxiety :learnedresponses versus personality traits 显示文摘 | Eli I Uziel N Baht R | 1997 | Cammunity Dent Oral Epidemiol1997，25，3： | 1 |
| 15 | Diumal temperature ahemations (DIF/drop)affect chlorophyll content and chlorophyll a/ chlorophyll b ratio in Melissa officinalis L and Ocimum basilicum L but not in Viola x wittrockiana Gains显示文摘 | Ingunn M V Roar M Eli R | 2003 | Science Horticult2003，97，： | 1 |
| 16 | Antecedents of dental anxiety:learned responses versus personality traits显示文摘 | Uziel N Baht R | 1997 | Commnity Dent Oral Epidemiol1997，25，： | 1 |
| 17 | The use of GPR and VES in delineating a contamination plume in a landfill site:a case study in SE Brazil显示文摘 | Porsani J L Filho W M Elis V R | 2004 | Journal of Applied Geophysics2004，55，： | 1 |
| 18 | Cross-linked Macroporous Chitosan Anion-exchange Membranes for Protein Separations显示文摘 | Xia F Z Eli R | 1998 | J of Membrane Sci1998，148，： | 1 |
| 19 | MRI findings in the painful poststroke shoulder显示文摘 | Rajiv R Sepideh H Elie P | 2008 | Stroke2008，39，6： | 1 |
| 20 | Off-pump versus on-pump coronary bypass in high-risk subgroups显示文摘 | Taro Yokoyama Fritz J Baumgartner Ali Gheissari Eli R Capouya George P Panagiotides Richard J Declusin | 2000 | The Annals of Thoracic Surgery2000，，5： | 1 |
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