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| 1 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 2 | Mitochondrial transcription termination factor 2 binds to entire mitochondrial DNA and negatively regulates mitochondrial gene expression显示文摘(mTERF2 ) Mitochondrial 抄写结束因素 2 是绑在 mitochondrial DNA 的 mitochondrial 矩阵蛋白质。以前的研究证明了 mTERF2 的 overexpression 能禁止房间增长,但是机制到目前为止一直不是明确的。这研究试图在 vivo 介绍 mTERF2 的有约束力的模式给 mitochondrial DNA (mtDNA ) ,并且在 mtDNA, mRNA 抄写,和蛋白质翻译的复制上调查了 mTERF2 的生物功能。到全部 mtDNA 的 mTERF2 绑定经由染色质 immunoprecipitation 分析被识别。当 mTERF2 是在 HeLa 房间的 overexpressed 时,线粒体基因的 mtDNA 复制效率和表示层次显著地被禁止。mtDNA 内容的抑制水平是有 mRNA 和 mitochondrial 蛋白质表示的减少的层次的一样。总的来说, mTERF2 可能基于它 mtDNA 复制上的否定效果是一个细胞生长禁止者,它最后下面调整在是必要的为的线粒体的氧化 phosphorylation 部件,细胞是的所有精力新陈代谢。 | Weiwei Huang Min Yu Yang Jiao Jie Ma Mingxing Ma Zehua Wang Hong Wu Deyong Tan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 17 |
| 3 | Effect of temperature switchover on the degradation of antibiotic chloramphenicol by biocathode bioelectrochemical system显示文摘Exposure to chloramphenicol(CAP),a chlorinated nitroaromatic antibiotic,can induce CAP-resistant bacteria/genes in diverse environments. A biocathode bioelectrochemical system(BES) was applied to reduce CAP under switched operational temperatures.When switching from 25 to 10°C,the CAP reduction rate(kCAP) and the maximum amount of the dechlorinated reduced amine product(AMCl,with no antibacterial activity) by the biocathode communities were both markedly decreased. The acetate and ethanol yield from cathodophilic microbial glucose fermentation(with release of electrons) was also reduced. Formation of the product AMCl was enhanced by the biocathode dechloridation reaction compared with that produced from pure electrochemical or microbial dechloridation processes. The electrochemical and morphological analyses of cathode biofilms demonstrated that some cathodophilic microbes could adapt to low temperature and play a key role in CAP degradation. The resilient biocathode BES has a potential for the treatment of CAP-containing wastewater in temperature fluctuating environments. | Deyong Kong Bin Liang Duu-Jong Lee Aijie Wang Nanqi Ren | 2014 | Journal of Environmental Sciences2014，26，8： | 10 |
| 4 | Zinc sensitizes prostate cancer cells to sorafenib and regulates the expression of Livin显示文摘在前列腺 carcinogenesis,正常积累锌的上皮的房间被转变成不积累锌的恶意的房间。锌的增加的层次被显示了在前列腺癌症房间与下面调整的 anti-apoptotic 蛋白质通过 caspase 依赖的机制导致 apoptosis。我们的以前的学习显示出那,作为 apoptosis 的禁止者的一个成员蛋白质(国际机场) 家庭, Livin 能在人的前列腺癌症的开始起一个重要作用并且由改变 G1S 房间周期转变支持房间增长。在现在的学习,我们测量了前列腺癌症房间的 apoptosis 敏感到锌和 sorafenib 并且发现那锌敏化前列腺癌症房间到导致 sorafenib 的 apoptosis。令人惊讶地,我们也发现 Livin 不同于它的对应物 Survivin 和 cIAP2,没总是被减少;相反,它赔偿地在前列腺癌症房间在 48 h 在调停锌的 apoptosis 被增加。我们可以扩充 sorafenib 的效果,并且也第一次揭示的结果提议潜力治疗联合,那增加的 Livin 表情可以在对锌的前列腺癌症房间的早房间死亡反应起一个作用。 | Xiaochi Chen Xiangyu Che Jianbo Wang Feng Chen Xuejian Wang Zhiwei Zhang Bo Fan Deyong Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 5 |
| 5 | Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica显示文摘Recent studies indicated that type II Toxoplasma gondii(Tg)GRA15II favored the generation of classically activated macrophages(M1),whereas type I/III TgROP16I/III promoted the polarization of alternatively activated macrophages(M2).A number of studies have demonstrated that M2 cells are involved in the pathogenesis of the liver fibrogenesis caused by Schistosoma japonicum.The purpose of the present study was to explore the inhibitory effect of Toxoplasma-derived TgGRA15II on mouse hepatic fibrosis with schistosomiasis.The gra15II and rop16I/III genes were amplified from strains T.gondii PRU and Chinese 1 Wh3,respectively.Lentiviral vectors containing the gra15II or rop16I/III plasmid were constructed and used to infect the RAW264.7 cell line.The polarization of the transfected cells was evaluated,followed by co-culture of the biased macrophages with mouse hepatic stellate JS1 cells.Then,mice were injected with GRA15II-driven macrophages via the tail vein and infected with S.japonicum cercariae.TgGRA15II induced a M1-biased response,whereas TgROP16I/III drove the macrophages to a M2-like phenotype.The in vitro experiments indicated that JS1 cell proliferation and collagen synthesis were decreased following co-culture with TgGRA15II-activated macrophages.Furthermore,mice inoculated with TgGRA15II-biased macrophages displayed a notable alleviation of collagen deposition and granuloma formation in their liver tissues.Our results suggest that TgGRA15II-induced M1 cells may dampen the M2 dominant pathogenesis of hepatic fibrosis and granulomatosis.These results provide insights into the use of parasite-derived immunomodulators as potential anti-fibrosis agents and to re-balance the schistosomiasis-induced immune response. | Yuanyuan Xie Huiqin Wen Ke Yan Shushu Wang Xuesong Wang Jian Chen Yuanling Li Yuanhong Xu Zhengrong Zhong Jilong Shen Deyong Chu | 2018 | Cellular & Molecular Immunology2018，15，2： | 4 |
| 6 | MULTI-TILLERING DWARF1, a new allele of BRITTLE CULM 12, affects plant height and tiller in rice显示文摘Plant height and tillering are crucial factors determining rice plant architecture and influencing rice grain production. In this study, multi-tillering dwarf1(mtd1), a stable multi-tiller and dwarf mutant, was screened from the ethylmethane sulfonate-treated japonica rice variety Wuyunging7. Compared with the wild type, mtd1 mutant exhibited pleiotropic phenotypes, including dwarfism, more tillers, brittle culms and delayed heading date.By employing map-based cloning strategy, the gene MTD1 was finally mapped to an approximately 66-kb region on the short arm of chromosome 9. Sequencing results showed that the gene LOC_Os09g02650(BC12) in mtd1 mutant had a single nucleotide substitution(G to A), which generated a premature translation stop. Over-expressing MTD1/BC12 coding sequence rescued all the phenotypes of mtd1 mutants including plant height and tillers, which confirms that BC12 is the mutated gene in mtd1 mutant.Quantitative reverse transcription-PCR analysis showed that MTD1/BC12 could negatively regulate the expression of MONOCULM 1, IDEAL PLANT ARCHITECTURE1 and Tillering and Dwarf 1, and control rice tillering. Remarkably, a-amylase activity analysis and gibberellic acid(GA)treatment showed that the dwarf phenotype of mtd1 mutant was dependent on GA biosynthesis pathway. These results facilitated to further uncover the molecular mechanism of the growth and development in rice. | Haiping Yu Deyong Ren Yangzhou Zhu Jiangmin Xu Yuexing Wang Ruifang Liu Yunxia Fang Zhenyuan Shi Jiangjie Pan Mei Lu Bojun Ma Jiang Hu Yuchun Rao | 2016 | Science Bulletin2016，61，23： | 3 |
| 7 | Genome-wide association study and transcriptome analysis reveal new QTL and candidate genes for nitrogen-deficiency tolerance in rice显示文摘The development of rice cultivars with improved nitrogen use efficiency(NUE)is desirable for sustainable agriculture.Achieving this goal depends in part on understanding how rice responds to low soil nitrogen(N)and identifying causative genes underlying this trait.To identify quantitative trait loci(QTL)or genes associated with low N response,we conducted a genome-wide association study(GWAS)using a diverse panel of 230 rice accessions and performed a transcriptomic investigation of rice accessions with differential responses to low N stress at two N levels.We detected 411 GWAS-associated genes in 5 QTL and 2722 differentially expressed genes in response to low N,of which 24 were identified by both methods and ranked according to gene annotations,literature queries,gene expression,and genetic diversity analysis.The large-scale datasets obtained from this study reveal low N-responsive characteristics and provide insights towards understanding the regulatory mechanisms of N-deficiency tolerance in rice,and the candidate genes or QTL would be valuable resources for increasing rice NUE via molecular biotechnology. | Qing Li Xueli Lu Changjian Wang Lan Shen Liping Dai Jinli He Long Yang Peiyuan Li Yifeng Hong Qiang Zhang Guojun Dong Jiang Hu Guangheng Zhang Deyong Ren Zhenyu Gao Longbiao Guo Qian Qian Li Zhu Dali Zeng | 2022 | The Crop Journal2022，10，4： | 3 |
| 8 | FABRICATION AND TEST OF AN ELECTROMAGNETIC VIBRATING RING GYROSCOPE BASED ON SOI WAFER显示文摘Mode matching is the key to improve the performance of micro-machined vibrating ring gyroscopes.Mass and stiffness asymmetries can lend to normal modes badly mismatch for gyroscopes fabricated by single-crystal silicon.The mismatch of the normal nodes results in large normal mode frequency split and degraded sensitivity.To address this issue,a Silicon-On-Insulator(SOI) wafer is used to fabricate the sensor chips.Meanwhile,a compensate disk and the backside coated negative photo resist(AZ303) is employed to weaken the Lag and Footing effect during the Deep Reactive Ion Etching(DRIE) process.Test results reveal that frequency split between the normal modes is of less than 10 Hz before the following electronic tuning.Thus,the mode matching of the electromagnetic vibrating ring gyroscope is probable to be realized. | Liu Jili Chen Deyong Wang Junbo | 2014 | Journal of Electronics(China)2014，31，2： | 2 |
| 9 | Simulation of Heat and Mass Transfer in a Grain Pile on the Basis of a 2D Irregular Pore Network显示文摘The so-called pore network model has great advantages in describing the process of heat and mass transfer in porous media.In order to construct a random two-dimensional(2D)irregular pore network model for an unconsolidated material,image processing technology was used to extract the required topological and geometric information from a 2D sample of soybean particles,and a dedicated algorithm was elaborated to merge some adjacent small pores.Based on the extracted information,a 2D pore network model including particle information was reconstructed and verified to reflect the pore structure of discrete particles.This method was used to reconstruct a random 2D irregular pore network model of wheat.Accordingly,a multi-scale heat and mass transfer model was implemented to simulate the drying of wheat.The simulation results were consistent with the experimental results,which indicates that the reconstructed irregular pore network model can effectively simulate the real pore structure inside unconsolidated porous media.The present approach may be regarded as the foundation for establishing in the future a three-dimensional pore network model and studying the heat and mass transfer process in a grain pile. | Pengxiao Chen Kai Huang Fenghe Wang Weijun Xie Shuo Wei Deyong Yang | 2019 | Fluid Dynamics & Materials Processing2019，15，4： | 2 |
| 10 | A rice XANTHINE DEHYDROGENASE gene regulates leaf senescence and response to abiotic stresses显示文摘Xanthine dehydrogenase, a member of the molybdenum enzyme family, participates in purine metabolism and catalyzes the generation of ureides from xanthine and hypoxanthine. However, the mechanisms by which xanthine dehydrogenase affects rice growth and development are poorly understood. In the present study, we identified a mutant with early leaf senescence and reduced tillering that we named early senescence and less-tillering 1(esl1). Map-based cloning revealed that ESL1 encodes a xanthine dehydrogenase, and it was expressed in all tissues. Chlorophyll content was reduced and chloroplast maldevelopment was severe in the esl1 mutant. Mutation of ESL1 led to decreases in allantoin, allantoate, and ABA contents. Further analysis revealed that the accumulation of reactive oxygen species in esl1 resulted in decreased photosynthesis and impaired chloroplast development, along with increased sensitivity to abscisic acid and abiotic stresses. Ttranscriptome analysis showed that the ESL1 mutation altered the expression of genes involved in the photosynthesis process and reactive oxygen species metabolism.Our results suggest that ESL1 is involved in purine metabolism and the induction of leaf senescence.These findings reveal novel molecular mechanisms of ESL1 gene-mediated plant growth and leaf senescence. | Jiangmin Xu Chenyang Pan Han Lin Hanfei Ye Sheng Wang Tao Lu Qianyu Chen Kairu Yang Mei Lu Qian Qian Deyong Ren Yuchun Rao | 2022 | The Crop Journal2022，10，2： | 1 |
| 11 | Can tamsulosin facilitate expulsion of ureteral stones A meta-analysis of randomized controlled trails显示文摘 | FAN Bo YANG Deyong WANG Jianbo | 2013 | Int J Urol2013，20，8： | 1 |
| 12 | Conspicuous cruciform silk decorations deflect avian predator attacks显示文摘Although camouflage as an effective antipredator defense strategy is widespread across animals,highly conspicuous color patterning is not uncommon either.Many orb-web spiders adorn their webs with extra bright white silk.These conspicuous decorations are hypothesized to deter predators by warning the presence of sticky webs,camouflaging spiders,acting as a decoy,or intimidating predators by their apparent size.The decorations may also deflect predator attacks from spiders.However,empirical evidence for this deflection function remains limited.Here,we tested this hypothesis using the X-shaped silk cruciform decorations built by females of Argiope minuta.We employed visual modeling to quantify the conspicuousness of spiders and decorations from a perspective of avian predators.Then,we determined actual predation risk on spiders using naïve chicks as predators.Spider bodies and decorations were conspicuous against natural backgrounds to the avian visual systems.Chicks attacked the spider main bodies significantly less frequently on the decorated webs than on the undecorated webs,thus reducing predation risk.When both spiders and decorations were present,chicks also attacked the spider main bodies and their legs or decorations,and not randomly:they attacked the legs or decorations sooner and more frequently than they attacked the main bodies,independent of the ratio of the surface area between the decoration and spider size.Despite the increase in detectability,incorporating a conspicuous cruciform decoration to the web effectively defends the spider by diverting the attack toward the decoration or leg,but not by camouflaging or intimidating,thus,supporting the deflection hypothesis. | Bingjun WANG Long YU Nina MA Zengtao ZHANG Deyong GONG Rui LIU Daiqin LI Shichang ZHANG | 2022 | Integrative Zoology2022，17，5： | 1 |
| 13 | Livin regulates prostate cancer cell invasion by impacting the nf-icb signaling pathway and the expression of FN and CXCR4 显示文摘 | FENG CHEN DEYONG YANG SHUJING WANG | 2012 | IUBMB Life2012，64，3： | 1 |
| 14 | Stratigraphic Sequence and Sedimentary Systems in the Middle-Southern Continental Slope of the East China Sea from Seismic Reflection Data: Exploration Prospects of Gas Hydrate显示文摘Many evidences for gas hydrate bearing sediments had been found in the continental slope of the East China Sea,such as bottom simulating reflections(BSRs),undersea gas springs,pyrite associated with methane leakage,mud diapirs/mud volcanos,bottom-water methane anomalies and so on.In this study,six key stratigraphic interfaces including T_0(seafloor),T_1(LGM,23 kyr B.P.),T_2(2.58 Myr),T_3(5.33 Myr),T_4(11.02 Myr)and T_5(16.12 Myr)were identified,and then five third-order sequences of SQIII1 to SQIII5 were divided.However,T5 in southern continental slope is not found,which shows that the middle-northern Okinawa Trough had begun to rift in the early Miocene,earlier than the southern segment.Four system tracts including lowstand systems tract(LST),transgressive systems tract(TST),highstand systems tract(HST)and falling stage systems tract(FSST)are further divided.The marine erosion interface of 11.02 Myr and regressive unconformity interface of 23 kyr B.P.indicate two large-scale sea level drop events in the research area.Seven typical seismic facies identified in the continental slope are continental shelf-edge deltas,littoral fluvial-delta plains,incised channels or submarine canyons,slope fans,submarine fans or coastal sandbars,littoral-neritic finegrained sediments,mud volcanos and some other geological bodies respectively.The minimum water depth for hydrate occurrence in the Okinawa Trough is 630 m,and the thickness of gas hydrate stability zone in continental slope is between 0 and 590 m.The calculated bottom boundary of hydrate stability zone is slightly deeper than BSRs on the seismic sections.The re-depositional turbidite sand bodies,such as canyon channels,slope fans and submarine fans developed in Quaternary strata,are the predominant hydrate reservoirs.According to developing process,the dynamic accumulation of hydrate systems can be divided into three evolutionary stages including canyon erosion and hydrate stability zone migration stage,sediments destabilizing and methane leakage stage,and channel filling and hydrate re-occurrence stage. | LI Deyong CHEN Hongyan XU Shujuan XING Junhui CHENG Honggang WANG Jinkai | 2019 | Journal of Ocean University of China2019，18，6： | 1 |
| 15 | Expression of the IAP protein family acts cooperatively topredict prognosis in human bladder cancer patients 显示文摘 | XIAOCHICHEN TIEZHENG WANG DEYONG YANG etal | 2013 | OncolLett2013，5，4： | 1 |
| 16 | Demands and technical developments of clinical flow cytometry with emphasis in quantitative,spectral,and imaging capabilities显示文摘As the gold-standard method for single-cell analysis,flow cytometry enables high-throughput and multiple-parameter characterization of individual biological cells.This review highlights the demands for clinical flow cytometry in laboratory hematology(e.g.,diagnoses of minimal residual disease and various types of leukemia),summarizes state-of-the-art clinical flow cytometers(e.g.,FACSLyricTMby Becton Dickinson,DxFLEX by Beckman Coulter),then considers innovative technical improvements in flow cytometry(including quantitative,spectral,and imaging approaches)to address the limitations of clinical flow cytometry in hematology diagnosis.Finally,driven by these clinical demands,future developments in clinical flow cytometry are suggested. | Ting Zhang Mengge Gao Xiao Chen Chiyuan Gao Shilun Feng Deyong Chen Junbo Wang Xiaosu Zhao Jian Chen | 2022 | Nanotechnology and Precision Engineering2022，5，4： | 1 |
| 17 | Flume Tank Simulation on Depositional Mechanism and Controlling Factors of Beach-Bar Reservoirs显示文摘The beach-bar reservoir has become an important exploration target in China, but its depositional mechanism and controlling factors have not yet been fully modeled. They have become an inhibitory factor for the exploration and development of beach-bar reservoirs. The depositional mechanism of beach-bars and their controlling factors have been studied by means of a flume experiment including seven runs under controlled boundary conditions which were the water level(Run 1, Run 2 and Run 3), wave parameters(Run 1, Run 4 and Run 5) and initial slope(Run 1, Run 6 and Run 7). The experiment revealed that the development of beach-bar was controlled by water level, wave parameters and initial slope. The deposited locations of distal bar and nearshore bar were controlled by the water level. Two beach-bars were migrated downward when the water level falls(Run 1, Run 2 and Run 3). The width and thickness of distal bar and nearshore bar were controlled by wave parameters, especially the wave height. They increased with the scale of wave. But, the maximum thickness is limited by the water level(Run 1, Run 4 and Run 5). The distance between distal bar and nearshore bar was controlled by the initial slope. It became shorter with the steeper slope. Distal bar and nearshore bar changed into one bar when the initial gradient was greater than 1/20(Run 1, Run 6 and Run 7). The results suggest formative mechanism and controlling factors related to beach-bars. | Chenlin Hu Yuanfu Zhang Deyong Feng Min Wang Zaixing Jiang Chaowei Jiao | 2017 | Journal of Earth Science2017，28，6： | 1 |
| 18 | Oxidation and hot corrosion behavior of a novel enamel-Al2O3 composite coating on K38G superalloy显示文摘 | Zheng Deyong Zhu Shenglong Wang Fuhui | | 0，，20： | 1 |
| 19 | The role of macrophage reprogramming induced by GRA15II,a polypeptide effector molecule of Toxoplasma gondii,in liver diseases in model mice显示文摘Toxoplasma gondii is a widespread parasite that may infect nearly all warm-blooded vertebrates.1 As an obligatory intracellular apicomplexan parasite,T.gondii has three different types of secretory organelles,including micronemes,rhoptries(ROP),and dense granules(GRAs),during invasion of host cells.2 Initially,the parasite replicates in a variety of host cell types as tachyzoites,especially in macrophages and dendritic cells(DCs). | Yihong Cai Yanxia Yu Yanling Wang Yuan Zhang Qingli Luo Li Yu Jian Du Deyong Chu Jilong Shen | 2020 | Cellular & Molecular Immunology2020，17，7： | 1 |
| 20 | Parameterization of water component absorption in an inland eutrophic lake and its seasonal variability: a case study in Lake Taihu显示文摘 | Deyong Sun Yunmei Li Qiao Wang Chengfeng Le Changchun Huang Lizhen Wang | 2009 | International Journal of Remote Sensing2009，，13： | 1 |
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