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| 1 | IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。 | Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright | 2018 | Cellular & Molecular Immunology2018，15，5： | 17 |
| 2 | Diagnosis and surgical management of breast cancer metastatic to the spine显示文摘Breast cancer is the most common malignancy and the second leading cause of death in Western women. Breast cancer most commonly metastasizes to the bone and has a particular affinity with the spine, accounting for 2/3 of osseous metastases discovered. With significant improvements in cancer therapies, the number of patients at risk for symptomatic spinal metastases is likely to increase. Patients may suffer from intractable pain and neurological dysfunction, negatively influencing their quality of life. Timely diagnosis of patients is crucial and has been aided by several breakthrough advances in imaging techniques which aid in detection, staging, and follow-up of bone metastases. Breast metastases are usually responsive to hormonal therapy and pharmacologic interventions, but skeletal metastases often require surgical intervention. The treatments are palliative but goals include the preserving or restoring neurologic function, ensuring spinal stability, and relieving pain. Advances in surgical techniques and instrumentation have allowed more effective decompres-sion and stabilization of the spine, and with the support of recent evidence the trend has shifted towards using more advanced surgical options in appropriately selected patients. In this review, the clinical presentation, diagnosis, patient selection, and surgical management of breast cancer metastatic to the spine are discussed. | Derek G Ju Alp Yurter Ziya L Gokaslan Daniel M Sciubba | 2014 | World Journal of Clinical Oncology2014，5，3： | 4 |
| 3 | Diffusion with hydrolysis and ion association in aqueous solutions of beryllium sulfate 显示文摘 | Hao Ling Lu Ruanhui Derek G L | 1996 | Journal of Solution Chemistry1996，25，3： | 1 |
| 4 | The immunophysiological impaet of bacterlal CpC DNA on the gut显示文摘 | James L Derek M | 2006 | Clin Chim Acta2006，364，12： | 1 |
| 5 | A functional methodology for determining the groundwater regime needed to maintain the health of groundwater - dependent vegetation 显示文摘 | Derek E Ray F Robyn L | 2006 | Australian Journal of Botany2006，54，2： | 1 |
| 6 | From Rumors to Facts, and Facts to Rumors: The Role of Certainty Decay in Consumer Communications 显示文摘 | Dubois D Derek D R Zakary L T | 2011 | Journal of Marketing Research2011，48，6： | 1 |
| 7 | Occupational exposures in healthcare workers in University Hospital Dubrava--10 year follow-up study显示文摘 | Serdar T Derek L Unic'A | 2013 | Cent Eur J Public Health2013，21，3： | 1 |
| 8 | Vitamin C and quinapril abrogate LVH and endothelial dysfunction in aortic-banded guinea pigs显示文摘 | John P Salah I Derek L Donaldson F Lewis M | 2001 | Am J Physiol Heart Circ Physiol2001，281，： | 1 |
| 9 | Problem-Based Learning and the medi- cal school: another case of the emperor' s new clothes显示文摘 | Richard B David I Derek L | 2005 | Advances in Physiology Education2005，29，4： | 1 |
| 10 | Tracking with vir- tual slides: a tool to study diagnostic error in histopathol- ogy显示文摘 | Darren T Chee H L Derek M | 2009 | Histopathology2009，55，1： | 1 |
| 11 | Cost effectiveness of a manual based coping strategy programme in promoting the mental health of family carers of people with dementia (the START (STrAtegies for RelaTives) study): a pragmatic randomised controlled trial显示文摘 | Martin Knapp Derek King Renee Romeo Barbara Schehl Julie Barber Mark Griffin Penny Rapaport Debbie Livingston Cath Mummery Zuzana Walker Juanita Hoe Elizabeth L Sampson Claudia Cooper Gill Livingston | 2013 | BMJ (oct )2013，，252： | 1 |
| 12 | Specific recognition of the human neuroendocrine receptor for vasoactive intestinal peptide by anti-peptide antibodies显示文摘 | Edward J Derek R Jeffrey L K | 1994 | Mol Cell Neurosci1994，5，2： | 1 |
| 13 | Modeling Terrestrial Laser Scanner Data for Precise Structural Deformation Measurement显示文摘 | Stuart J G Derek D L | 2007 | Journal of Surveying Engineering2007，，5： | 1 |
| 14 | Influence of calcium nitrite inhibitor and crack width on corrosion of steel in high performance concrete subjected to a simulated marine environment显示文摘 | PEDRO M THEODERO W B DEREK H L | 2004 | Cement and Concrete Composites2004，26，3： | 1 |
| 15 | A Realistic' Elaslic Rod Model fir Real-time Simulation of Mininm|ly lnvasi;'e Vas- cular Interventions 显示文摘 | Wen Tang Pierre Lagadec Derek Glou(l | 2010 | Vis Comput2010，26，： | 1 |
| 16 | Problem-based learning and the medical school:another case of the emperor's new clothes显示文摘 | Richard B David 1 Derek L | 2005 | Advances in PhysiologyEducation2005，29，： | 1 |
| 17 | Problem-based learning and the medical school: another case of the emperor's new clothes 显示文摘 | Richard B David I Derek L | 2005 | Advances in Physiology Education2005，29，： | 1 |
| 18 | Cognitive-Behavior therapy for depressed cancer patients in a medical care setting显示文摘 | Derek R John L Bell Lejuez CW | 2008 | Hopko Behavior therapy2008，39，1： | 1 |
| 19 | A Method for Automated Registra- tion of Unorganized Point Cloud显示文摘 | Kwang H B Derek D L | 2008 | ISPRS Journal Photo- grammetry ~ Remote Sensing2008，63，： | 1 |
| 20 | Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England:a repeated cross-sectional study in primary care显示文摘 | LUIS N C ELIANA L M DEREK P | | 0，，09： | 1 |
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