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| 1 | A new model for the secondary structure of the 5' non-coding RNA of poliovirus is supported by biochemical and genetic data that also show that RNA secondary structure is important in neurovirulence显示文摘 | Skinner M A Racaniello V R Dunn G | 1989 | J Mol Biol1989，207，2： | 1 |
| 2 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 3 | Nitrogen - 15 signals of anthropogenic nutrient loading in reef corals 显示文摘 | Heikoop J M Risk M J Lazier A V Edinger E N Jompa J Limmon G V Dunn J J Browne D R Schwarcz H P | 2000 | Marine Pollution Bulletin2000，40，7： | 1 |
| 4 | Ration, growth, and measures of somatic and organ condition in relation to meal frequency in winter flounder, Pseudopleuronectes anvericanus, with hypotheses regarding population homeostasis 显示文摘 | Tyler A V Dunn R S | 1976 | J Fish Res Bd Can1976，33，： | 1 |
| 5 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 6 | Piezoelectric constant for binary piezoelectric 0-3 connectivity composites and the effect of mixed connectivity显示文摘 | Jayasundere N Smith B V Dunn J R | 1994 | Appl Phsy1994，76，5： | 1 |
| 7 | Laparoscopic radical nephrectomy显示文摘 | Dunn M D McDougall E M Clayman R V | 2000 | J Endourol2000，14，84： | 1 |
| 8 | Piezoelectric constant for binary piezoelectric 0-3 connectivity composites and the effect of mixed connectivity显示文摘 | JAYASUNDERE N SMITH B V DUNN J R | 1994 | Japan Appl Phsy1994，76，5： | 1 |
| 9 | Laparoscopic radicalnephrectomy显示文摘 | Dunn M D McDougall E M Clayman R V | 2000 | J Endourol2000，14，： | 1 |
| 10 | The antlpsychotle aripiprazole is apotent, partial agonist at the human 5-HTIA receptor (abstract) 显示文摘 | Jordan S Koprivica V Chen R Dunn R Tottori K Kikuchi T | 2001 | Eur neuropsychopharmacol2001，11，3： | 1 |
| 11 | Transcript profiling of human platelets using microarray and serial analysis of gene expression显示文摘 | Gnatenko D V Dunn J J McCorkle S R | 2003 | Blood2003，101，6： | 1 |
| 12 | The role of dynamics in enzyme activity显示文摘 | Daniel R M Dunn R V Finney J L | 2003 | Annu Rev Biophys Biomol Struct2003，32，： | 1 |
| 13 | A critical function for type I interferons in cancer immunoediting 显示文摘 | Dunn GP Bruce AT Sheehan KC Shankaran V Uppaluri R Bui JD | 2005 | Nat Immunol2005，6，7： | 1 |
| 14 | Compound-specific amino acid isotopic proxies for detecting freshwater resource consumption 显示文摘 | Webb E C Honch N V Dunn P J H Eriksson G Liden K Evemhed R P | 2015 | Journal of Archaeological Science2015，63，10： | 1 |
| 15 | Preliminary FoodNet Data on the Incidence of Infection with Pathogens Transmitted Commonly Through Food - 10 States, 2008显示文摘 | Vugia D Cronquist A Cartter M Tobin-D’Angelo M Blythe D Smith K Lathrop S Morse D Cieslak P Dunn J Holt K G Henao O L Hoekstra R M Angulo F J Griffin P M Tauxe R V Trivedi K K | 2009 | MMWR Morbidity and Mortality Weekly Report2009，，13： | 1 |
| 16 | Lysosomal cathepsin B: correlation with metastatic potential 显示文摘 | Sloane B F Dunn J R Honn K V | 1981 | Science1981，212，4499： | 1 |
| 17 | Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma显示文摘BACKGROUND In the contemporary era of cancer immunotherapy,an abundance of clinical and translational studies have reported radiotherapy(RT)and immunotherapies as a viable option for immunomodulation of many cancer subtypes,with many related clinical trials ongoing.In locally advanced disease,chemotherapy or chemoradiotherapy followed by surgical excision of the tumour remain the principal treatment strategy in oesophageal adenocarcinoma(OAC),however,the use of the host immune system to improve anti-tumour immunity is rapidly garnering increased support in the curative setting.AIM To immunophenotype OAC patients’immune checkpoint(IC)expression with and without radiation and evaluate the effects of checkpoint blockade on cell viability.METHODS In the contemporary era of cancer immunotherapy,an abundance of studies have demonstrated that combination RT and IC inhibitors(ICIs)are effective in the immunomodulation of many cancer subtypes,with many related clinical trials ongoing.Although surgical excision and elimination of tumour cells by chemotherapy or chemoradiotherapy remains the gold standard approach in OAC,the propagation of anti-tumour immune responses is rapidly garnering increased support in the curative setting.The aim of this body of work was to immunophenotype OAC patients’IC expression with and without radiation and to establish the impact of checkpoint blockade on cell viability.This study was a hybrid combination of in vitro and ex vivo models.Quantification of serum immune proteins was performed by enzyme-linked immunosorbent assay.Flow cytometry staining was performed to evaluate IC expression for in vitro OAC cell lines and ex vivo OAC biopsies.Cell viability in the presence of radiation with and without IC blockade was assessed by a cell counting kit-8 assay.RESULTS We identified that conventional dosing and hypofractionated approaches resulted in increased IC expression(PD-1,PD-L1,TIM3,TIGIT)in vitro and ex vivo in OAC.There were two distinct subcohorts with one demonstrating significant upregulation of ICs and the contrary in the other cohort.Increasing IC expression post RT was associated with a more aggressive tumour phenotype and adverse features of tumour biology.The use of anti-PD-1 and anti-PD-L1 immunotherapies in combination with radiation resulted in a significant and synergistic reduction in viability of both radiosensitive and radioresistant OAC cells in vitro.Interleukin-21(IL-21)and IL-31 significantly increased,with a concomitant reduction in IL-23 as a consequence of 4 Gray radiation.Similarly,radiation induced an anti-angiogenic tumour milieu with reduced expression of vascular endothelial growth factor-A,basic fibroblast growth factor,Flt-1 and placental growth factor.CONCLUSION The findings of the current study demonstrate synergistic potential for the use of ICIs and ionising radiation to potentiate established anti-tumour responses in the neoadjuvant setting and is of particular interest in those with advanced disease,adverse features of tumour biology and poor treatment responses to conventional therapies. | Noel E Donlon Maria Davern Fiona O'Connell Andrew Sheppard Aisling Heeran Anshul Bhardwaj Christine Butler Ravi Narayanasamy Claire Donohoe James J Phelan Niamh Lynam-Lennon Margaret R Dunne Stephen Maher Jacintha O'Sullivan John V Reynolds Joanne Lysaght | 2022 | World Journal of Gastroenterology2022，28，21： | 1 |
| 18 | Preliminary FoodNet Data on the Incidence of Infection with Pathogens Transmitted Commonly Through Food - 10 States, 2007显示文摘 | Vugia D Cronquist A Hadler J Tobin-D'Angelo M Blythe D Smith K Lathrop S Morse D Cieslak P Dunn J White P L Guzewich J J Henao O L Hoekstra R M Scallan E Angulo F J Griffin P M Tauxe R V Behravesh C Barton | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，14： | 1 |
| 19 | Laparoscopic management of renal cystic disease显示文摘 | Dunn M D Clayman R V | 2000 | World J U rol2000，18，5： | 1 |
| 20 | Functional profiling of a human cytomegalovirus genome显示文摘 | Dunn W Chou C Li H Hai R Patterson D Stolc V Zhu H Liu F | 2003 | PNAS2003，100，14： | 1 |
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