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| 1 | 参与式渭南地震情景构建:中国地震风险对策的行动研究示范显示文摘中国政府层面自上而下的防震减灾管理卓有成效;但是,对于提升全社会的整体防震减灾能力而言,尚需推动基于此而又有民众与基层自下而上广泛参与的全社会治理模式。为发展这种模式积累经验,渭南市地震情景构建示范项目借助参与式行动研究范式,特别关注了中国防震减灾工作当前存在的以下2点广泛不足:一是社会民众与基层的自下而上办法薄弱,且与政府层面自上而下对策之间的相互衔接与促进不足;二是科学研究向实际减灾对策的转化不足,特别是针对自下而上办法的科学研究与应用转化不足。取得的主要进展有:1)基于广泛参与理念,通过'研究者'和'减灾实践者'、'相关者'、'当事人'2方面人员间的密切合作,共同诊断评估了渭南面临的主要地震灾害风险及隐患、共同提炼了针对性的减灾对策改进建议等,从而使情景构建所得的结果或认识更加可靠、所提对策建议更加符合当地实际需要;借助行动研究过程平台,尝试了风险评估、风险沟通和风险对策改进3大环节的无缝衔接与同步互动,促进了科学研究与实际应用的直接对接与就地转化。2)基于多尺度、多层面视角和同时为'政府'或'部门'与'基层'或'民众'两大类用户服务。在关注改进自上而下对策的同时,针对薄弱的自下而上办法,特别是就这两大对策途径间最广泛与最可持续的接口——宣传教育和家庭、学校、社区减灾,开展了大规模的专项调查分析,梳理了系列化的现今本底与改进方向。3)聚焦改善减灾宣教和促进风险沟通,编创了由'故事'引导的2版内容与形式均有显著差别的地震情景叙事读本:政府版和公众版,以期借助'故事'和艺术呈现'故事'带动人们更好地理解与应用情景构建结果和认识,借助'故事'演绎社会性灾害脆弱成分——'留守儿童家庭与贫困'之于灾害的强化与叠加效应,促进人们对地震灾害风险更加全面与深入的认识;在理性刻板科学中融入感性与人文艺术情怀,以引导共识与共鸣、改善减灾态度、培养减灾价值观,进而激发减灾行动和减灾参与意愿,特别是激励人们就相关问题进行长期思考和持续行动改善。以上3方面进展,从总体上实现了对中国防震减灾工作存在的前述2点广泛不足的有益研讨与部分弥补推动尝试。参与式渭南地震情景构建行动研究示范,对国内相关工作具有抛砖引玉的作用,也为国际同类工作积累了中国经验。 | 苏桂武 Janise Rodgers 田青 齐文华 Philip England Timothy Sim John Young 王东明 李志强 冯希杰 孙磊 陈鲲 Emily So Barry Parsons 赵金礼 石建梁 袁志祥 Yue Cao 周旗 魏本勇 David Milledge Alexander Densmore | 2020 | 地震地质2020，42，6： | 6 |
| 2 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 3 | Cisplatin ototoxicity involves cytokines and STAT6 signaling network显示文摘我们此处调查了在支持 inflammatory cytokines 和 cisplatin ototoxicity 的生产表明串联的 STAT 的角色。cisplatin 注射引起的一个重要听觉缺陷在 Balb/c 被观察(野类型, WT ) 并且 STAT4 −/−, 然而并非在 STAT6 −/− 老鼠。而且,蛋白质的表示层次和支持 inflammatory cytokines 的 mRNA,包括 TNF-α, IL-1β,并且 IL-6,显著地在 WT 和 STAT4 −/−, 然而并非 STAT6 −/− 老鼠的浆液和蜗被增加。Organotypic 文化表明 stereocilia 捆的形状和在从 STAT6 −/− 鼠标的 Corti 的机关的感觉毛细胞层的数组在有 cisplatin 的处理以后是未经触动的,而那些高度在处理以后从 WT 和 STAT4 −/− 鼠标被弄歪并且弄乱。Cisplatin 在 HEI-OC1 听觉的房间导致了 STAT6 的 phosphorylation,并且由显著地保护的 STAT6 特定的 siRNA 的 STAT6 击倒从导致 cisplatin 的房间死亡的 HEI-OC1 听觉的房间和禁止的支持 inflammatory cytokine 生产。我们进一步证明 cisplatin 导致的 IL-4 和 IL-13 与 IL-4 受体 alpha 和 IL-13Rα 由绑定调制了 STAT6 的 phosphorylation; 1。这些调查结果建议发信号的 STAT6 在调停 cisplatin 的支持 inflammatory cytokine 生产和 ototoxicity 起一个枢轴的作用。 | Hyung-Jin Kim Gi-Su Oh Jeong-Han Lee Ah-Ra Lyu Hye-Min Ji Sang-Heon Lee Jeho Song Sung-Joo Park Yong-Ouk You Jeong-Dug Sul Channy Park Sang-Young Chung Sung-Kyun Moon David J Lim Hong-Seob So Raekil Park | 2011 | Cell Research2011，21，6： | 2 |
| 4 | Anovel experimental design for comparative two dimensional gel analysis: Two-Dimensional diference gel electrophoresis incorporating a pooled internal standard显示文摘 | Alban A David SO Bjordenten L | 2003 | Proteomics2003，3，1： | 1 |
| 5 | Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8显示文摘 | John So Jason Navari Feng-Qiang Wang David A. Fishman | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 6 | Early Experience With Laparoscopic Radical Gastrectomy for Advanced Gastric Cancer显示文摘 | Peter M. Y. Goh Ameer Z. Khan Jimmy B. Y. So David Lomanto Wei-Keat Cheah Rajah Muthiah Anil Gandhi | 2001 | Surgical Laparoscopy, Endoscopy & Percutaneous Te2001，，2： | 1 |
| 7 | A real-time smart sensor for high-resolution frequency estimation in power systems 显示文摘 | GRANADOS-LIEBERMAN David ROMERO-TRONCO- SO Rene J | 2009 | Sensors2009，9，9： | 1 |
| 8 | Cloning and characterization of the 3′‐untranslated region of the human excitatory amino acid transporter 2 transcript显示文摘 | Seon‐YoungKim WeiChao So‐YoungChoi David J.Volsky | 2003 | Journal of Neurochemistry2003，，6： | 1 |
| 9 | A novel experimental design for comparative two-dimensional gel analysis:two-dimensional difference gel electrophoresis incorporating a pooled internal standard 显示文摘 | Alban A David SO Bjordesten L | 2003 | Proteomics2003，3，： | 1 |
| 10 | Human cholecystokinin-A receptor is not an oncofetal protein 显示文摘 | David WS Msc MD Chi SO | 2000 | Dig Dis Sci2000，45，3： | 1 |
| 11 | Endoscopic submucosal dissection of gastric lesions by using a Master and Slave Transluminal Endoscopic Robot (MASTER)显示文摘 | Khek-Yu Ho Soo Jay Phee Asim Shabbir Soon Chiang Low Van An Huynh Andy Prima Kencana Kai Yang Davide Lomanto Bok Yan Jimmy So Y.Y. Jennie Wong S.C. Sydney Chung | 2010 | Gastrointestinal Endoscopy2010，，3： | 1 |
| 12 | A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard显示文摘 | David SO Bjorkesten L | 2003 | Proteomics2003，3，1： | 1 |
| 13 | A novel experimental design for comparative two-dimensional gel analysis:two dimensional difference gel electrophoresis incorporating a pooled internal standard 显示文摘 | Alban A David SO Bjorkesten L | 2003 | Proteomics2003，3，1： | 1 |
| 14 | LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2)显示文摘 | John So Feng-qiang Wang Jason Navari Jeremy Schreher David A. Fishman | 2005 | Gynecologic Oncology2005，，3： | 1 |
| 15 | E-Cadherin/ β -Catenin Complex and the Epithelial Barrier显示文摘 | Xinrui Tian Zhuola Liu Bo Niu Jianlin Zhang Thian Kui Tan So Ra Lee Ye Zhao David C. H. Harris Guoping Zheng Sanford I. Bernstein | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 16 | A Current-Compa- rator-Based System For Calibrating High-Voltage Current Transformers Under Actual Operating Conditions 显示文摘 | Eddy So Rejean Arseneau David Bennett | 2011 | IEEE Transactions On Instru- mentation and Measurement2011，60，7： | 1 |
| 17 | A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard显示文摘 | Alban A David SO Bjorkesten L | 2003 | Proteomics2003，3，1： | 1 |
| 18 | A novel experimental de sign for comparative two-dimensional gel analysis: two-dimen sional difference gel electrophoresis incorporating a pooled inter nal standard显示文摘 | Alban A David SO Bjorkesten L | 2003 | Proteomics2003，3，1： | 1 |
| 19 | Topographyguided eustomized laser-assisted subepithelial keratectomy for the treatment of postkeratoplasty astigmatism显示文摘 | Madhavan S R David P SO'Brart Parul Patel | 2006 | Journal of Cataract & Refractive Surgery2006，32，6： | 1 |
| 20 | A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electro-phoresis incorporating a pooled internal standard显示文摘 | Alban A David SO Bjorkesten L | 2003 | Proteomics2003，3，： | 1 |
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