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| 1 | What Security Questions Do Developers Ask? A Large-Scale Study of Stack Overflow Posts显示文摘安全总是是一个流行、批评的话题。与信息技术的快速的发展,它总是正在吸引民族注意。然而,自从安全有长历史,它论及改变很多的大量话题,从经典密码学到最近流行活动安全。有需要调查安全相关的话题和趋势,它能是为安全研究人员,安全教育者和安全专业人员的一个指南。到地址上述在这篇论文,我们需要在栈溢出上在安全相关的问题上进行大规模研究。栈溢出是一个流行联机问题和答案地点让软件开发者传达,协作,并且分享与对方一起的信息。在在栈溢出上张贴的众多的问题之中有许多不同话题,安全相关的问题占据一个大比例并且有一个重要、重要的位置。我们首先使用二条启发规则从数据集提取基于帖子的标签与安全有关的问题。然后我们使用一个先进话题模型,潜伏的 Dirichlet 分配(LDA ) 调节了使用基因算法(GA ) ,基于他们的文章聚类不同安全相关的问题。在获得安全相关的问题的不同话题以后,我们使用他们的元数据做各种各样的分析。我们总结所有话题进五个主要范畴,并且也调查不同话题的流行和困难。基于我们的学习的结果,我们为研究人员,教育者和专业人员结束几个含意。 | Xin-Li Yang David Lo Xin Xia Zhi-Yuan Wan Jian-Ling Sun | 2016 | Journal of Computer Science & Technology2016，31，5： | 8 |
| 2 | 卒中治疗专业学术圆桌会议临床前推荐更新版显示文摘首份卒中治疗专业学术圆桌会议(Stroke Yherapy Academic Industry Roundtable,STAIR)推荐于1999年出版,旨在提高潜在的急性卒中治疗方法的临床前研究质量。虽然这些推荐意见被认为是合理的,但并未得到严格的遵循和验证。为了更好地向临床转化,有关候选急性卒中疗法的临床前试验的质量和广度已取得实质性进展。更新后的STAIR临床前推荐进一步强调了最初提出的建议,即通过适当的生理学监测在多种动物物种中采用组织学和功能结局来确定可重复的剂量反应和时间窗。更新后的STAIR推荐意见包括:高质量科学研究的基本原则应消除随机和评价偏倚,预先确定纳入和排除标准,计算合适的效能和样本量,并公开潜在的利益冲突。应在年轻的健康雄性动物中进行初步评价之后,在雌性、高龄动物和伴有合并症(如高血压、糖尿病和高胆固醇血症)的动物中做进一步研究。此外还要在动物实验中应用临床相关生物学标志物。尽管只有通过临床试验产生基于此的有效疗法之后才能证实该推荐意见的有效性,但遵循这些推荐有望提高成功的机会。 | Marc Fisher Giora Feuerstein David W. Howells Patricia D. Hum Thomas A. Kent Sean I. Savitz Eng H. Lo 吕志宿(译) 罗本燕(译) | 2009 | 国际脑血管病杂志2009，17，8： | 5 |
| 3 | Multi-Factor Duplicate Question Detection in Stack Overflow显示文摘栈溢出是一个流行联机问题和答案地点让软件开发者分享他们的经验和专家知识。在在栈溢出张贴的众多的问题之中,二或更多可以他们表示一样的点并且因此是副本互相。副本问题更努力使栈溢出成为地点维护,浪费能被用来回答另外的问题的资源,并且引起开发者不必要地等已经是可得到的答案。到副本的问题询问的还原剂,栈溢出允许问题作为其它的副本手工地显著。因为有几千个问题,提交每天叠溢出,手工地识别副本问题是一个困难的工作。因此,对能在检测这些副本问题帮助的一条自动化途径有需要。到地址上述在这份报纸,我们需要建议一条自动化途径说出作为输入拿一个新问题并且由考虑多重因素检测这个问题的潜在的副本的 DupPredictor。DupPredictor 提取标题,对一个问题并且也的描述标注那被纳入这个问题。当张贴一个问题时,这些个信息(标题,描述,和一些标签) 是一个用户需要到输入的强制信息。DupPredictor 然后由使用一个话题模型计算每个问题的潜伏的话题。为每个问题,下次,它由比较他们的标题,描述,潜伏的话题,和标签计算四个类似分数。这四个类似分数最后一起被联合导致包括地考虑多重因素的一个新类似分数。检验 DupPredictor 的利益,我们在包含超过 200 万个问题的一个总数的栈溢出数据集上执行一个实验。结果证明 DupPredictor 能完成 63.8% 的一个 recall-rate@20 分数。我们把我们的途径与栈溢出,和 DupPredictor 的标准搜索引擎作比较在 40.63% 改进它的 recall-rate@10 分数。我们也把我们的途径与仅仅使用标题,描述,话题,和标签类似的途径和被用来检测副本错误报告,和 DupPredictor 的 Runeson et al.s 途径作比较分别地在 27.2% , 97.4% , 746.0% , 231.1% ,和 16.4% 改进他们的 recall-rate@10 分数。 | 张芸 David Lo 夏鑫 孙建伶 | 2015 | Journal of Computer Science & Technology2015，30，5： | 5 |
| 4 | High-Impact Bug Report Identification with Imbalanced Learning Strategies显示文摘在实践,一些错误比其它有更多的影响并且因此值得更立即的注意。由于紧密的时间表和有限人的资源,开发者们不能有足够的时间检查所有错误。因此,他们经常专注于高度有力的错误。在文学,有感染力的错误被用来指在意外时间或地点出现并且带更意外的效果的错误(即,吃惊错误) ,或打破先存在的功能并且破坏用户经验(即,破裂错误) 。不幸地,在追踪系统的一个错误从几千份错误报告识别有感染力的错误不是容易的功绩。因此,能识别有感染力的错误报告的一种自动化技术能帮助开发者早知道他们,快速修正他们,并且最小化他们引起的损坏。就那而言,仅仅错误的一个小比例是有感染力的错误,有感染力的错误报告的鉴定是一项困难的任务。在这份报纸,我们建议一条途径由利用学习策略的 imbalanced 识别有感染力的错误报告。我们调查各种各样的变体,其各个联合学习策略和一个特别分类算法的一特别 imbalanced 的有效性。特别地,我们为处理 imbalanced 数据和四个最先进的文本分类算法从四个不同开放源代码工程在四数据集上进行实验选四为广泛地使用的策略。我们主要在有感染力的错误的二种类型上执行分析研究,即,吃惊错误和破裂错误。结果证明不同变体有不同表演,并且最好表现的变体重击(合成少数在采样上技术)为吃惊错误鉴定和 RUS (随机的在采样下面)的+ KNN (K近邻居)为破裂错误鉴定的+ NB (天真的 Bayes )由 Thung 等超过二条最先进的途径的F1分数。并且加西亚和 Shihab。 | Xin-Li Yang David Lo Xin Xia Qiao Huang Jian-Ling Sun | 2017 | Journal of Computer Science & Technology2017，32，1： | 4 |
| 5 | Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo显示文摘 | Heather E. Fleming Viktor Janzen Cristina Lo Celso Jun Guo Kathleen M. Leahy Henry M. Kronenberg David T. Scadden | 2008 | Cell Stem Cell2008，，3： | 2 |
| 6 | TagCombine: Recommending Tags to Contents in Software Information Sites显示文摘现在,软件工程师使用许多联机媒介寻找并且变得通知了新、有趣的技术,并且学习从并且互相帮助。我们指帮助软件工程师作为软件信息地点在软件开发,维护,和测试进程改进他们的性能的这些种联机媒介。在这份报纸,我们建议 TagCombine,在软件信息地点分析目标的一个自动标签建议方法。TagCombine 有三个不同部件:1 ) 把标签建议看作一个多标签的多标签评价部件学习问题;2 ) 从类似的目标推荐标签的基于类似的评价部件;3 ) 标签术语基于评价考虑在不同术语和标签之间的关系,并且在在目标分析术语以后推荐标签的部件。我们在四个软件信息地点上评估 TagCombine,问不同,问 Ubuntu, Freecode,和栈溢出。越过四个工程的 On averaging, TagCombine 完成 recall@5 和 recall@10 到 0.619 8 和 0.762 5 分别地,它改进 Al-Kofahi 等建议的 TagRec。在 14.56% 和 10.55% 分别地,并且标签建议方法由 Zangerle 等求婚了。在 12.08% 和 8.16% 分别地。 | 王新宇 夏鑫 David Lo | 2015 | Journal of Computer Science & Technology2015，30，5： | 2 |
| 7 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 8 | Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog显示文摘 | Michael Rera Sepehr Bahadorani Jaehyoung Cho Christopher L. Koehler Matthew Ulgherait Jae H. Hur William S. Ansari Thomas Lo D. Leanne Jones David W. Walker | 2011 | Cell Metabolism2011，，5： | 2 |
| 9 | LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease显示文摘Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD. | Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 10 | Complications Associated With Double Balloon Enteroscopy at Nine US Centers显示文摘 | Lauren B. Gerson Jeffrey Tokar Michael Chiorean Simon Lo G. Anton Decker David Cave Doumit BouHaidar Daniel Mishkin Charles Dye Oleh Haluszka Jonathan A. Leighton Alvin Zfass Carol Semrad | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 2 |
| 11 | Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses显示文摘His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome. | Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia Sanna Rosengren Andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 12 | On Locating Malicious Code in Piggybacked Android Apps显示文摘为在机器人生态系统检测恶意的包裹设计有效途径和工具,研究人员们逐渐地被要求有恶意软件的深理解。因此有需要提供一个框架因为把的恶意软件和定位恶意的节目在应用软件代码以内碎裂以便造恶意的样品的全面数据集。向探讨这需要,我们在一条基于工具的途径把 HookRanker 称为的这个工作求婚,它基于恶意软件行为代码被触发的路提供潜在地恶意的包裹的评价的表。与 piggybacked 应用软件的一张地面真相的实验,我们能自动地为如此的包裹与 83.6% 的 accuracy@5 从 piggybacked 机器人应用软件定位恶意的包裹那为如此的包裹通过方法祈祷和 82.2% 的 accuracy@5 被触发那独立地被触发。 | Li Li Daoyuan Li Tegawende F. Bissyande Jacques Klein Haipeng Cai David Lo Yves Le Traon | 2017 | Journal of Computer Science & Technology2017，32，6： | 2 |
| 13 | IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo显示文摘 | Madeline M. Fort Jeanne Cheung David Yen Joana Li Sandra M. Zurawski Sylvia Lo Satish Menon Teresa Clifford Brisdell Hunte Robin Lesley Tony Muchamuel Stephen D. Hurst Gerard Zurawski Michael W. Leach Daniel M. Gorman Donna M. Rennick | 2001 | Immunity2001，，6： | 2 |
| 14 | Remote Sensing of Complex Permittivity by Multipole Resonances in RCS显示文摘 | DAVID J BURR YUEN T LO | 1973 | IEEE Transactions on Antennas and Propagation1973，21，4： | 1 |
| 15 | Relation- ship between severity of blackleg (Leptosphaeria macu- lans/L, biglobosa species complex) and subsequent pri- mary inoculum production on oilseed rape stubble 显示文摘 | Lo -Pelzer E Aubertot J N David O | 2009 | Plant Pathology2009，58，1： | 1 |
| 16 | Complications Associated With Double Balloon Enteroscopy at Nine US Centers显示文摘 | Lauren B. Gerson Jeffrey Tokar Michael Chiorean Simon Lo G. Anton Decker David Cave Doumit BouHaidar Daniel Mishkin Charles Dye Oleh Haluszka Jonathan A. Leighton Alvin Zfass Carol Semrad | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 1 |
| 17 | Environment toxins and endometriosis 显示文摘 | Hulusi BZ Aylin A David LO | 1997 | Obstet Gynecol Clin Nor Am1997，24，： | 1 |
| 18 | Numerical study of pleated fabric cartridges during pulse-jet cleaning显示文摘 | Li-Ming Lo Shih-Cheng Hu Da-Ren Chen David Y.H. Pui | 2009 | Powder Technology2009，，1： | 1 |
| 19 | Ursodiol and Colorectal Cancer or Dysplasia Risk in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Meta-Analysis显示文摘 | Jonathan D. Hansen Sonal Kumar Wai-Kit Lo David M. Poulsen Umme-Aiman Halai Kathy C. Tater | 2013 | Digestive Diseases and Sciences2013，，11： | 1 |
| 20 | Treatment of endometriosis显示文摘 | David LO E1izabeth AP | 2001 | N Eng J Med2001，345，4： | 1 |
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