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| 1 | A rice XANTHINE DEHYDROGENASE gene regulates leaf senescence and response to abiotic stresses显示文摘Xanthine dehydrogenase, a member of the molybdenum enzyme family, participates in purine metabolism and catalyzes the generation of ureides from xanthine and hypoxanthine. However, the mechanisms by which xanthine dehydrogenase affects rice growth and development are poorly understood. In the present study, we identified a mutant with early leaf senescence and reduced tillering that we named early senescence and less-tillering 1(esl1). Map-based cloning revealed that ESL1 encodes a xanthine dehydrogenase, and it was expressed in all tissues. Chlorophyll content was reduced and chloroplast maldevelopment was severe in the esl1 mutant. Mutation of ESL1 led to decreases in allantoin, allantoate, and ABA contents. Further analysis revealed that the accumulation of reactive oxygen species in esl1 resulted in decreased photosynthesis and impaired chloroplast development, along with increased sensitivity to abscisic acid and abiotic stresses. Ttranscriptome analysis showed that the ESL1 mutation altered the expression of genes involved in the photosynthesis process and reactive oxygen species metabolism.Our results suggest that ESL1 is involved in purine metabolism and the induction of leaf senescence.These findings reveal novel molecular mechanisms of ESL1 gene-mediated plant growth and leaf senescence. | Jiangmin Xu Chenyang Pan Han Lin Hanfei Ye Sheng Wang Tao Lu Qianyu Chen Kairu Yang Mei Lu Qian Qian Deyong Ren Yuchun Rao | 2022 | The Crop Journal2022，10，2： | 1 |
| 2 | Comparative proteomic analysis reveals the effects of different fatty acid forms on high-fat diet mice显示文摘Long-chain omega-3 polyunsaturated fatty acids(LC-PUFAs),known for having many health benefits,are usually present in three forms:triglycerides(TG),ethyl esters(EE),and phospholipid(PL).In this study,the effects of these three LC-PUFAs forms(fish oil for TG and EE,krill oil for PL)on the obese mice were compared,and the proteomic changes that focused on lipid metabolism were evaluated via label-free quantitative proteomics analysis.Compared with the model group,all three of the LC-PUFA form supplementations(labeled as the FO-TG group,FO-EE group and KO-PL groups)could significantly reduce body weight gain(P<0.01).Low-density lipoprotein cholesterol levels were significantly decreased,whereas high-density lipoprotein cholesterol levels were significantly increased in the FO-TG group and FO-EE group(P<0.01),and especially in the PL group(P<0.001).Furthermore,proteomics analysis results suggested that some differentially expressed genes involved in the fatty acid degradation and oxidation pathways had a higher expression fold in the KO-PL group than in the FO-TG or FO-EE groups.Our results showed that dietary LC-PUFAs can reduce fat deposition and inhibit lipogenesis in the liver by upregulating the expression of proteins that are involved in the fatty acid degradation and oxidation pathways.Additionally,KO-PL elicits stronger effects than FO-TG or FO-EE. | Jiaping Pan Huan Wang Ye Li Chenyang Lu | 2022 | Food Science and Human Wellness2022，11，2： | 1 |
| 3 | Redifferentiation of human hepatoma cells induced by green tea polyphenols显示文摘 | Bo Zhou Jing Pan Fang Dai Chenyang Zhao Liping Zhang Qingyi Wei Li Yang Rongliang Zheng Zhongli Liu | 2004 | Research on Chemical Intermediates2004，，6： | 1 |
| 4 | A multicolor nanoprobe for detection and imaging of umor-related mRNAs in living cells显示文摘 | Li Na Chang Chenyang Pan Wei | 2012 | Angew Chem Int Ed2012，51，30： | 1 |
| 5 | In vivo non-enzymatic repair of DNA oxidative damage by polyphenols显示文摘 | Xiaorong Tan Chenyang Zhao Jing Pan Yimin Shi Guoan Liu Bo Zhou Rongliang Zheng | 2009 | Cell Biology International2009，，6： | 1 |
| 6 | Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study显示文摘Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter cohort of LTRs was identified in the four lung transplant centers.Paired fecal and serum specimens were collected and divided into AR,Pl,and event-free(EF)groups according to the diagnosis at sampling.Fecal samples were determined by metagenomic sequencing. | Junqi Wu Chongwu Li Peigen Gao Chenhong Zhang Pei Zhang Lei Zhang Chenyang Dai unpeng Zhang Bowen Shi Mengyang Liu Junmeng Zheng Bo Pan Zhan Chen Chao Zhang Wanqing Liao Weihua Pan Wenjie Fang Chang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 7 | Targeting protein phosphatases for the treatment of inflammation-related diseases:From signaling to therapy显示文摘Inflammation is the common pathological basis of autoimmune diseases,metabolic diseases,malignant tumors,and other major chronic diseases.Inflammation plays an important role in tissue homeostasis.On one hand,inflammation can sense changes in the tissue environment,induce imbalance of tissue homeostasis,and cause tissue damage.On the other hand,inflammation can also initiate tissue damage repair and maintain normal tissue function by resolving injury and restoring homeostasis.These opposing functions emphasize the significance of accurate regulation of inflammatory homeostasis to ameliorate inflammation-related diseases.Potential mechanisms involve protein phosphorylation modifications by kinases and phosphatases,which have a crucial role in inflammatory homeostasis.The mechanisms by which many kinases resolve inflammation have been well reviewed,whereas a systematic summary of the functions of protein phosphatases in regulating inflammatory homeostasis is lacking.The molecular knowledge of protein phosphatases,and especially the unique biochemical traits of each family member,will be of critical importance for developing drugs that target phosphatases.Here,we provide a comprehensive summary of the structure,the“double-edged sword”function,and the extensive signaling pathways of all protein phosphatases in inflammation-related diseases,as well as their potential inhibitors or activators that can be used in therapeutic interventions in preclinical or clinical trials.We provide an integrated perspective on the current understanding of all the protein phosphatases associated with inflammationrelated diseases,with the aim of facilitating the development of drugs that target protein phosphatases for the treatment of inflammation-related diseases. | Jie Pan Lisha Zhou Chenyang Zhang Qiang Xu Yang Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 8 | Influence of Ag substitution on thermoelectric properties of the quaternary diamond-like compound Zn_(2)Cu_(3)In_(3)Te_(8)显示文摘The quaternary diamond-like compounds,A_(2)Cu_(3)In_(3)Te_(8)(A=Cd,Zn,Mn,Mg),are a new class of thermoelectric materials recently proposed by complex structure design.Among them,the Zn_(2)Cu_(3)In_(3)Te_(8) compound possesses reasonable electrical transport properties but relatively high lattice thermal conductivity.Herein,the effects of Ag substitution on the phase stability and thermoelectric properties of Zn_(2)Cu_(3)In_(3)Te_(8) compound are reported.It is revealed that only the In sites show an appreciable tolerance for Ag doping.Ag substitution at the In sites introduces extra holes and thus results in improved electrical transport properties.Furthermore,the introducing of Ag lowers the sound velocities and enhances the phonon scattering of the Zn_(2)Cu_(3)In_(3)Te_(8) compound,which leads to a substantially reduction in lattice thermal conductivity.Finally,in virtue of the optimization in both electrical and thermal transport properties,the maximal zT value of Zn_(2)Cu_(3)In_(2.8)Ag_(0.2)Te_(8) sample reaches 0.62 at 823 K,which is 43%higher than the pristine sample. | Qidong Zhang Lili Xi Jiye Zhang Chenyang Wang Li You Shanshan Pan Kai Guo Zhili Li Jun Luo | 2021 | Journal of Materiomics2021，7，2： | 0 |
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