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| 1 | 融合创新及其对中国创新驱动发展的意义显示文摘实施创新驱动发展战略,是应对发展环境变化、把握发展自主权、提高核心竞争力的必然选择,是加快转变经济发展方式、破解经济发展深层次矛盾和问题的必然选择,是更好引领中国经济发展新常态、保持中国经济持续健康发展的必然选择。在回顾创新理论发展的基础上,本文介绍了融合创新的概念,分析了融合创新的4个关键支撑、5个构建模块以及创新发展路线图。本文认为,融合创新基于对众多社会、经济、环境问题的整体性、交互性和复杂性的认识,强调创新目标、创新主体和创新受益者、跨学科方法的融合,综合技术创新、组织创新、社会过程创新、金融创新、制度创新等领域,采用差异化策略将个体行为转变为集体行动,遵循社会化学习、社会资本形成和集体行动路线图,避免在解决纷繁复杂的社会、经济和环境问题时顾此失彼的现象,是对创新模式的反思和再创新。基于融合创新理论体系,本文对中国新时期作为国家优先战略的创新驱动发展战略进行了理论解析并提出了融合型创新驱动发展建议。 | 章文光 Ji Lu Laurette Dubé | 2016 | 管理世界2016，32，6： | 29 |
| 2 | Developments in metallic biodegradable stents显示文摘 | H. Hermawan D. Dubé D. Mantovani | 2009 | Acta Biomaterialia2009，，5： | 2 |
| 3 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 4 | A comparison of pixel-based and object-based image analysis with selected machine learning algorithms for the classification of agricultural landscapes using SPOT-5 HRG imagery显示文摘 | Dennis C. Duro Steven E. Franklin Monique G. Dubé | 2011 | Remote Sensing of Environment2011，，： | 2 |
| 5 | Investigation on removal pathways of Di 2-ethyl hexyl phthalate from synthetic municipal wastewater using a submerged membrane bioreactor显示文摘Highly hydrophobic Di 2-ethyl hexyl phthalate(DEHP) is one of the most prevalent plasticizers in wastewaters. Since its half-life in biological treatment is around 25 days, it can be used as an efficiency indicator of wastewater treatment plant for the removal of hydrophobic emerging contaminants. In this study, the performance of submerged membrane bioreactor was monitored to understand the effect of DEHP on the growth of aerobic microorganisms. The data showed that the chemical oxygen demand(COD)and ammonia concentration were detected below 10 and 1.0 mg/L, respectively for operating conditions of hydraulic retention time(HRT) = 4 and 6 hr, sludge retention time(SRT) = 140 day and sludge concentration between 11.5 and 15.8 g volatile solid(VS)/L. The removal efficiency of DEHP under these conditions was higher and ranged between 91% and 98%. Results also showed that the removal efficiency of DEHP in biological treatment depended on the concentration of sludge, as adsorption is the main mechanism of its removal. For the submerged membrane bioreactor, the pore size is the pivotal factor for DEHP removal, since it determines the amount of soluble microbial products coming out of the process. Highly assimilated microorganisms increase the biodegradation rate, as 74% of inlet DEHP was biodegraded; however, the concentration of DEHP inside sludge was beyond the discharge limit. Understanding the fate of DEHP in membrane bioreactor,which is one of the most promising and futuristic treatment process could provide replacement for conventional processes to satisfy the future stricter regulations on emerging contaminants. | Mehdi Zolfaghari Patrick Drogui Brahima Seyhi Satinder Kaur Brar Gerardo Buelna Rino Dubé Nouha Klai | 2015 | Journal of Environmental Sciences2015，27，11： | 2 |
| 6 | Epidermal growth factor receptor inhibits colitis-associated cancer in mice显示文摘 | Dubé Philip E Yan Fang Punit Shivesh Girish Nandini McElroy Steven J Washington M Kay Polk D Brent | 2012 | EN2012，，8： | 2 |
| 7 | Applications of reaction calorimetry in reaction kinetics and thermal hazard evaluation显示文摘 | Yih - Siting Dub Chang - Chia Hsu Chen - Shah Kao | 1996 | Thermochimica Acta1996，285，1： | 1 |
| 8 | Mechanical properties and rapid consolidation of binderless nanostruetured tantalum carbide显示文摘 | Kim B R Woo K D DUb J M | 2009 | Ceram Int2009，35，： | 1 |
| 9 | Parallel synthesis of alipopeptide library by h razone-based chemical ligation 显示文摘 | Dubs P Bourel-Bonnet L Subra G | 2007 | Journal of Combinatorial Chemistry2007，9，6： | 1 |
| 10 | Glutathione deficiency is associated with impaired survival in HIV disease 显示文摘 | HERZENBERG L A DE ROSA S C DUBS J G | 1997 | Proc Nat Acad Sci1997，94，5： | 1 |
| 11 | Exploring women's paychoneuroendocrine responses to cancer threat:insights from a computer-based guided imngery tesk显示文摘 | Ma Z Faber A Dubé L et el | 2007 | Can J Nurs Res2007，39，1： | 1 |
| 12 | 查看详情显示文摘 | Jhan Yiruei Lin Chihyuan Dub Jenqgong | | 0，，1516： | 1 |
| 13 | Assessing the role of claudins in maintain-ing the integrity of epididymal tight junctions using novel humanepididymal cel-l lines显示文摘 | Dubé E Dufresne J Chan PT | | 0，，06： | 1 |
| 14 | A delay-partitioning approach to the stability analysis of discrete-time systems显示文摘 | MENG X Y LAM J DUB Z | 2010 | Automat2010，46，3： | 1 |
| 15 | The role of protein tyrosine phosphatase 1B in Ras signaling 显示文摘 | Dub N Cheng A Tremblay ML | 2004 | Proc Nail Acad Sci USA2004，101，7： | 1 |
| 16 | Standardization of cardiac troponin I assays: round Robin of ten candidate reference materials显示文摘 | Christenson RH Dub SH Apple FS | 2001 | Clin Chem2001，47，3： | 1 |
| 17 | Quanti- fication and minimization of uncertainty by geostatistical simulations during the characterization of contaminated sites: 3-D approach to a multi-element contamination 显示文摘 | BOUDREAULT J P DUB]~ J S MARCOTFE D 2016 | 2016 | Geoderma2016，264，： | 1 |
| 18 | Peripherally Inserted Central Venous Catheters Are Not Superior to Central Venous Catheters in the Acute Care of Surgical Patients on theWard显示文摘 | Turcotte S Dub(E) S Beauchamp G | 2006 | World J Surg2006，30，8： | 1 |
| 19 | Antioxidant Activity of 3- aryl-benzofu,'an-2---one Stabilizers (IrganoxHP- 136) in Polypropylene 显示文摘 | Mar'in A Greci L Dubs P | 2002 | Polymer Degradation and''Stability2002，76，3： | 1 |
| 20 | Mechanical properties of polycrystalline cBN obtained from pyrolytic gBN by direct transformation technique 显示文摘 | Dub S N Petrusha I A | 2006 | High Pressure Research2006，26，2： | 1 |
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