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2篇 您的检索式：作者名="Ricky Patel"

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		题名	作者	年代	出处	被引量
	1	IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。	Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright	2018	Cellular & Molecular Immunology2018，15，5：	17
	2	Colonic tumour precipitating caecal volvulus within a diaphragmatic hernia显示文摘An 85-year-old woman presented with sudden onset of generalised abdominal pain and absolute constipation for 4 d.On examination she had a distended abdomen.Plain abdominal radiograph revealed a gas filled viscous within the left upper quadrant.Subsequent computed tomography suggested caecal volvulus herniated through a left diaphragmatic hernia.The patient underwent reduction of the internal hernia,right hemicolectomy and mesh repair of the diaphragmatic hernia.Postoperative recovery was uneventful.Histology revealed a Dukes’A colonic cancer within the caecum.Herniation of caecal volvulus through a diaphragmatic hernia is a very rare condition and may have been precipitated by the colonic tumour.	Ricky Harminder Bhogal Kambiz Maleki Rajan Patel	2013	World Journal of Gastrointestinal Surgery2013，5，9：	0

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