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| 1 | Progress of gastric cancer etiology:N-nitrosamides in the 1990s显示文摘INTRODUCTIONStomach carcinoma is still the leading cause of cancer deathin China and the second one in the world.Its possiblecauses include:A)chemical factors such as intragastricformation of N-nitroso compounds(NOC)and high saltintake;B)biological factors such as infection | Da Jun Deng Laboratory of Cancer Etiology,Beijing Medical University School of Oncology& Beijing Institute for Cancer Research,100034,China | 2000 | World Journal of Gastroenterology2000，6，4： | 27 |
| 2 | Staging laparoscopy improves treatment decision-makingfor advanced gastric cancer显示文摘AIM To evaluate the clinical value of staging laparoscopyin treatment decision-making for advancedgastric cancer (GC).METHODS: Clinical data of 582 patients with advancedGC were retrospectively analyzed. All patientsunderwent staging laparoscopy. The strength ofagreement between computed tomography (CT) stage,endoscopic ultrasound (EUS) stage, laparoscopic stage,and final stage were determined by weighted Kappastatistic (Kw). The number of patients with treatmentdecision-changes was counted. A χ 2 test was used toanalyze the correlation between peritoneal metastasisor positive cytology and clinical characteristics.RESULTS: Among the 582 patients, the distributions ofpathological T classifications were T2/3 (153, 26.3%),T4a (262, 45.0%), and T4b (167, 28.7%). Treatmentplans for 211 (36.3%) patients were changed after staging laparoscopy was performed. Two (10.5%) of19 patients in M1 regained the opportunity for potentialradical resection by staging laparoscopy. Unnecessarylaparotomy was avoided in 71 (12.2%) patients. Thestrength of agreement between preoperative T stageand final T stage was in almost perfect agreement (Kw= 0.838; 95% confidence interval (CI): 0.803-0.872;P 〈 0.05) for staging laparoscopy; compared with CTand EUS, which was in fair agreement. The strengthof agreement between preoperative M stage andfinal M stage was in almost perfect agreement (Kw= 0.990; 95% CI: 0.977-1.000; P 〈 0.05) for staginglaparoscopy; compared with CT, which was in slightagreement. Multivariate analysis revealed that tumorsize (≥ 40 mm), depth of tumor invasion (T4b), andBorrmann type (Ⅲ or Ⅳ) were significantly correlatedwith either peritoneal metastasis or positive cytology.The best performance in diagnosing P-positive wasobtained when two or three risk factors existed.CONCLUSION: Staging laparoscopy can improvetreatment decision-making for advanced GC anddecrease unnecessary exploratory laparotomy. | Yan-Feng Hu Zhen-Wei Deng Hao Liu Ting-Yu Mou Tao Chen Xin Lu Da Wang Jiang Yu Guo-Xin Li | 2016 | World Journal of Gastroenterology2016，22，5： | 17 |
| 3 | Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-β in rats with unilateral ureteral obstruction显示文摘Astragalus mongholicus(AM) derived from the dry root of Astragalus membranaceus Bge.var.mongolicus(Bge.) Hsiao is a widely used traditional Chinese medicine.The present study investigated the potential role of AM on renal fibrosis on a rat model of unilateral ureteral obstruction(UUO).We divided 48 Sprague-Dawley rats randomly into 4 groups:sham-operated group(Sham),untreated UUO group,AM-treated(10 g/(kg·d)) UUO group,and losartan-treated(20 mg/(kg·d)) UUO group as positive control.Haematoxylin & eosin(HE) and Masson staining were used to study the dynamic histological changes of the kidneys 7 and 14 d after operation.The expressions of fibronectin(FN),type I collagen(colI),hepatocyte growth factor(HGF),transforming growth factor-β1(TGF-β1),and α-smooth muscle actin(α-SMA) were analyzed by real-time polymerase chain reaction(PCR),immunohistochemistry staining,and Western blot.Results show that,similar to losartan,AM alleviated the renal damage and decreased the deposition of FN and colI from UUO by reducing the expressions of TGF-β1 and α-SMA(P<0.05),whereas HGF increased greatly with AM treatment(P<0.05).Our findings reveal that AM could retard the progression of renal fibrosis.The renoprotective effect of AM might be related to inhibition of myofibroblast activation,inducing of HGF and reducing of TGF-β1 expression. | Chuan ZUO Xi-sheng XIE Hong-yu QIU Yao DENG Da ZHU Jun-ming FAN | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，5： | 15 |
| 4 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 5 | Two new secoiridoid glycosides from the roots of Picrorhiza scrophulariiflora显示文摘从 Picrorhiza scrophulariiflora 的根,二新 secoiridoid glycosides,命名 picrosecosides 我和 II (1, 2 ) 被孤立。他们的结构根据化学药品和 spectropic 证据被阐明。 | Lian Chun Zou Tong Fei Zhu Shu Cai Gan Da Cheng Wang Yu Zhang Xu Ming Deng | 2008 | Chinese Chemical Letters2008，19，10： | 8 |
| 6 | Two new phenylethanoid glycosides and a new secoiridoid glycoside from the roots of Picrorhiza scrophulariiflora显示文摘二新 phenylethanoid glycosides,命名 scroside H (1 ) , scroside 我(2 ) ,并且新 secoiridoid glycoside,命名 picrogentioside 我(3 ) ,从地下被孤立 Picrorhiza scrophulariiflora 的部分。他们的结构根据分光镜的证据被阐明。 | Lian Chun Zou Zhi Hui Yan Tong Fei Zhu Hua Xiang Da Cheng Wang Xu Ming Deng | 2010 | Chinese Chemical Letters2010，21，9： | 7 |
| 7 | Reactivation of a huge ancient landslide by surface water infiltration显示文摘An ancient landslide, situated in Deqin County, Yunnan Province, China, was used to investigate the reactivation by water infiltration. This study considers the infiltration process and landslide stability using finite-element method(FEM)-based models. The results show that the reactivation of old landslide deposit was triggered by the long-term leakage of diversion ditch before October 2012, and the reactivation was triggered again by the intense rainfall on 7-9 October 2012. The old cracks, which formed in the earlier reactivation of landslide, played a key role for the rainfall infiltration. They offered a preferential path for much more rainfall to infiltrate fast into deep soil, and caused wetting front to move down faster in landslide. The old slip zone with lower permeability was another important factor to cause the infiltrated water to accumulate and form a high pore water pressure above slip zone. Then the high pore water pressure decreased the shear strength of slip zone and triggered the reactivation of the old landslide deposit again. | TU Guo-xiang HUANG Da DENG Hui | 2019 | Journal of Mountain Science2019，16，4： | 6 |
| 8 | An Outbreak of Multidrug-Resistant Tuberculosis in a Secondary School --Hubei Province, 2019显示文摘What is already known about this topic?Multidrug-resistant tuberculosis(MDR-TB)is a type of tuberculosis with resistance to common treatments such as isoniazid and rifampicin.MDR-TB is a major global health challenge and needs to be controlled tightly through prevention measures,early diagnosis,and full treatment and management.What is added by this report?This outbreak was the first MDR-TB related public health emergency in Hubei Province.In total,five MDR-TB cases and nine clinically diagnosed cases were identified within one class in a secondary school.Students and teachers from other classes were monitored,but no other cases were found.What are the implications for public health practice?The implementation of TB prevention and control measures in schools is important to increase knowledge on TB and to raise awareness on protecting personal wellbeing.The Automatic Early Warning Information System alerted the local health department and allowed for a timely response to prevent further disease spread. | Mengxian Zhang Tang Wang Shuangyi Hou Jianjun Ye Liping Zhou Zhong Zhang Zhiqiang Deng Qin Da Guoming Li Shiyue Li | 2019 | China CDC weekly2019，1，5： | 5 |
| 9 | Near-Real-Time Carbon Emission Accounting Technology Toward Carbon Neutrality显示文摘Climate change is the greatest environmental threat to humans and the planet in the 21st century.Global anthropogenic greenhouse gas emissions are one of the main causes of the increasing number of extreme climate events.Cumulative carbon dioxide(CO_(2))emissions showed a linear relationship with cumulative temperature rise since the pre-industrial stage,and this accounts for approximately 80%of the total anthropogenic greenhouse gases.Therefore,accurate and reliable carbon emission data are the foundation and scientific basis for most emission reduction policymaking and target setting.Currently,China has made clear the ambitious goal of achieving the peak of carbon emissions by 2030 and achieving carbon neutrality by 2060.The development of a finer-grained spatiotemporal carbon emission database is urgently needed to achieve more accurate carbon emission monitoring for continuous implementation and the iterative improvement of emission reduction policies.Near-real-time carbon emission monitoring is not only a major national demand but also a scientific question at the frontier of this discipline.This article reviews existing annual-based carbon accounting methods,with a focus on the newly developed real-time carbon emission technology and its current application trends.We also present a framework for the latest near-real-time carbon emission accounting technology that can be widely used.The development of relevant data and methods will provide strong database support to the policymaking for China’s“carbon neutrality”strategy.Finally,this article provides an outlook on the future of real-time carbon emission monitoring technology. | Zhu Liu Taochun Sun Ying Yu Piyu Ke Zhu Deng Chenxi Lu Da Huo Xiang Ding | 2022 | Engineering2022，8，7： | 5 |
| 10 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 11 | Room temperature ozone sensing properties of p-type CuCrO 2 nanocrystals显示文摘 | Shu Zhou Xiaodong Fang Zanhong Deng Da Li Weiwei Dong Ruhua Tao Gang Meng Tao Wang | 2009 | Sensors & Actuators: B Chemical2009，，1： | 1 |
| 12 | Generation of human hepatocytes from extended pluripotent stem cells显示文摘Dear Editor,Human pluripotent stem cells have great potential for application in regenerative medicine,as they permit the generation of different lineages of functional cell types via directed differentiation.1 However,application of conventional human pluripotent stem cells is limited due to several factors,including heterogeneity in pluripotency,differentiation bias,relatively slow proliferation,and poor single-cell survival.2 Toovercome these problems. | Qiming Wang Da Sun Zhen Liang Junyi Wang Xinxing Zhong Yulin Lyu Junning Cao Zhongqing Lin Yuanyuan Du Zhenchuan Miao Shichun Lu Cheng Li Jun Xu Yan Shi Hongkui Deng | 2020 | Cell Research2020，30，9： | 1 |
| 13 | Unsupervised image segmentation using a simple MRF model with a new implementation scheme 显示文摘 | Deng HW Clausi DA | 2004 | Pattern Recognition2004，37，12： | 1 |
| 14 | Mesenehymal stem cells spontaneously express neural proteins in cul- ture and are neurogenic after transplantation显示文摘 | Deng J Petersen BE Steindler DA | 2006 | Stem Cells2006，24，4： | 1 |
| 15 | Macrophages regulate the angiogenic switch in a mouse model of breast cancer 显示文摘 | Lin 15Y Li JF Gnatovskiy L Deng Y Zhu L Grzesik DA | 2006 | Cancer Res2006，66，11： | 1 |
| 16 | Urinary concentrations of phenols, oxidative stress biomarkers and thyroid cancer: Exploring associations and mediation effects显示文摘Phenols have been shown to influence the cellular proliferation and function of thyroid in experimental models. However, few human studies have investigated the association between phenol exposure and thyroid cancer, and the underlying mechanisms are also poorly understood. We conducted a case-control study by age- and sex-matching 143 thyroid cancer and 224 controls to investigate the associations between phenol exposures and the risk of thyroid cancer, and further to explore the mediating role of oxidative stress. We found that elevated urinary triclosan (TCS), bisphenol A (BPA) and bisphenol S (BPS) levels were associated with increased risk of thyroid cancer (all P for trends < 0.05), and the adjusted odds ratios (ORs) comparing the extreme exposure groups were 3.52 (95% confidence interval (CI):2.08, 5.95), 2.06 (95% CI: 1.06, 3.97) and 7.15 (95% CI: 3.12, 16.40), respectively. Positive associations were also observed between urinary TCS, BPA and BPS and three oxidative stress biomarkers measured by 8-hydroxy-2 -deoxyguanosine (8-OHdG), 8-iso-prostaglandin F(8-iso PGF) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), as well as between urinary 8-iso PGFand HNE-MA and the risk of thyroid cancer. Mediation analysis showed that urinary 8-iso PGFmediated 28.95%, 47.06% and 31.08% of the associations between TCS, BPA and BPS exposures and the risk of thyroid cancer, respectively (all P < 0.05). Our results suggest that exposure to TCS, BPA and BPS may be associated with increased risk of thyroid cancer and lipid peroxidation may be an intermediate mechanism. Further studies are warranted to confirm the findings. | Pan-Pan Chen Pan Yang Chong Liu Yan-Ling Deng Qiong Luo Yu Miao Min Zhang Fei-Peng Cui Jia-Yue Zeng Tian Shi Ting-Ting Lu Da Chen Long-Qiang Wang Chun-Ping Liu Ming Jiang Qiang Zeng | 2022 | Journal of Environmental Sciences2022，34，10： | 1 |
| 17 | Synthesis and Characterization of a Novel Galactosylated Cholesterol显示文摘A novel galactosylated cholesterol with mono-galactoside moiety, (5-cholesten-3-yl)-4-oxo-4-[2-(lactobionylamido)ethylamido]butanoate 6 was synthesized. Its chemical structurewas characterized by IR, ESI-MS, C NMR, H NMR. Doxorubicin entrapped in the liposomes 13 1containing 10% mol/mol 6 was rapidly accumulated in liver and mainly uptake by parenchymalcells in mice. | Shao Ning WANG Ying Kun QIU Hui XU Yi Hui DENG Da Wei CHEN | 2006 | Chinese Chemical Letters2006，17，2： | 1 |
| 18 | Neural transdifferentiation potential of hepatic oval cells in the neonatal mouse brain显示文摘 | Deng J Steindler DA Laywell ED | 2003 | Exp Neurol2003，182，2： | 1 |
| 19 | Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation显示文摘 | Deng J Petersen BE Steindler DA | | 0，，04： | 1 |
| 20 | Mesenchymal stem cells spontaneously express neural proteins in culture and are neurongenic after transplantation显示文摘 | Deng J Petersen BE Steindler DA | 2006 | Stem Cells2006，24，4： | 1 |
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