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| 1 | ETV6-RUNX1阳性儿童急性淋巴细胞白血病基因表达谱聚类的临床特征显示文摘目的通过基因表达谱研究儿童ETV6-RUNX1阳性急性淋巴细胞白血病(ALL)异质性,探索不同聚类分组临床特征,为临床个性化诊疗及利用测序技术探索预后相对不良组预测模型提供可行性参考。方法应用改进的基因片段分析技术对2016年8月至2019年6月北京儿童医院收治的264例初诊ALL患儿的骨髓标本进行57个分型基因检测和聚类分析,重点分析56例ETV6-RUNX1阳性患者的基因表达谱与临床特点、免疫表型和早期化疗反应的关系。结果基因分型聚类显示ETV6-RUNX1阳性ALL被分为两组:E/R-1组(45例,80.4%)和E/R-2组(11例,19.6%)。E/R-2聚类离散度大于E/R-1,spearman相关系数分别为0.788、0.901;E/R-2、E/R-1组初诊PLT中位数分别为104(27~644)×10^9/L、50(8~390)×10^9/L(P<0.01),初诊骨髓原始幼稚细胞比例分别为0.830(0.270~0.975)、0.935(0.445~0.990)(P<0.05);CD22^+CD34^+CD20^CD117^-CD56^-免疫组合在E/R-2组占比更高(P<0.001);E/R-2和E/R-1组化疗第33天流式细胞术检测的微小残留病(MRD)转阴例数分别为5例(55.6%)和32例(88.9%)(P=0.064),去除临界值病例敏感性分析转阴例数分别为5例(55.6%)和32例(91.4%)(P=0.035);第33天PCR检测的MRD转阴例数分别为7例(77.8%)和36例(100.0%)(P=0.047)。结论ETV6-RUNX1阳性ALL患儿在基因表达谱层面存在异质性,符合E/R-2表达特征的患儿可能初诊时血小板减少倾向小但早期化疗反应相对不良。 | 郑雪岭 王子阳 孙嫣然 张寒 高超 张瑞东 刘怡 彭亚光 Jing-Dong JHan 郑胡镛 | 2020 | 中华血液学杂志2020，41，5： | 2 |
| 2 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 3 | Triaxial accelerometer based fall detection method using a self-constructing cascade-AdaBoost-SVM Classifier显示文摘 | Cheng W Ch Jhan D M | 2013 | IEEE Journal of Biomedical and Health Informatics2013，17，2： | 1 |
| 4 | 查看详情显示文摘 | Jhan Yiruei Lin Chihyuan Dub Jenqgong | | 0，，1516： | 1 |
| 5 | Effect of replacing pork backfat with yams (Dioscorea alata) on quality characteristics of Chinese sausage显示文摘 | TAN F J L1AO F Y JHAN Y J ct al | 2007 | Journal of Food Engineering2007，79，： | 1 |
| 6 | Preparation of visi ble-light-active Ag and In-doped ZnS thin film photoelectrodes by reactive magnetron co-sputtering 显示文摘 | Huang C M Cheng K W Jhan Y R et aI | 2007 | Thin Solid Films2007，515，2021： | 1 |
| 7 | An energy-aware framework for dynamic software management in mobile computing systems 显示文摘 | Fei Y Zhong L Jhan K | 2008 | ACM Trans on Embedded Computing System2008，7，3： | 1 |
| 8 | Improved capacity and rate capability of Ru-doped and carbon-coated LhTi5O12 anode material显示文摘 | Lin C Y Jhan Y R Dub J G | 2011 | Journal of alloys and compounds2011，509，24： | 1 |
| 9 | A molecular dynamics study of grain boundary migration without the participation of secondary grain boundary dislocations 显示文摘 | Jhan R J Bristowe P D | 1990 | Scripta Materialia1990，24，： | 1 |
| 10 | The Role of Pentacyclic Triterpenoids in the Allelopathic Effects of Alstonia scholaris显示文摘 | Chao-Min Wang Hsiao-Ting Chen Tsai-Chi Li Jen-Hsien Weng Yun-Lian Jhan Shi-Xun Lin Chang-Hung Chou | 2014 | Journal of Chemical Ecology2014，，： | 1 |
| 11 | Fluid-structure interaction of FRP wind turbine blades under aerodynamic effect显示文摘 | Lee Y J Jhan Y T | 2012 | Composites Part B2012，43，5： | 1 |
| 12 | Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation显示文摘 | Chen R S Jhan J Y Su Y J | 2009 | Exp Cell Res2009，315，15： | 1 |
| 13 | Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells显示文摘 | Ko J C Ciou S C Jhan J Y | 2009 | Mol Cancer Res2009，7，8： | 1 |
| 14 | Gold nanoparticles in- crease endothelial paracellular permeability by altering components of endothelial tight junctions,and increaseBlood-Brain barrier permeability in mice 显示文摘 | Li CH Shyu MK Jhan C | 2015 | Toxicol Sci2015，148，1： | 1 |
| 15 | A cascade classifier using Adaboost algo- rithm and support vector machine for pedestrian detection 显示文摘 | W Cheng D Jhan | 2011 | In: 2011 IEEE International Conference on Systems Mall and Cybernetics (SMC) Anchorage AK : IEEE Press2011，2011，： | 1 |
| 16 | Randomized Trial of Continuous Subcutaneus Insulin infusion and intensive injection therapy in Type 1 Diabetes for patients with Long-standing poor Glycemic Control显示文摘 | Jhans Deries Frank J Snoek A | 2002 | Diabetes Care2002，25，： | 1 |
| 17 | Human cytomegalovirus:recent aspects from molecular biology显示文摘 | Mach M Stamminger T Jhan G | 1998 | J Gen Virol1998，70，： | 1 |
| 18 | Discrete pulse modulation strategies for high-frequency inverter systems显示文摘 | VENKATARAMANAN G DIVAN D M JHANS T M | 1993 | IEEE Transactions on Power Electronics1993，8，3： | 1 |
| 19 | An algorithm for synthesis of reversible logic circuits显示文摘 | P Gupta A Agrawal K Jhan | 2006 | IEEE Trans CAD ICS2006，25，11： | 1 |
| 20 | NOx abatement in exhaust from lean-burn combustion engines by reduction of NO2over silver-containing zeolite catalysts 显示文摘 | Jhan A Martens Anne Cauvel | 1998 | Angewandte Chemie International Edition1998，37，1： | 1 |
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