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| 1 | Osteonecrosis of the femoral head: An update in year 2012显示文摘Osteonecrosis is a phenomenon involving disruption to the vascular supply to the femoral head, resulting in articular surface collapse and eventual osteoarthritis. Although alcoholism, steroid use, and hip trauma remain the most common causes, several other etiologies for osteonecrosis have been identified. Basic science research utilizing animal models and stem cell applications continue to further elucidate the pathophysiology of osteonecrosis and promise novel treatment options in the future. Clinical studies evaluating modern joint-sparing procedures have demonstrated significant improvements in outcomes, but hip arthroplasty is still the most common procedure performed in these affected younger adults. Further advances in joint-preserving procedures are required and will be widely studied in the coming decade. | Anjan P Kaushik Anusuya Das Quanjun Cui | 2012 | World Journal of Orthopedics2012，3，5： | 68 |
| 2 | Total hip arthroplasty in developmental dysplasia of the hip: Review of anatomy, techniques and outcomes显示文摘Total hip arthroplasty(THA) in developmental dysplasia of the hip(DDH) presents many challenges to the reconstructive surgeon. The complex femoral and acetabular anatomy makes standard reconstruction technically challenging. Acetabular coverage can be improved by medialization of the component or augmentation of the deficient areas with bone graft. Femoral shortening osteotomies are considered in cases of severe dysplasia and frankly dislocated hips. Each patient's unique anatomy dictates what options of reconstruction are available. The functional outcomes of THA in DDH are generally excellent, though higher rates of mechanical failure have been reported in this group. This article reviews the anatomy, classification, technical considerations, and outcomes of THA in patients with DDH. | Scott Yang Quanjun Cui | 2012 | World Journal of Orthopedics2012，3，5： | 21 |
| 3 | A review of UHMWPE wear-induced osteolysis:the role for early detection of the immune response显示文摘In a world where increasing joint arthroplasties are being performed on increasingly younger patients,osteolysis as the leading cause of failure after total joint arthroplasty(TJA) has gained considerable attention.Ultra-high molecular weight polyethylene wear-induced osteolysis is the process by which prosthetic debris mechanically released from the surface of prosthetic joints induces an immune response that favors bone catabolism, resulting in loosening of prostheses with eventual failure or fracture. The immune response initiated is innate in that it is nonspecific and self-propagating, with monocytic cells and osteoclasts being the main effectors. To date, detecting disease early enough to implement effective intervention without unwanted systemic side effects has been a major barrier. These barriers can be overcome using newer in vivo imaging techniques and modules linked with fluorescence and/or chemotherapies. We discuss the pathogenesis of osteolysis, and provide discussion of the challenges with imaging and therapeutics. We describe a positron emission tomography imaging cinnamoyl-Phe-(D)-Leu-Phe-(D)-Leu-Phe-Lys module,specific to macrophages, which holds promise in early detection of disease and localization of treatment.Further research and increased collaboration among therapeutic and three-dimensional imaging researchers are essential in realizing a solution to clinical osteolysis in TJA. | Adrese M Kandahari Xinlin Yang Kevin A Laroche Abhijit S Dighe Dongfeng Pan Quanjun Cui | 2016 | Bone Research2016，4，2： | 7 |
| 4 | Current concepts in management of femoroacetabular impingement显示文摘Femoroacetabular impingement(FAI)is an increasingly recognized condition,which is believed to contribute to degenerative changes of the hip.This correlation has led to a great deal of interested in diagnosis and treatment of FAI.FAI can be divided into two groups:cam and pincer type impingement.FAI can lead to chondral and labral pathologies,that if left untreated,can progress rapidly to osteoarthritis.The diagnosis of FAI involves a detailed history,physical exam,and radiographs of the pelvis.Surgical treatment is indicated in anatomic variants known to cause FAI.The primary goal of surgical treatment is to increase joint clearance and decrease destructive forces being transmitted through the joint.Treatment has been evolving rapidly over the past decade and includes three primary techniques:open surgical dislocation,mini-open,and arthroscopic surgery.Open surgical dislocation is a technique for dislocating the femoral head from the acetabulum with a low risk of avascular necrosis in orderto reshape the neck or acetabular rim to improve joint clearance.Mini-open treatment is performed using the distal portion of an anterior approach to the hip to visualize and to correct acetabular and femoral head and neck junction deformities.This does not involve frank dislocation.Recently,arthroscopic treatment has gained popularity.This however does have a steep learning curve and is best done by an experienced surgeon.Short-to mid-term results have shown relatively equal success with all techniques in patients with no or only mild evidence of degenerative changes.Additionally,all techniques have demonstrated low rates of complications. | Adam S Wilson Quanjun Cui | 2012 | World Journal of Orthopedics2012，3，12： | 4 |
| 5 | 酒精对骨髓多能干细胞PPARγ及骨钙素mRNA表达的影响显示文摘目的 :观察酒精对骨髓多能干细胞 (D1细胞 )成脂转录因子 (PPARγ)mRNA和成骨基因骨钙素mRNA表达的影响。方法 :以不同浓度 (0 (对照组 ) ,0 .0 9,0 .15 ,0 .2 1mol/L)酒精处理D1细胞 14d ,苏丹ⅠV染色 ,采用计算机图像分析软件确定脂肪细胞百分比 ,采用RT PCR技术检测细胞中PPARγ及骨钙素mRNA表达。结果 :对照组脂肪细胞生成很少 ,酒精处理组脂肪细胞生成显著增多 ,脂肪细胞百分比随酒精浓度增大而增多 (P <0 .0 0 1)。各组与对照组PPARγmRNA表达差异无统计学意义。 0 .0 9,0 .15 ,0 .2 1mol/L酒精组骨钙素mRNA表达降低 ,分别比对照组减少 38%、4 3%和 5 4 % (P <0 .0 0 1)。结论 :酒精能够导致骨髓多能干细胞大量分化为脂肪细胞 ,可能是酒精在脂肪酸旁路代谢下游所起的作用 ,这可能与酒精性骨坏死的发生机制有关。 | 李月白 王义生 Quanjun Cui Gwo-Jaw Wang Gary Balian | 2004 | 郑州大学学报(医学版)2004，39，5： | 2 |
| 6 | Reducing costly falls after total knee arthroplasty显示文摘AIM To investigate whether adductor canal nerve block(ACB) reduces patient falls when compared to femoral nerve block(FNB) after total knee arthroplasty(TKA). METHODS We conducted an institutional review of all-cause falls after TKA from January 2013 to August 2016 using a quality improvement database. Our inclusion criteria were patients with diagnosis of primary knee osteoarthritis who underwent primary unilateral TKA with either a FNB or an ACB and sustained a fall during their hospitalization. We excluded patients who had revision TKA and extensor mechanism reconstruction. We also excluded patients with a history of post-traumatic arthritis, prior history of lower extremity fracture, history of neurological disease, or cerebrovascular disease. RESULTS A total of 834 patients had TKA with femoral nerve block and knee immobilizer(FNB + KI). Of those patients, 11(1.3%) experienced a fall during their hospital stay. In contrast, 791 patients had TKA with ACB. Of those patients, only one(0.13%) patient fall was recorded within this group. We used the Fisher's exact test to compare the differences between the two groups. The difference between the two groups achieves statistical significance(P = 0.006). We also found that 11 out of the 12 patients that fell had a right TKA procedure while one patient had a left TKA procedure. Nine out of twelve patients that fell were female, while only three patients were male.CONCLUSION Given the reduction in the number of falls with ACB, it is recommended that ACB be considered the preferred analgesia for patients undergoing a TKA procedure. | Surajudeen Adebola Bolarinwa Wendy Novicoff Quanjun Cui | 2018 | World Journal of Orthopedics2018，9，10： | 2 |
| 7 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 8 | Steroid effects on osteogenesis through mesenchymal cell gene expression显示文摘 | Xudong Li Li Jin Quanjun Cui Gwo-Jaw Wang Gary Balian | 2005 | Osteoporosis International2005，，1： | 1 |
| 9 | Steroid effects on osteogenesis through mesenchymal cell gene expression显示文摘 | Xudong Li Li Jin Quanjun Cui Gwo-Jaw Wang Gary Balian | 2005 | Osteoporosis International2005，，1： | 1 |
| 10 | Steroid effects on osteogenesis through mesenchymal cell gene expression显示文摘 | Xudong Li Li Jin Quanjun Cui Gwo-Jaw Wang Gary Balian | 2005 | Osteoporosis International2005，，1： | 1 |
| 11 | Lovastatin inhibits adipogenie and stimulates usteogenic differentiation by suppressing PPAR γ 2 and increasing Cbfa1/Runx2 expression in bone marrow mesenehymal cell euhures显示文摘 | Xudong Li Quanjun Cui Chinghai Kao | 2003 | Bone2003，33，4： | 1 |
| 12 | Steroid effects on osteogenesis through mesenchymal cell gene expression显示文摘 | Xudong Li Li Jin Quanjun Cui Gwo-Jaw Wang Gary Balian | 2005 | Osteoporosis International2005，，1： | 1 |
| 13 | 乙醇诱导小鼠导致骨髓多能干细胞成脂分化显示文摘 | 王义生 李月白 Quanjun Cui Gary Balian Gwo-Jaw Wang | 2004 | 基础医学与临床2004，24，5： | 1 |
| 14 | Effects of alcohols on shape-tuning and luminescence-enhancing of C 70 nanocrystals显示文摘 | Dedi Liu Wen Cui Mingguang Yao Quanjun Li Tian Cui Bingbing Liu Dongping Liu Bertil Sundqvist | 2013 | Optical Materials2013，，2： | 1 |
| 15 | Corrections in alpha angle following two different operative approaches for CAM-type femoral acetabular impingement-Ganz surgical hip dislocation vs anterior mini-open显示文摘BACKGROUND Femoroacetabular impingement(FAI)is a predisposing factor for secondary osteoarthritis of the hip joint.The two extensively described impingement mechanisms of FAI are CAM and Pincer-type.Initially managed conservatively,operative intervention should be offered to the persistently symptomatic patient.The measurement of the alpha angle is considered a standard method of assessing the severity of pathology in Cam-type FAI on pre-operative plain radiographs.The radiological correction of the alpha angle has not been previously compared between different surgical approaches.We hypothesize that there is no difference in alpha angle correction between Ganz surgical hip dislocation and the anterior mini-open approach.AIM To compare the magnitude of alpha angle correction achieved by using the Ganz surgical hip dislocation and the anterior mini-open approach.METHODS This is a retrospective study assessing seventy-nine patients identified in a 5-year period.These patients had preoperative radiographic evidence of FAI and underwent surgery by a single surgeon at our institution,a tertiary care center.Patients with missing radiographic documentation,radiographs with insufficient quality which then precluded accurate measurement of the angleα,a diagnosed congenital condition,isolated type II pathology(Pincer),and history of prior surgery were excluded from the study.Either the Ganz surgical hip dislocation or the anterior mini open approach was used.Postoperative radiographic evaluation of the alpha angle between the two surgical methods was done and corrected for age and gender using two-sample t-tests and Chi-square analyses.RESULTS A total of 79 patients met the inclusion and exclusion criteria.Forty-seven males(mean age of 35.3,range 16-53)and 32 females(mean age 36.7,range 16-60)were enrolled.Forty-seven patients underwent the anterior mini-open approach,and 32 underwent the Ganz surgical hip dislocation.There were no significant differences in age between the two surgical groups or in pre-and post-operative alpha angles based on patient gender.The mean pre-operative alpha angle for the Ganz surgical hip dislocation group was 88.0 degrees(SD 12.3)and 99.4 degrees(SD 7.2)for the anterior mini-open group.Mean post-operative angles were 49.9 degrees(SD 4.3)for the Ganz surgical hip dislocation and 43.8(SD 4.3)degrees for the anterior mini-open group.There was a statistically significant difference in patient’s pre-operative and post-operative angles(P=0.000)with both surgical approaches.CONCLUSION Statistically significant decreases in alpha angle were noted for both surgical techniques,with larger decreases seen in the anterior mini-open group. | Emanuel C Haug Wendy M Novicoff Quanjun Cui | 2020 | World Journal of Orthopedics2020，11，1： | 1 |
| 16 | Impingement-free Hip Motion: The ‘Normal’ Angle Alpha after Osteochondroplasty显示文摘 | Mirjam Neumann MD Quanjun Cui MD Klaus A. Siebenrock MD Martin Beck MD | 2009 | Clinical Orthopaedics and Related Research2009，，3： | 1 |
| 17 | Comparison of lumbar spine fusion using mixed and cloned marrow cells显示文摘 | Cui MD Quanjun X Ming F | 2001 | Spine2001，26，21： | 1 |
| 18 | Retraction note to four articles published in World Journal of Orthopaedics显示文摘Retraction Note to four articles published in World Journal of Orthopaedics:(1)Iwamoto J,Sato Y,Takeda T,Matsumoto H.Return to sports activity by athletes after treatment of spondylolysis.World J Orthop 2010;1(1):26-30 PMID:22474624 DOI:10.5312/wjo.v1.i1.26;(2)Iwamoto J,Sato Y,Takeda T,Matsumoto H.Effectiveness of exercise for osteoarthritis of the knee:A review of the literature.World J Orthop 2011;2(5):37-42 PMID:22474634 DOI:10.5312/wjo.v2.i5.37;(3)Iwamoto J,Sato Y,Takeda T,Matsumoto H.Analysis of stress fractures in athletes based on our clinical experience.World J Orthop 2011;2(1):7-12 PMID:22474626 DOI:10.5312/wjo.v2.i1.7;and(4)Iwamoto J,Takada T,Sato Y,Matsumoto H.Effect of risedronate on speed of sound in postmenopausal women with osteoporosis.World J Orthop 2013;4(4):316-322 PMID:24147269 DOI:10.5312/wjo.v4.i4.316.These articles[1-4]have been retracted at the request of the Editors-in-Chief as misconduct over authorship of the paper was detected and confirmed. | Quanjun Cui | 2018 | World Journal of Orthopedics2018，9，3： | 0 |
| 19 | Field-free approaches for deterministic spin–orbit torque switching of the perpendicular magnet显示文摘All-electrical driven magnetization switching attracts much attention in next-generation spintronic memory and logic devices,particularly in magnetic random-access memory(MRAM)based on the spin–orbit torque(SOT),i.e.SOT-MRAM,due to its advantages of low power consumption,fast write/read speed,and improved endurance,etc.For conventional SOT-driven switching of the magnet with perpendicular magnetic anisotropy,an external assisted magnetic field is necessary to break the inversion symmetry of the magnet,which not only induces the additional power consumption but also makes the circuit more complicated.Over the last decade,significant effort has been devoted to field-free magnetization manipulation by using SOT.In this review,we introduce the basic concepts of SOT.After that,we mainly focus on several approaches to realize the field-free deterministic SOT switching of the perpendicular magnet.The mechanisms mainly include mirror symmetry breaking,chiral symmetry breaking,exchange bias,and interlayer exchange coupling.Furthermore,we show the recent progress in the study of SOT with unconventional origin and symmetry.The final section is devoted to the industrial-level approach for potential applications of field-free SOT switching in SOT-MRAM technology. | Hao Wu Jing Zhang Baoshan Cui Seyed Armin Razavi Xiaoyu Che Quanjun Pan Di Wu Guoqiang Yu Xiufeng Han Kang L Wang | 2022 | Materials Futures2022，1，2： | 0 |
| 20 | Generation of knockout rabbits using transcription activator-like effector nucleases显示文摘Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platformscontributing to redefine the boundaries of modern biological research. They are composed of a non-specificcleavage domain and a tailor made DNA-binding module, which enables a broad range of genetic modifications byinducing efficient DNA double-strand breaks at desired loci. Among other remarkable uses, these nucleases havebeen employed to produce gene knockouts in mid-size and large animals, such as rabbits and pigs, respectively.This approach is cost effective, relatively quick, and can produce invaluable models for human disease studies,biotechnology or agricultural purposes. Here we describe a protocol for the efficient generation of knockout rabbitsusing transcription activator-like effector nucleases, and a perspective of the field. | Yu Wang Nana Fan Jun Song Juan Zhong Xiaogang Guo Weihua Tian Quanjun Zhang Fenggong Cui Li Li Philip N Newsome Jon Frampton Miguel A Esteban Liangxue Lai | 2014 | Cell Regeneration2014，3，1： | 0 |
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