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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | 美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准显示文摘背景和目的:1/3的个体会罹患卒中和(或)痴呆,而且,除卒中或痴呆外,2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能,而痴呆的诊断标准则集中在认知障碍的晚期阶段,且在很大程度上偏向Alzheimer病(AD)的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体,尤其是在早期阶段,而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法:美国国立神经疾病和卒中研究所(MINDS)与加拿大卒中网(CSN)召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员,为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果:将这些讨论的结果发表于此。结论:一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者,使不同的研究具有可比性,并且通过整合知识来加速研究进展的步伐。 | Vladimir Hachinski Costantino Iadecola Ron C.Petersen Monique M.Breteler David L.Nyenhuis Sandra E.Black William J.Powers Charles DeCarli Jose G.Merino Raj N.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dichgans John R.Marler Gabrielle G.Leblanc 李焰生(译) 俞羚(译) 高枚春(译) 张静芳(译) 熊昕丽(译) 邹静(译) 林岩(译) 潘元美(译) | 2007 | 国际脑血管病杂志2007，15，1： | 63 |
| 3 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 4 | Crop Phenomics and High-Throughput Phenotyping:Past Decades,Current Challenges,and Future Perspectives显示文摘Since whole-genome sequencing of many crops has been achieved,crop functional genomics studies have stepped into the big-data and high-throughput era.However,acquisition of large-scale phenotypic data has become one of the major bottlenecks hindering crop breeding and functional genomics studies.Nevertheless,recent technological advances provide us potential solutions to relieve this bottleneck and to explore advanced methods for large-scale phenotyping data acquisition and processing in the coming years.In this article,we review the major progress on high-throughput phenotyping in controlled environments and field conditions as well as its use for post-harvest yield and quality assessment in the past decades.We then discuss the latest multi-omics research combining high-throughput phenotyping with genetic studies.Finally,we propose some conceptual challenges and provide our perspectives on how to bridge the phenotype-genotype gap.It is no doubt that accurate high-throughput phenotyping will accelerate plant genetic improvements and promote the next green revolution in crop breeding. | Wanneng Yang Hui Feng Xuehai Zhang Jian Zhang John H.Doonan William David Batchelor Lizhong Xiong Jianbing Yan | 2020 | Molecular Plant2020，13，2： | 38 |
| 5 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 6 | 2018年急性缺血性卒中患者早期管理指南美国心脏协会/美国卒中协会为医疗专业人员制定的指南显示文摘背景和目的本指南旨在在单个文件中为治疗成年急性动脉性缺血性卒中患者的临床医生提供最新全面的系列推荐意见。目标读者为院前急救人员、医生、综合医疗保健人员和医院管理人员。本指南将取代2013年版指南及其后续更新。方法写作组成员由美国心脏协会卒中委员会的科学声明监督委员任命,代表各领域的医学专家。严格遵循美国心脏协会的利益冲突原则。不允许写作组成员对存在企业利益关系的相关议题进行讨论或投票。所有推荐意见必须得到写作组成员的一致通过,除非企业利益关系妨碍了成员投票。由4名同行评议专家以及卒中委员会的科学声明监督委员会和领导委员会成员对指南草案进行发布前评审。本指南采用了美国心脏病学学会/美国心脏协会2015年推荐意见分类和证据级别标准以及新版美国心脏协会指南格式。结果本指南详细介绍了院前医疗、紧急和急诊评估、静脉和血管内治疗以及院内管理,包括在发病后最初2周内启用的二级预防措施。本指南支持院前和院内卒中医疗系统的一体化概念。结论本指南基于目前可获得的最佳证据。然而,许多情况资料有限,迫切需要对急性缺血性卒中的治疗进行持续研究。 | William J. Powers Alejandro A. Rabinstein Teri Ackerson Opeolu M. Adeoye Nicholas C. Bambakidis Kyra Becker José Biller Michael Brown Bart M. Demaerschalk Brian Hoh Edward C. Jauch Chelsea S. Kidwell Thabele M. Leslie-Mazwi Bruce Ovbiagele Phillip A. Scott Kevin N. Sheth Andrew M. Southerland Deborah V. Summers David L. Tirschwell 徐加平 刘慧慧 张霞 石际俊 黄志超 尤寿江 郭志良 肖国栋 杜万良 曹勇军 | 2018 | 国际脑血管病杂志2018，26，2： | 19 |
| 7 | 全球土地利用与土地覆被变化:进行综合研究显示文摘人类活动正以空前的速度、幅度和空间规模改变着陆地环境。人类对土地的利用所引起土地覆被变化是全球环境变化的主要原因和重要组成部分。目前不仅有关土地利用和土地覆被变化的全球性数据比较缺乏,而且我们还需要更为深入地了解造成这些变化的基本驱动力。虽然到目前已经提出了多种具有显著作用的驱动力,但对土地改变的单因素解释已证明是不够的。人类引起变化的原因是如何相互作用,在什么环境下某个因素的作用是重要的,这些都是需要系统研究的问题。当前正通过一些密切相关的研究重点而制定一项阐明这些问题的国际性跨学科规划。根据环境的一般状态、人类驱动力和土地覆被动态,将世界划分成几部分,然后对每部分的状态下发生的各种作用过程进行仔细研究。其成果将成为共同努力开发的全球土地模型的基础,该土地模型能对土地改变模式做出预测。 | B.L.TurnerⅡ William B.Meyer David L.Skole 陈百明 | 1994 | 人类环境杂志1994，23，1： | 18 |
| 8 | The Ozone Component of Global Change:Potential Effects on Agricultural and Horticultural Plant Yield,Product Quality and Interactions with Invasive Species显示文摘The productivity,product quality and competitive ability of important agricultural and horticultural plants in many regions of the world may be adversely affected by current and anticipated concentrations of ground-level ozone(O3).Exposure to elevated O3 typically results in suppressed photosynthesis,accelerated senescence,decreased growth and lower yields.Various approaches used to evaluate O3 effects generally concur that current yield losses range from 5% to 15% among sensitive plants.There is,how-ever,considerable genetic variability in plant responses to O3.To illustrate this,we show that ambient O3 concentrations in the eastern United States cause substantially different levels of damage to otherwise similar snap bean cultivars.Largely undesirable effects of O3 can also occur in seed and fruit chemistry as well as in forage nutritive value,with consequences for animal production.Ozone may alter herbicide efficacy and foster estab-lishment of some invasive species.We conclude that current and projected levels of O3 in many regions worldwide are toxic to sensitive plants of agricultural and horticultural significance.Plant breeding that incorporates O3 sensitivity into selection strategies will be increasingly necessary to achieve sustainable production with changing atmospheric composition,while reductions in O3 precursor emissions will likely benefit world food pro-duction and reduce atmospheric concentrations of an important greenhouse gas. | Fitzgerald Booker Russell Muntifering Margaret McGrath Kent Burkey Dennis Decoteau Edwin Fiscus William Manning Sagar Krupa Arthur Chappelka David Grantz | 2009 | Journal of Integrative Plant Biology2009，51，4： | 18 |
| 9 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 10 | 连栽杉木(Cunninghamia lancelata(Lamb) Hook)林中树桩分解过程中的化学组分变化趋势显示文摘采用以空间代替时间的方法,对连栽杉木(Cunninghamialancelata(Lamb)Hook)人工林中采伐剩余树桩的分解过程进行了研究.根据Olson的分解模型,计算出连栽杉木纯林中树桩的分解速率为0.02695,树桩在分解过程中的前2年是一个氮素增加积累过程,当杉木树桩的C/N在463.2±27.3时开始净氮释放.树桩磷含量的变化与氮变化模式相类似,但钾的表现不同,钾的含量在树桩分解过程中一直是单调降低.利用固体高分辨核磁共振技术结合魔角旋转(MAS)和交叉极化(CP)技术,研究了杉木树桩的腐殖化过程及碳结构的变化.树桩中由纤维素和半纤维素组成的多糖碳和乙缩醛被首先分解,而由蜡质和表皮素等化合物组成的烷基碳,由酚类、木质素、单宁和石蜡等化合物组成的芳香族碳,及由酯、有机酸、酮和醛等化合物组成的羧基碳的分解速度较多糖碳和乙缩醛慢. | 黄志群 徐志红 Sue Boyd David Williams | 2005 | 科学通报2005，50，21： | 15 |
| 11 | Anterior knee pain following primary total knee arthroplasty显示文摘Despite improvements in technique and technology for total knee arthroplasty(TKA),anterior knee pain impacts patient outcomes and satisfaction.Addressing the prosthetic and surgical technique related causes of pain after TKA,specifically as it relates to anterior knee pain,can aid surgeons in addressing these issues with their patients.Design features of the femoral and patellar components which have been reported as pain generators include: Improper femoral as well as patellar component sizing or designs that result in patellofemoral stuffing; a shortened trochlear groove distance from the flange to the intercondylar box; and then surgical technique related issues resulting in: Lateral patellar facet syndrome; overstuffed patella/flange combination; asymmetric patellar resurfacing,improper transverse plane component rotation resulting in patellar subluxation/tilt.Any design consideration that allows impingement of extensor mechanism anatomical elements has the possibility of impacting outcome by becoming a pain generator.As the number of TKA procedures continues to increase,it is increasingly critical to develop improved,evidence based prostheses that maximize function and patient satisfaction while minimizing pain and other complications. | David Shervin Katelyn Pratt Travis Healey Samantha Nguyen William M Mihalko Mouhanad M El-Othmani Khaled J Saleh | 2015 | World Journal of Orthopedics2015，6，10： | 15 |
| 12 | Factors associated with time to laparoscopic cholecystectomy for acute cholecystitis显示文摘AIM: To determine patient and process of care factors associated with performance of timely laparoscopic cholecystectomy for acute cholecystitis. METHODS: A retrospective medical record review of 88 consecutive patients with acute cholecystitis was conducted. Data collected included demographic data, co-morbidities, symptoms and physical findings at presentation, laboratory and radiological investigations, length of stay, complications, and admission service (medical or surgical). Patients not undergoing cholecystectomy during this hospitalization were excluded from analysis. Hierarchical generalized linear models were constructed to assess the association of pre-operative diagnostic procedures, presenting signs, and admitting service with time to surgery.RESULTS: Seventy cases met inclusion and exclusion criteria, among which 12 were admitted to the medical service and 58 to the surgical service. Mean ± SD time to surgery was 39.3 ± 43 h, with 87% of operations performed within 72 h of hospital arrival. In the adjusted models, longer time to surgery was associated with number of diagnostic studies and endoscopic retrograde cholangio-pancreatography (ERCP, P = 0.01) as well with admission to medical service without adjustment for ERCP (P < 0.05). Patients undergoing both magnetic resonance cholangiopancreatography (MRCP) and computed tomography (CT) scans experienced the longest waits for surgery. Patients admitted to the surgical versus medical service underwent surgery earlier (30.4 ± 34.9 vs 82.7 ± 55.1 h, P < 0.01), had less post-operative complications (12% vs 58%, P < 0.01), and shorter length of stay (4.3 ± 3.4 vs 8.1 ± 5.2 d, P < 0.01).CONCLUSION: Admission to the medical service and performance of numerous diagnostic procedures, ERCP, or MRCP combined with CT scan were associated with longer time to surgery. Expeditious performance of ERCP and MRCP and admission of medically stable patients with suspected cholecystitis to the surgical service to speed up time to surgery should be considered. | Chris N Daniak David Peretz Jonathan M Fine Yun Wang Alan K Meinke William B Hale | 2008 | World Journal of Gastroenterology2008，14，7： | 13 |
| 13 | 国际糖尿病足工作组:糖尿病足溃疡分类指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘国际糖尿病足工作组(IWGDF)自1999年以来一直以循证为基础发布糖尿病足病的预防和管理指南。本文中针对日常临床工作中糖尿病足溃疡的分类提出了新指南,并对既有的分类进行了综述。新指南只对现患糖尿病足溃疡进行分类,不包括用于定义未来溃疡风险的分类系统。本指南的制定是基于对现有文献的综述以及专家对最大程度影响临床结局的8个关键因素的鉴定。分类级别是根据关键因素的数量、内部和外部有效性验证以及使用意向而制定的。判定分类评分的关键因素有3种:患者相关的因素(终末期肾衰竭)、肢体相关的因素(周围动脉病变和保护性感觉丧失)和溃疡相关的因素(面积、深度、部位、单发或多发以及感染)。特殊分类系统要考虑以下5种临床情况:①卫生专业人员之间交流;②预测单个溃疡预后;③对个案临床决策的辅助;④伤口评估,有感染或无感染及周围动脉病变(评估灌注及血管重建的潜在益处);⑤用于地方、区域或国家人群结局的稽查。指南推荐:①医务人员之间交流使用SINBAD系统。②无适用于预测个体溃疡预后的分类。③感染的评估采用美国传染病学会/国际糖尿病足工作组(IDSA/IWGDF)分类系统。④评估灌注及血管重建的潜在获益使用创面、缺血、足感染(WIfI)系统。⑤人群结局的稽查使用SINBAD系统。 | Matilde Monteiro-Soares David Russell Edward J Boyko William Jeffcoate Joseph L Mills Stephan Morbach Fran Game 无 王爱红(译) 冉兴无(审校) | 2019 | 感染.炎症.修复2019，20，4： | 10 |
| 14 | The Subcellular Localization and Blue-Light- Induced Movement of Phototropin 1-GFP in Etiolated Seedlings of Arabidopsis thalianaw显示文摘Phototropin 1 (phot1 ) 是为向光性,叶绿体运动,有气孔的洞,叶扩大,并且响应蓝光的太阳的追踪的一个光敏电阻器。有 PHOT1::GFP 的后面的更早的工作(Sakamoto 和布里格斯, 2002 ) ,我们调查了模式细胞并且在 34 d 的 phot1 的 subcellular 本地化 Arabidopsis thalinana 的旧变白的幼苗。是从本国的在上游的序列表示了, PHOT1::GFP 熔化蛋白质在子叶的离开轴心的纸巾并且在胚轴的伸长的区域强烈被表示。它中等在根顶附近在射击 / 根转变地区并且在房间被表示。一个荧光信号在根外皮,根帽子,和根是无法发现的顶端的分裂组织本身。子叶边缘附近的叶肉房间的血浆膜显得一致地标记但是跨墙由最近的房间部门创造了更强烈被标记。单个房间类型标记的模式与房间类型和发展舞台变化。蓝光的处理原因 PHOT1::GFP,均匀地相对开始在血浆膜散布了,与强烈标记的有小斑点的区域和完全缺乏在胚轴延伸区域在外皮的房间观察的 fluorescencea 现象最好的另外的区域重新组织变得进不同马赛克。伴随物与或追随者这个重组,进在所有房间类型的细胞质的 PHOT1::GFP 行动除了警卫房间调查了。它在黑暗在几个小时以后由未辩别出的机制从细胞质消失。它在细胞质的外观也不它在黑暗的最终的消失被翻译禁止者酮环己酰亚胺也不阻止,尽管后者过程被延迟。我们假设那 blue-light-induced phot1 重新本地化调制 blue-light-activated 信号 transduction。 | Ying-Lang Wan William Eisinger David Ehrhardt Ulrich Kubitscheck Frantisek Baluska Winslow Briggs | 2008 | Molecular Plant2008，1，1： | 10 |
| 15 | 利用稳定性同位素区分河岸C4草地生态系统夜晚碳通量显示文摘河岸生态系统在全球碳循环过程中起着重要作用。涡度相关技术虽然能够被用来测量整个生态系统的净碳通量,但是,把净碳通量区分为组分通量的贡献将显著提高人们对生态系统碳循环的理解。稳定性同位素技术能够把净碳通量区分为具有不同同位素特征的组分通量。实验结果表明,因为考虑了同位素及CO2在取样和分析过程中的不确定性,与传统的Ordinary Least Square法相比,Bayesian法所获得的生态系统夜间呼吸释放CO2的同位素值(δ13CR)显著减小了标准误差。δ13CR具有明显的季节变化,并且受土壤含水量和大气水汽压亏缺(VPD)的影响。δ13CR与土壤含水量之间存在着正相关关系,而与VPD之间存在着负相关关系。2006年和2007年生长季,以及2005年旱季,土壤呼吸对夜晚河岸C4草地生态系统呼吸的贡献约为80%。2005年雨季,土壤呼吸只占河岸C4草地生态系统呼吸的40%左右。年际间土壤呼吸的贡献率的变化很有可能是2006年的水淹造成的。因为,通过沉降作用,水淹可以为C4草地生态系统提供额外的可供微生物分解的有机质。 | 孙伟 David Williams | 2008 | 湿地科学2008，6，2： | 9 |
| 16 | Microtubules Are Essential for Guard-Cell Function in Vicia and Arabidopsis显示文摘放射状地安排的外皮的微导管是警卫房间的一个突出的特征。表示 GFP 导管素的警卫房间在微导管的外观看了一致变化 stomata 什么时候开了或关门。当 stomata 关门了,警卫房间显示出更少微导管结构,是否由转移导致了到黑暗,骆驼毛的织物,氢过氧化物,或钠氢碳酸盐。警卫房间不知(关上的 stomata ) 在轻处理上在微导管结构和有气孔的孔显示出增加。GFP-EB1,标记加结束成长的微导管,没在有气孔的闭合上在汇编的正结束或速度的数字显示出变化。因为当微导管结构数字衰退了时,加结束和正结束的生长的率成长的数字没变化,微导管不稳定性或重新整理一定为微导管的明显的损失负责。当外皮的微导管变得拆卸,有关上的 stomata 的警卫房间与开的 stomata 比那些显示出更多的 cytosolic GFP 荧光,尽管与在全部的荧光的大网损失。指向微导管的药在 Vicia 和 Arabidopsis 堵住了警卫房间功能。Oryzalin 破坏了警卫房间微导管并且阻止了有气孔的开和 taxol 稳定的警卫房间微导管和推迟的有气孔的闭合。煤气的交换大小显示为荧光灯标签的蛋白质的 transgenes 没破坏正常有气孔的功能。在微导管与我们的禁止者研究相结合的警卫房间的这些动态变化在警卫房间功能为微导管的一个活跃角色提供证据。 | William Eisinger David Ehrhardt Winslow Briggs | 2012 | Molecular Plant2012，5，3： | 9 |
| 17 | Macrophage inhibitory cytokine-1/growth differentiation factor-15 in premalignant and neoplastic tumours in a high-risk pancreatic cancer cohort显示文摘BACKGROUND Pancreatic cancer(PC)is a leading cause of cancer related mortality worldwide,with poor survival due to late diagnosis.Currently,biomarkers have limited use in early diagnosis of PC.Macrophage inhibitory cytokine-1 or growth differentiation factor-15(MIC-1/GDF15)has been implicated as a potential serum biomarker in PC and other malignancies.AIM To determine the role of MIC-1/GDF15 in detecting pre-malignant pancreatic lesions and neoplastic tumours in an asymptomatic high-risk cohort part of Australian Pancreatic Cancer Screening Program.METHODS A feasibility prospective single centre cohort study was performed.Participants recruited for yearly surveillance with endoscopic ultrasound(EUS)had serial fasting blood samples collected before EUS for MIC-1/GDF15,C-reactive protein and carbohydrate antigen 19-9.Patients were stratified into five groups based on EUS findings:Normal;pancreatic cysts,branch-duct intraductal papillary mucinous neoplasm;diffuse non-specific abnormalities;and neoplastic tumours.MIC-1/GDF15 serum levels were quantified using ELISA.Participants in whom EUS demonstrated abnormalities but not malignancy were closely followed up with magnetic resonance imaging(MRI)or computed tomography.RESULTS One hundred twenty participants were prospectively recruited from 2011-2018.Forty-seven participants(39.2%)had an abnormal EUS and five participants(4.2%)were diagnosed with neoplastic tumours,three by EUS(two pancreatic and one liver)and two by MRI/computed tomography(breast cancer,bladder cancer),which were performed for follow up of abnormal EUS.Baseline serum MIC-1/GDF15 was a significant predictor of neoplastic tumours on receiver operator characteristic curve analysis[area under curve(AUC)=0.814,P=0.023].Baseline serum MIC-1/GDF15 had moderate predictive capacity for branch-duct intraductal papillary mucinous neoplasm(AUC=0.644)and neoplastic tumours noted on EUS(AUC=0.793),however this was not significant(P=0.188 and 0.081 respectively).Serial serum MIC-1/GDF15 did not demonstrate a significant percentage change between a normal and abnormal EUS(P=0.213).Median baseline MIC-1/GDF15 was greater in those with neoplastic tumours(Median=1039.6,interquartile range=727.0-1977.7)compared to those diagnosed with a benign lesion(Median=570.1,interquartile range=460.7-865.2)on EUS and MRI(P=0.012).CONCLUSION In this pilot study MIC-1/GDF15 has predictive capacity for neoplastic tumours in asymptomatic individuals with a genetic predisposition for PC.Further imagining may be warranted in patients with abnormal EUS and raised serum MIC-1/GDF15.Larger multicentric prospective studies are required to further define the role of MIC-1/GDF15 as a serological biomarker in pre-malignant pancreatic lesions and neoplastic tumours. | Robert Sean O’Neill Sam Emmanuel David Williams Alina Stoita | 2020 | World Journal of Gastroenterology2020，26，14： | 8 |
| 18 | History and Progress of the North American Soil Geochemical Landscapes Project,2001-2010显示文摘In 2007,the U.S.Geological Survey,the Geological Survey of Canada,and the Mexican Geological Survey initiated a low-density(1 site per 1600 km2,13323 sites) geochemical and mineralogical survey of North American soils(North American Soil Geochemical Landscapes Project).Sampling and analytical protocols were developed at a series of workshops in 2003-2004 and pilot studies were conducted from 2004-2007.The ideal sampling protocol at each site includes a sample from 0-5 cm depth,a composite of the soil A horizon,and a sample from the soil C horizon.The <2-mm fraction of each sample is analyzed for Al,Ca,Fe,K,Mg,Na,S,Ti,Ag,Ba,Be,Bi,Cd,Ce,Co,Cr,Cs,Cu,Ga,In,La,Li,Mn,Mo,Nb,Ni,P,Pb,Rb,Sb,Sc,Sn,Sr,Te,Th,Tl,U,V,W,Y,and Zn by inductively coupled plasma-mass spectrometry and inductively coupled plasma-atomic emission spectrometry following a near-total digestion in a mixture of HCl,HNO3,HClO4,and HF.Separate methods are used for As,Hg,Se,and total C on this same size fraction.The major mineralogical components are determined by a quantitative X-ray diffraction method.Sampling in the conterminous U.S.was completed in 2010(c.4800 sites) with chemical and mineralogical analysis currently underway.In Mexico,approximately 66% of the sampling(871 sites) had been done by the end of 2010 with completion expected in 2012.After completing sampling in the Maritime provinces and portions of other provinces(472 sites,7.6% of the total),Canada withdrew from the project in 2010.Preliminary results for a swath from the central U.S.to Florida clearly show the effects of soil parent material and climate on the chemical and mineralogical composition of soils.A sample archive will be established and made available for future investigations. | David B.Smith William F.Cannon Laurel G.Woodruff Francisco Moreira Rivera Andrew N.Rencz Robert G.Garrett | 2012 | 地学前缘2012，19，3： | 7 |
| 19 | 水力压裂监测新方法显示文摘深入了解水力压裂裂缝的几何形态和延伸情况有助于改善低渗油气藏压裂增产作业效果,改善油气井产能并提高油气采收率。应用地震方法对水力压裂裂缝进行监测和描述已经有多年了,而新的地震硬件和处理技术的出现使得这类监测更加有效、可靠。 | Les Bennett Joeol Le Calvez David R. ( Rich ) Sarver Kevin Tanner W.S.(Scott)Birk George Waters Julian Drew Gw e nola Michaud Paolo Primiero Leo Eisner Rob Jones David Leslie Michael John Williams Jim Govenlock Richard C. ( Rick ) Klein Kazuhiko Tezuka | 2007 | 国外测井技术2007，22，4： | 7 |
| 20 | 利用Cryo-SEM和图像处理技术评价老化和再生沥青低温抗裂性的新方法显示文摘高掺量RAP沥青混合料的低温抗裂性是一个受到关注的问题,以前的研究中常使用各种再生剂使温度裂缝的数量达到最小。该文采用傅里叶变换红外光谱测定沥青的氧化程度。为了评价老化沥青和再生沥青的低温抗裂性,首先采用低温扫描电镜(CryoSEM)获取断裂表面的图像,然后使用图像处理技术分析Cryo-SEM图像,结合再生沥青产生的断裂面比老化沥青少。最后根据断裂指数对每种沥青的低温抗裂性进行排序。采用Cryo-SEM技术结合图像处理技术可以更加形象地观察沥青断裂表面,而且可以通过计算断裂指数来评价沥青的低温抗裂性。 | 冯新军 陈旺 Ali Mokhtari Hosin David Lee R.Christopher Williams | 2018 | 中外公路2018，38，5： | 7 |
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